BMC Veterinary Research最新文献

{"title":"Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction.","authors":"Jamie Henry, Masayasu Ukai, Markos Antonakakis, Tianjian Zhou, Julie A Moreno, Agnieszka Z Burzynska, Stephanie McGrath","doi":"10.1186/s12917-025-04973-9","DOIUrl":"https://doi.org/10.1186/s12917-025-04973-9","url":null,"abstract":"<p><strong>Background: </strong>Canine cognitive dysfunction (CCD) is a naturally occurring disease in aged dogs that shares behavioral and pathological similarities with Alzheimer's disease (AD). Despite this, in vivo imaging of CCD has been limited, and to our knowledge, no studies have investigated the use of diffusion tensor imaging (DTI) to assess brain atrophy in this condition. The primary aim of this study was to determine whether DTI could detect differences in white matter microstructure between aged dogs with CCD and cognitively healthy aged dogs. A secondary aim was to evaluate correlations between DTI parameters and cognitive scores derived from the Canine Dementia Scale (CADES). We hypothesized that dogs with CCD would show lower fractional anisotropy (FA) and higher mean diffusivity (MD), axial diffusivity (AxD), and radial diffusivity (RD) in the corpus callosum (CC) and thalamus. We further hypothesized that these changes would correlate with cognitive dysfunction severity.</p><p><strong>Results: </strong>DTI revealed significant differences in white matter diffusivity between CCD and cognitively healthy aged dogs. Dogs with CCD had higher MD in the thalamus compared to healthy controls (CCD: 0.00063 mm²/s, IQR 0.00062-0.00066; n = 20, Healthy: 0.00060 mm²/s, IQR 0.00060-0.00063; n = 10; p = 0.022). CADES scores positively correlated with MD in the CC (rho=0.343, p = 0.0471) and thalamus (rho=0.483, p = 0.0038), and with RD in the thalamus (rho=0.416, p = 0.0144).</p><p><strong>Conclusions: </strong>These results demonstrate that DTI can detect changes in white matter integrity in the canine brain in both CCD and cognitively healthy aged dogs. Our findings suggest that axonal degeneration, as reflected by increased MD and RD values, correlates with worsening cognitive impairment. These patterns align with findings reported in Alzheimer's disease and support the potential use of DTI to monitor neuropathological progression in dogs with CCD. Overall, our results highlight the utility of DTI in characterizing structural brain changes associated with CCD and reinforce the translational relevance of CCD as a model for AD. Further research is required to determine whether DTI can reliably differentiate CCD from normal aging in clinical settings.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"550"},"PeriodicalIF":2.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the prevalence of environmental and host-related risk factors and the zoonotic potential of leptospirosis in domestic dogs in regions impacted by environmental changes.","authors":"Parsa Heydari, Mohammadreza Tirbandpay, Ramin Ghasemishayan","doi":"10.1186/s12917-025-05023-0","DOIUrl":"https://doi.org/10.1186/s12917-025-05023-0","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis is a globally distributed zoonosis with significant public and veterinary health implications. Domestic dogs serve both as sentinels and reservoirs, particularly in ecologically dynamic settings influenced by urbanization and climate change. However, the global understanding of canine leptospirosis remains fragmented due to inconsistent diagnostic practices and variable regional data.</p><p><strong>Objectives: </strong>To synthesize global evidence on the seroprevalence, dominant serovars, and risk factors associated with Leptospira infection in domestic dogs, and to evaluate the implications for public health within a One Health framework.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a systematic review was conducted across four databases (PubMed, Scopus, Web of Science, and WeLib) for studies published between 2000 and 2024. Observational studies using the Microscopic Agglutination Test (MAT) on domestic dogs were included. Data were extracted on seroprevalence, serovar distribution, and environmental, behavioral, and socio-economic risk factors. The Newcastle-Ottawa Scale was used for quality assessment. A narrative synthesis was conducted due to heterogeneity in methodologies.</p><p><strong>Results: </strong>The systematic search identified 1,842 records, with 26 studies included, involving 13,827 dogs across 12 countries. Seroprevalence ranged from 9.1% to 75.0%, with higher rates in South America and Asia due to tropical climates. Dominant serovars included Leptospira interrogans serovar Canicola and Leptospira interrogans serovar Icterohaemorrhagiae, while Leptospira borgpetersenii serovar Sejroe emerged in specific regions. Environmental (e.g., water proximity, OR = 1.5-5.1), behavioral (e.g., rodent hunting, OR = 2.4-4.5), and socioeconomic (e.g., poverty, OR = 2.5-4.0) risk factors were identified. Dogs served as sentinels and reservoirs, guiding One Health interventions.