{"title":"Novel Therapy for Unresectable Hilar Cholangiocarcinoma âÂÂKlatskinTumorâ Utilizing Percutaneous Irreversible Electroporation: A Case Report","authors":"N. Mazal, D. West","doi":"10.4172/2167-7964.1000258","DOIUrl":"https://doi.org/10.4172/2167-7964.1000258","url":null,"abstract":"Unresectable hilar cholangiocarcinoma ‘Klatskin Tumor’ is a rare malignancy with limited treatment options and an overall poor prognosis. Percutaneous Irreversible Electroporation (IRE) is a relatively new ablative procedure with potential for treating unresectable cholangiocarcinoma, improving morbidity, and ultimately prolonging survival. The main benefit of IRE relies in the non-thermal technology which can be considered in patients with hilar tumors given the criticality of the adjacent vessels and bile ducts. This case report describes a 71 year old female with unresectable Bismuth-Corlette Stage IV cholangiocarcinoma who underwent IRE with disease control 13 months after treatment.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44832624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Pichon, S. Champiat, M. Aumont, D. Loussouarn, Frénel Js, M. Mahé, C. demoor-goldschmidt
{"title":"Glioblastoma of the Conus Medullaris Following Treatment of Hodgkin'sLymphoma: History of a Case and Literature Review","authors":"B. Pichon, S. Champiat, M. Aumont, D. Loussouarn, Frénel Js, M. Mahé, C. demoor-goldschmidt","doi":"10.4172/2167-7964.1000257","DOIUrl":"https://doi.org/10.4172/2167-7964.1000257","url":null,"abstract":"Purpose: Reports of a glioblastoma arising in a previously irradiated field are rare in the literature, even more so in the conus medullaris of the spinal cord. Method: Case report and review of the literature reporting other radiation-induced intra-medullary glioblastomas. Results: We report a case of glioblastoma of the conus, which subsequently metastasized to the brain, arising in a 45 years old man, nine years after treatment for Hodgkin's lymphoma, which had included the administration of 41 Gy to the brain and spinal cord. Conclusion: Despite a well-conducted treatment by several lines of chemotherapy, the pronostic of radiationinduced glioblastoma is poor especially since these patients often cannot benefit from a re-irradiation due to the maximum dose supported by the spinal cord. Implications of cancer survivors: Associations are now established between therapeutic exposures and specific complications but considerable inter-individual variability is observed for a given therapeutic exposure. In this context, identification of genetic susceptibilities for specific treatment-associated late effect is a very promising future approach. Improvement in our knowledge on genetic susceptibilities may help define more personalized primary therapies that weigh treatment efficacy with the risk of late complications.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47615707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Apparent Diffusion Coefficient in Glial Tumors","authors":"Tanyel Fc, A. Gokoglu, B. Tucer, Y. Caner","doi":"10.4172/2167-7964.1000256","DOIUrl":"https://doi.org/10.4172/2167-7964.1000256","url":null,"abstract":"Background: Diffusion-Weighted Imaging (DWI) is one of the fast developing techniques in the field of MRI. This method uses the random diffusion motion of water molecule depending on physiological and anatomical characteristics of living organisms. Aim: To calculate the apparent diffusion coefficient and diffusion values in order to determine the degree in the glial tumors. Patients and methods: In the study, cases were selected among those who presented with a diagnosis of intracranial mass to Neurosurgery Department of Erciyes University, Medicine School. Overall, 20 patients were included to the study: 7 patients with Glioblastoma Multiforme (GBM), 4 patients with anaplastic astrocytoma (AA), 4 patients with diffuse astrocytoma, 3 patients with ependymoma and 2 patients with low-grade astrocytoma. The apparent diffusion coefficient (ADC) images were acquired from echo-planar diffusion-weighted images (DWIs). For each tumor, the mean ADC values and the mean diffusion value were measured at a large region of interest (ROI) defined within tumor and at symmetrical normal brain tissue. Statistical analyses were performed by using SPSS 15.0 Statistical Package Program. Results: We calculated mean ADC values (2.91 × 10-3 mm2/s, 0.69 × 10-3 mm2/s, 3.13 × 10-3 mm2/s, 2.41 × 10-3 mm2/s and 