发布求助

文献互助智能选刊最新文献

BMB Reports最新文献

筛选

英文中文

Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems. 造血干细胞移植的挑战与创新：探索骨髓龛位和新模型系统。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-08-01

Byung-Chul Lee

{"title":"Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems.","authors":"Byung-Chul Lee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hematopoietic stem cell transplantation (HSCT) remains an indispensable therapeutic strategy for various hematological diseases. This review discusses the pivotal role of bone marrow (BM) niches in influencing the efficacy of HSCT and evaluates the current animal models, emphasizing their limitations and the need for alternative models. Traditional animal models, mainly murine xenograft, have provided significant insights, but due to species-specific differences, are often constrained from accurately mimicking human physiological responses. These limitations highlight the importance of developing alternative models that can more realistically replicate human hematopoiesis. Emerging models that include BM organoids and BM-on-a-chip microfluidic systems promise enhanced understanding of HSCT dynamics. These models aim to provide more accurate simulations of the human BM microenvironment, potentially leading to improved preclinical assessments and therapeutic outcomes. This review highlights the complexities of the BM niche, discusses the limitations of current models, and suggests directions for future research using advanced model systems. [BMB Reports 2024; 57(8): 352-362].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"352-362"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway. 下调的 CDK10 通过激活 JNK/c-Jun 信号通路促进肺癌的癌症进展和放射抗性。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Chaojin Hong, Yimei Meng, Anchen Qiu, Haibo Zhang, Liu Yang, Yupeng Hong, Yumei Huang

引用次数: 0

Prmt7 is required for the osteogenic differentiation of mesenchymal stem cells via modulation of BMP signaling. Prmt7是间充质干细胞通过调节BMP信号分化成骨所必需的。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Tuan Anh Vuong, Yan Zhang, June Kim, Young-Eun Leem, Jong-Sun Kang

引用次数: 0

Identification and structure of AIMP2-DX2 for therapeutic perspectives. 鉴定 AIMP2-DX2 并确定其结构，展望治疗前景。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Hyeon Jin Kim, Mi Suk Jeong, Se Bok Jang

{"title":"Identification and structure of AIMP2-DX2 for therapeutic perspectives.","authors":"Hyeon Jin Kim, Mi Suk Jeong, Se Bok Jang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Regulation of cell fate and lung cell differentiation is associated with Aminoacyl-tRNA synthetases (ARS)-interacting multifunctional protein 2 (AIMP2), which acts as a non-enzymatic component required for the multi-tRNA synthetase complex. In response to DNA damage, a component of AIMP2 separates from the multi-tRNA synthetase complex, binds to p53, and prevents its degradation by MDM2, inducing apoptosis. Additionally, AIMP2 reduces proliferation in TGF-β and Wnt pathways, while enhancing apoptotic signaling induced by tumor necrosis factor-β. Given the crucial role of these pathways in tumorigenesis, AIMP2 is expected to function as a broad-spectrum tumor suppressor. The full-length AIMP2 transcript consists of four exons, with a small section of the pre-mRNA undergoing alternative splicing to produce a variant (AIMP2-DX2) lacking the second exon. AIMP2-DX2 binds to FBP, TRAF2, and p53 similarly to AIMP2, but competes with AIMP2 for binding to these target proteins, thereby impairing its tumor-suppressive activity. AIMP2-DX2 is specifically expressed in a diverse range of cancer cells, including breast cancer, liver cancer, bone cancer, and stomach cancer. There is growing interest in AIMP2-DX2 as a promising biomarker for prognosis and diagnosis, with AIMP2-DX2 inhibition attracting significant interest as a potentially effective therapeutic approach for the treatment of lung, ovarian, prostate, and nasopharyngeal cancers. [BMB Reports 2024; 57(7): 318-323].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"318-323"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma. VSTM2L 是胆管癌中一个很有前景的治疗靶点和预后可溶性生物标志物。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Jungwhoi Lee, Woogwang Sim, Jungsul Lee, Jae-Hoon Kim

