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Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome. 关注SARS-CoV-2变异体和孕产妇疫苗接种状况对新生儿结局的影响
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2025-01-07 DOI: 10.1136/bmjpo-2024-003109
Nadine Mand, Ulrich Pecks, Matthias Hutten, Rolf Felix Maier, Mario Rüdiger
{"title":"Influence of SARS-CoV-2 variants of concern and maternal vaccination status on neonatal outcome.","authors":"Nadine Mand, Ulrich Pecks, Matthias Hutten, Rolf Felix Maier, Mario Rüdiger","doi":"10.1136/bmjpo-2024-003109","DOIUrl":"10.1136/bmjpo-2024-003109","url":null,"abstract":"<p><p>SARS-CoV-2 infection during pregnancy can adversely affect maternal and neonatal health, although risks vary depending on the variant of concern (VOC). Omicron, although highly infectious, causes fewer maternal and neonatal complications than earlier VOC, so vaccination may be considered unnecessary in planned pregnancy. Using data from the CRONOS registry, we compared pregnancy outcomes according to VOC and vaccination status. We found that vaccination during pregnancy reduced preterm birth rates compared with unvaccinated or vaccinated women with Omicron infection, without increasing severe neonatal outcomes. Given the risks associated with preterm birth, the study consistently supports vaccination recommendations for women planning pregnancy.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"9 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal outcomes in offspring of mothers with pregestational diabetes: a hospital-based multicentre prospective cohort study protocol. 妊娠期糖尿病母亲的后代新生儿结局:一项基于医院的多中心前瞻性队列研究方案
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2025-01-07 DOI: 10.1136/bmjpo-2024-003002
Anju Philip Thurkkada, Radhamany Kunjukutty, Manu Raj, Sobha S Nair, Annie Soman, Sethulakshmi Ramachandran, Renjitha Bhaskaran, Vishnu Renjith
{"title":"Neonatal outcomes in offspring of mothers with pregestational diabetes: a hospital-based multicentre prospective cohort study protocol.","authors":"Anju Philip Thurkkada, Radhamany Kunjukutty, Manu Raj, Sobha S Nair, Annie Soman, Sethulakshmi Ramachandran, Renjitha Bhaskaran, Vishnu Renjith","doi":"10.1136/bmjpo-2024-003002","DOIUrl":"10.1136/bmjpo-2024-003002","url":null,"abstract":"<p><strong>Introduction: </strong>Pregestational diabetes mellitus (PGDM) occurs when a woman becomes pregnant after having diabetes mellitus. The presence of diabetes during the entire pregnancy can have an adverse impact on fetal and neonatal outcomes. The objective of this study is to examine the association between PGDM and neonatal outcomes at birth.</p><p><strong>Methods and analysis: </strong>This prospective hospital-based cohort study is ongoing at three tertiary-level hospitals in Kerala, India. The study targets to recruit 1260 pregnant women. All pregnant women above the age of eighteen who had confirmed pregnancy in an early pregnancy scan and in the first trimester of pregnancy visiting the three study sites for antenatal care will be included in the study. Those who will have a miscarriage, an abortion or twin pregnancies will be excluded from the study. All pregnant women will be evaluated for diabetic state via RBS, HbA1c and FBS based on the International Association of Diabetes and Pregnancy Study Groups criteria during their initial visit to the study sites. PGDM will be diagnosed by the following criteria-FBS ≥126 mg% OR HbA1c ≥6.5 mg% OR Random blood glucose ≥200 mg% on the initial visit or documented prior to the index pregnancy. Neonatal outcomes among the newborn babies will be assessed on the day of birth. We will report adjusted ORs with 95% CI for significant associations derived from multivariable logistic regression analysis.</p><p><strong>Ethics and dissemination: </strong>The present study received ethical approval from the three study sites. Informed consent will be obtained from the study participants before data collection.</p><p><strong>Trial registration number: </strong>CTRI/2024/06/068978.</p><p><strong>Conclusion: </strong>Early identification and management of PGDM among mothers will probably help to prevent adverse neonatal outcomes at birth.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"9 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mobile health van as an intervention to provide clinical support and health promotion to street children and marginalised populations in the National Capital Region of Delhi: a mixed-methods evaluation. 移动保健车作为一种干预措施,向德里国家首都地区的街头儿童和边缘化人口提供临床支持和健康促进:一项混合方法评价。
