BMC Ophthalmology最新文献

{"title":"Retinal sensitivity above macular neovascularization under anti-VEGF therapy in exudative neovascular age-related macular degeneration.","authors":"Laurenz Pauleikhoff, Martin Ziegler, Isabel Bachmeier, Siqing Yu, Beatriz Garcia Armendariz, Daniel Pauleikhoff","doi":"10.1186/s12886-025-03946-8","DOIUrl":"10.1186/s12886-025-03946-8","url":null,"abstract":"<p><strong>Purpose: </strong>Growth of macular neovascularization (MNV) associated with development of complete retinal pigment epithelial and outer retina atrophy (cRORA) been observed in eyes neovascular age-related macular degeneration (nAMD) under effective anti-vascular endothelial growth factor (VEGF) therapy. We aimed to evaluate the influence of the presence of MNV on the sensitivity of the overlaying retina both in patients with or without cRORA and to generate hypotheses about their association.</p><p><strong>Methods: </strong>Pilot study on nAMD patients undergoing long-term anti-VEGF therapy that had also undergone microperimetry testing. Area of MNV and, if present, associated cRORA were identified on optical coherence tomography (OCT) volume scans and transposed onto en-face near-infrared images. Mesopic microperimetry performed at the same visit was then superimposed. Retinal sensitivity above the MNV and the surrounding retina were compared, excluding areas of cRORA.</p><p><strong>Results: </strong>Twenty-six eyes (19 f, 7 m; age 79.3 ± 5.7 y; fu 4.0 ± 1.8 y; 7.4 ± 2.5 inj./y) were classified into a no cRORA (n = 11) and a cRORA group (n = 15). In the no cRORA group, mean retinal sensitivity above the MNV did not differ from the surrounding retina (20.9 ± 2.8 vs. 22.0 ± 2.4, p = 0.33), while in the cRORA group, a lower sensitivity above the MNV in comparison to the surrounding retina was observed (16.2 ± 3.4 vs. 19.9 ± 2.0, p = 0.001).</p><p><strong>Conclusion: </strong>In the absence of cRORA, retinal sensitivity above the MNV did not differ significantly from that of the surrounding retina. These results could indicate a possible nutritional function of the MNV to the overlying retina in cases where no cRORA is present.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"123"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of retinopathy of prematurity on visual acuity, refraction, biometric values, retinal and choroidal thickness in school-aged children.","authors":"Ali Kutay Kılınç, O Ozdemir, D E Acar, M U Işık","doi":"10.1186/s12886-025-03965-5","DOIUrl":"10.1186/s12886-025-03965-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This study aimed to investigate the long-term effects of retinopathy of prematurity (ROP) on visual function and ocular anatomy. We compared biometric values, foveal thickness, and choroidal thickness among children with a history of ROP (stratified by treatment status), premature infants without ROP, and term-born children.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional study was conducted between september 2021 and february 2022 at the Ophthalmology Department of Ankara Bilkent City Hospital. The study included 54 eyes from 29 children who received laser photocoagulation treatment for ROP (ROP-Tx Group), 52 eyes from 26 children who developed ROP but did not require treatment (ROP-nonTx Group), 51 eyes from 25 children born prematurely without ROP (Premature Group), and 54 eyes from 27 healthy term children of the same age group (Control Group). One eye of a single premature infant was included in the ROP-nonTx group, while the other eye was included in the Premature group. The first three groups included patients who were followed up under the Retinopathy of Prematurity protocol at Zekai Tahir Burak Hospital between 2008 and 2016, while the control group consisted of 5-12 years old who presented for a routine eye examination without any ocular complaints or history of prematurity. Non-cycloplegic and cycloplegic refractive errors, best corrected visual acuity (BCVA), keratometry, axial length (AL) and anterior chamber depth (ACD), optical coherence tomography (OCT) central macula and choroid thickness measurements were performed in all cases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Premature infants treated with laser photocoagulation for retinopathy of prematurity exhibited significant differences in all measured ocular parameters compared to the term-born control group (p &lt; 0.05). These parameters included reduced best corrected visual acuity (0.1 logMar), steeper keratometry values (K2: 47.95 Dioptre, K1: 45.83 Dioptre), more