0.70 × 10-3 mm2/s) and mean diffusion values (0.11 × 10-3 mm2/s, 1.6 × 10-3 mm2/s, 0.10 × 10-3 mm2/s, 1.58 × 10-3 mm2/s, 0.90 × 10-3 mm2/s) for GBM, AA, diffuse astrocytoma, low degree astrocytoma and ependymoma, respectively. The diffusion value of normal brain was calculated to be 0.85 × 10-3 mm2/s. A P-value <0.05 was considered statistically significant. We estimated a significant difference between GBM and AA (p=0.001). Although there were marked differences among diffuse astrocytomas, low degree astrocytoma and ependymoma, the difference did not reach statistical significance. Conclusion: The mean ADC value, the mean diffusion value and intensity region may provide additional information in determining tumor degree in malignant glial tumors.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":"2017 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43456985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of MRI Characterization of the Carotid Artery in theUnderstanding of Stroke","authors":"S. Creagh, A. Ortiz, J. Fumero, A. Paydar","doi":"10.4172/2167-7964.1000255","DOIUrl":"https://doi.org/10.4172/2167-7964.1000255","url":null,"abstract":"Carotid artery stenosis accounts for approximately 10% of ischemic strokes. Improved methods of diagnosis of cerebrovascular atherosclerosis would result in significant improvement in quality of life and major savings in health care costs. Imaging plays a critical role evaluating patients suspected of acute stroke. Magnetic Resonance Imaging (MRI's) significant advantages over DUS in carotids imaging can pay off its cost by means of improved patient outcome. Although DUS is frequently performed to evaluate carotid disease, there is nonuniformity in practice among laboratories. MRI can detect and quantify major compositional features of the carotid plaque and comprehensively evaluate its complications. A high level of agreement exists between high-resolution in vivo MRI, gross, and histological findings on the thickness and sites of potential rupture of the fibrous cap in advanced carotid artery atherosclerosis. MRI is capable of classifying and distinguishing different stages of atherosclerotic lesions. It can also examine the mechanisms of regression, progression, and endothelial dysfunction of the carotid plaque. Carotid MRI is a histologically validated, non-invasive imaging method that can track atherosclerotic disease progression and regression. It can quantitatively evaluate parameters associated with plaque morphology and composition. MRI is able to quantify high-grade carotid artery stenosis and occlusion with good accuracy and reproducibility and provides an opportunity to prospectively examine the relationship between plaque features and subsequent cerebrovascular events. The aim of this article is to examine the efficacy of MRI versus DUS in identifying vulnerable carotid lesions in the acute stroke patient that can account for stroke etiology or mechanism.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42271330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arfat M, Zahiruddin Md, Yadav Yc, Brig T, Prabhakar Vsm, Gupta Ak
{"title":"Evaluation of Epidemiological Trends and Severity of Traumatic BrainInjury Using Multi-Detector Computed Tomography Scanner in UttarPradesh University of Medical Sciences Hospital","authors":"Arfat M, Zahiruddin Md, Yadav Yc, Brig T, Prabhakar Vsm, Gupta Ak","doi":"10.4172/2167-7964.1000254","DOIUrl":"https://doi.org/10.4172/2167-7964.1000254","url":null,"abstract":"Background: MDCT is very well diagnosed and detecting haemorrhages, skull fracture with the help of new technique like 3D, Volume Rendering Technique (VRT), Multi-planar Reconstruction (MPR) and Maximum Intensity Projection. To evaluate of the epidemiological trends and severity of Traumatic Brain Injury (TBI) using multi-detector computed tomography scanner. \u0000Methods: The Present study was conducted with 61 patients, age between 2 year to 70 year mean age (36 Years) presenting to emergency department of Uttar Pradesh University of Medical Sciences, Saifai, Etawah, with a history of acute head trauma from Dec 2015 to May 2016. All patients were examined using 64 MDCT. \u0000Results: Traumatic brain injury caused by various reasons like 65.57% Road Traffic Accidents (RTA) and 19.67% Fall From Height (FFH) being and 14.75% hit by hard object. Loss of consciousness was the most common complaint of the 60.65% TBI patients followed by 6.56% Vomiting and headache, 21.31% facial injury and 1.47% scalp wounds. All TBI patients were diagnosed by MDCT who was observed 37.7% skull fractures, 9.83%, extra dural hematoma, 14.75% Sub Dural hematoma, 13.11% Sub archnoid haemorrhage, 6.55% Intra cerebral hematoma, 27.86% brain contusions and 9.83% diffuse cerebral edema. \u0000Conclusion: MDCT is well characterized to various type severities of the brain injury TBI patients. The present study data is indicated 65.57% majority of TBI patients is suffered by Road traffic accidents involving young adult males predominant.