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2025-01-07 DOI: 10.1136/bmjpo-2024-002988
Rajeev Seth, Tanu Girotra Girotra, Id Mohammad, Yawar Qaiyum, Indra Taneja, Shanti Raman
{"title":"Mobile health van as an intervention to provide clinical support and health promotion to street children and marginalised populations in the National Capital Region of Delhi: a mixed-methods evaluation.","authors":"Rajeev Seth, Tanu Girotra Girotra, Id Mohammad, Yawar Qaiyum, Indra Taneja, Shanti Raman","doi":"10.1136/bmjpo-2024-002988","DOIUrl":"10.1136/bmjpo-2024-002988","url":null,"abstract":"<p><strong>Background: </strong>Urban health challenges, particularly for street and slum-dwelling children and families, have emerged as one of the most significant health concerns in India. While there is little published on effective healthcare delivery to these populations, mobile health vans (MHV) have been proposed as a proactive pathway to providing outreach healthcare. Our aims were to evaluate the impact of Bal Umang Drishya Sanstha (BUDS) MHV in providing health and support services to the urban slum populations in Delhi National Capital Region (NCR), focusing on benefits to children.</p><p><strong>Methods: </strong>This was a mixed-methods evaluation, using routinely collected data. We collated and reviewed available data recorded by the BUDS staff in their health record system from June 2017 to December 2023. Qualitative data were provided by two recent focus group discussions carried out in the community; one with 18 mothers and another with a mixed group of 12 adults-all had used MHV clinics for children in their families. We chose two typical case studies that were reported to the funding bodies.</p><p><strong>Results: </strong>Between 2017 and 2023, there were a total of 41 062 clinic visits for children<18 years, with visits increasing steadily and peaking at 8864 in 2023. Just under 10% of encounters were referred to specialist services, 122 children were diagnosed with disability. Health education sessions were provided mainly in group settings, to over 70 000 children. Themes extracted from focus group discussions were enhanced access to healthcare, quality of care, value adds from MHV and suggestions for improvement. Families expressed overwhelming appreciation of BUDS MHV. Case studies illustrated the benefits of facilitated access to tertiary healthcare.</p><p><strong>Conclusions: </strong>MHV can serve as a valuable source of primary healthcare for street and slum-dwelling children and their families. Other benefits are empowering communities with health literacy and negotiating pathways to tertiary care.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"9 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parental separation following preterm delivery in Canada: a population-based cohort study. 加拿大早产后父母分离:一项基于人群的队列研究。
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-31 DOI: 10.1136/bmjpo-2023-002408
Deepak Louis, Ava Nykiforuk, Aaron Chiu, Sapna Oberoi, Chelsea Ruth, Lisa Flaten, James Bolton, Hamman Akil, Fabiana Bacchini, Karen Netzel, Kristene Cheung, Lisa M Lix, Allan Garland
{"title":"Parental separation following preterm delivery in Canada: a population-based cohort study.","authors":"Deepak Louis, Ava Nykiforuk, Aaron Chiu, Sapna Oberoi, Chelsea Ruth, Lisa Flaten, James Bolton, Hamman Akil, Fabiana Bacchini, Karen Netzel, Kristene Cheung, Lisa M Lix, Allan Garland","doi":"10.1136/bmjpo-2023-002408","DOIUrl":"10.1136/bmjpo-2023-002408","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between preterm delivery and parental separation and identify associated risk factors.</p><p><strong>Methods: </strong>All opposite sex, married or common-law parents whose relationship status was available at index delivery and for the next 5 years were eligible in this retrospective population-based cohort study in Manitoba, Canada. Parents of children born preterm were matched 1:5 to parents of children born full-term. Parental separation within 5 years of childbirth was the primary outcome. Secondary outcome was the time to separation. Multivariable Poisson regression model was created to estimate the 5-year incidence rate ratios (IRR) of the primary outcome.