{"title":"VSTM2L is a promising therapeutic target and a prognostic soluble-biomarker in cholangiocarcinoma.","authors":"Jungwhoi Lee, Woogwang Sim, Jungsul Lee, Jae-Hoon Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the present study is to provide a rational background for silencing the V-set and transmembrane domain containing 2 like (VSTM2L) in consort with recognising soluble VSTM2L against cholangiocarcinoma. A therapeutic target against cholangiocarcinoma was selected using iterative patient partitioning (IPP) calculation, and it was verified by in vitro and in silico analyses. VSTM2L was selected as a potential therapeutic target against cholangiocarcinoma. Silencing the VSTM2L expression significantly attenuated the viability and survival of cholangiocarcinoma cells through blockade of the intracellular signalling pathway. In silico analysis showed that VSTM2L affected the positive regulation of cell growth in cholangiocarcinoma. Liptak's z value revealed that the expression of VSTM2L worsened the prognosis of cholangiocarcinoma patients. In addition, soluble VSTM2L was significantly detected in the whole blood of cholangiocarcinoma patients compared with that of healthy donors. Our report reveals that VSTM2L might be the potential therapeutic target and a soluble prognostic biomarker against cholangiocarcinoma. [BMB Reports 2024; 57(7): 324-329].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"324-329"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Stomach clusterin as a gut-derived feeding regulator. 勘误：作为肠源性摄食调节因子的胃集束素

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Cherl NamKoong, Bohye Kim, Ji Hee Yu, Byung Soo Youn, Hanbin Kim, Evonne Kim, So Young Gil, Gil Myoung Kang, Chan Hee Lee, Young-Bum Kim, Kyeong-Han Park, Min-Seon Kim, Obin Kwon

引用次数: 0

Electrophysiological insights with brain organoid models: a brief review. 脑器官模型的电生理学见解：简要回顾。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-07-01

Rian Kang, Soomin Park, Saewoon Shin, Gyusoo Bak, Jong-Chan Park

{"title":"Electrophysiological insights with brain organoid models: a brief review.","authors":"Rian Kang, Soomin Park, Saewoon Shin, Gyusoo Bak, Jong-Chan Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Brain organoid is a three-dimensional (3D) tissue derived from stem cells such as induced pluripotent stem cells (iPSCs) embryonic stem cells (ESCs) that reflect real human brain structure. It replicates the complexity and development of the human brain, enabling studies of the human brain in vitro. With emerging technologies, its application is various, including disease modeling and drug screening. A variety of experimental methods have been used to study structural and molecular characteristics of brain organoids. However, electrophysiological analysis is necessary to understand their functional characteristics and complexity. Although electrophysiological approaches have rapidly advanced for monolayered cells, there are some limitations in studying electrophysiological and neural network characteristics due to the lack of 3D characteristics. Herein, electrophysiological measurement and analytical methods related to neural complexity and 3D characteristics of brain organoids are reviewed. Overall, electrophysiological understanding of brain organoids allows us to overcome limitations of monolayer in vitro cell culture models, providing deep insights into the neural network complex of the real human brain and new ways of disease modeling. [BMB Reports 2024; 57(7): 311-317].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"311-317"},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway. T-plastin 通过 FAK/AKT/Slug 轴信号通路促进人肺癌细胞的上皮-间质转化。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-06-01

Soon Yong Park, Hyeongrok Choi, Soo Min Choi, Seungwon Wang, Sangin Shim, Woojin Jun, Jungkwan Lee, Jin Woong Chung

{"title":"T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.","authors":"Soon Yong Park, Hyeongrok Choi, Soo Min Choi, Seungwon Wang, Sangin Shim, Woojin Jun, Jungkwan Lee, Jin Woong Chung","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T-plastin (PLST), a member of the actin-bundling protein family, plays crucial roles in cytoskeletal structure, regulation, and motility. Studies have shown that the plastin family is associated with the malignant characteristics of cancer, such as circulating tumor cells and metastasis, by inducing epithelialmesenchymal transition (EMT) in various cancer cells. However, the role of PLST in the EMT of human lung cancer cells remains unclear. In this study, we observed that PLST overexpression enhanced cell migratory and invasive abilities, whereas its downregulation resulted in their suppression. Moreover, PLST expression levels were associated with the expression patterns of EMT markers, including E-cadherin, vimentin, and Slug. Furthermore, the phosphorylation levels of focal adhesion kinase (FAK) and AKT serine/threonine kinase (AKT) were dependent on PLST expression levels. These findings indicate that PLST induces the migration and invasion of human lung cancer cells by promoting Slug-mediated EMT via the FAK/AKT signaling pathway. [BMB Reports 2024; 57(6): 305-310].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"305-310"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinctive contribution of two additional residues in protein aggregation of Aβ42 and Aβ40 isoforms. Aβ42 和 Aβ40 异构体蛋白质聚集过程中另外两个残基的独特作用。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-06-01

