BMJ Paediatrics Open最新文献

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Children growing up amid polycrises: implications for child development and children with disabilities. 在多重危机中成长的儿童:对儿童发展和残疾儿童的影响。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-28 DOI: 10.1136/bmjpo-2026-005217
Olaf Kraus de Camargo, Jeffrey Goldhagen, Raúl Mercer
{"title":"Children growing up amid polycrises: implications for child development and children with disabilities.","authors":"Olaf Kraus de Camargo, Jeffrey Goldhagen, Raúl Mercer","doi":"10.1136/bmjpo-2026-005217","DOIUrl":"10.1136/bmjpo-2026-005217","url":null,"abstract":"","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the efficacy of artificial intelligence as a patient education tool in paediatric care: a cross-sectional comparative study. 评估人工智能作为儿科护理患者教育工具的功效:一项横断面比较研究。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-25 DOI: 10.1136/bmjpo-2026-004890
Ellaha Haidar, Alice Ruan
{"title":"Evaluating the efficacy of artificial intelligence as a patient education tool in paediatric care: a cross-sectional comparative study.","authors":"Ellaha Haidar, Alice Ruan","doi":"10.1136/bmjpo-2026-004890","DOIUrl":"10.1136/bmjpo-2026-004890","url":null,"abstract":"","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural and interagency influences on mandated health assessments for children in out-of-home care in Sweden: a qualitative study of child protection services workers. 对瑞典家庭外照料儿童强制性健康评估的结构和机构间影响:对儿童保护服务工作者的定性研究。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-25 DOI: 10.1136/bmjpo-2026-005108
Godfried Van Agthoven, Gabriel Otterman, Rajna Knez, Kathi Makoroff, Laura Korhonen
{"title":"Structural and interagency influences on mandated health assessments for children in out-of-home care in Sweden: a qualitative study of child protection services workers.","authors":"Godfried Van Agthoven, Gabriel Otterman, Rajna Knez, Kathi Makoroff, Laura Korhonen","doi":"10.1136/bmjpo-2026-005108","DOIUrl":"10.1136/bmjpo-2026-005108","url":null,"abstract":"<p><strong>Background: </strong>Children in out-of-home care (OOHC) have significantly poorer physical, mental and dental health than their peers. In Sweden, child protection services (CPS) are required to initiate health assessments (HAs) when a child is placed in OOHC. Despite this statutory requirement, fewer than half of eligible children undergo an HA. Factors influencing implementation remain poorly understood.</p><p><strong>Methods: </strong>This qualitative study explored CPS caseworkers'change experiences of initiating and coordinating HAs for children placed in OOHC in Sweden. Five semi-structured focus group discussions were conducted with 18 CPS caseworkers. Participants were recruited nationwide through purposive snowball sampling. Data were analysed using reflexive thematic analysis, applying a decision-making ecology framework to interpret individual, organisational and interagency influences.</p><p><strong>Results: </strong>Four interrelated themes captured factors influencing implementation across the HA pathway: (1) Ideally, we do it for the child (initiation); (2) Negotiation and uncertainty (scheduling); (3) What we request is not always what we receive (conduct); and (4) Variable reporting and the challenge of closing the loop (reporting and follow-up). Across all phases, CPS caseworkers assumed a de facto coordinating role to compensate for fragmented interagency structures.</p><p><strong>Conclusions: </strong>From the perspective of CPS caseworkers, organisational and interagency factors influenced HAs across the assessment pathway. Fragmented routines and unclear responsibilities may reduce their usefulness for care planning and follow-up. Strengthening shared ownership and improving assessment, reporting and follow-up processes may support implementation. HAs may be most useful as part of a broader pathway of assessment, referral, care planning and follow-up.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using cognitive interviews with children to test the content validity of a paediatric patient reported experience measure. 使用儿童认知访谈来测试儿科患者报告经验测量的内容效度。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-25 DOI: 10.1136/bmjpo-2026-004589
