BMC Geriatrics最新文献

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Understanding how, for whom and under what circumstances telecare can support independence in community-dwelling older adults: a realist review.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-27 DOI: 10.1186/s12877-024-05650-6
Lauren Fothergill, Niall Hayes, Yvonne Latham, Jenny Hamilton, Saiqa Ahmed, Carol Holland
{"title":"Understanding how, for whom and under what circumstances telecare can support independence in community-dwelling older adults: a realist review.","authors":"Lauren Fothergill, Niall Hayes, Yvonne Latham, Jenny Hamilton, Saiqa Ahmed, Carol Holland","doi":"10.1186/s12877-024-05650-6","DOIUrl":"10.1186/s12877-024-05650-6","url":null,"abstract":"<p><strong>Background: </strong>There is substantial interest among policy makers in using telecare to support independence in older adults. However, research on how telecare can be most beneficial in promoting independence is limited. This realist review aimed to understand the contexts in which telecare can support independence and for whom, to aid older people in remaining at home.</p><p><strong>Methods: </strong>This realist review is consistent with the RAMESES quality and reporting standards. We followed a five-step process to conduct the review: (1) locating existing theories and concepts, (2) searching for evidence (3), selecting data, (4) extracting data, and (5) synthesising data. We analysed 32 studies published between 2004 and 2023 to identify core mechanisms of how telecare may lead to positive or negative impacts in the form of context-mechanism-outcome (CMO) configurations. CMOs were grouped into overall domains and contributed to an overall programme theory of how telecare works.</p><p><strong>Results: </strong>Four key domains across 12 CMO configurations were identified, which suggest how telecare can support older adults in living independently (1). Telecare services should support older adults' goal of staying at home by providing reassurance of help in an emergency and aid in detecting age-related deterioration (2). Telecare that supports autonomy by enabling choice over technological resources may support self-reliance and control over one's life, including choosing the level of monitoring, freedom to call for help if needed, and the ability to customise technology to suit needs (3). Telecare that enables connections to existing or new social networks may reduce loneliness and social isolation for those who lack social resources. Finally (4), telecare must integrate into everyday life by fitting people's existing context, skills, resources, and identity. To improve telecare implementation, consideration must be given to these mechanisms; otherwise, interventions risk being abandoned or underutilised and, as a result, may not adequately support older adults to remain living at home safely, creating a false sense of security.</p><p><strong>Conclusions: </strong>Assessments of an individual's needs and preferences should be carried out to ensure that telecare enables autonomy, supports the goal of remaining at home, facilitates connections to social support, and promotes integration into everyday life.</p><p><strong>Study registration: </strong>PROSPERO CRD42021292384.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"59"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The obesity paradox in osteoporosis risk among older adults is mostly driven by women: a population-based prospective study.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-27 DOI: 10.1186/s12877-025-05704-3
Qingfeng Luo, Shiyong Zhang, Zixin Liang, Danni Wang, Yanlin Zhong, Bin Xia, Peng Xie, Can Wang, Jinqiu Yuan, Ziji Zhang, Xingsheng Li
