International journal of pharmaceutical sciences and research最新文献

{"title":"COVID-19 pandemic-a fortunate scenario for pharmaceutical scientists","authors":"K. Swapna, Y. Reddy","doi":"10.13040/IJPSR.0975-8232.12(10).5300-07","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(10).5300-07","url":null,"abstract":"Covid-2019: The pandemic that shook the entire world. There is no sarcasm if one says there will be a Pre and Post- COVID-19 world. Worldwide, millions of cases have been identified, and heaps have died. So many nations worldwide have issued a lockdown to stop the coronavirus's unfolding, which triggered giant financial fallout. Like each and every incident has two dimensions, Covid-19 possesses both positive and negative aspects. This unfortunate pandemic's positive aspect has been a fortunate scenario for many sectors, including pharmaceutical scientists all over the world, who are striving their best to discover antibodies that can fight the novel coronavirus. This review article mainly aims to study how this deadly pandemic has become a fortunate scenario for pharmaceutical scientists based on the data gathered (sources: websites, web blogs, reports on the internet study, newspapers, etc.). But there are some positive aspects, such as reducing pollution, reducing traffic accidents, and recognizing the importance of sanitation, hygiene, and social distancing. This pandemic revealed that there is a need to improve healthcare systems and clinical research. The pandemic situation has been a boon to the positive aspects of the pharma industry globally.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79312866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiotherapy against SARS-COV-2: Risk or benefit","authors":"N. Neupane, A. Adhikari, S. Alok, A. Singh, Amita Verma","doi":"10.13040/IJPSR.0975-8232.12(9).4580-87","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(9).4580-87","url":null,"abstract":"The noble coronavirus SARS-CoV-2 results in a devastating, multisystem disease among which COVID-19 pneumonia creates serious complications and most of COVID-19 related deaths. COVID-19 patients develop a systemic inflammatory response through interleukin (IL) and tumor necrosis factors. In COVID-19 patients, cytokine storm controlling is the key step for treatment because cytokine attacks own body cells instead of fighting with the virus. We reviewed several literatures to summarize the safety and efficacy of LD-RT in COVID-19 patients. Low dose chest radiation may reduce the inflammation in the lungs in severely ill patients. The radiation offset an immune system called AS a cytokine storm. Several randomized/non-randomized, single/multi-centered, open/close clinical trials are underway in U.S, India, Iran and around the globe. Early studies showed LD-RT reduces the inflammatory cytokines, time of hospitalization, duration of ventilation, and a number of deaths. However, some researchers warned for radiation-induced cancer (lung, breast, and esophageal) and cardiovascular diseases. So, further extensive preclinical studies should be conducted to identify the risk-benefit ratio in COVID-19 patients.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85807974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of the treatment vaccines for COVID-19 (Coronavirus disease-2019) - Review on current status","authors":"S. Surapaneni","doi":"10.13040/IJPSR.0975-8232.12(9).4676-83","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(9).4676-83","url":null,"abstract":"A Novel virus, coronavirus 2 (SARS-CoV-2), in 2019 from Wuhan, China which is globally expanded, causing the severe acute respiratory syndrome. Coronavirus is transmitted human to animal or human to human through airborne droplets. Coronavirus causes respiratory infections like pneumonia, cold, sneezing and coughing, while in animals, it causes diarrhoea and upper respiratory diseases. The virus outbreak has been declared a public health emergency of international concern by the World Health Organization (WHO), Since Covid -19 rapidly spread throughout the world from the Hunan seafood market at Wuhan, South China. The virus enters into the human cell through the membrane ACE-2 exopeptidase receptor. WHO and ECDC guided to stay away from a public place and close contact with contaminated individuals and pets. Coronavirus (2019-CoV), first and foremost, was isolated on 7th January 2020 at Wuhan market China. Here we have encapsulated the current clinical features data to guide budding Covid-19 about the Prevention, Diagnosis, Treatments and Prevention. Throughout the world, the disease has caused a range of degrees of sickness. The patient manifests various symptoms, usually Fever, Cough, Sore throat, Breathlessness, Fatigue. We collected the data from various, articles Research Report, and WHO guidelines in this review. It is necessary to give awareness to the readers that new data is updating nearly every hour regarding clinical characteristics, diagnosis, treatment strategies, and outcomes COVID-19. The disease is being treated through general treatment, symptomatic treatment, using some antiviral drugs, oxygen therapy and altering the immune system. WHO declared the SARS-Cov-2 virus in March 2020 as a global pandemic. It is necessary to identify the major causes and detach the suspected people from the confirmed cases of COVID-19 to prevent the possible transmission of infection to other patients and health care staff. It will be possible to assess this global disaster's full health, social and economic impact only when the pandemic ends. This review represents a picture of the current state of the treatment for Covid-19.