Dongjoon Im, Tae Su Choi

{"title":"Distinctive contribution of two additional residues in protein aggregation of Aβ42 and Aβ40 isoforms.","authors":"Dongjoon Im, Tae Su Choi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Amyloid-β (Aβ) is one of the amyloidogenic intrinsically disordered proteins (IDPs) that self-assemble to protein aggregates, incurring cell malfunction and cytotoxicity. While Aβ has been known to regulate multiple physiological functions, such as enhancing synaptic functions, aiding in the recovery of the blood-brain barrier/brain injury, and exhibiting tumor suppression/antimicrobial activities, the hydrophobicity of the primary structure promotes pathological aggregations that are closely associated with the onset of Alzheimer's disease (AD). Aβ proteins consist of multiple isoforms with 37-43 amino acid residues that are produced by the cleavage of amyloid-β precursor protein (APP). The hydrolytic products of APP are secreted to the extracellular regions of neuronal cells. Aβ 1-42 (Aβ42) and Aβ 1-40 (Aβ40) are dominant isoforms whose significance in AD pathogenesis has been highlighted in numerous studies to understand the molecular mechanism and develop AD diagnosis and therapeutic strategies. In this review, we focus on the differences between Aβ42 and Aβ40 in the molecular mechanism of amyloid aggregations mediated by the two additional residues (Ile41 and Ala42) of Aβ42. The current comprehension of Aβ42 and Aβ40 in AD progression is outlined, together with the structural features of Aβ42/Aβ40 amyloid fibrils, and the aggregation mechanisms of Aβ42/Aβ40. Furthermore, the impact of the heterogeneous distribution of Aβ isoforms during amyloid aggregations is discussed in the system mimicking the coexistence of Aβ42 and Aβ40 in human cerebrospinal fluid (CSF) and plasma. [BMB Reports 2024; 57(6): 263-272].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"263-272"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor antigen PRAME is a potential therapeutic target of p53 activation in melanoma cells. 肿瘤抗原 PRAME 是黑色素瘤细胞中 p53 激活的潜在治疗靶点。

IF 2.9 3区生物学

BMB Reports Pub Date : 2024-06-01

Yong-Kyu Lee, Hyeon Ho Heo, Nackhyoung Kim, Ui-Hyun Park, Hyesook Youn, Eun-Yi Moon, Eun-Joo Kim, Soo-Jong Um

{"title":"Tumor antigen PRAME is a potential therapeutic target of p53 activation in melanoma cells.","authors":"Yong-Kyu Lee, Hyeon Ho Heo, Nackhyoung Kim, Ui-Hyun Park, Hyesook Youn, Eun-Yi Moon, Eun-Joo Kim, Soo-Jong Um","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Upregulation of PRAME (preferentially expressed antigen of melanoma) has been implicated in the progression of a variety of cancers, including melanoma. The tumor suppressor p53 is a transcriptional regulator that mediates cell cycle arrest and apoptosis in response to stress signals. Here, we report that PRAME is a novel repressive target of p53. This was supported by analysis of melanoma cell lines carrying wild-type p53 and human melanoma databases. mRNA expression of PRAME was downregulated by p53 overexpression and activation using DNA-damaging agents, but upregulated by p53 depletion. We identified a p53-responsive element (p53RE) in the promoter region of PRAME. Luciferase and ChIP assays showed that p53 represses the transcriptional activity of the PRAME promoter and is recruited to the p53RE together with HDAC1 upon etoposide treatment. The functional significance of p53 activationmediated PRAME downregulation was demonstrated by measuring colony formation and p27 expression in melanoma cells. These data suggest that p53 activation, which leads to PRAME downregulation, could be a therapeutic strategy in melanoma cells. [BMB Reports 2024; 57(6): 299-304].</p>","PeriodicalId":9010,"journal":{"name":"BMB Reports","volume":" ","pages":"299-304"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

8
9
...
10

下一页尾页

联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1

京公网安备 11010802042870号

Book学术文献互助

Book学术文献互助群
群号：604180095

Book学术官方微信