myopic spherical equivalent (-0.87 Dioptre), shorter axial length (21.67 mm), decreased anterior chamber depth (3.04 mm), as well as increased central macular thickness (300.50 μm) and decreased central choroidal thickness (268.27 μm). Infants who developed ROP but did not require laser treatment also exhibited significant differences compared to the control group, including steeper keratometry values (K2: 46.62 Dioptre, K1: 45.24 Dioptre) shorter axial length (22.01 mm), and increased central macular thickness (250.05 μm). Interestingly, anterior chamber depth was significantly unexpected way different (3.47 mm) only in the premature group without ROP compared to the term-born controls (p &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The study found that prematurity, ROP, and eye development are closely connected. Premature infants who treated with laser photocoagulation for ROP had the most significant differences in eye structure and vision compared to full-term infants. Even premature i","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"122"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responding to comments on \"Astigmatism in Duane Retraction syndrome\".","authors":"Masoud Khorrami-Nejad, Mohamad Reza Akbari, Babak Masoomian, Hayder Ali Mahmood, Kim Daneshvar, Ali Majdi","doi":"10.1186/s12886-025-03951-x","DOIUrl":"10.1186/s12886-025-03951-x","url":null,"abstract":"<p><p>This response addresses readers' comments on our study published in BMC Ophthalmology, which analyzed astigmatic variations among Duane Retraction Syndrome (DRS) subtypes. We clarified that our retrospective study relied on clinical data rather than advanced imaging due to practical limitations. Differences in DRS subtype prevalence were attributed to our focus on patients requiring surgical intervention rather than general epidemiological patterns. Age-related refractive variations across different DRS subtypes were found to be statistically insignificant, confirming that age differences did not influence the observed refractive patterns. The potential paradoxical effects of co-contraction and palpebral fissure narrowing on corneal curvature are notable, as both factors can simultaneously influence corneal changes. However, co-contraction may have a more prominent effect on corneal curvature than palpebral fissure narrowing, leading to a tendency toward against-the-rule astigmatism. Data inconsistencies in Table 3 were corrected, and the omission of key symbols in formulas was acknowledged. The insights provided by readers underscore the need for future studies incorporating advanced diagnostics and corneal topographic data to achieve a deeper understanding of astigmatism in DRS.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"128"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual effects of trifocal intraocular lens implantation in cataract patients with different refractive states.","authors":"Jin Zhou, Xue Zhan, Yan Huo, Jian Ye","doi":"10.1186/s12886-025-03963-7","DOIUrl":"10.1186/s12886-025-03963-7","url":null,"abstract":"<p><strong>Aims: </strong>To compare the visual effect and subjective satisfaction of cataract patients with different refractive states after trifocal intraocular lens (IOL) implantation.</p><p><strong>Methods: </strong>This retrospective study describes 134 eyes of 86 patients that were implanted with trifocal IOL (TFNT00). Patients were allocated into three groups according to their preoperative axial length (AL): A group (AL ≤ 24 mm), B group (24 mm < AL < 26 mm), and C group (AL ≥ 26 mm). Postoperative visual acuity, defocus curve, visual quality and subjective satisfaction were collected and compared, and the postoperative follow-up time was at least 3 months (3 months to 3 years).</p><p><strong>Results: </strong>The uncorrected intermediate visual acuity (UIVA) and uncorrected near visual acuity (UNVA) of A group was significantly better than B group (P = 0.008 and P = 0.016). The UNVA of C group was significantly better than B group (P = 0.047). The defocus curve showed that the visual acuity of three groups from 40 cm to 5 m was better than 0.16 (LogMAR). The near vision satisfaction of B group was significantly lower than A group and C group (P<0.001 and P = 0.004).</p><p><strong>Conclusions: </strong>For cataract patients with different refractive states, trifocal IOL implantation can provide good visual and refractive outcomes. For cataract patients with low and moderate myopia, the UIVA and UNVA were worse, and the subjective satisfaction of near vision was also worse than the hyperopia and emmetropia and the high myopia.