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Comparative pathogenesis of Ethiopia/Habru/2014 Lineage-IV peste des petits ruminants virus in goats and cattle. 埃塞俄比亚/哈布鲁/2014 Lineage-IV 小反刍兽疫病毒在山羊和牛中的致病机理比较。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-17 DOI: 10.1186/s12917-024-04313-3
Fasil Aklilu, Hagos Ashenafi, Tesfu Kassa, Hassen Chaka, Demeke Sibhatu, Dereje Shegu, Abde Aliy Mohammed, Redeat Belaineh, Menbere Kidane, Hagos Asgedom, Tesfaye Chibssa, Getnet Mekonnen, Asegedetch Sirak, Solomon Gebredufe, Claudia Schulz, Catherine M Herzog, Vivek Kapur
{"title":"Comparative pathogenesis of Ethiopia/Habru/2014 Lineage-IV peste des petits ruminants virus in goats and cattle.","authors":"Fasil Aklilu, Hagos Ashenafi, Tesfu Kassa, Hassen Chaka, Demeke Sibhatu, Dereje Shegu, Abde Aliy Mohammed, Redeat Belaineh, Menbere Kidane, Hagos Asgedom, Tesfaye Chibssa, Getnet Mekonnen, Asegedetch Sirak, Solomon Gebredufe, Claudia Schulz, Catherine M Herzog, Vivek Kapur","doi":"10.1186/s12917-024-04313-3","DOIUrl":"https://doi.org/10.1186/s12917-024-04313-3","url":null,"abstract":"<p><strong>Background: </strong>Peste des Petits Ruminants (PPR) is a highly contagious viral disease primarily affecting goats and sheep, with clinical manifestations ranging from peracute disease to subclinical infection, particularly in atypical hosts such as cattle. The role of atypical hosts such as cattle to the spread of PPR remains controversial, with conflicting reports in the literature. Despite its worldwide significance, considerable knowledge gaps exist regarding the pathogenesis and clinical progression in both primary and atypical hosts. This study aimed to elucidate the tissue tropism, pathogenesis, virus shedding, clinical progression, and pathology associated with experimental PPR virus infection in indigenous goats and cattle. To this end, 32 animals-16 goats and 16 cattle-were intranasally inoculated with the Ethiopia/Habru/2014 Lineage-IV strain of the PPR virus followed by detailed clinical evaluations and systematic sampling at pre-established intervals to assess serological conversion, viral shedding, and the pathogenesis of the infection across both species.</p><p><strong>Results: </strong>The results show that goats exhibited typical clinical signs 4 days post-inoculation, with seroconversion by day 6 and early detection of viral RNA in swabs and tissues by day 3 and virus isolation starting day 4. In contrast, cattle exhibited minimal clinical signs, with seroconversion occurring at day 8 with viral RNA detected in tissue samples at day 4 and virus isolation starting day 6 in tissues and in a single nasal swab at day 8. Clinical scores and tissue positivity rates significantly differed between goats and cattle (P = 0.007 and P < 0.001, respectively). While goats exhibited expected gross and histopathological lesions, cattle showed only nonspecific lesions.</p><p><strong>Conclusions: </strong>Together, our findings highlight the importance of comparative pathology studies for better understanding virus dynamics and transmission pathways that may help inform more effective PPR control programs. Future research should explore the pathogenesis of different PPRV lineages in cattle, assessing variations in disease progression and potential for epidemiological impact.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occurrence and characterization of ESKAPE organisms on the hands of veterinary students before patient contact at a veterinary academic hospital, South Africa. 南非一家兽医学术医院的兽医专业学生在接触病人之前手部出现 ESKAPE 微生物的情况及特征。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-17 DOI: 10.1186/s12917-024-04322-2
Dikeledi C Sebola, James W Oguttu, Mogaugedi N Malahlela, Marleen M Kock, Daniel N Qekwana