{"title":"The obesity paradox in osteoporosis risk among older adults is mostly driven by women: a population-based prospective study.","authors":"Qingfeng Luo, Shiyong Zhang, Zixin Liang, Danni Wang, Yanlin Zhong, Bin Xia, Peng Xie, Can Wang, Jinqiu Yuan, Ziji Zhang, Xingsheng Li","doi":"10.1186/s12877-025-05704-3","DOIUrl":"10.1186/s12877-025-05704-3","url":null,"abstract":"<p><strong>Objectives: </strong>The obesity paradox is common among older adults at risk for various diseases. Although this paradox has also been observed in the association between obesity and osteoporosis, the available evidence remains controversial. This study aimed to investigate the association between obesity and OP risk in an older population.</p><p><strong>Methods: </strong>A cross-sectional and prospective study was conducted using data from 177,734 participants in the UK Biobank. The association of body mass index (BMI), waist circumference (WC), and fat percentage with BMD was examined using Spearman correlation analysis with baseline BMD data. Cox proportional hazards regression analysis was used to investigate the association between obesity and OP risk. Restricted cubic spline (RCS) were used to assess the nonlinear associations of BMI, WC, and fat percentage with OP.</p><p><strong>Results: </strong>Baseline cross-sectional analyses revealed a significant positive association between BMI, WC, and fat percentage with BMD in women, whereas this association was very weak in men. A total of 8,998 OP patients were identified during a median follow-up period of 13.7 years. Cox analyses showed that obesity as defined by BMI, WC, and fat percentage was associated with a 33%, 23%, and 31% reduction in the risk of OP in older women but not in men, respectively. Conjoint analysis showed that lower BMI was associated with increased risk of OP in older adults, whereas the lowest risk was observed in women with higher BMI and higher body fat. RCS revealed an inverse J-shaped nonlinear association between obesity metrics and OP risk in women.</p><p><strong>Conclusion: </strong>Lower BMI is an independent risk factor for OP in older adults, and the obesity paradox for OP risk exists only in women.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"58"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of sedentary time, sleep duration and physical exercise with multimorbidity among older adults in Shanghai, China: a cross-sectional study based on national physical fitness surveillance data.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-27 DOI: 10.1186/s12877-025-05701-6
Kai Li, Jingjing Wang, Yuqin Rao, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Dao Wang, Chen Wang, Bao Liu
{"title":"Associations of sedentary time, sleep duration and physical exercise with multimorbidity among older adults in Shanghai, China: a cross-sectional study based on national physical fitness surveillance data.","authors":"Kai Li, Jingjing Wang, Yuqin Rao, Fanhui Zheng, Ying Chen, Bo Zhai, Jintao Hong, Dao Wang, Chen Wang, Bao Liu","doi":"10.1186/s12877-025-05701-6","DOIUrl":"10.1186/s12877-025-05701-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Multimorbidity has emerged as a significant challenge for healthcare systems globally. This study aims to examine the associations between key determinants of lifestyle behavior and various multimorbidity patterns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In a cross-sectional sample of older adults (aged 60-79) from the Fifth National Physical Fitness Surveillance in Shanghai, latent class analysis (LCA) was used to identify multimorbidity patterns among 9 chronic diseases. Multinomial logistic regression was performed to analyze the associations between sedentary time, sleep duration, physical exercise, and the different multimorbidity patterns. Weighted analysis was performed to appropriately account for complex sampling designs and provide more robust results.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 13,465 study participants (unweighted mean age 69.3 years; weighted mean age 67.4 years, 50.7% female), the overall prevalence of multimorbidity was 40.9%-42.3%. Four latent classes among the older adults were identified, with the relatively healthy class (63.6%-64.6%) had an average of less than 1 chronic disease. The other 3 classes, namely the metabolic-cardiovascular-joint-digestive-respiratory disease class (2.9%-3.0%), the metabolic-cardiovascular disease class (14.5%-15.5%), and the joint-digestive-respiratory disease class (17.9%-18.0%), each had an average of more than 2 chronic diseases, representing different multimorbidity patterns. Prolonged sedentary time (&gt; 3 h/day) increased the odds of belonging to the metabolic-cardiovascular-joint-digestive-respiratory disease class by 