Karlen R Barr, Erika Fortunati, Zachary Studniberg, Jessica Nikolovski, Leslie White, Sarah Elliott, Lynn McCartney, Dianna Smith-McCue, Mary Noah, Girish Swaminathan, James R John, Claire Treadgold, Aaron Hall, Ann Dadich, Barb Vernon, Elesha Toscano, Harriet Hiscock, Josephine Chow, Leanne Johnston, Lisa Whitehead, Mandie Foster, Valerie Sung, Valsamma Eapen
{"title":"Using cognitive interviews with children to test the content validity of a paediatric patient reported experience measure.","authors":"Karlen R Barr, Erika Fortunati, Zachary Studniberg, Jessica Nikolovski, Leslie White, Sarah Elliott, Lynn McCartney, Dianna Smith-McCue, Mary Noah, Girish Swaminathan, James R John, Claire Treadgold, Aaron Hall, Ann Dadich, Barb Vernon, Elesha Toscano, Harriet Hiscock, Josephine Chow, Leanne Johnston, Lisa Whitehead, Mandie Foster, Valerie Sung, Valsamma Eapen","doi":"10.1136/bmjpo-2026-004589","DOIUrl":"10.1136/bmjpo-2026-004589","url":null,"abstract":"<p><strong>Background: </strong>Paediatric patient reported experience measures (pPREMs) can help children's voices be heard to evaluate and improve healthcare delivery. However, no standardised child-completed pPREM has been co-designed with children and validated in Australia. This research aimed to test the content validity of a co-created pPREM using an iterative, participatory approach with children.</p><p><strong>Methods: </strong>21 children aged 6-11 years were recruited across four Australian hospitals. Children participated in online cognitive interviews to evaluate pPREM items and rating scales (using 'stars' or 'smiley faces') for their understandability, usability, relevance and importance related to their needs in hospital. Framework analysis was conducted iteratively, with items refined after the first round of interviews based on children's feedback.</p><p><strong>Results: </strong>Most (n=20; 95%) children understood the instructions. After nine interviews, two items were revised: 'Someone I knew could stay with me' changed to 'Family and friends could be with me' and 'I was able to talk to other patients', to 'I was able to talk to other kids in hospital'. Following these revisions, all children understood most (13 of 18=72%) items. In the remaining five items, some phrases, such as 'Care and treatment', were not easily understood, and items were edited according to children's feedback. Most children (n=14; 67%) preferred the 'smiley faces' rating system, and 83% (n=15) reported the number of questions as the right amount. Children generally found all items important, although some items did not apply to all and a 'Does not apply to me' response option was added.</p><p><strong>Conclusions: </strong>Children aged 6-11 years can meaningfully engage with a co-designed pPREM. Cognitive interviews and an iterative approach helped identify and rectify comprehension issues. It is feasible to involve children in the design of pPREMs and doing so strengthens pPREMs' usability and understandability.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental awareness, attitudes and decision-making of off-label use in children: a systematic review and meta-analysis. 家长对儿童超说明书用药的认识、态度和决策:一项系统回顾和荟萃分析。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-24 DOI: 10.1136/bmjpo-2026-004987
Tingyu Cao, Yujing Fei, Rong Jiang, Rong Shao
{"title":"Parental awareness, attitudes and decision-making of off-label use in children: a systematic review and meta-analysis.","authors":"Tingyu Cao, Yujing Fei, Rong Jiang, Rong Shao","doi":"10.1136/bmjpo-2026-004987","DOIUrl":"10.1136/bmjpo-2026-004987","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate parental awareness, acceptance, refusal rate and influencing factors of off-label use in children, aiming to provide evidence for optimising informed consent and physician-parent communication.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, Elsevier ScienceDirect, CNKI, Wanfang and VIP from inception to March 2026 for observational, mixed-methods and qualitative studies on parental awareness, attitudes and decision-making about off-label use in children. A random-effects single-group rate meta-analysis pooled awareness and refusal rates; conditional acceptance rates were summarised narratively due to extreme heterogeneity in operational definitions; unconditional acceptance rates were reported as individual study estimates. Influencing factors and psychological experiences were synthesised thematically.