</p><p><strong>Conclusions: </strong>Canine leptospirosis is shaped by environmental, behavioral, and socio-economic drivers, with marked regional disparities. Dogs play a dual role as sentinels and reservoirs, necessitating integrated One Health interventions including targeted vaccination, environmental control, and community education. Standardization of diagnostics and expanded surveillance in underrepresented regions are critical for effective global leptospirosis control.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"564"},"PeriodicalIF":2.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effectiveness and adverse events of oxycodone as a pain-relieving agent in 103 dogs with tumors: a retrospective study.","authors":"Byung-Gee Ko, Tae-Hyun Kim, Hyun Namkung, Hye-Gyu Lee, Young-Jun Kang, Ga-Hee Youn, Kyoung-Won Seo, Hwa-Young Youn, Min-Ok Ryu","doi":"10.1186/s12917-025-04987-3","DOIUrl":"https://doi.org/10.1186/s12917-025-04987-3","url":null,"abstract":"<p><strong>Background: </strong>Oxycodone, a semi-synthetic opioid, has been widely used in human medicine for the management of tumor-related pain due to its potent analgesic properties. This study aimed to evaluate the efficacy and safety of oxycodone in managing tumor-related pain in dogs, addressing the current lack of research on effective analgesic options for canine cancer dogs. Medical records of 103 tumor-bearing dogs treated with oxycodone were retrospectively reviewed.</p><p><strong>Results: </strong>Oxycodone demonstrated an analgesic effect ranging from 23.1 to 63.6%, depending on the anatomical origin of the tumor. Improvement was observed in 67.7% of dogs with metastatic lesions. In the monotherapy group, the mean pain relief score increased from 8.73 ± 1.27 before treatment to 9.65 ± 1.53 after administration (p < 0.0001). In the combination therapy group, score rose from 8.75 ± 1.20 to 9.83 ± 1.87 (p = 0.0002). Across the entire canine patient cohort, the mean pain relief score increased from 8.74 ± 1.23 to 9.74 ± 1.70 following treatment (p < 0.0001). Adverse effects included lethargy (n = 6), diarrhea (n = 2), vomiting (n = 1), tachypnea (n = 1), and stargazing (n = 1). All were self-limiting and resolved after discontinuation of the drug.</p><p><strong>Conclusions and clinical importance: </strong>Oxycodone demonstrated an overall favorable analgesic profile and could be a well-tolerated and promising pain management solution, both as monotherapy and in combination therapy, for tumor-related pain in dogs, including those with advanced-stage tumors.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"555"},"PeriodicalIF":2.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single‑dose levamisole at breeding alters early pregnancy immune-endocrine profiles without affecting fertility in ewes.","authors":"Ali Rişvanlı, Abdugani Abdurasulov Kholmurzaevich, Kursantbek Attokurov Sharabidinovich, Pirimkul Mamatkalykov Mamatkalykovych, Aiturgan Duyshobayeva, Elmurat Obdunov, Burak F Yuksel, Mert Turanlı, Ibrahim Seker, Timur Eshimbekov, Rosa Abdyldaeva Tynaibekovna","doi":"10.1186/s12917-025-04984-6","DOIUrl":"10.1186/s12917-025-04984-6","url":null,"abstract":"<p><strong>Background: </strong>Reproductive efficiency in sheep is influenced by complex interactions between the endocrine and immune systems, particularly during early pregnancy. Immunomodulators such as levamisole are known to enhance immune responses and have been investigated for their potential to improve reproductive outcomes in various animal species. However, the effects of levamisole administered at the time of breeding on both pregnancy rates and key immunoendocrine markers in ewes remain unclear. This study aimed to evaluate the effects of levamisole, administered at varying doses during breeding, on pregnancy rates and selected immune and endocrine parameters in ewes. A total of 30 ewes were randomly assigned to three groups (n = 10 each): a control group received subcutaneous saline; the second group received levamisole at 2.5 mg/kg; and the third group received 7.5 mg/kg, all administered at the time of breeding. Blood samples were collected on days 0, 10, and 20 post-breeding. Levels of IFN-γ, IL-2, TNF-α, progesterone, activin A, activin B, follistatin, and total immunoglobulin (Ig) were measured using commercial ELISA kits.</p><p><strong>Results: </strong>Pregnancy rates did not differ statistically between the groups (p > 0.05). However, on day 10, pregnant ewes in the 2.5 mg/kg group showed significantly higher activin A levels (p < 0.05). Activin B levels were elevated in pregnant ewes in both the control group (day 10) and the 7.5 mg/kg group (day 20) (p < 0.05). Follistatin levels were higher on day 10 in pregnant control animals (p < 0.05). IFN-γ and IL-2 levels increased in pregnant animals, particularly in control and 7.5 mg/kg groups, respectively. Progesterone levels peaked on day 10 in all groups.