Nobuhiro Koyama, Y. Shibagaki, Mitsuru Okuwaki, S. Hattori, H. Tomoda
{"title":"流感病毒夺帽活性新抑制剂卵孢蛋白的发现","authors":"Nobuhiro Koyama, Y. Shibagaki, Mitsuru Okuwaki, S. Hattori, H. Tomoda","doi":"10.15344/2394-1502/2020/137","DOIUrl":null,"url":null,"abstract":"During our screening of microbial origins, we found that fungal strain BF-0073 produces an inhibitor of the cap-snatching activity of influenza virus. Compound (1) was isolated from the culture broth of fungal strain BF-0073 by solvent extraction and preparative HPLC. Based on structural analyses using MS and NMR, 1 was identified as oosporein. Compound 1 inhibited the cap-snatching activity of influenza virus A in a dose-dependent manner, with an IC50 value of 20.0 μg/mL. Figure 1: Structure of oosporein.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"29 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Discovery of Oosporein as a New Inhibitor of Influenza Virus Cap-snatching Activity\",\"authors\":\"Nobuhiro Koyama, Y. Shibagaki, Mitsuru Okuwaki, S. Hattori, H. Tomoda\",\"doi\":\"10.15344/2394-1502/2020/137\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"During our screening of microbial origins, we found that fungal strain BF-0073 produces an inhibitor of the cap-snatching activity of influenza virus. Compound (1) was isolated from the culture broth of fungal strain BF-0073 by solvent extraction and preparative HPLC. Based on structural analyses using MS and NMR, 1 was identified as oosporein. Compound 1 inhibited the cap-snatching activity of influenza virus A in a dose-dependent manner, with an IC50 value of 20.0 μg/mL. Figure 1: Structure of oosporein.\",\"PeriodicalId\":90866,\"journal\":{\"name\":\"International journal of pharmaceutical sciences and research\",\"volume\":\"29 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of pharmaceutical sciences and research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15344/2394-1502/2020/137\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of pharmaceutical sciences and research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15344/2394-1502/2020/137","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Discovery of Oosporein as a New Inhibitor of Influenza Virus Cap-snatching Activity
During our screening of microbial origins, we found that fungal strain BF-0073 produces an inhibitor of the cap-snatching activity of influenza virus. Compound (1) was isolated from the culture broth of fungal strain BF-0073 by solvent extraction and preparative HPLC. Based on structural analyses using MS and NMR, 1 was identified as oosporein. Compound 1 inhibited the cap-snatching activity of influenza virus A in a dose-dependent manner, with an IC50 value of 20.0 μg/mL. Figure 1: Structure of oosporein.
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