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"125"},"PeriodicalIF":1.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of effective optical zone and decentration on visual quality after smile for different astigmatism types.","authors":"Xuyun Meng, Hui Ding, Zhenduo Yang, Xiaodan Chen, Shisi Hu, Xingwu Zhong","doi":"10.1186/s12886-025-03948-6","DOIUrl":"10.1186/s12886-025-03948-6","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the refractive outcomes and visual quality among different types of astigmatism following SMILE and evaluate effective optical zone (EOZ) features, decentration and their potential effects on visual quality.</p><p><strong>Methods: </strong>This study included 101 left eyes of 101 patients who underwent SMILE. Patients were grouped according to astigmatism types (with-the-rule [WTR], against-the-rule [ATR] and oblique astigmatism) and decentered displacement (major axis > minor axis and major axis < minor axis). We compared the refractive outcomes, visual quality, EOZ and decentration 3 months postoperatively and analyzed correlations between corneal aberrations and EOZ parameters.</p><p><strong>Results: </strong>The visual and refractive outcomes were favorable in different types of astigmatism. The induced corneal aberrations, EOZ and total decentration were comparable among three groups (all p >.05). There was a strong positive correlation (r =.828, p <.001) between preoperative cylinder axis and the angle of EOZ. The postoperative induced changes in spherical aberration (0.02 ± 0.15 vs. 0.08 ± 0.13, p =.037), coma (0.22 ± 0.27 vs. 0.36 ± 0.25, p =.010), total HOAs (0.28 ± 0.24 vs. 0.42 ± 0.31, p =.009) and LOAs (0.16 ± 0.62 vs. 0.49 ± 0.84, p =.023) were fewer in group with greater decentered displacement along the major axis than the minor axis.</p><p><strong>Conclusions: </strong>Favorable outcomes were observed in different types of astigmatism. Postoperative refractive errors, visual acuity, and induced corneal aberrations showed no significant differences between groups with WTR, ATR, and oblique astigmatism. The angle of EOZ was closely associated with cylinder axis. EOZ provided greater tolerance to decentration, with fewer induced corneal aberrations along the major axis compared to the minor axis. The combined impacts of EOZ and decentration on visual quality should be noted.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"121"},"PeriodicalIF":1.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective evaluation of the clinical monitoring period prior to referral for glaucoma surgery with the emphasis on visual field test results.","authors":"Jesper L Hougaard, Boel Bengtsson","doi":"10.1186/s12886-025-03925-z","DOIUrl":"10.1186/s12886-025-03925-z","url":null,"abstract":"<p><strong>Purpose: </strong>To survey the monitoring of patients who underwent glaucoma surgery with the purpose of identifying routines possibly delaying the referral process.</p><p><strong>Methods: </strong>We conducted an observational retrospective study of the 2-year period prior to referral of a cohort of patients who underwent trabeculectomy or Xen® Gel Stent implantation at Skåne University Hospital (SUS), Sweden. Data were retrieved from medical records; variables of particular interest were related to intraocular pressure (IOP) measurements and visual field (VF) tests.</p><p><strong>Results: </strong>Out of 330 patients who underwent surgery, 139 were included. There were 20 referring clinics in total; SUS and two clinics in private practice accounted for 55.4% of all referrals. Prior to referral, the most common number of VF tests per patient was three, and 43.2% (60/139) had ≥ 10 IOP measurements. According to the last VF test, 51.1% had lost > 50% of a full VF. During the 2-year period, 21.9% (28/128 with ≥ 2 VF tests) progressed from ≥ 50% to < 50% remaining of a full VF. The median rate of progression of VF damage was -6.8%/year in the 107 patients who had ≥ 3 VFs, and 67.3% (72/107) were projected, by extrapolation of the linear trend, to lose > 50% of a full VF if the referral had been postponed for 2 years. At the time of the last IOP measurement prior to referral, 84% (117/139) of the patients were on ≥ 3 IOP-lowering agents, and the IOP ranged from 11-45 mmHg, with a median of 20 mmHg.