{"title":"Occurrence and characterization of ESKAPE organisms on the hands of veterinary students before patient contact at a veterinary academic hospital, South Africa.","authors":"Dikeledi C Sebola, James W Oguttu, Mogaugedi N Malahlela, Marleen M Kock, Daniel N Qekwana","doi":"10.1186/s12917-024-04322-2","DOIUrl":"https://doi.org/10.1186/s12917-024-04322-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the presence of ESKAPE organisms on the hands of students working in the intensive care unit (ICU) at a veterinary academic hospital.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among students working in an ICU at a veterinary academic hospital in South Africa. Students were sampled before the start of the ICU shift using a modified glove-juice method. Standard microbiological techniques and a series of polymerase chain reaction (PCR) assays were used to identify and characterize the bacteria. All the isolates were tested for resistance against a specific panel of antibiotics using the disk diffusion method. Proportions of bacterial species and their antimicrobial-susceptibility profiles were calculated.</p><p><strong>Results: </strong>At screening, all the veterinary students (n = 62) carried at least one of the ESKAPE organisms on their hands. Escherichia coli was the most isolated organism (76%, 47/62), followed by P. aeruginosa (48%, 30/62), A. baumannii (47%, 29/62), E. faecium (35%, 22/62), K. pneumoniae (27%, 17/62), and S. aureus (24%, 15/62). A reduced proportion of isolates were recovered from the samples, E. coli (26%, 12/47), E. faecium (23%, 5/22), P. aeruginosa (43%, 13/30), A. baumannii (24%,7/29), K. pneumoniae (41%, 7/17), and S. aureus (20%, 3/15). Most of the organisms showed a high proportion of resistance to at least one antibiotic. Multidrug resistance was reported among just over half (56%, 5/9) of E. coli, 40% (2/5) of E. faecium, 100% (13/13) of P. aeruginosa, and 33% (1/3) of S. aureus isolates.</p><p><strong>Conclusion: </strong>Students working in the ICU carry several organisms belonging to the ESKAPE group of organisms before contact with patients. Moreover, MDR resistance was common among this group of organisms. The findings of the present study underscore the importance of infection prevention and control (IPC) strategies to help reduce the likelihood of the spread of these organisms to personnel, owners, family members, and patients.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiology, gene expression, and behavior as potential indicators of oxidative stress in piglets. 作为仔猪氧化应激潜在指标的生理、基因表达和行为。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-16 DOI: 10.1186/s12917-024-04320-4
Raúl David Guevara, Jose J Pastor, Sergi López-Vergé, Xavier Manteca, Gemma Tedo, Pol Llonch
{"title":"Physiology, gene expression, and behavior as potential indicators of oxidative stress in piglets.","authors":"Raúl David Guevara, Jose J Pastor, Sergi López-Vergé, Xavier Manteca, Gemma Tedo, Pol Llonch","doi":"10.1186/s12917-024-04320-4","DOIUrl":"https://doi.org/10.1186/s12917-024-04320-4","url":null,"abstract":"<p><p>The goal of the current study was to develop a pig model to investigate oxidative stress with a low negative impact on piglet welfare. Four independent trials (A, B, C, and D) were performed using a single intraperitoneal shot of lipopolysaccharide (LPS) as an immune challenge, aiming to assess the minimal LPS dose for piglets of different age to trigger a measurable acute oxidative stress response in healthy animals. In trial A, piglets received an LPS dose of 25 µg/KgBW at 41 days post-weaning (p.w.). In trial B, piglets received 25 µg/KgBW of LPS at 28 days p.w., in trials C And D, piglets were injected with 50 µg/KgBW of LPS at 21 days p.w., respectively. Piglets were randomly allocated either to the T1) Control group with saline solution (Ctrl), or T2) LPS challenge (LPS). The oxidative stress response was measured through the enzymatic activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT), in both plasma and intestinal tissues. Intestinal gene expression of oxidative stress and inflammatory markers was assessed. Discomfort behaviors (panting, prostration, trembling, and vomits) were also recorded. Plasmatic and intestinal oxidative stress response was inconsistent across the four trials even when the dose and pig age were similar, possibly due to individual variability. Relative gene expression differences of anti-inflammatory cytokines (IL10), oxidation precursor (iNOS), and