</p><p><strong>Results: </strong>Seven studies were included. The pooled parental awareness rate was 20.2% (95% CI: 10.6% to 31.9%), conditional acceptance ranged from 20.6% to 85.1% due to inconsistent operational definitions, unconditional acceptance was reported in two studies with individual estimates of 18.2% and 22.7%, and refusal was 36.5% (95% CI: 14.6% to 61.8%). Influencing factors fell into three themes: child clinical characteristics, parental cognition and emotion, and physician communication and qualification.</p><p><strong>Conclusion: </strong>Parental awareness of off-label use in children is low. Part of parents accept conditionally; unconditional acceptance is limited, and refusal rates are relatively high. These three themes interact throughout the decision-making process. Postdecision caregiving experiences may lead to long-term scepticism and influence future attitudes. In clinical practice, informed consent should shift from procedural notification to trust-centred communication. Prescription and drug supply processes should be optimised to reduce parental care burden.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socioeconomic differences in primary healthcare use before childhood cancer diagnosis: a register-based cohort study in Sweden. 儿童癌症诊断前初级卫生保健使用的社会经济差异:瑞典一项基于登记的队列研究
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-24 DOI: 10.1136/bmjpo-2026-005059
Julia Reißinger, Christina-Evmorfia Kampitsi, Maria Feychting, Hanna Mogensen, Marios Rossides, Eric Chen, Arja Harila, Kleopatra Georgantzi, Giorgio Tettamanti, Javier Louro
{"title":"Socioeconomic differences in primary healthcare use before childhood cancer diagnosis: a register-based cohort study in Sweden.","authors":"Julia Reißinger, Christina-Evmorfia Kampitsi, Maria Feychting, Hanna Mogensen, Marios Rossides, Eric Chen, Arja Harila, Kleopatra Georgantzi, Giorgio Tettamanti, Javier Louro","doi":"10.1136/bmjpo-2026-005059","DOIUrl":"10.1136/bmjpo-2026-005059","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of childhood cancer remains challenging because initial symptoms are common, nonspecific and have low predictive value in primary healthcare (PHC). We assessed whether socioeconomic differences shape pre-diagnostic PHC pathways before childhood cancer diagnosis.</p><p><strong>Methods: </strong>We conducted a register-based matched cohort study using PHC data from three Swedish regions between 2001 and 2022, covering 54% of the general paediatric population in Sweden. Children aged 0-19 years with a first cancer diagnosis were matched 1:25 to cancer-free population references by age, sex and region. In-person PHC physician contacts in the year before the index date were analysed. Logistic and negative binomial regression models were used to assess socioeconomic differences in PHC utilisation and PHC contact frequency, respectively stratified by diagnostic group.</p><p><strong>Results: </strong>The study included 3711 childhood cancer patients and 93 181 references. Children with cancer had more PHC contacts than population references in the year before diagnosis (mean 2.28 vs 1.27, mean difference 1.01, 95% CI 0.94 to 1.08; p<0.001), although 22%-49% had no PHC contact 3 months before diagnosis depending on diagnostic group. Maternal educational gradients in PHC use were present in the general paediatric population but largely absent among children with cancer. An exception was central nervous system (CNS) tumours, for which children of mothers with low educational attainment had 28% more prediagnostic PHC contacts than those with highly educated mothers.</p><p><strong>Conclusion: </strong>Socioeconomic differences in PHC utilisation by maternal educational level largely diminish as children approach a cancer diagnosis, except for CNS tumours, where increased contacts among children of mothers with low educational attainment may indicate a prolonged or delayed diagnosis.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying factors associated with childhood stunting in West Java, Indonesia: an explanatory sequential mixed-methods study. 确定与印度尼西亚西爪哇儿童发育迟缓相关的因素:一项解释性顺序混合方法研究。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-23 DOI: 10.1136/bmjpo-2026-004666