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45724589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tsapaki, Paraskeva Dk, A. Giannakopoulos, Chatzoglou, D. Nikolopoulos, P. Angelogiannopoulou, S. Papaeuthimiou, S. Kottou
{"title":"Patient and Staff Radiation Exposure during Endoscopic RetrogradeCholangio-Pancreatography: Eight Years of Dose Monitoring","authors":"Tsapaki, Paraskeva Dk, A. Giannakopoulos, Chatzoglou, D. Nikolopoulos, P. Angelogiannopoulou, S. Papaeuthimiou, S. Kottou","doi":"10.4172/2167-7964.1000253","DOIUrl":"https://doi.org/10.4172/2167-7964.1000253","url":null,"abstract":"The aim of the study was to analyze eight years of patient and staff radiation exposure data during Endoscopic Retrograde Cholangio-Pancreatography (ERCP). Parameters recorded and calculated were: patient age, kermaarea product (KAP), fluoroscopy time (T) and total number of images (I) in 1632 ERCP procedures. An experienced endoscopist (more than 10 years of practice) performed the ERCPs and was monitored by a thermoluminescent dosemeter worn over a 0.25 mm lead apron. Patient mean (SD) age was 70.6 (14.8) years. Median (max) of KAP value was 15.6 (371.2) Gy.cm2. Median (max) of T and I were 3.3 (50.0) min and 3 (10) images, respectively. Median values of KAP showed a reduction over the eight years, although median values of T and I showed a slight increase during the same period. KAP and T values of the present study appeared to be close to those reported in similar studies in the literature. Monthly endoscopist radiation dose was negligible due to the proper use of lead apron, collar and two leadarticulated ceiling mounted shields (90 cm width each).","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42277458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takafumi Yamada, Kazuhiro Saito, Yoichi Araki, Jinho Park, J. Matsubayashi, T. Nagao, M. Kakihana, N. Ikeda, K. Tokuuye
{"title":"Efficacy of ADC Histogram Analysis for Differentiating Thymic Cancerfrom Thymoma","authors":"Takafumi Yamada, Kazuhiro Saito, Yoichi Araki, Jinho Park, J. Matsubayashi, T. Nagao, M. Kakihana, N. Ikeda, K. Tokuuye","doi":"10.4172/2167-7964.1000252","DOIUrl":"https://doi.org/10.4172/2167-7964.1000252","url":null,"abstract":"Objective: An ADC histogram which was derived from the Region of Interest (ROI) set over the entire tumor may distinguish thymoma from thymic cancer and provide less bias and reproducibility. To evaluate the utility of ADC histogram analysis for differentiating thymic cancer from thymoma in comparison with conventional MRI findings. \u0000Materials and methods: The subjects consisted of 31 patients with 27 thymomas and 4 thymic cancers. Diffusionweighted imaging was performed with b values of 100 and 800 s/mm2. Data acquired from each slice were summed up to derive voxel-by-voxel ADC values for the entire tumor and an ADC histogram was generated. The mean, standard deviation, minimum, maximum, 5th, 25th, 50th, 75th, 90th percentiles, mode, skewness, and kurtosis were derived from the ADC histogram. MRI findings were evaluated in terms of contour, capsulization, septum, hemorrhage, necrosis or cystic change, lymph node swelling, pleural effusion, major vascular invasion, and homogeneity. \u0000Results: Significant differences were observed in the minimum ADC, contour, and major vascular invasion between thymoma and thymic cancer (p=0.010, p=0.03, and p=0.009, respectively). The sensitivities and specificities when the minimum ADC was 70 × 10−6 mm2/s or lower, when the contour was lobular or irregular, and when the presence of vascular invasion was considered to be thymic cancer were 75% and 93%, 100% and 37%, and 25% and 100%, respectively. \u0000Conclusion: Minimum ADC was useful for distinguishing thymic cancer from thymoma, and it had an additional value to the routine MRI sequence.