Blood Pressure最新文献

{"title":"Hypertension and Burden of Myocardial Infarction in China: Risk Factors, Gender Differences, and Temporal Trends from a National Chronic Disease Surveillance Study (2021-2023).","authors":"Xiaoling Zhang, Dan Huang, Jianxun Zhao, Jinhui Wu","doi":"10.1080/08037051.2025.2487584","DOIUrl":"https://doi.org/10.1080/08037051.2025.2487584","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction (MI) remains a leading global cause of morbidity and mortality, with rising prevalence in China. Hypertension persists as a predominant modifiable risk factor. This study investigates MI prevalence, trends, and risk factors using data from China CDC's Chronic Disease Surveillance program.</p><p><strong>Methods: </strong>Data from 258,742 participants (2021-2023) were analyzed. Demographic characteristics, risk factors, and gender/urban-rural disparities in MI prevalence were assessed. Multivariate logistic regression identified significant risk factors.</p><p><strong>Results: </strong>Hypertension was the leading MI risk factor (64.3%), followed by dyslipidemia (58.6%) and smoking (42.3%). Men had higher MI prevalence than women (58.2% vs. 41.8%), and urban residents surpassed rural residents (56.7% vs. 43.3%), with significant lifestyle disparities (e.g., physical inactivity, smoking). Multivariate analysis identified age ≥60 years (OR = 2.75, 95% CI:2.46-3.08), hypertension, dyslipidemia, smoking, and obesity (BMI ≥25) as key risk factors. MI incidence increased by 3.14% nationally from 2021 to 2023.</p><p><strong>Conclusions: </strong>China's MI burden is escalating, with notable gender, age, and residence disparities. Older adults and individuals with hypertension, dyslipidemia, smoking, or obesity face elevated risks. Hypertension contributes to nearly two-thirds of MI cases, emphasizing the urgency for targeted prevention strategies, particularly in high-risk groups (hypertensive individuals, older adults, urban populations).</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"1-27"},"PeriodicalIF":1.8,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness analysis of radiofrequency renal denervation for uncontrolled hypertension in Sweden.","authors":"T Kahan, M L Lundsby Johansen, A M Ryschon, K N Cao, M Kolovetsios, P Lindgren, J B Pietzsch","doi":"10.1080/08037051.2025.2487583","DOIUrl":"https://doi.org/10.1080/08037051.2025.2487583","url":null,"abstract":"<p><strong>Introduction: </strong>Radiofrequency renal denervation (RF RDN) is a catheter-based therapy for uncontrolled hypertension. This model-based analysis examined the cost-effectiveness of RF RDN in Sweden.</p><p><strong>Methods: </strong>Clinical events, costs, quality-adjusted life-years (QALYs) were projected over 10-year and lifetime horizons with a decision-analytic Markov model. The model accounted for seven primary health states, including hypertension alone, myocardial infarction (MI), stroke, other symptomatic coronary heart disease (CHD), heart failure (HF), end-stage renal disease (ESRD), and death; health state transitions were informed by multivariate risk equations. Clinical evidence from the SPYRAL HTN-ON MED trial informed the treatment effect modeled (-4.9 mmHg reduction in office systolic blood pressure (SBP) vs. sham). Costs, utilities, and post-event mortality were obtained from Swedish literature where possible, with the base case conducted from the healthcare payer perspective. The primary outcome of the analysis was the incremental cost-effectiveness ratio (ICER), with the cost-effectiveness of RF RDN vs. standard of care (SoC) evaluated against an assumed willingness-to-pay threshold of SEK 500,000 per QALY gained. Extensive sensitivity analyses were performed.</p><p><strong>Results: </strong>At 10-years, the relative risks for RF RDN were 0.80 for stroke, 0.88 for MI, 0.89 for CHD, 0.72 for HF, 0.96 for ESRD, 0.86 for cardiovascular death and 0.93 for all-cause death. Over lifetime, RF RDN led to incremental costs and QALYs of SEK 63,136 (total costs SEK 497,498 for RF RDN vs. SEK 434,362 for SoC) and 0.45 (total QALYs 14.79 for RF RDN vs. 14.34 for SoC), yielding an ICER of SEK 139,280 per QALY gained. RF RDN was cost-effective across all scenarios and sensitivity analyses.</p><p><strong>Conclusion: </strong>Model projections suggest RF RDN to be a cost-effective therapy for uncontrolled including resistant hypertension in Sweden based on contemporary clinical evidence.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"1-14"},"PeriodicalIF":1.