Dwita Nitoya Esterini, Anahí Venzor Strader, Muhummed Nadeem Kasmani, Nia Reviani, Peter Rohloff
{"title":"Identifying factors associated with childhood stunting in West Java, Indonesia: an explanatory sequential mixed-methods study.","authors":"Dwita Nitoya Esterini, Anahí Venzor Strader, Muhummed Nadeem Kasmani, Nia Reviani, Peter Rohloff","doi":"10.1136/bmjpo-2026-004666","DOIUrl":"10.1136/bmjpo-2026-004666","url":null,"abstract":"<p><strong>Objective: </strong>Stunting impairs child development and long-term economic productivity. In Indonesia, prevalence has declined substantially but progress has slowed. We aim to understand the contextual factors of childhood stunting in two rural communities in the Sumedang district, West Java, which is prioritised by health authorities due to its high stunting prevalence.</p><p><strong>Methods: </strong>We used an explanatory sequential mixed-methods design. A cross-sectional household survey (172 children under 5 years of age) informed the adaptation of interview guides for a qualitative phase consisting of 34 in-depth interviews with caregivers and community key informants, which were analysed inductively and integrated with the survey findings in a joint display.</p><p><strong>Results: </strong>Measured stunting prevalence was similar in the two communities (20.5% and 29.8%) and higher than the routine district estimates. Exploratory models showed common associations such as with household wealth, consistent with the wider literature. The interviews uncovered important resources and risks. These included informal nutrition education networks, delegated caregiver arrangements, coping with food insecurity through borrowing, credit, subsistence farming and fishing and health-worker accompaniment and village-funded social assistance programmes as buffers.</p><p><strong>Conclusions: </strong>Stunting in these communities was high and socially patterned. Sustained reductions will require ongoing intergenerational policies that address structural socioeconomic disadvantage and strengthen caregiving environments, rather than stand-alone nutrition or health interventions.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsy in children with cerebral palsy: perinatal, clinical and neuroimaging correlates - a cross-sectional study from a tertiary care centre in North India. 脑瘫儿童癫痫:围产期、临床和神经影像学相关性——来自印度北部三级保健中心的横断面研究。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-23 DOI: 10.1136/bmjpo-2026-005050
Arvinder Wander, Roshwanth A, Sameer Peer, Ratan Gupta, D Vignesh, Rajni Sharma, Madhu S Gaddigoudar, Soumya Swaroop Sahoo, Vaibhav Saini, Anuradha Raj
{"title":"Epilepsy in children with cerebral palsy: perinatal, clinical and neuroimaging correlates - a cross-sectional study from a tertiary care centre in North India.","authors":"Arvinder Wander, Roshwanth A, Sameer Peer, Ratan Gupta, D Vignesh, Rajni Sharma, Madhu S Gaddigoudar, Soumya Swaroop Sahoo, Vaibhav Saini, Anuradha Raj","doi":"10.1136/bmjpo-2026-005050","DOIUrl":"10.1136/bmjpo-2026-005050","url":null,"abstract":"<p><strong>Background: </strong>Cerebral palsy (CP) frequently coexists with epilepsy, amplifying disability through compounded neurological impairments. This cross-sectional study at a tertiary care centre in Northern India characterises seizure profiles, epilepsy severity, motor function, neuroimaging correlates and perinatal predictors in 95 children aged 1-13 years with CP and epilepsy.</p><p><strong>Methods: </strong>Consecutive paediatric neurology patients underwent prospective evaluation with clinical, electroencephalographic and MRI assessments to characterise seizures in CP and examine their relation to Gross Motor Function Classification System (GMFCS) and MRI severity. Epilepsy severity was assessed using the Early Childhood Epilepsy Severity Scale (E-CHESS), CP severity using GMFCS and MRI severity using the scoring system by Trivedi <i>et al</i>. MRI findings and perinatal factors were analysed in relation to epilepsy severity in children with CP.