</p><p><strong>Conclusions: </strong>While the measured immune and endocrine parameters varied, these changes did not impact the pregnancy rates.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"546"},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of antibiotic use, biosecurity and mortality in semi-intensive broiler farms in Kenya.","authors":"Naomi P Kemunto, Dishon M Muloi, Eugine L Ibayi, Jane K Njaramba, Vivian Hoffmann, Mike Murphy, Søren S Nielsen, Arshnee Moodley","doi":"10.1186/s12917-025-04948-w","DOIUrl":"10.1186/s12917-025-04948-w","url":null,"abstract":"<p><p>The indiscriminate use of antibiotics in food-producing animals contributes to antimicrobial resistance (AMR), posing a global threat. Understanding the factors associated with antibiotic use is critical to combat resistance while maintaining animal health. This study examined antibiotic use practices, mortality rates, biosecurity levels, as well as the associations between biosecurity and antibiotic use, and between biosecurity and mortality, in semi-intensive broiler farms in Kenya.The study was conducted in 129 semi-intensive farms with total flock sizes between 200 and 2000 birds across three peri-urban counties in Kenya. Data were collected prospectively over one production cycle, with farms visited biweekly using questionnaires and a drug bin approach. Biosecurity levels were assessed by a panel of experts who weighted scores for various external and internal biosecurity subcategories. Directed acyclic graphs (DAG) described potential relationships between explanatory variables, confounders and outcome. Logistic regression analysis was conducted with antibiotic use as the outcome variable. Explanatory variables with P < 0.25 in the univariable logistic regression were included in the multivariable regression. Similarly, linear regression was conducted using mortality as the outcome.Overall, 72% of farms used antibiotics, primarily for prophylaxis (66%), with erythromycin and oxytetracycline being the most commonly used antibiotics. The median mortality rate across the production cycle was 6%. There was no significant difference in mortality between farms using antibiotics and those not using antibiotics. Biosecurity practices were low, with a median biosecurity score of 14.3/67.9. Univariable screening suggested potential associations between antibiotic use and vaccination of day-old chicks, flock size, cleaning protocol for chicken drinkers, resting period between batches, feed store cleaning, water source, distance from neighbouring farms, and age. However, these were not significant in multivariable logistic regression. Linear regression showed an association between mortality and biosecurity measures, specifically disease management and visitor entry regulation.This study highlights widespread antibiotic use, low biosecurity implementation, and variability in mortality rates in the farms surveyed. There is a gap in farmers' implementation of effective biosecurity measures and understanding of prudent antibiotic use. An urgent need exists to develop comprehensive data collection methodologies, education, and interventions to promote responsible antibiotic stewardship and cost-effective biosecurity practices among poultry farmers in Kenya.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"541"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding how veterinarians' knowledge, attitudes, and practices influence antibiotic prescription: a systematic review of survey studies.","authors":"Ana Sousa, Leonardo de Rago, Jacinta O Pinho, Marta Estrela, Ana Cláudia Coelho, Paula Alexandra Oliveira, Adolfo Figueiras, Fátima Roque, Maria Teresa Herdeiro","doi":"10.1186/s12917-025-05001-6","DOIUrl":"10.1186/s12917-025-05001-6","url":null,"abstract":"<p><strong>Introduction: </strong>The misuse and/or overuse of antibiotics in animals has been a subject of concern due to the intensification of antimicrobial resistance (AMR). Veterinarians are at the front line of antibiotic prescription and their decision-making process is impacted by several non-clinical factors. The aim of this systematic review was to identify and understand how veterinarians' attitudes, knowledge, perceptions, and experience influence antibiotic prescription practices.</p><p><strong>Methods: </strong>We systematically searched MEDLINE/PubMed, Web of Knowledge, and CAB International databases. Quantitative and mixed methods studies with veterinary graduates were included, with no time restrictions. Articles written in English, Spanish, and Portuguese were considered. Quality assessment was performed with JBI's cross-sectional critical appraisal tool.