56%-57% (unweighted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.27-1.94; weighted OR 1.56, 95% CI 1.36-1.80), the metabolic-cardiovascular disease class by 38% (unweighted OR 1.38, 95% CI 1.25-1.53; weighted OR 1.38, 95% CI 1.29-1.48), and the joint-digestive-respiratory disease class by 30%-32% (unweighted OR 1.32, 95% CI 1.19-1.45; weighted OR 1.30, 95% CI 1.22-1.38). Shorter sleep duration (&lt; 7 h/day) also increased the odds of membership in the metabolic-cardiovascular disease class by 48%-49% (unweighted OR 1.49, 95% CI 1.35-1.65; weighted OR 1.48, 95% CI 1.38-1.58), the metabolic-cardiovascular-joint-digestive-respiratory disease class by 37%-47% (unweighted OR 1.47, 95% CI 1.19-1.80; weighted OR 1.37, 95% CI 1.19-1.58), and the joint-digestive-respiratory disease class by 41%-42% (unweighted OR 1.42, 95% CI 1.29-1.56; weighted OR 1.41, 95% CI 1.32-1.50). Each additional daily hour of low-intensity physical exercise (LIPE) reduced the odds of membership in the metabolic-cardiovascular-joint-digestive-respiratory disease class by 24%-25% (unweighted OR 0.76, 95% CI 0.64-0.90; weighted OR 0.75, 95% CI 0.66-0.84), the joint-digestive-respiratory disease class by 20%-21% (unweighted OR 0.79, 95% CI 0.73-0.86; weighted OR 0.80, 95% CI 0.76-0.85), and the metabolic-cardiovascular disease class by 11%-12% (unweighted OR 0.88, 95% CI 0.8","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"61"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effectiveness and choice of public pension scheme among Donglan county residents in China.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-27 DOI: 10.1186/s12877-024-05651-5
Li Zhu, Zixuan Peng, Qucheng Deng, Xiumei Zhang
{"title":"The effectiveness and choice of public pension scheme among Donglan county residents in China.","authors":"Li Zhu, Zixuan Peng, Qucheng Deng, Xiumei Zhang","doi":"10.1186/s12877-024-05651-5","DOIUrl":"10.1186/s12877-024-05651-5","url":null,"abstract":"<p><strong>Background: </strong>China has made strides to achieve universal pension coverage through implementing the Public Pension Scheme for Urban and Rural Residents (PPSURR) program since 2014. This study explores the effectiveness of implementing the PPSURR in an impoverished county in China and investigates the determinants of residents' choice on the contribution level of the PPSURR.</p><p><strong>Methodology: </strong>Binary logit regression models were conducted using datasets extracted from the Chinese General Social Survey in 2021 and datasets collected through surveying 321 residents in Donglan county, China.</p><p><strong>Result: </strong>The PPSURR is demonstrated to be effective in reducing coverage gap between urban and rural residents in Donglan county, indicating the feasibility to utilize administrative support and public policies (such as financial subsidies) to address the urban-rural disparity in pension coverage at the county-level. Our study also found that county residents who are rich, had higher education attainment and better understanding towards policies were more likely to participate in the PPSURR; insured residents with higher income and live in urban area were more likely to select a higher contribution level.</p><p><strong>Conclusion: </strong>It's urgent to gradually narrow benefits gap between urban and rural residents. Policy makers are suggested to offer more financial assistance for those from less wealthy backgrounds, promote public understanding towards related policies, and reduce the regional disparities.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"62"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent depressive symptom trajectory is associated with cognitive impairment: a population-based longitudinal study of aging in Taiwan.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-27 DOI: 10.1186/s12877-025-05706-1
Hsiao-Chen Lin, Wai-Lam Lao, Te-Chia Tseng, Chih-Jung Yeh