</p><p><strong>Results: </strong>Spastic quadriplegic CP was predominant (78.9%), and generalised tonic-clonic seizures were the most common seizure types. E-CHESS was weakly and non-significantly associated with GMFCS (r=0.079, p=0.12); MRI severity increased with E-CHESS scores (p=0.0427); grey matter injury was associated with severe seizures, while white matter lesions were more often associated with moderate severity. Low/moderate 5 min APGAR score was strongly associated with severe seizures (adjusted OR 47.4-52.1, p<0.013), and children with quadriplegic CP more often showed perinatal compromise, including low 5 min APGAR scores.</p><p><strong>Conclusion: </strong>Epilepsy severity in CP was associated with grey matter MRI injury and low 5 min APGAR but showed less association with motor impairment. Low 5 min APGAR scores may serve as early clinical markers of increased risk of severe seizure in CP and may help prioritise MRI assessment and closer seizure surveillance. This study emphasises the need for parallel management strategies-addressing seizures and motor deficits separately but comprehensively.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory bidirectional Mendelian randomisation analysis of cerebrospinal fluid metabolites associated with cerebral palsy and epilepsy. 脑脊液代谢物与脑瘫和癫痫相关的探索性双向孟德尔随机分析。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-21 DOI: 10.1136/bmjpo-2025-004390
Longkun Mao, Ting Cui, Yun Liu, Xianrui Chen, Kaishou Xu
{"title":"Exploratory bidirectional Mendelian randomisation analysis of cerebrospinal fluid metabolites associated with cerebral palsy and epilepsy.","authors":"Longkun Mao, Ting Cui, Yun Liu, Xianrui Chen, Kaishou Xu","doi":"10.1136/bmjpo-2025-004390","DOIUrl":"10.1136/bmjpo-2025-004390","url":null,"abstract":"<p><strong>Background: </strong>Cerebral palsy (CP) and epilepsy are prevalent neurodevelopmental disorders with shared aetiological complexities. This study employs bidirectional Mendelian randomisation (MR) to investigate associations consistent with potential causal effects between cerebrospinal fluid (CSF) metabolites and the pathogenesis of CP and epilepsy.</p><p><strong>Methods: </strong>We conducted a two-sample MR analysis using genome-wide association study (GWAS) data from FinnGen, including 482 CP cases, 11 740 epilepsy cases and European ancestry controls. Instrumental variables for 338 CSF metabolites were selected using a relaxed threshold (p<1×10<sup>-5</sup>) due to the modest size of the metabolite GWAS. Nominal statistical significance was defined as p<0.05; to account for multiple comparisons, Benjamini-Hochberg false discovery rate (FDR) correction (Q<0.05) was applied across all five MR methods for each outcome.</p><p><strong>Results: </strong>Six CSF metabolites showed nominal significant associations with CP risk in inverse variance weighted analyses, after FDR correction, three remained significant: 3-hydroxypyridine sulfate (OR=1.23, Q=0.040), isoleucine (OR=0.49, Q=0.046) and sphingomyelin (OR=1.12, Q=0.040). 17 metabolites were linked to epilepsy, of these, five remained significant after FDR correction, including 2,3-dihydroxy-5-methylthio-4-pentenoate (OR=0.81, Q=0.009) and 3-ureidopropionate (OR=1.09, Q=0.024). γ-Glutamylvaline showed nominally significant associations with both disorders but in opposite directions (CP: OR=1.25, p=0.040; epilepsy: OR=0.95, p=0.031); neither survived FDR correction. Reverse MR analyses did not support reverse associations for CP (all p>0.05), although genetic liability to epilepsy was associated with two CSF metabolites. Sensitivity analyses did not detect evidence of directional pleiotropy.</p><p><strong>Conclusions: </strong>These findings provide hypothesis-generating evidence regarding metabolic pathways potentially involved in CP and epilepsy and may inform future experimental and clinical investigations. Independent validation and functional studies are required before clinical application can be considered.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we back to normal? Evaluating the impact of the COVID-19 pandemic on referrals to a child protection service in a tertiary care centre in Vienna, Austria. 我们恢复正常了吗?评估COVID-19大流行对奥地利维也纳一家三级保健中心儿童保护服务转诊的影响。
IF 2.6 4区 医学
BMJ Paediatrics Open Pub Date : 2026-09-19 DOI: 10.1136/bmjpo-2026-005049
Chryssa Grylli, Sophie Klomfar, Johanna Brandlechner, Laura Schaller, Katharina Weimann, Anastasia Pantazidou, Eva Mora-Theuer, Christoph Krall, Catherine Quantin, Susanne Greber-Platzer
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