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44954475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessing Oxygenation Response to Eribulin in a Patient with RecurrentBreast Cancer after Resistance to Endocrine Therapy","authors":"S. Ueda, T. Saeki, T. Yamane, I. Kuji","doi":"10.4172/2167-7964.1000250","DOIUrl":"https://doi.org/10.4172/2167-7964.1000250","url":null,"abstract":"We present our initial experience with a novel method of functional hypoxia imaging. 18F-fluoromisonidazole-positron emission tomography/computed tomography and diffuse optical spectroscopic imaging were used to noninvasively evaluate the biological effects induced by eribulin monotherapy in a patient treated for recurrent breast cancer with acquired resistance to endocrine therapy. Eribulin monotherapy clearly induced reoxygenation, indicated by the markedly reduced 18F-fluoromisonidazole uptake and enhanced oxygen saturation levels in the lesion. These observations suggest that the reversal of hypoxia can be captured utilizing 18F-fluoromisonidazole positron emission tomography/computed tomography and diffuse optical spectroscopic imaging.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41538101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Abdulghaffara, M. Nasr, W. Shahin, Elder Am, Akl Th
{"title":"3-T Magnetic Resonance Diffusion-Weighted Imaging (DWI) forCharacterization of Hepatic Masses","authors":"W. Abdulghaffara, M. Nasr, W. Shahin, Elder Am, Akl Th","doi":"10.4172/2167-7964.1000249","DOIUrl":"https://doi.org/10.4172/2167-7964.1000249","url":null,"abstract":"Objective: To evaluate the role of DWI and ADC in differentiating benign from malignant hepaticmasses \u0000Materials and methods: Forty-one patients with fifty-two focal hepatic masses were included in our study. MRI \u0000 was done using coronal T2-weighted single-shot turbo spin-echo, breath hold axial 3-D gradient-echo, breath hold 2- \u0000 D gradient-echo in and out-of-phase, respiratory-triggered axial turbo spin-echo T2 sequence with fat saturation, \u0000 followed by free breathing Diffusion-weighted MR imaging using a single-shot spin-echo echo planar imaging \u0000 sequence and finally triphasic -MRI. \u0000Results: Forty-one patients (Fifty-two lesions) were included in our study. Twenty-three lesions were benign; \u0000 eight of them were cysts (mean ADC values of 3.15 ± 0.34 × 10-3 mm2/s) and fifteen lesions were hemangiomas \u0000 (mean ADC values of 2.10 ± 0.25 × 10-3 mm2/s). Twenty-nine lesions were malignant; twelve HCC lesions (mean \u0000 ADC values of 1.10 ± 0.32 × 10-3 mm2/s) and seventeen masses were metastasis (mean ADC values of 0.96 ± 0.23 \u0000 × 10-3 mm2/s). Sensitivity and specificity of DWI in differentiating malignant from benign hepatic masses were 96.6% \u0000 and 95.7% respectively. \u0000Conclusion: DWI is an easy technique to obtain and to be evaluated. ADC values can differentiate benign from \u0000 malignant liver masses with high sensitivity and specificity.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46613080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cyst of the Canal of Nuck Mimicking Inguinal Hernia: A Case Report","authors":"L. Acu, B. Acu","doi":"10.4172/2167-7964.1000251","DOIUrl":"https://doi.org/10.4172/2167-7964.1000251","url":null,"abstract":"A 22-year-old female patient was referred to our department by general surgeon for a suspected left-sided inguinal hernia. She had a painful tender mass in her left groin. On physical examination, there was a palpable mass in the region of her left inguinal canal. US and pelvic CT examination were performed. Sonographic examination, revealed a well-defined cystic mass with internal septae and thin wall, located in the left inguinal canal extending along the course of the round ligament. On CT images, there was a thin-walled cystic mass in the left inguinal canal and intraabdominal extension of the canal of Nuck. Diagnosis of cyst of the canal of Nuck was confirmed by surgery and subsequent histopathologic evaluation. Hydrocele of the canal of Nuck is a rarely encountered entity. It should be on the differential diagnosis list of groin swellings in female patients. Radiologists must be aware of the imaging findings of hydrocele of the canal of Nuck to diagnose this entity before surgery.","PeriodicalId":90030,"journal":{"name":"OMICS journal of radiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7964.1000251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42092904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}