</p><p><strong>Results: </strong>Parents of 6367 children born preterm (n=164 for <28 weeks, n=1196 for 28-33 weeks, n=5007 for 34-36 weeks) and parents of 30 663 children born full-term were included. Compared with parents of children born term (4.2%), only parents of children born at 34-36 weeks had a higher incidence rate of separation (5.5%, IRR: 1.26; 1.09-1.45, p=0.002), although parents of children born at 28-33 weeks (5.4%, IRR: 1.20; 0.93-1.55, p=0.16), and at<28 weeks (5.5%, IRR: 1.27; 0.66-2.45, p=0.48) had similar IRRs. Time to separation was similar between all groups.</p><p><strong>Conclusions: </strong>Parents of children born at 34-36 weeks had higher separation rates than parents of children born full-term. The risk factors identified can be used to identify and provide supports to at-risk parents.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the performance of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) and highly aspherical lenslets (HAL) spectacles. 欧洲儿童和青少年离焦合并多段(DIMS)和高度非球面透镜(HAL)眼镜近视控制效果的比较
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-31 DOI: 10.1136/bmjpo-2024-003187
Andrea Lembo, Irene Schiavetti, Massimiliano Serafino, Roberto Caputo, Paolo Nucci
{"title":"Comparison of the performance of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) and highly aspherical lenslets (HAL) spectacles.","authors":"Andrea Lembo, Irene Schiavetti, Massimiliano Serafino, Roberto Caputo, Paolo Nucci","doi":"10.1136/bmjpo-2024-003187","DOIUrl":"10.1136/bmjpo-2024-003187","url":null,"abstract":"<p><strong>Purpose: </strong>A performance comparison of two myopia control spectacle lens designs, defocus incorporated multiple segments (DIMS) and highly aspherical lenslets (HAL), at slowing myopia progression in a European child/adolescent population. Previous research directly comparing these designs has been limited to Chinese participants and 1-year follow-up. The prevalence of myopia in European child/adolescent has been estimated at 22.60%.</p><p><strong>Methods: </strong>Retrospective cohort study of individuals (6-17 years) with myopia progression. Participants wore DIMS (Hoya MiyoSmart) or HAL (Essilor Stellest) spectacles for a minimum of 2 years. Axial length (AL) and cycloplegic autorefraction (spherical equivalent refraction (SER)) were measured at baseline and 1 and 2 years.</p><p><strong>Results: </strong>Mean 1-year SER changes for DIMS were -0.34D (±0.46 SD) and HAL -0.30D (±0.30); 2-year changes for DIMS were -0.50D (±0.64 SD) and HAL -0.63D (±0.56). Mean 1-year AL increases for DIMS were 0.19 mm (±0.56) and HAL 0.15 mm (±0.47); 2-year increases for DIMS were 0.29 mm (±0.63) and HAL 0.32 mm (±0.72). For equivalence margins of 0.25D and 0.50D for SER at 1 and 2 years, respectively, and similarly 0.20 mm and 0.30 mm margins for AL, DIMS and HAL lenses were equivalent apart from AL at 1 year where the 0.21 mm 95% CI upper limit just exceeded 0.20 mm. At both 1 and 2 years, none of the differences in mean SERs or ALs between DIMS and HAL were clinically or statistically significant (p≥0.05 Mann-Whitney U test). Using linear mixed model analysis, the interaction between lens type and time did not significantly affect SER or AL at 1- or 2-year follow-up (p≥0.05). 38.4% of children/adolescents with DIMS had no SER progression at 2 years, compared with 21.9% with HAL (p=0.047).</p><p><strong>Conclusion: </strong>In a European population, DIMS and HAL lenses are essentially equivalent in their ability to reduce myopia progression and AL elongation over a 2-year follow-up period.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and correlates of child labour in five low-income countries: a descriptive study based on UNICEF Multiple Indicator Cluster Surveys 6 (MICS6). 五个低收入国家童工的流行情况及其相关关系:基于儿童基金会多指标类集调查6的描述性研究。
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-31 DOI: 10.1136/bmjpo-2024-002871
Nick Spencer, Geir Gunnlaugsson, Shanti Raman