{"title":"Persistent depressive symptom trajectory is associated with cognitive impairment: a population-based longitudinal study of aging in Taiwan.","authors":"Hsiao-Chen Lin, Wai-Lam Lao, Te-Chia Tseng, Chih-Jung Yeh","doi":"10.1186/s12877-025-05706-1","DOIUrl":"10.1186/s12877-025-05706-1","url":null,"abstract":"<p><strong>Background: </strong>To investigate the associations between five depressive symptom trajectories and cognitive impairment in Taiwan's older population. In addition, we investigated the moderating factors influencing these associations.</p><p><strong>Methods: </strong>This population-based, longitudinal, cohort study was conducted on the basis of the Taiwan Longitudinal Study on Aging. Data corresponding to the fifth (2003), sixth (2007), and seventh (2011) survey waves were analyzed, focusing on individuals aged ≥ 65 years. Depressive symptom trajectories were analyzed using the 10-item Centre for Epidemiological Studies Depression scale, and cognitive function was assessed using the Short Portable Mental State Questionnaire. Logistic regression models were adjusted for various covariates such as sociodemographic, lifestyle, and health-related variables. We also investigated moderating effects of sex, age, type 2 diabetes mellitus, hypertension, and coronary heart disease.</p><p><strong>Results: </strong>Five trajectories of depressive symptoms included 1,549 older individuals were identified. Approximately 36.09%, 47.13%, 5.68%, 6.20%, and 4.91% exhibited no, mild, decreasing, increasing, and persistent depressive symptom trajectories, respectively. The odds ratios for cognitive impairment were 3.17 (95% confidence interval [CI]: 1.41-7.15) in Model 1; 3.24 (95% CI: 1.42-7.41) in Model 2; and 2.95 (95% CI: 1.24-7.00) in Model 3 in individuals with persistent depressive symptom trajectory. Only persistent depressive symptom trajectory reached statistical significance in all three models. Cognitive decline was evident across all trajectories. The rate of cognitive decline was more rapidly in the persistent depressive symptom trajectory, nearly twofold to no depressive symptom trajectory, which the corresponding β values (score/year) were - 0.0862, - 0.1020, - 0.1192, - 0.1206, and - 0.1683 for the no, mild, decreasing, increasing, and persistent depressive symptom trajectories, respectively. Female sex, older age, type 2 diabetes mellitus, and coronary heart disease were significant moderators on the risk of cognitive impairment.</p><p><strong>Discussion: </strong>Persistent depressive symptoms is associated with cognitive impairment in older adults. Identifying high-risk subgroups is crucial for targeted assistance. Policymakers and health-care professionals should be informed accordingly.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"60"},"PeriodicalIF":3.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between intrinsic capacity and functional ability in older adults.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-25 DOI: 10.1186/s12877-025-05709-y
Somayeh Ahmadi, Pouya Farokhnezhad Afshar, Kazem Malakouti, Mojtaba Azadbakht
{"title":"The relationship between intrinsic capacity and functional ability in older adults.","authors":"Somayeh Ahmadi, Pouya Farokhnezhad Afshar, Kazem Malakouti, Mojtaba Azadbakht","doi":"10.1186/s12877-025-05709-y","DOIUrl":"10.1186/s12877-025-05709-y","url":null,"abstract":"<p><strong>Introduction: </strong>Intrinsic Capacity in integrated geriatric care emphasizes the importance of a thorough functional assessment. Monitoring the intrinsic capacity of older individuals provides standardized and reliable information to prevent early disability. This study assessed the relationship between intrinsic capacity and functional ability in older adults.</p><p><strong>Method: </strong>This cross-sectional study involved 210 older individuals aged 60 and above referred to Rasoul Akram Hospital. Data collection included ADL and IADL scales, the Snellen chart, the Hearing Handicap Inventory, the hand dynamometer, the TUG test, the AMT test, and the GDS. Data analysis was conducted using SPSS software v.26 via independent t-tests, ANOVA, Pearson correlation coefficient, and multiple regression analysis.</p><p><strong>Results: </strong>The participants were 70.13 ± 7.04 years. 57.6% were older females and 42.4% were older males. Age showed a significant and inverse correlation with both ADL (P < 0.001, r = -0.23) and IADL (P < 0.001, r = -0.39). The adjusted coefficient of determination (R²) for the five domains of intrinsic capacity (sensory, cognitive, locomotion, psychological, vitality) as well as age and BMI was 0.16 for ADL and 0.32 for IADL.</p><p><strong>Conclusion: </strong>Age and TUG could only weakly explain ADL changes, while vision, hand grip strength, cognition, and age had moderate predictive ability of IADL. Therefore, by assessing these predictors, we can predict disability before it occurs and make necessary interventions.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"57"},"PeriodicalIF":3.4,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sleep patterns and depression in older adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2007-2014.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-24 DOI: 10.1186/s12877-024-05633-7