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86714009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on evidence-based clinical research in traditional medicine for combat COVID-19","authors":"J. I. D. Diddeniya, P. K. Perera","doi":"10.13040/IJPSR.0975-8232.12(9).4588-99","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(9).4588-99","url":null,"abstract":"Covid-19, caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a life-threatening disease that has been declared a global pandemic. Even with the intervention of numerous medical systems to combat Covid-19, an effective remedy is not yet in sight rather than supportive therapies accompanied with anti-viral drugs and vaccines. The usage of these medicines has caused for unexpected side effects, and at present, various mutant forms of this virus have been identified from different countries. Hence, the necessity of an effective treatment regimen is highly expected. The attention direct towards Traditional Medicine (TM) is increasing day by day as it is well known for immune modulation. Therefore, this review was conducted with the aim of systematically reviewing the relevant literature of TM based on clinical studies conducted on Covid-19 patients and provides a summary on the evidence-based potential use of TM in the treatment of Covid-19. This review was conducted by using the databases;Science direct and PubMed for studies published from 1st of December 2019 to 1st of February 2021. In order to obtain further data, a manual search was also carried out. After scrutinizing all the articles, there were 29 total articles included in this present review. The evidence suggested that TM could regulate immunity and gives anti-viral, anti-inflammatory effects along with disease management and prevention. However, if these treatment modalities have any public health implications, further randomized controlled trials in humans will be needed.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"305 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77420436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products against coronaviruses","authors":"V. Sharma, R. Kaushik, C. Majee, J. Jain","doi":"10.13040/IJPSR.0975-8232.12(8).4143-50","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(8).4143-50","url":null,"abstract":"Background: World Health Organization states that antibacterial/antimicrobial resistance (AMR) can threaten the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi. Objective: This review aims to discuss the plants and their derivatives having anti-corona virus/ viral activity. Methods: For the preparation of this review article, all the relevant information was gathered from accessible and inaccessible resources (Web, Books, Thesis, etc.). Results: It has been accepted worldwide that the uses of herbal products provide stronger immunity which helps to fight against these microbial species. SARSCoV2 virus is now a pandemic, affecting many countries around the globe. This long series of herbal species may interfere with the target-specific proteins named S Protein, S protein- ACE-2 interaction, Helicase protein, N Protein, 3CLpr, PL pro to prevent the viral replication in the host. Traditional herbal medicine not only inhibits the virus attachment to the host body but also prevents replication and boosts up the host immune system. Natural remedies reduce the viral load and, in such conditions, the immunity becomes stronger, and so the patient can recover soon. Conclusion: The herbs-natural compounds with antiviral activity can effectively inhibit/blockade the CoV-host protein. Herbal medicine having immune boost-up property will play a major role as an anti-corona virus drug.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75336612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent development in the formulations of ginger for therapeutic applications and an overview towards the action on sars-cov-2","authors":"D. Rynjah, T. Chakraborty, A. Das, J. Islam, S. Bordoloi, B. Baishya, N. Hasan","doi":"10.13040/IJPSR.0975-8232.12(7).3537-48","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(7).3537-48","url":null,"abstract":"Ginger or Zingiber officinale, Roscoe of the Zingiberaceae family is a rhizome that is widely found and most consumed in South east Asian countries;also used as a traditional remedy to treat various ailments like nausea, vomiting, pain, arthritis, indigestion, gastro reflux, cardiovascular disease, diabetes, obesity, microbes, cancer, inflammation, oxidation, and wounds to name some of its activity which is based on the various chemical constituents present in ginger as it is found to contain more than 400 different compounds which include sugar, protein, and fats. The major phenolic active constituents of ginger are 6-gingerol, 6-shogaol and 6- paradol;which are safe and showing only a few insignificant adversarial effects. Here, this review aims to summarize and discuss the ideas on how ginger is formulated and improve from conventional to novel formulations using novel techniques;to improve the pharmacological, biopharmaceutical and chemical properties of ginger extract and its compounds. Different novel formulations of ginger like a tablet, capsule, powder, cream, gel, transdermal patch, nanoparticles, liposomes and phytosomes along with its therapeutic actions that were developed in recent years. Future aspects in research are suggested for the advances in the novel formulation of ginger using each isolated compound and improving bioavailability, therapeutic effect, and delivery. Also, this article discusses the in silico studies that have been carried out for ginger and its phytochemicals that may be considered as potential agents in the treatment of SARS-CoV-2.