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characterization of Blood Pressure Phenotypes: The BP Phenotype Score.","authors":"Maha A Al-Mohaissen, Maisa A Al Zohaifi, Terry Lee, Nada A Almalki, Hend Aleiban, Rabah A Al-Mehisen","doi":"10.1080/08037051.2025.2486284","DOIUrl":"https://doi.org/10.1080/08037051.2025.2486284","url":null,"abstract":"<p><strong>Background: </strong>Evidence has linked blood pressure (BP) phenotypes with certain clinical, psychosocial, and occupational features, and characteristic BP variability.</p><p><strong>Objective: </strong>We aimed to evaluate the value of a diagnostic score developed from these characteristics in predicting BP phenotypes, when used in a manner comparable to the application of out-of-office techniques.</p><p><strong>Methods: </strong>Adult patients with no prior diagnosis of hypertension attending their office appointments, were prospectively enrolled. Their clinical, psychosocial, and occupational data were collected. 3-consecutive pre-appointment BP measurements, and BP variability with standing and the 6-minute walk test (6MWT) were obtained. All participants underwent 24-hour BP monitoring which was paired with office BP as the reference standard for BP phenotyping. Two scores were developed from the variables selected using linear regression analysis to differentiate between masked hypertension (MH) and normotension, and sustained hypertension (SH) and white coat hypertension (WCH).</p><p><strong>Results: </strong>In total 212 participants completed the study. Among office-normotensives, a score of 7 (calculated from the variables (points): dyslipidemia (3), irritable bowel syndrome (IBS) (3), orthostatic increase in SBP > 5 mmHg (1), SBP increase > 10 after 6MWT (1), and BP ≥ 130/80 after 6MWT (3)) identified MH with 90% sensitivity, 86% specificity, 96% negative predictive value (NPV), and 70% positive predictive value (PPV). Conversely, among office-hypertensives, a score of 6 (variables (points): male sex (2), lack of IBS (2), ≥3 metabolic syndrome criteria (3), obesity (3), standing BP ≥ 140/90 (3), BP ≥ 140/90 after 6MWT (1)) identified SH with 82% sensitivity, 78% specificity, 90% PPV, and 64% NPV.</p><p><strong>Conclusions: </strong>BP phenotypes correspond to distinct clinical phenotypes and can be predicted with acceptable sensitivity and specificity using BP phenotype scores. This novel approach to BP phenotyping provides an accessible addition, not a replacement, to available out-of-office techniques, particularly useful for screening for MH, and to support office diagnosis of SH when out-of-office measures are unavailable or not tolerated.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"1-22"},"PeriodicalIF":1.8,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends and Relevant Factors of Hypertension in China: A Cross-Sectional Study Based on National Surveys from 2002 to 2019.","authors":"Xiaoling Zhang, Jinhui Wu","doi":"10.1080/08037051.2025.2468172","DOIUrl":"https://doi.org/10.1080/08037051.2025.2468172","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the temporal trends in hypertension prevalence in China from 2002 to 2019, focusing on age-specific, sex-specific, and regional differences, as well as identifying key factors associated with hypertension.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted using data from the China Chronic Disease and Risk Factor Surveillance (CCDRFS) program, involving 120,000 adults aged 18 years and older. Prevalence rates were calculated using descriptive statistics, and multivariable logistic regression was performed to identify significant relevant factors, including age, sex, body mass index (BMI), smoking, alcohol consumption, and physical activity.</p><p><strong>Results: </strong>The prevalence of hypertension in China increased from 18.9% in 2002 to 29.6% in 2019 (P < 0.001). The most substantial increase occurred in individuals aged 18-44 years, where prevalence tripled from 5.3% to 12.8%. Hypertension prevalence was higher in men (34.2%) than in women (25.4%) by 2019. Significant regional variations were observed, with the western regions exhibiting the highest prevalence (32.9%). Logistic regression identified age, BMI, smoking, alcohol consumption, and physical inactivity as significant relevant factors for hypertension.</p><p><strong>Conclusion: </strong>Hypertension prevalence in China has risen substantially over the past two decades, particularly among younger adults. These findings highlight the need for targeted prevention strategies that address modifiable risk factors and accommodate regional disparities. Further research is warranted to explore underlying mechanisms and to develop comprehensive prevention and treatment strategies.