antioxidant markers (GPx4, MnSOD, and CAT) were detected between Ctrl and LPS treatment (P < 0.05) when assessed. Behavioral observations were sensitive to the LPS dose relative to Ctrl (P < 0.05) in all four trials. These results suggest that behavioral observations can be used as a non-invasive methodology to detect the presence of oxidative stress in pigs in challenging conditions. Behavioral observations were more sensitive than other indicators (i.e., biomarkers and gene expression) in the current study. However, a sensitivity scale system needs to be developed to qualify and rank the impact of oxidative stress in pigs.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An apparently healthy female British shorthair cat with a rare complication of colonic stenosis after flank approach ovariohysterectomy. 一只看似健康的雌性英国短毛猫在侧腹卵巢切除术后出现结肠狭窄的罕见并发症。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-16 DOI: 10.1186/s12917-024-04328-w
Yixing Xie, Yintong Deng, Jiaxun Mai, Heyu Li, Yizhou Chen
{"title":"An apparently healthy female British shorthair cat with a rare complication of colonic stenosis after flank approach ovariohysterectomy.","authors":"Yixing Xie, Yintong Deng, Jiaxun Mai, Heyu Li, Yizhou Chen","doi":"10.1186/s12917-024-04328-w","DOIUrl":"10.1186/s12917-024-04328-w","url":null,"abstract":"<p><strong>Background: </strong>Colonic stenosis is a rare postoperative complication of ovariohysterectomy in cats, leading to dyschezia and fecal diameter reduction. In cats, while there are reports of colonic stenosis after midline approach ovariohysterectomy, there are no specific reports of flank approach ovariohysterectomy.</p><p><strong>Case presentation: </strong>This report describes a severe case of a one-year-old British shorthair female cat presenting with gastrointestinal signs, including dyschezia and reduced fecal diameter, three weeks after flank approach ovariohysterectomy. Despite abdominal radiography, proctography with barium sulfate, colonoscopy, CT, and hematological analysis, the cause of colonic stenosis remained unclear. During exploratory laparotomy, an annular tissue band was found encircling the descending colon, resulting in severe local stenosis. After excision of the tissue band, the presenting clinical signs of the cat were rapidly improved. This result suggests that colonic stenosis caused by tissue band should be considered when diagnosing postoperative complications in flank approach ovariohysterectomy in cats.</p><p><strong>Conclusion: </strong>Colon stenosis due to annular tissue band restriction should be considered one of the differentials for postoperative complications in flank approach ovariohysterectomy in cats.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune protective, stress indicators, antioxidant, histopathological status, and heat shock protein gene expression impacts of dietary Bacillus spp. against heat shock in Nile tilapia, Oreochromis niloticus. 膳食芽孢杆菌对尼罗罗非鱼(Oreochromis niloticus)热休克的免疫保护、应激指标、抗氧化、组织病理学状态和热休克蛋白基因表达的影响。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-16 DOI: 10.1186/s12917-024-04303-5
Samia Elbahnaswy, Gehad E Elshopakey, Abdelwahab A Abdelwarith, Elsayed M Younis, Simon J Davies, Mai A M El-Son
{"title":"Immune protective, stress indicators, antioxidant, histopathological status, and heat shock protein gene expression impacts of dietary Bacillus spp. against heat shock in Nile tilapia, Oreochromis niloticus.","authors":"Samia Elbahnaswy, Gehad E Elshopakey, Abdelwahab A Abdelwarith, Elsayed M Younis, Simon J Davies, Mai A M El-Son","doi":"10.1186/s12917-024-04303-5","DOIUrl":"https://doi.org/10.1186/s12917-024-04303-5","url":null,"abstract":"<p><p>This research evaluated the efficacy of mixed Bacillus strains probiotic supplements in mitigating acute thermal-induced stress in Nile tilapia (Oreochromis niloticus). Three experimental fish groups involved 135 Nile tilapia (49 ± 2 g); one control (no added probiotics), 0.5, and 1% of selected Bacillus strains (B. subtilis, B. licheniformis, and B. pumilus) for 58 days. After the feeding period, growth parameters, immunological