miR-328-5p 在早期内皮炎症和晚期动脉粥样硬化中发挥关键负调控因子的作用。

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
BMB Reports Pub Date : 2024-08-01
Yangxia Zhang, Yingke Li, Zhisheng Han, Qingyang Huo, Longkai Ji, Xuejia Liu, Han Li, Xinxing Zhu, Zhipeng Hao
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引用次数: 0

摘要

早期促动脉粥样硬化炎症是导致动脉粥样硬化的重要危险因素。尽管如此,驱动这种病理进展的确切分子机制在很大程度上仍然难以捉摸。我们的研究揭示了微小RNA miR-328-5p通过调节JUNB(JunB原癌基因)的稳定性在抑制内皮炎症中的关键作用。干扰 miR-328-5p 的水平会导致单核细胞对内皮细胞的粘附增强和跨内皮迁移增强,而过表达则会减轻这些炎症过程。此外,miR-328-5p 还能阻碍巨噬细胞向促炎 M1 表型极化,并对体内动脉粥样硬化斑块的形成产生负面影响。通过将JUNB确定为miR-328-5p的直接靶点,我们的研究强调了miR-328-5p作为炎症性动脉粥样硬化治疗靶点的潜力。重新引入JUNB能有效抵消miR-328-5p的抗动脉粥样硬化作用,这凸显了药物miR-328-5p靶向治疗炎症性动脉粥样硬化的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
miR-328-5p functions as a critical negative regulator in early endothelial inflammation and advanced atherosclerosis.

Early proatherogenic inflammation constitutes a significant risk factor for atherogenesis development. Despite this, the precise molecular mechanisms driving this pathological progression largely remain elusive. Our study unveils a pivotal role for the microRNA miR-328-5p in dampening endothelial inflammation by modulating the stability of JUNB (JunB proto-oncogene). Perturbation of miR-328-5p levels results in heightened monocyte adhesion to endothelial cells and enhanced transendothelial migration, while its overexpression mitigates these inflammatory processes. Furthermore, miR-328-5p hinders macrophage polarization toward the pro-inflammatory M1 phenotype, and exerts a negative influence on atherosclerotic plaque formation in vivo. By pinpointing JUNB as a direct miR-328-5p target, our research underscores the potential of miR-328-5p as a therapeutic target for inflammatory atherosclerosis. Reintroduction of JUNB effectively counteracts the anti-atherosclerotic effects of miR-328-5p, highlighting the promise of pharmacological miR-328-5p targeting in managing inflammatory atherosclerosis. [BMB Reports 2024; 57(8): 375-380].

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来源期刊
BMB Reports
BMB Reports 生物-生化与分子生物学
CiteScore
5.10
自引率
7.90%
发文量
141
审稿时长
1 months
期刊介绍: The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.
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