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"1-11"},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradialytic Hypotension Pathophysiology and Therapy Update: Review and Update.","authors":"Elmukhtar Habas, Amnna Rayani, Aml Habas, Kalifa Farfar, Eshrak Habas, Khaled Alarbi, Ala Habas, Elmehdi Errayes, Gamal Alfitori","doi":"10.1080/08037051.2025.2469260","DOIUrl":"https://doi.org/10.1080/08037051.2025.2469260","url":null,"abstract":"<p><p>BackgroundIntradialytic hypotension (IDH) is the most prevalent complication during hemodialysis (HD) sessions, affecting 10% to 12% of patients. It is linked with temporary ischemic stress in vital organs, increasing patient mortality. Various definitions of IDH have been proposed, and a strong correlation has been found between patient outcomes and the absolute lowest systolic blood pressure. The most probable underlying pathophysiology of IDH involves a reduced effective blood volume and decreased plasma tonicity. Optimizing the dialysis prescription and interventions during and after the dialysis session is sometimes effective for reducing IDH risk.Aim and MethodThis review discusses the pathophysiology, prevention, and therapy of IDH updates. To achieve this aim, Scopus, EMBASE, PubMed, Google, and Google Scholar were searched for articles published in the last two decades using phrases and keywords.ConclusionIntradialytic pathophysiology is ambiguous and unclear. The evidence for the effectiveness of the known therapies and maneuvers is limited. Ideally, IDH prevention should be the target; however, IDH management is sometimes needed. Different obstacles require further clinical research.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"1-18"},"PeriodicalIF":1.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised trial comparing usual versus strict home blood pressure control in elderly patients with hypertension: protocol and initial progress.","authors":"Dong-Yan Zhang, Yi-Qing Zhang, De-Wei An, Yi-Bang Cheng, Song-Tao Tang, Min Liu, Jue Li, Jan A Staessen, Ji-Guang Wang, Yan Li","doi":"10.1080/08037051.2025.2472192","DOIUrl":"https://doi.org/10.1080/08037051.2025.2472192","url":null,"abstract":"<p><p><b>Objective</b>. The optimal level of home blood pressure (HBP) for the prevention of cardiovascular complications is unknown. The Home Blood Pressure Intervention in the Community Trial (HomeBP, [NCT05858944]) is addressing this issue by randomising elderly hypertensive patients to standard or tight HBP control.<b>Methods and analysis</b>. HomeBP is an investigator-initiated randomised clinical trial with open design and blinded endpoint evaluation. Eligible patients of either sex, aged 60-80 years, having uncontrolled home hypertension (≥135/85 mm Hg) after medication for at least 2 weeks will be recruited nationwide in China at up to 200 community healthcare centres. After stratification for centre and the presence of office hypertension (≥140/90 mm Hg), 10,000 patients will be randomised in a 1:1 proportion to a target HBP of 125-134/75-84 mm Hg or <125/75 mm Hg and followed up for 4 years. The primary outcome is a composite of cardiovascular death, non-fatal myocardial infarction, coronary revascularisation, unstable angina pectoris or heart failure requiring hospitalisation, and non-fatal stroke. Follow-up visits are scheduled monthly for 3 months after randomisation and 3<b>-</b>monthly thereafter. Patients record HBP for 7 consecutive days before every visit. A unique feature of the trial is the information technology setup, allowing the secure and instantaneous flow of HBP and other data to the study coordinating centre, where a standardised HBP report is generated. Hypertension specialists at Ruijin Hospital, Shanghai and at local tertiary hospitals provide treatment recommendations, which are transmitted to the caregivers at the community centres, who then fine-tune the treatment recommendations in a shared decision process with the patients to meet the values and clinical needs of the patients. Currently, 2281 patients have been randomised with no between-group differences in the baseline characteristics.<b>Trial registration number.</b> URL: https://www.clinicaltrials.gov; Unique identifier: NCT05858944.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"1-16"},"PeriodicalIF":1.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor.","authors":"Jorge Polónia, Raul Marques Pereira","doi":"10.1080/08037051.2024.2385159","DOIUrl":"10.1080/08037051.2024.2385159","url":null,"abstract":"","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":"33 1","pages":"2385159"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and its correlation with autonomic nervous system dysfunction, heart rate variability and chronic inflammation.","authors":"Bo He, Dapeng Ji, Bo Zhang","doi":"10.1080/08037051.2024.2405156","DOIUrl":"https://doi.org/10.1080/08037051.2024.2405156","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the relationship between hypertension, dysregulation of the autonomic nervous system, heart rate variability (HRV), and chronic inflammation.