{"title":"Prevalence and correlates of child labour in five low-income countries: a descriptive study based on UNICEF Multiple Indicator Cluster Surveys 6 (MICS6).","authors":"Nick Spencer, Geir Gunnlaugsson, Shanti Raman","doi":"10.1136/bmjpo-2024-002871","DOIUrl":"10.1136/bmjpo-2024-002871","url":null,"abstract":"<p><strong>Background: </strong>The Convention on the Rights of the Child states that children need to be protected from 'any work that is likely to be hazardous or to interfere with the child's education, or to be harmful to the child's health or physical, mental, spiritual, moral or social development'. We aimed to determine the prevalence and correlates of child labour in five low-income African countries using the sixth wave of UNICEF Multiple Indicator Cluster Surveys (MICS6).</p><p><strong>Methods: </strong>Data on child labour, reported by the household respondent for a randomly selected child (5-17 years), were extracted from MICS6 reports from Chad, Guinea Bissau, Malawi, Sierra Leone and Togo. Prevalence rates were extracted from three categories of child labour (household chores, economic activity and hazardous work) stratified by gender, age, wealth and residence.</p><p><strong>Results: </strong>140 598 children aged 5-17 years (61.2% 5-11; 22.0% 12-14; 16.8% 15-17) were included in the reports; 59 090 (42%) were engaged in child labour. The highest proportion of child labourers by age was 12-14 years old (61.1%) followed by 15-17 years old (51.1%) and 5-11 years old (36.1%). There were differences between countries, with Chad having the highest proportion of working children. Gender differences in working were limited (43.9% boys vs 40.3% girls); rural children were almost twice as likely to be working compared with urban children (47.5% rural vs 25.6% urban) as were children in the poorest quintile compared with those in the wealthiest quintile (46.9% vs 23.7%). Over a third (35.3%) of working children were exposed to hazardous conditions. Older, male, rural or poor children were over-represented among those in hazardous work.</p><p><strong>Conclusions: </strong>Almost half of all children in these five sub-Saharan African countries are engaged in labour, of which one-third are in hazardous work. MICS6 surveys do not report on working children's health; however, working puts their health and development at risk.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between phosphate and 30-day in-hospital mortality in paediatric ICU: a retrospective cohort study. 磷酸盐与儿科ICU住院30天死亡率之间的关系:一项回顾性队列研究
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-31 DOI: 10.1136/bmjpo-2024-003171
Yiyi Ding, Yaqin Lei, Yufang Zhu, Hongwei Zhang, Yunbin Xiao
{"title":"Association between phosphate and 30-day in-hospital mortality in paediatric ICU: a retrospective cohort study.","authors":"Yiyi Ding, Yaqin Lei, Yufang Zhu, Hongwei Zhang, Yunbin Xiao","doi":"10.1136/bmjpo-2024-003171","DOIUrl":"10.1136/bmjpo-2024-003171","url":null,"abstract":"<p><strong>Background: </strong>Death rates in the intensive care unit (ICU) and paediatric ICU (PICU) are approximately 10.8% and 9.13%, respectively. Serum phosphate irregularities, such as low or high phosphate levels, significantly impact ICU patient outcomes. However, the connection between serum phosphate concentrations on admission and PICU mortality has not been investigated.</p><p><strong>Methods: </strong>Information was collected from 12 881 PICU patients at the Children's Hospital, Zhejiang University School of Medicine, over an 8-year period from 2010 to 2018. The data were retrieved from the PIC database (http://pic.nbscn.org).</p><p><strong>Results: </strong>A multiple linear regression model was used to assess associations between phosphate and 30-day PICU mortality, finding a significant positive relationship (OR 1.27, 95% CI 1.08 to 1.49). Generalised additive models were also developed, showing a non-linear association between serum phosphate and 30-day PICU mortality. In the two-phase linear regression analysis, the critical point for serum phosphate concentration was identified as 1.2 mmol/L. To the left of this point, serum phosphate levels were inversely correlated (OR 0.2, 95% CI 0.10 to 0.41), whereas to the right, a positive relationship was observed (OR 1.99, 95% CI 1.66 to 2.39).</p><p><strong>Conclusions: </strong>The findings demonstrated a relationship between serum phosphate levels and 30-day PICU mortality. The relationship was represented by a U-shaped curve. Hypophosphataemia and hyperphosphataemia increased the risk of 30-day PICU death.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing neonatal Sequential Organ Failure (nSOFA) scores in suspected late-onset neonatal sepsis among preterm infants: implications for morbidity and mortality. 评估新生儿顺序器官衰竭(nSOFA)评分在疑似晚发型新生儿败血症的早产儿:对发病率和死亡率的影响。
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-29 DOI: 10.1136/bmjpo-2024-002884