parameters, stress biochemical markers, and antioxidant parameters in addition to genes related to stress and histopathological changes in fish, were assessed; subsequently subjected to heat shock at 36 ± 0.5 ◦C for 2 h. Before the heat challenge, our results exhibited a marked increase in the growth efficacy (P < 0.05), lower marked serum levels of triglycerides and cholesterol, and tissue malondialdehyde (MDA) levels along with significantly increased superoxide dismutase (SOD) and catalase (CAT) enzymes activity in fish-fed Bacillus probiotic at 0.5% concerning the control group (P < 0.05). There were no significant changes in the serum levels of glucose, cortisol, lactate, phagocytic activity, respiratory burst (ROS), total immunoglobulin Ig, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), total protein, albumin, globulin, uric acid, urea, creatinine, as well as HSP70, GST, and GPx mRNA expression in most of the probiotic groups compared to the control group (P > 0.05). When Nile tilapia was exposed to heat stress, supplementation with Bacillus probiotic in the diet significantly decreased most of the indices related to serum biochemical (ALT (P < 0.01; P < 0.001), AST (P < 0.01), LDH (P < 0.01), urea (P < 0.05), and creatinine (P < 0.01)), triglycerides (P < 0.001; (P < 0.01)), cholesterol (P < 0.01; (P < 0.05)), glucose (P < 0.001), and cortisol (P < 0.01; (P < 0.05)), with tissue oxidative stress MDA levels (P < 0.05), and HSP70 mRNA expression (P < 0.01; P < 0.001), aligned with the stressed control group. In addition, a notable upsurge in the total protein, albumin, globulin, phagocytic and ROS activities, and total Ig, as well as the enzymatic antioxidant ability (SOD, CAT) (P < 0.01), with GST and GPx mRNA expression (P < 0.05; P < 0.01), were shown in fish-fed Bacillus spp. post-exposure compared with the stressed control group. Besides, no histopathological alterations were revealed in the spleen and brain of fish pre- and post-heat exposure. According to our findings, diet supplementation of Bacillus species has the potential to combat the suppressive effects of heat shock in Nile tilapia.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand. 更正:泰国与犬认知功能障碍综合征 (CCDS) 相关的血浆蛋白质组变化。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-15 DOI: 10.1186/s12917-024-04330-2
Sataporn Phochantachinda, Boonrat Chantong, Onrapak Reamtong, Duangthip Chatchaisak
{"title":"Correction: Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand.","authors":"Sataporn Phochantachinda, Boonrat Chantong, Onrapak Reamtong, Duangthip Chatchaisak","doi":"10.1186/s12917-024-04330-2","DOIUrl":"https://doi.org/10.1186/s12917-024-04330-2","url":null,"abstract":"","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and characterization of Streptococcus agalactiae inducing mass mortalities in cultured Nile tilapia (Oreochromis niloticus) with trials for disease control using zinc oxide nanoparticles and ethanolic leaf extracts of some medicinal plants. 诱导尼罗罗非鱼(Oreochromis niloticus)大量死亡的无乳链球菌的分离和特征描述,以及使用纳米氧化锌颗粒和一些药用植物的乙醇叶提取物控制疾病的试验。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-15 DOI: 10.1186/s12917-024-04298-z
Ebtsam Sayed Hassan Abdallah, Walaa Gomaa Mohamed Metwally, Soad Abdel Latief Hassan Bayoumi, Moataz Ahmed Mohamed Abdel Rahman, Mahmoud Mostafa Mahmoud
{"title":"Isolation and characterization of Streptococcus agalactiae inducing mass mortalities in cultured Nile tilapia (Oreochromis niloticus) with trials for disease control using zinc oxide nanoparticles and ethanolic leaf extracts of some medicinal plants.","authors":"Ebtsam Sayed Hassan Abdallah, Walaa Gomaa Mohamed Metwally, Soad Abdel Latief Hassan Bayoumi, Moataz Ahmed Mohamed Abdel Rahman, Mahmoud Mostafa Mahmoud","doi":"10.1186/s12917-024-04298-z","DOIUrl":"https://doi.org/10.1186/s12917-024-04298-z","url":null,"abstract":"<p><strong>Background: </strong>Streptococcus agalactiae (Group B streptococcus, GBS) induces a serious infection that can harm not only aquatic life but also humans and other animals. In a fish farm in southern Egypt, Nile tilapia (Oreochromis niloticus) has developed an epidemic with clinical symptoms resembling piscine streptococcosis.