</p><p><strong>Conclusion: </strong>In general, in the 2-year period prior to referral for surgery, the number of IOP measurements was high, and the number of VF examinations seemed acceptable in most cases. Nevertheless, > 50% had advanced to severe VF loss and fast progression prior to referral. The IOP level is a known risk factor for disease progression that should be monitored at least by VF tests, but the frequent IOP measurements observed in our study, probably due to treatment changes, may have delayed the time to referral.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"120"},"PeriodicalIF":1.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in expression of inflammatory cytokines and ocular indicators in pre-diabetic patients with cataract.","authors":"Yixun Chen, Yan Meng, Mengjia Tan, Jun Ma, Jian Zhu, Min Ji, Huaijin Guan","doi":"10.1186/s12886-025-03892-5","DOIUrl":"10.1186/s12886-025-03892-5","url":null,"abstract":"<p><p>Pre-diabetes is the preceding condition of diabetes, and in some cases, fundus changes have been seen in pre-diabetes. The inflammatory response is widely recognized as being involved in the pathophysiologic process of diabetic eye disease. Therefore, we aimed to acquire understanding of the role of early altered blood glucose levels in the development and etiology of diabetic ocular disorders from the perspective of inflammation. In this study, serum, tear, aqueous humor and vitreous fluid samples were collected from patients undergoing cataract surgery. VEGF, IL-6, TNF-a, MCP-1, APOA-1, ICAM-1, VCAM-1, PEDF, TSP-1 were measured by ELISA. The quantity of hyperreflective retinal spots (HRS) was counted by optical coherence tomography OCT images. We found that the levels of inflammatory cytokines are already altered in pre-diabetes. Levels of pro-inflammatory cytokine expression and quantity of HRS can reflect the disease process to some extent.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"119"},"PeriodicalIF":1.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of intravitreal faricimab injection in previously treated neovascular age-related macular degeneration eyes: a case series.","authors":"Maria A Bantounou, Mohammed Elsheikh, Adelehin Ijasan, Cynthia Santiago","doi":"10.1186/s12886-025-03953-9","DOIUrl":"10.1186/s12886-025-03953-9","url":null,"abstract":"<p><strong>Background: </strong>Faricimab is a novel anti-vascular endothelial growth factor agent, used to treat patients with neovascular age-related macular degeneration (nAMD). This study assessed efficacy and safety of faricimab in previously treated eyes.</p><p><strong>Methods: </strong>This retrospective study included previously treated nAMD patients who had received at least three faricimab injections. Baseline data were collected from February 2023 to September 2023, and follow-up data were collected until April 2024. The patients were divided into two cohorts: (1) the \"Loaded\" cohort, which received four weekly injections prior to treatment extension, and (2) the \"Interval-Matched\" cohort, which continued on the same treatment interval as their previous regimen. Efficacy was evaluated based on the primary outcome measures: central subfield thickness (CST), the presence of macular fluid, and visual outcomes. Safety was assessed through the secondary outcome measure of adverse event reporting.</p><p><strong>Result: </strong>Two hundred thirty-seven participants (297 eyes) were included with a mean age of 80.7 ± 7 years, 44% were males. 2,237 faricimab injections were administered (7.5 ± 1.9 per eye). In the loaded cohort, CST decreased from 315.1 ± 86.0 µm to 288.0 ± 63.6 µm (p < 0.001). The percentage of dry macula increased from 11.0% to 42.5% (p < 0.001). Vision changed from 67.9 ± 12.3 to 69.3 ± 13.4 letters (p = 0.002), and the injection interval extended from 5.3 ± 1.3 to 6.4 ± 2.1 weeks (p < 0.001). For the interval-matched cohort, CST decreased from 302.8 ± 57.4 µm to 291.2 ± 62.6 µm (p = 0.001). The percentage of dry macula increased from 22.5% to 47.7% (p < 0.001). Vision changed from 65.9 ± 13.8 to 65.0 ± 17.1 letters (p = 0.613), and the injection interval extended from 6.6 ± 2.8 to 7.9 ± 3.2 weeks (p < 0.001). 68 (28.7%) adverse events were reported, of which 9 (3.8%) were serious.</p><p><strong>Conclusion: </strong>Faricimab showed beneficial anatomical response with stable vision, and less injections. The loaded cohort exhibited superior outcomes but needed more injections.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"117"},"PeriodicalIF":1.