</p><p><strong>Results: </strong>Our search retrieved 4722 documents, with 59 being included. Articles' publication year ranged from 2004 to 2023, with most (n = 55) using a quantitative approach, and the remaining ones (n = 4) using mixed methods. Veterinary practices were categorized into four groups: livestock (n = 24), small animals (n = 14), equine (n = 5), and mixed practice (broader scope; n = 17). Intrinsic factors identified as potentially influencing veterinarians' antibiotic prescription included: socio-demographic factors (n = 39) and attitudes and concerns: self-confidence (n = 31); need to satisfy clients' expectations (n = 19); fear (n = 27); lack of knowledge (n = 21). Extrinsic factors were also identified in several studies: clients' lack of knowledge and/or training regarding AMR, appropriate antimicrobial use, and good production practices (n = 24); substandard hygiene conditions and biosecurity protocols (n = 14); time constraints (n = 4); cost of laboratory tests (n = 12); antibiotic policies and/or guidelines (n = 22); antibiotics cost (n = 20), and withdrawal period (n = 11); animal-related factors (n = 21), namely breeding and animals' behavior.</p><p><strong>Conclusion: </strong>This systematic review provides an updated and comprehensive understanding of non-clinical factors that can influence veterinarians' antibiotic prescription practices. High client demand, self-confidence, need to satisfy clients' expectations, deficient biosecurity, fear, lack of awareness from animal owners and farmers about AMR and appropriate antimicrobial use, and inadequate policies/guidelines were associated with higher antibiotic prescription among veterinarians. Many of the identified factors are potentially modifiable. Within the One Health approach, this can help in the design of interventions focusing on appropriate antibiotic use in animals to tackle AMR.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"543"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis.","authors":"Jiaqi Zhao, Jingju Wang, Peizhao Han, Cai Yin, Shushu Gu, Hui Ji, Xiaoming Wang, Liping Wang, Jinhu Huang","doi":"10.1186/s12917-025-04975-7","DOIUrl":"10.1186/s12917-025-04975-7","url":null,"abstract":"<p><strong>Background: </strong>The global spread of multidrug-resistant (MDR) bacteria prompts the exploration of innovative antimicrobial strategies. Phage lysins-peptidoglycan hydrolases known for species-specific activity and low resistance potential-offer promising alternatives to conventional antibiotics. However, their typically narrow spectrum limits broad therapeutic application. To overcome this limitation, we leveraged the wide distribution of streptococcal mobilizable prophage (SMphage) families across Streptococcus species as a strategy to discover lysins with inherent broad-spectrum potential. Within these conserved prophages, we expressed PlyNJ3, an SMphage-derived endolysin homolog identified in S. suis, and evaluated its therapeutic efficacy in infection models.</p><p><strong>Results: </strong>PlyNJ3 exhibited potent lytic activity against a broad panel of streptococci, including diverse S. suis clinical isolates (15 serotypes), 83.3% of S. uberis, and key strains of S. agalactiae, S. dysgalactiae, and S. pyogenes. Optimal bacteriolytic activity occurred at physiological temperature (37 °C) with dose-dependent efficacy. Electron microscopy revealed PlyNJ3-mediated cell wall perforation, cytoplasmic content release, and structural disintegration. In a murine invasive S. suis infection model, high-dose intraperitoneal PlyNJ3 (0.9 mg/head) conferred 87.5% survival, while synergism with ampicillin prolonged survival. Intramuscular administration in a murine thigh infection model enhanced bacterial clearance compared to intraperitoneal delivery. Phylogenetic and structural analysis confirmed conservation across SMphage-derived lysins, underpinning their broad streptococcal target potential.</p><p><strong>Conclusions: </strong>Our findings establish SMphage-derived lysins as a conserved, therapeutically valuable class of antimicrobials with inherent broad-spectrum potential across diverse streptococcal pathogens. Building on the previously demonstrated in vivo efficacy of PlySK1249 against S. dysgalactiae and S. agalactiae, we show that its structural homolog, PlyNJ3, exhibits robust therapeutic activity against S. suis infections. Together, these results validate the SMphage lysin platform for generating precision-targeted agents against specific streptococcal infections.