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73268786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological association of covid-19 with type i diabetes mellitus and asthma in the pediatric population and its management strategy","authors":"T. Spurthi, K. Mathivanan, M. Rajanandh","doi":"10.13040/IJPSR.0975-8232.12(7).3618-21","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(7).3618-21","url":null,"abstract":"Background and Aim: Coronavirus 2019 (COVID-19) is a pervasive emergency affecting 1-5% of children, among whom the majority are with preexisting comorbidities. This commentary aim is to highlight two such prominent childhood comorbidities, i.e., asthma and type 1 diabetes mellitus (T1-DM), with their pathophysiological link to COVID-19. Method: We searched the Google Scholar and PubMed databases till August 15, 2020, and retrieved the data connected to our aim for reviewing. Results: Asthma and T1-DM in children affect the COVID-19 progression due to their interlinked disease mechanisms with infection. Th-2 (T-helper) low endotype asthma and TI-DM connect by decreased ACE (angiotensin-converting enzyme) receptor expression, whereas Th-2 high endotype intensifies the COVID-19 via declining the IFNs (interferons) related anti-viral effect. Addressing these comorbidities therapeutically in this pandemic includes continuity in respective disease control treatment plans with the use of pressurized metered-dose inhaler (pMDI) with a spacer rather than nebulizers or keeping the low incidence of exacerbations by inhaled/oral corticosteroid and/or Montelukast in children with asthma is recommended. In the case of T1-DM, blood glucose of 70-144mg/dL and <0.6 mmol/L of blood ketone levels to be maintained without stopping Insulin dosing should be followed. Conclusion: Elevating the immunity with regular telemedicine and proper adherence to a prescribed action plan can address the present state of infection in children with asthma or T1-DM, or both.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77189779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of nanomedicine to combat covid-19- a review","authors":"Rani N. Sonia, R. Sheoran, N. Pawar","doi":"10.13040/IJPSR.0975-8232.12(7).3560-66","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(7).3560-66","url":null,"abstract":"COVID-19 has been proved to create a pandemic over the world within a few years. All scientists and health workers are trying to develop an effective treatment with collaboration. Various strategies such as antiviral, antibacterial, and antimalarial drugs have been employed to treat COVID- 19, but they were found to relieve the symptoms only. The formation of various variants of the virus in various global parts made the treatment of COVID-19 more difficult. Developing an effective vaccine is the main goal of clinicians and scientists, which is under clinical trials, and some vaccines which have been approved for the treatment such as COVAXIN, COVISHIELD, ASTRA Zenaca, and SPUTNIK V vaccines are being used to develop antibodies against COVID-19, but due to spread of variants of virus these vaccines are not supposed to be 100 percent protective against the virus. With the help of nanotechnology, the treatment of SARS- CoV-2 can be made efficient due to its direct target on viral cells and modifying its genetic material functionings. In this review, we summarized the role of nanomedicine in the treatment of SARS-CoV-2.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76844576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anguish owed by covid-19 pandemic: need of consideration to boost immunity through food habits and ayush recommendations","authors":"P. Mishra, R. R. Mishra","doi":"10.13040/IJPSR.0975-8232.12(7).3549-59","DOIUrl":"https://doi.org/10.13040/IJPSR.0975-8232.12(7).3549-59","url":null,"abstract":"World Health Organization (WHO) designated the COVID-19 or more commonly called Coronavirus disease, a \"public health emergency of international concern\" on January 30, 2020, and declared it a pandemic on March 11, 2020, which threatens human wellbeing around the world. With no proven pharmacological treatment, therapy (such as plasma, bacteriophage, virophage) drug approved by Food and Drug Administration (FDA) against COVID-19 and the frequent transmission of infection resulting in progression of infected person;made the situation more critical. The critical pandemic situation created by COVID-19 realized that nutrition becomes a priority to boost immune function as what we eat can have severe health impacts and medical consequences. The present assessment focused on enhancing awareness among people to maintain a healthy lifestyle through balanced food, nutrition, and eating habits, and AYUSH recommendations to overcome inevitably caused distress due to pandemic situation.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85922803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmaceutical applications of next generation printing technologies: A brief literature review","authors":"O. Baisya, S. Bhowmick, C. Sengupta, A. Bhowmik","doi":"10.13040/ijpsr.0975-8232.12(6).2995-05","DOIUrl":"https://doi.org/10.13040/ijpsr.0975-8232.12(6).2995-05","url":null,"abstract":"Next-generation printing or commonly known as three-dimensional (3D) printing (3DP), is a fabrication process of construction of a 3D object using a computer-aided design or digital 3D model. The 3D object is created layer by layer by depositing, joining, or solidifying a feedstock material such as thermoplastic polymer under the control of a computer-designed program. It is considered the latest technology that has the potential to address complex medical and pharmaceutical problems, such as prototyping essential medical devices, equipment, and novel drug delivery systems. The ability of 3DP to produce medications with accurate specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes, sizes, and textures, in a limited time period. In spite of many potential medical and economic benefits of 3DP, some technical and regulatory challenges are associated with the widespread application of 3DPin the pharmaceutical sector;those need to be addressed by proper research so that the benefit of this technology can be utilized fully. Along with 3DP, more advanced and sophisticated printing technologies like 4D/5D printing are also introduced and have already been explored in biomedical applications. However, the utility of these technologies in the pharmaceutical drug manufacturing process is still in the early experimental phase and gradually evolving. This review article illustrates the recent trends, challenges, and future prospects of 3D Pin pharmaceutical applications, along with the highlights of the ongoing transition from 3D to 4D/5D printing.","PeriodicalId":90866,"journal":{"name":"International journal of pharmaceutical sciences and research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85201829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}