</p><p><strong>Results: </strong>Initial microscopic inspection of the affected fish brain and kidney indicated the presence of Gram-positive cocci. S. agalactiae was effectively isolated and identified using nucleotide homology of the 16S rRNA and species-specific PCR. The partial 16S rRNA sequence was deposited in the GenBank database at the NCBI and given the accession number MW599202. Genotyping using RAPD analysis indicated that the isolates in the present study belonged to the same genotypes and had the same origin. The challenge test, via immersion (9.2 × 10<sup>7</sup>, 9.2 × 10<sup>6</sup>, and 9.2 × 10<sup>5</sup> CFU/ml for 1 h) or intraperitoneal injection (4.6 × 10<sup>7</sup>, 4.6 × 10<sup>6</sup>, and 4.6 × 10<sup>5</sup> CFU/fish), elicited clinical symptoms resembling those of naturally infected fish with a mortality rate as high as 80%. The ability to create a biofilm as one of the pathogen virulence factors was verified. Zinc oxide nanoparticles and the ethanolic leaf extracts of nine medicinal plants demonstrated considerable antibacterial activities against the tested S. agalactiae strain with low minimum bactericidal concentrations (MBC) and minimum inhibitory concentrations (MIC). The ethanolic leaf extracts from Lantana camara and Aberia caffra showed potent antibacterial activity with MBC values of 0.24 and 0.485 mg/ml, and MIC values of 0.12 & 0.24 mg/ml, respectively.</p><p><strong>Conclusion: </strong>This study isolated S. agalactiae from O. niloticus mortalities in a fish farm in Assiut, Egypt. The pathogen persists in fish environments and can escape through biofilm formation, suggesting it cannot be easily eliminated. However, promising findings were obtained with in vitro control employing zinc oxide nanoparticles and medicinal plant extracts. Nevertheless further in vivo research is needed.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11475875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and genetic characterization of five novel bat coronaviruses from Yunnan, China. 中国云南五种新型蝙蝠冠状病毒的鉴定和遗传特征。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-12 DOI: 10.1186/s12917-024-04310-6
Qian Li, Yutong Hou, Baoyang Huang, Xiang Le, Binghui Wang, Xueshan Xia
{"title":"Identification and genetic characterization of five novel bat coronaviruses from Yunnan, China.","authors":"Qian Li, Yutong Hou, Baoyang Huang, Xiang Le, Binghui Wang, Xueshan Xia","doi":"10.1186/s12917-024-04310-6","DOIUrl":"https://doi.org/10.1186/s12917-024-04310-6","url":null,"abstract":"<p><strong>Background: </strong>Coronaviruses (CoVs) represent a serious threat to human health and have become a major transmissible, endemic, and causative pathogen in humans; they represent a major health concern, given their ability to cause infectious diseases. Bats are natural hosts for diverse viruses. Many transmission events of CoVs and identification of multiple novel CoVs in bats has increased attention towards their capacity to serve as hosts for zoonotic viruses.</p><p><strong>Results: </strong>In this study, 61 bats from Yunnan Province were analyzed, identifying seven CoVs, including three α- and two β-CoVs with full-genome sequences. Among the five identified alpha-CoVs, four belong to the Decacovirus subgenus and one to the Minunacovirus subgenus. Two beta-CoVs were also identified, both belonging to the Sarbecovirus subgenus.The genetic structures revealed similarities to known strains such as HKU10 and SARS-CoV-2, along with novel findings such as the Minunacovirus subgenus CoV YJ3c/f and unique ORF patterns. Our results demonstrated that strain JCC9 has a unique recombination pattern and shows a higher binding affinity to civet and pangolin ACE2 receptors, then the HpJC8xc strain transmits and recombines between hosts (bats), indicating a potential risk of crossing the interspecies barrier and infecting other animals.