Şerife Kurul, Joyce J Reijnierse, Hugo J Koppens, Wes Onland, Sinno H P Simons, Irwin K M Reiss, H Rob Taal, Douwe H Visser
{"title":"Assessing neonatal Sequential Organ Failure (nSOFA) scores in suspected late-onset neonatal sepsis among preterm infants: implications for morbidity and mortality.","authors":"Şerife Kurul, Joyce J Reijnierse, Hugo J Koppens, Wes Onland, Sinno H P Simons, Irwin K M Reiss, H Rob Taal, Douwe H Visser","doi":"10.1136/bmjpo-2024-002884","DOIUrl":"10.1136/bmjpo-2024-002884","url":null,"abstract":"<p><strong>Background: </strong>The neonatal Sequential Organ Failure Assessment (nSOFA) score is an organ dysfunction score developed for predicting mortality risk in preterm neonates with proven late-onset neonatal sepsis (LONS) and necrotising enterocolitis. However, the utility of the nSOFA score in determining the risk of retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD) or mortality in patients with suspected LONS is unknown.</p><p><strong>Methods: </strong>We performed a dual-centre retrospective cohort study of preterm (gestational age <32 weeks) neonates suspected of LONS, from 2016 to 2020 at two neonatal intensive care units. The nSOFA scores (range 0-15) were calculated for each suspected LONS episode at various time points around the sepsis evaluation. A nSOFA burden score was calculated, by counting each time point the nSOFA score was ≥4 during all sepsis episodes (in the time period -6 to 48 hours). The association with 10-day sepsis-related mortality and severe ROP and BPD was assessed.</p><p><strong>Results: </strong>A total of 1157 episodes of suspected LONS in 706 neonates occurred. The nSOFA was significantly associated with 10-day mortality at various time points. The nSOFA score 6 hours after drawing a blood culture (T6) was associated with 10-day sepsis-related mortality (adjusted OR (aOR) 1.31; 95% CI (1.22 to 1.40; p<0.001)), in a model corrected for gestational age, sex, age at evaluation and gestational age-adjusted birth weight. The nSOFA burden scores were positively associated with the risk for ROP (aOR 1.24; 95% CI 1.09 to 1.41; p=0.001) and BPD (aOR 1.30; 95% CI 1.13 to 1.50; p<0.001).</p><p><strong>Conclusion: </strong>Our findings show that the nSOFA score in preterm neonates suspected of LONS is associated with subsequent mortality, ROP and BPD. Incorporating nSOFA scores may help to identify sepsis survivors at the highest risk of adverse outcomes, who may require more intensive monitoring and adapted therapy.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptation of a positive youth development program in the community of Guangaje, Cotopaxi, Ecuador. 在厄瓜多尔科托帕希的 Guangaje 社区改编积极青年发展计划。
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-29 DOI: 10.1136/bmjpo-2024-003155
Isabel M Espinosa, Marisol Bahamonde, Rodrigo Ilaquiche, David Lee Wood
{"title":"Adaptation of a positive youth development program in the community of Guangaje, Cotopaxi, Ecuador.","authors":"Isabel M Espinosa, Marisol Bahamonde, Rodrigo Ilaquiche, David Lee Wood","doi":"10.1136/bmjpo-2024-003155","DOIUrl":"https://doi.org/10.1136/bmjpo-2024-003155","url":null,"abstract":"<p><p>This study explores the adaptation of a Positive Youth Development (PYD) programme for the Indigenous Quichua community in Guangaje, Ecuador, which faces chronic poverty and low educational attainment. In May, June 2023 we conducted focus groups with school teachers and indigenous community leaders, parents and middle school, high school and college students. We found a disconnect between students' aspirations for higher education and adults' emphasis on practical and vocational training. Findings highlight the need to strengthen youth internal assets and change adult perspectives to foster a supportive environment, empowering youth to be motivated and prioritise the long-term benefits of education beyond immediate economic challenges.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"8 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventing abusive head trauma: what do frontline healthcare workers (HCW) know about normal infant crying? 预防虐待性头部创伤:一线医护人员(HCW)对婴儿正常哭声了解多少?
IF 2 4区 医学
BMJ Paediatrics Open Pub Date : 2024-12-29 DOI: 10.1136/bmjpo-2024-003120
Freya Guinness, Ciara O'Neill, Brian Keating, Michelle Walsh, Farhana Sharif
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