Yi Niu, Yuqin Sun, Yijie Xie, Shun Yu
{"title":"Association between sleep patterns and depression in older adults: a cross-sectional study using data from the National Health and Nutrition Examination Survey 2007-2014.","authors":"Yi Niu, Yuqin Sun, Yijie Xie, Shun Yu","doi":"10.1186/s12877-024-05633-7","DOIUrl":"10.1186/s12877-024-05633-7","url":null,"abstract":"<p><strong>Objective: </strong>To assess the association between sleep patterns and sleep factors (sleep duration, trouble sleeping, sleep disorder) and the risk of depression in older adults.</p><p><strong>Methods: </strong>A total of 5636 participants (2754 men and 2882 women) aged 60 years and older from the 2007-2014 waves of the National Health and Nutrition Examination Survey (NHANES) were included. Sleep duration, sleep problems, and sleep disorders were assessed in the home by trained interviewers using the Computer-Assisted Personal Interviewing (CAPI) system. The combined sleep behaviours were referred to as 'sleep patterns (healthy, intermediate and poor)', with a 'healthy sleep pattern' defined as sleeping 7-9 h per night with no self-reported trouble sleeping or sleep disorders. Intermediate and poor sleep patterns indicated 1 and 2-3 sleep problems, respectively. Baseline characteristics of participants analysed using one-way logistic regression. Logistic multiple linear regression was used to assess the association of sleep factors and sleep patterns with the risk of depressive symptoms.Conduct subgroup analyses to ensure robustness of findings.</p><p><strong>Results: </strong>The overall prevalence of depression was 7.7% among the 5636 participants analysed, with the rate of depression in older women being 1.6 times higher than in older men. The prevalence of depression was higher in older adults with intermediate sleep pattern than in older adults with healthy sleep pattern (OR: 2.28, 95% CI: 1.71-3.03, p < 0.001). The prevalence of depression was higher in older adults with poor sleep pattern than in older adults with healthy sleep pattern (OR: 5.60, 95% CI: 4.25-7.39, p < 0.001). The findings were robust after controlling for sleep items in the PHQ-9.</p><p><strong>Conclusion: </strong>This nationally representative survey showed a relationship between sleep patterns and depression in older adults. However, the study population was limited to Americans, and we recommend continued investigation of the causal relationship and mechanisms between the two in the future, and further expansion of data sources in order to assess the applicability of the findings.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"56"},"PeriodicalIF":3.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced detection of mild cognitive impairment in Alzheimer's disease: a hybrid model integrating dual biomarkers and advanced machine learning.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-23 DOI: 10.1186/s12877-025-05683-5
John Sahaya Rani Alex, R Roshini, G Maneesha, Jeetashree Aparajeeta, B Priyadarshini, Chih-Yang Lin, Chi-Wen Lung