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"540"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midline vs. flank laparotomy- criteria for choosing the optimal surgical technique for uterine torsion correction in the mare.","authors":"Jan Samsel, Ozan Gündemir, Tomasz Szara, Maciej Witkowski","doi":"10.1186/s12917-025-04883-w","DOIUrl":"10.1186/s12917-025-04883-w","url":null,"abstract":"<p><p>Uterine torsion in mares belongs to maternal pregnancy disorders, accounting for 5-10% of complications in the last trimester of pregnancy. Two surgical techniques for repositioning uterine torsion are used: flank laparotomy in local anesthesia on a standing mare (SFL) and midline laparotomy carried out under general anesthesia (MI). The study aims to present the exact protocol used by the authors to qualify a mare with uterine torsion for surgery using one of the above-mentioned methods.A total of 19 mares were operated on, of which 13 underwent midline laparotomy under general anesthesia, and the flank approach in a standing position operated on 7. Of the seven mares operated on in standing position under local anesthesia, six recovered and gave birth to healthy foals. In one of the operated mares by this approach, repositioning of the uterus was unsuccessful, and torsion was finally resolved after performing a laparotomy in the midline. Out of 13 operated mares in the midline (including the last-mentioned case), seven mares recovered and gave birth to normal foals. Another mare underwent c.s. because of the impossibility of twisted uterus reposition, but its outcome was good. 2 other mares with dead fetuses at admission underwent c.s. as well. One of them was in a critical general condition and died during surgery; the outcome of the other one was good. 3 following mares from this group aborted dead fetuses during the first week after the operation. One of them was euthanized after abortion, because of post-operative complications, the other two recovered without complications.Based on their own experience and available literature, the authors currently use the following key when selecting an appropriate surgical technique for uterine torsion repositioning in the mare:A mare of a balanced character promising approval of the procedure in sedation and local anesthesia with pregnancy up to 320 days with a living fetus and no apparent advanced circulatory changes within the uterine wall and/or broad ligament (diagnosed by rectal palpation and/or ultrasound examination) and no suspicion of comorbidities - flank approach in standing position (standing flank laparotomy SFL).Nervous, unpredictable mare, pregnancy over 320 days, dead fetus and/or severely compromised uterine wall, suspicion of concomitant abdominal problems - midline incision in general anesthesia (MI).</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"542"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enoxolone pharmacokinetics, tissue distribution, and residue depletion in largemouth bass (Micropterus salmoides).","authors":"Chen Li, Xinnan Zhou, Yunshan Qiu, Lin Luo, Hongli Liu, Ping Ouyang, Yi Geng, Defang Chen, Xiaoli Huang","doi":"10.1186/s12917-025-04981-9","DOIUrl":"10.1186/s12917-025-04981-9","url":null,"abstract":"","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"545"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report on isolation of Listeria ivanovii from a cat.","authors":"Dorota Chrobak-Chmiel, Magdalena Kizerwetter-Świda, Ewelina Kwiecień, Ilona Stefańska, Rafał Sapierzyński, Rafał Nejfeld, Dorota Żabicka, Małgorzata Dziekiewicz-Mrugasiewicz, Magdalena Rzewuska","doi":"10.1186/s12917-025-05007-0","DOIUrl":"10.1186/s12917-025-05007-0","url":null,"abstract":"<p><strong>Background: </strong>Several Listeria species cause listeriosis. Listeria monocytogenes is responsible for the majority of clinical cases in animals. A less frequently isolated species is Listeria ivanovii, which causes infections mainly in ruminants, most often associated with reproductive disorders, such as abortions, stillbirths, or neonatal mortality. Sporadic infections with this microorganism have been described in other animal species; however, no literature data, to our knowledge, describe the infection of L. ivanovii in cats.</p><p><strong>Case presentation: </strong>L. ivanovii was isolated from tissue samples collected from a kitten with symptoms of acute catarrhal gastroenteritis. Fragments of the liver, spleen, kidneys, and small intestine were collected post-mortem for microbiological examination. The isolated microorganism was identified as L. ivanovii based on its phenotypic properties and 16 S rRNA sequencing. The identification of subspecies L. ivanovii subsp. ivanovii was performed by comparative analysis of the sigB gene sequences.</p><p><strong>Conclusions: </strong>Listeria ivanovii, which is more commonly known as a ruminant pathogen, can also cause severe infections in cats. This is, to our knowledge, the first report on the isolation of this microorganism from internal organs in a cat. This finding underscores the importance of careful interpretation of isolation results when uncommon pathogens are involved, particularly in host species where their pathogenicity has not been previously documented.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":"21 1","pages":"544"},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}