</p><p><strong>Conclusions: </strong>The CoVs detected in the bats studied in this research exhibit high diversity. Genomic analysis revealed that CoVs in bats undergo frequent recombination events. Furthermore, recombination patterns and evolutionary analyses suggest that alpha-CoVs are more prone to cross-species transmission across different bat families/genera, whereas beta-CoVs demonstrate host specificity and tend to co-evolve with their bat hosts.Our finding suggest that bats, as hosts of CoVs, be constantly monitored to prevent outbreaks of new infections caused by viruses passing across interspecies barriers, and consequently, viral diseases in humans or livestock.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A field comparison study of two vaccine protocols against Erysipelothrix rhusiopathiae in two types of swine breeds in Spain. 在西班牙两种猪种中对两种预防红腹泻温热病疫苗方案进行实地比较研究。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-11 DOI: 10.1186/s12917-024-04065-0
E Sanchez-Tarifa, C Alonso, I Perez, L A García, A Fernández-Fontelo, O Gómez-Duran, B García-Morante, Francisco A García-Vázquez, I Hernández-Caravaca
{"title":"A field comparison study of two vaccine protocols against Erysipelothrix rhusiopathiae in two types of swine breeds in Spain.","authors":"E Sanchez-Tarifa, C Alonso, I Perez, L A García, A Fernández-Fontelo, O Gómez-Duran, B García-Morante, Francisco A García-Vázquez, I Hernández-Caravaca","doi":"10.1186/s12917-024-04065-0","DOIUrl":"10.1186/s12917-024-04065-0","url":null,"abstract":"<p><p>Erysipelas still causes large economic losses to pig industry. Maternal immunity is critical to prevent erysipelas in young animals, thus, intensive vaccination protocols or practices focused on the improvement of the maternally derived immunity could provide substantial benefits. The present study evaluates potential changes in antibodies levels in sows and their offspring using two types of tests (commercial ELISA, Ingenasa or rSpaA415 ELISA) when two different vaccination programs (before farrowing or after farrowing) against Erysipelothrix rhusiopathiae were applied to sows from Iberian (A) or conventional Large White-Landrace (B) pig farms. The results showed a statistical correlation between titers found in sows and their one-week old piglets in both tests. The overall mean of (log) antibody titers in farm B measured by the commercial ELISA test was significantly higher in pre-farrowing vaccinated sows compared to the post-farrowing vaccine protocol (p = 0.0278). Additionally, using the rSpaA415 ELISA test, the overall mean of (log) antibody titers was significantly higher in pre-farrowing sows (p = 0.0056) compared to sows following post-farrowing vaccine protocol (p = 0.0003) or non- vaccinated sows. None of the above-mentioned differences were found in farm A. The overall mean of (log) antibody titers in piglets from the pre-farrowing vaccination protocol was significantly higher than piglets from the post-farrowing vaccination protocol in farm A (p = 0.0059; rSpaA415 ELISA) and farm B (p = 0.0168 and p = 0.0098 for the commercial and rSpaA415 ELISA data, respectively). Additionally, higher proportion of piglets from pre-farrowing vaccinated sows remained seropositive during the post-weaning period (days 42 to 84) compared to piglets from non-vaccinated or post-farrowing vaccinated groups in both farms A and B.</p>","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Nano-selenium supplementation: improving growth, digestibility and mineral absorption in freshwater fish, Catla catla. 更正:纳米硒补充剂:改善淡水鱼 Catla catla 的生长、消化和矿物质吸收。
IF 2.3 2区 农林科学
BMC Veterinary Research Pub Date : 2024-10-11 DOI: 10.1186/s12917-024-04318-y
Nisar Ahmad, Syed Makhdoom Hussain, Shafaqat Ali, Muhammad Farrukh Tahir, Pallab K Sarker, Mudassar Shahid
{"title":"Correction: Nano-selenium supplementation: improving growth, digestibility and mineral absorption in freshwater fish, Catla catla.","authors":"Nisar Ahmad, Syed Makhdoom Hussain, Shafaqat Ali, Muhammad Farrukh Tahir, Pallab K Sarker, Mudassar Shahid","doi":"10.1186/s12917-024-04318-y","DOIUrl":"10.1186/s12917-024-04318-y","url":null,"abstract":"","PeriodicalId":9041,"journal":{"name":"BMC Veterinary Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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