{"title":"Enhanced detection of mild cognitive impairment in Alzheimer's disease: a hybrid model integrating dual biomarkers and advanced machine learning.","authors":"John Sahaya Rani Alex, R Roshini, G Maneesha, Jeetashree Aparajeeta, B Priyadarshini, Chih-Yang Lin, Chi-Wen Lung","doi":"10.1186/s12877-025-05683-5","DOIUrl":"10.1186/s12877-025-05683-5","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a complex, progressive, and irreversible neurodegenerative disorder marked by cognitive decline and memory loss. Early diagnosis is the most effective strategy to slow the disease's progression. Mild Cognitive Impairment (MCI) is frequently viewed as a crucial stage before the onset of AD, making it the ideal period for therapeutic intervention. AD is marked by the buildup of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs), which are believed to cause neuronal loss and cognitive decline. Both Aβ plaques and NFTs accumulate for many years before the clinical symptoms become apparent in AD. As a result, in this study, CerebroSpinal Fluid (CSF) biomarker information is combined with hippocampal volumes to differentiate between MCI and AD. For this, a novel two-stage hybrid learning model that leverages 3D CNN and the notion of a Fuzzy and Machine learning model is proposed. A 3D-CNN architecture is employed to segment the hippocampus from the structural brain 3D-MR images and quantify the hippocampus volume. In stage 1, the hippocampus volume is passed through thirteen machine learning models and fuzzy clustering for classifying symptomatic AD and healthy brain (Normal Control - NC). The CSF data is fuzzified to capture the inherent uncertainty and overlap in clinical data. The identified symptomatic AD data in the stage1 are further classified into MCI and AD with the aid of a fuzzified CSF biomarker in stage 2. The experimental work presented in this study utilized the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. The proposed hybrid model achieved an average accuracy of 93.6% for distinguishing between NC and symptomatic AD and 93.7% for discriminating between MCI and AD. This approach enhances diagnostic accuracy and provides a more comprehensive assessment, allowing for earlier and more targeted therapeutic interventions.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"54"},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the relationship between indoor ventilation frequency and anxiety and depression symptoms in older persons: based on the data of 2018 CLHLS.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-23 DOI: 10.1186/s12877-025-05710-5
Lu Lin, Pingping He, Xiaohui Qiu, Sihui Qiu, Jiangping Chen, Jin Wang
{"title":"Study on the relationship between indoor ventilation frequency and anxiety and depression symptoms in older persons: based on the data of 2018 CLHLS.","authors":"Lu Lin, Pingping He, Xiaohui Qiu, Sihui Qiu, Jiangping Chen, Jin Wang","doi":"10.1186/s12877-025-05710-5","DOIUrl":"10.1186/s12877-025-05710-5","url":null,"abstract":"<p><strong>Background: </strong>To investigate the association between indoor ventilation frequency and symptoms of depression and anxiety in older persons.</p><p><strong>Methods: </strong>A binary logistic regression model was used to analyze the effects of indoor ventilation frequency on depression and anxiety by using data from the 2018 Chinese longitudinal healthy longevity survey (CLHLS).</p><p><strong>Results: </strong>A total of 9,690 older persons with an average age of (83.20 ± 11.27) years were included, including 4,458 males (46.0%) and 5,232 females (54.0%). The average score of indoor ventilation frequency was (6.06 ± 1.98) points, including 770 people (7.9%) with low frequency, 3,066 people (31.6%) with medium frequency, and 5,854 people (60.4%) with high frequency. 842 (8.7%) had symptoms of depression and 204 (2.1%) had symptoms of anxiety. Compared with the older persons with low indoor ventilation frequency, the older persons with higher ventilation frequency had a lower incidence of depression (OR(95%CI) = 1.92 (1.50 ∼ 2.46), 1.51 (1.27 ∼ 1.79); P < 0.001). However indoor ventilation frequency was not associated with anxiety symptoms.</p><p><strong>Conclusion: </strong>Indoor ventilation frequency is related to depressive symptoms in older persons. Communities and families should pay more attention to indoor ventilation and intervene in time to promote and improve the mental health of older persons.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"55"},"PeriodicalIF":3.4,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationships among positive coping style, psychological resilience, and fear of falling in older adults.
IF 3.4 2区 医学
BMC Geriatrics Pub Date : 2025-01-22 DOI: 10.1186/s12877-025-05682-6
Siqi Liu, Han Xiao, Peiyao Qi, Mi Song, Yuan Gao, Hongying Pi, Qingqing Su
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