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of childhood obesity on retinal microvasculature and the role of biochemical markers for its early detection.","authors":"Sina Arabi, Mohsen Pourazizi, Motahar Heidari-Beni, Maryam Yazdi, Roya Kelishadi","doi":"10.1186/s12886-025-03942-y","DOIUrl":"10.1186/s12886-025-03942-y","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is a growing public health concern, associated with several systemic disorders including changes in retinal microvasculature. This study aims to assess the relationship between body composition, biochemical markers, and retinal microvascular changes in obese children.</p><p><strong>Methods: </strong>In this cross-sectional study, 45 overweight and obese children and 46 age- and sex-matched healthy individuals were evaluated. In addition to physical examination, anthropometric measurements were obtained using a body composition analyzer. A comprehensive ophthalmic assessment was conducted for all participants, which included advanced optical biometry, autorefractometry, visual acuity testing, and slit-lamp examination. Retinal microvasculature was assessed using optical coherence tomography angiography (OCT-A). Biochemical markers, including lipid profile, liver function tests, and CRP (as marker of inflammation), were also analyzed.</p><p><strong>Results: </strong>The mean ages were 10.18 and 9.40 years in the obese/overweight and normal weight groups, respectively. Increased foveal thickness (p = 0.04) and foveal vessel density (p = 0.01) in the superficial capillary plexus, and decreased vessel density in the inferior parafoveal region of the deep capillary plexus (p = 0.03) were observed in obese/overweight children. Adjusted and crude regression analysis showed significant associations between body mass index, percent body fat, fasting blood glucose, and serum alanine transaminase levels with foveal vessel density, as well as between body mass index and serum triglycerides levels with foveal thickness.</p><p><strong>Conclusions: </strong>Our findings suggest that childhood obesity is associated with significant alterations in retinal microvasculature. We propose that retinal health assessments and biochemical evaluations be considered in the clinical management of obese children.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"118"},"PeriodicalIF":1.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical assessment of brain adaptation following multifocal intraocular lens implantation.","authors":"Yutaro Nishi, Hiroyuki Nishi, Maiko Fukui, Miki Tatsumichi, Kayo Nishi, Okihiro Nishi","doi":"10.1186/s12886-025-03955-7","DOIUrl":"10.1186/s12886-025-03955-7","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to clinically and quantitatively evaluate the speed of brain adaptation following multifocal intraocular lens (IOL) implantation. The speed of brain adaptation is considered to vary among individuals and influence postoperative visual recovery.</p><p><strong>Methods: </strong>At our institution, a total of 24 cases underwent cataract surgery with the implantation of FineVision PodF (BVI/PhysIOL), PanOptix (Alcon), Intensity (Hanita Lenses), Tecnis Synergy (J&J), and Vivity (Alcon). The Mini-Mental State Examination (MMSE) test was performed postoperatively, at least one week after surgery. Patients whose corrected distance visual acuity (LogMAR) was better than 0 and who had no visual disturbance at 1 week postoperatively were classified as Group A (n = 14). Patients whose corrected distance visual acuity had not reached 0.1 and who still experienced visual disturbance at 1 month postoperatively were classified as Group B (n = 10). MMSE scores and test completion time for each group were retrospectively investigated as a pilot study.</p><p><strong>Results: </strong>The mean age in Group A was 62 ± 10 years, and in Group B, 76 ± 5.6 years (p < 0.05). The MMSE test scores were 28.9 ± 1.7 points in Group A and 29.2 ± 0.69 points in Group B, showing no significant difference (p = 0.68). However, the MMSE test completion time was 256 ± 50 s in Group A and 346 ± 67 s in Group B, with a significant difference (p < 0.05). The percentage of patients completing the test within 5 min was 93% (13 out of 14) in Group A and 20% (2 out of 10) in Group B.</p><p><strong>Conclusion: </strong>This study suggests that the speed of brain adaptation following multifocal IOL implantation may be reflected in MMSE test completion time. Future research is needed to further quantify brain adaptation speed using different IOL types, conditions, and refined test methods.</p>","PeriodicalId":9058,"journal":{"name":"BMC Ophthalmology","volume":"25 1","pages":"116"},"PeriodicalIF":1.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}