</p><p><strong>Methods: </strong>We analysed a cohort of 50 hypertensive patients treated at the affiliated Hospital of Jianghan University. The average systolic and diastolic blood pressures (BPs) in this group were 155.26 and 95.32 mmHg, respectively. A control group of 50 healthy volunteers, undergoing routine physical examinations at the same hospital, was also analysed.</p><p><strong>Results: </strong>The average systolic BP of the control group was 115.64 ± 10.27 mmHg, and the average diastolic BP was 75.33 ± 8.25 mmHg. In contrast, the experimental group exhibited an average systolic BP of 155.26 ± 20.13 mmHg and an average diastolic BP of 95.32 ± 12.16 mmHg. Both systolic and diastolic BPs were significantly higher in the hypertensive group (<i>p</i> < 0.05). The experimental group also demonstrated reduced HRV and skin conductance response, alongside increased BP variability (BPV), urinary epinephrine levels and prolonged pupillary light reaction time compared to controls (<i>p</i> < 0.05). Notably, Standard Deviation of Normal to Normal Intervals (SDNN) and Root Mean Square of Successive Differences (RMSSD) values were significantly lower in the experimental group (<i>p</i> < 0.05). Furthermore, levels of inflammatory markers such as CRP, TNF-α, IL-6 and IL-1β were markedly elevated in hypertensive patients (<i>p</i> < 0.05). Negative correlations were observed between systolic and diastolic BP with HRV metrics, while positive correlations were found between BP and BPV as well as urinary adrenaline levels.</p><p><strong>Conclusions: </strong>The findings indicate that hypertension is closely associated with autonomic nervous system dysfunction, reduced HRV and increased chronic inflammation. A comprehensive approach to hypertension management should integrate these interrelated physiological and pathological mechanisms, with potential therapeutic interventions targeting autonomic function and inflammatory states.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":"33 1","pages":"2405156"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sham-controlled randomised pilot trial on baroreflex activation therapy in patients with resistant hypertension: What will the future hold?","authors":"D Gordin, R Simonsen, I Tikkanen","doi":"10.1080/08037051.2024.2417887","DOIUrl":"10.1080/08037051.2024.2417887","url":null,"abstract":"","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":"33 1","pages":"2417887"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of childhood socioeconomic status with adulthood maximal exercise blood pressure: the Cardiovascular Risk in Young Finns Study.","authors":"Erika Kähönen, Emilia Kähönen, Kristiina Pälve, Janne Hulkkonen, Mika Kähönen, Olli T Raitakari, Nina Hutri, Terho Lehtimäki, Heikki Aatola","doi":"10.1080/08037051.2024.2323987","DOIUrl":"10.1080/08037051.2024.2323987","url":null,"abstract":"<p><strong>Purpose: </strong>Socioeconomic status has been related to resting blood pressure (BP) levels at different stages of life. However, the association of childhood socioeconomic status (SES) and adulthood exercise BP is largely unknown. Therefore, we studied the association of childhood SES with adulthood maximal exercise BP.</p><p><strong>Materials and methods: </strong>This investigation consisted of 373 individuals (53% women) participating in the Cardiovascular Risk in Young Finns Study who had data concerning family SES in childhood (baseline in 1980, at age of 6-18 years) and exercise BP response data in adulthood (follow-up in adulthood in 27-29 years since baseline). A maximal cardiopulmonary exercise test with BP measurements was performed by participants, and peak exercise BP was measured.</p><p><strong>Results: </strong>In stepwise multivariable analysis including childhood risk factors and lifestyle factors (body mass index, systolic BP, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, insulin, fruit consumption, vegetable consumption, and physical activity), lower family SES in childhood was associated with higher maximal exercise BP in adulthood (β value ± SE, 1.63 ± 0.77, <i>p</i> = 0.035). The association remained significant after further adjustment with participants SES in adulthood (β value ± SE, 1.68 ± 0.65, <i>p</i> = 0.011) and after further adjustment with adulthood body-mass index, systolic BP, maximal exercise capacity, and peak heart rate in exercise (β value ± SE, 1.25 ± 0.56, <i>p</i> = 0.027).</p><p><strong>Conclusions: </strong>These findings suggest that lower childhood family SES is associated with higher maximal exercise BP in adulthood.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":"33 1","pages":"2323987"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}