Blood PressurePub Date : 2025-12-01Epub Date: 2025-04-10DOI: 10.1080/08037051.2025.2490592
Sari Luthfiyah, Triwiyanto Triwiyanto, Adin Muafiro
{"title":"Letter to editor: validating the accuracy of Omron J760 electronic blood pressure monitor in the general population according to AAMI/ESH/ISO (ISO 81060-2:2018) + AMD1:2020.","authors":"Sari Luthfiyah, Triwiyanto Triwiyanto, Adin Muafiro","doi":"10.1080/08037051.2025.2490592","DOIUrl":"10.1080/08037051.2025.2490592","url":null,"abstract":"","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2490592"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Malignant hypertension, and if it was scleroderma? Lessons from two cases.","authors":"Réda Laamech, Diane Giovannini, Etienne Cellot, Sandra Jost, Benoit Franko","doi":"10.1080/08037051.2025.2482741","DOIUrl":"10.1080/08037051.2025.2482741","url":null,"abstract":"<p><p><b>Inroduction :</b> Scleroderma Renal Crisis (SRC) is characterised by acute hypertension, haemolytic anaemia (HA), and acute kidney injury (AKI). Often presenting as the first manifestation of scleroderma, it is frequently mistaken for malignant hypertension (MHT). Rapid recognition and differentiation of SRC from other hypertensive emergencies are essential for improving patient outcomes.We present two clinical cases that illustrate the diagnostic challenges of SRC in the context of MHT.</p><p><p><b>Case 1:</b> A 53-year-old man presented with severe hypertension (238/127 mmHg) and AKI (creatinine 390 μmol/L). He was diagnosed MHT due to the presence of grade III hypertensive retinopathy and HA. . However, a urine dipstick test detected haematuria, leading to further immune testing and, a renal biopsy, which confirmed SRC. Treatment with high-dose ramipril led to a sustained recovery of kidney function, 221 μmol/L after five years).</p><p><p><b>Case 2:</b> A 52-year-old man presented with chest pain, severe hypertension (253/132 mmHg), and AKI (creatinine 183 μmol/L). Initially managed as MHT, his kidney function worsened, prompting further investigation, which revealed haematuria and positive anti-nuclear antibodies. A renal biopsy confirmed SRC. High-dose ramipril was reintroduced, leading to partial kidney function recovery (creatinine 218 μmol/L after five years).</p><p><p><b>Key findings :</b> These cases underscore the importance of early detection of hematuria and autoimmune markers to expedite diagnosis of SRC in case of MHT. When SRC is suspected, high-dose angiotensin-converting enzyme inhibitors (ACEi) should be initiated immediately, even before biopsy confirmation and continued despite initial kidney function decline. Early intervention is crucial for optimising kidney outcomes and achieving effective blood pressure control.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2482741"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-03-17DOI: 10.1080/08037051.2025.2468172
Xiaoling Zhang, Jinhui Wu
{"title":"Temporal trends and relevant factors of hypertension in China: a cross-sectional study based on national surveys from 2002 to 2019.","authors":"Xiaoling Zhang, Jinhui Wu","doi":"10.1080/08037051.2025.2468172","DOIUrl":"10.1080/08037051.2025.2468172","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined temporal trends in hypertension prevalence across China (2002-2019), analyzing age-, sex-, and region-specific disparities and identifying key risk factors.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted using data from the China Chronic Disease and Risk Factor Surveillance (CCDRFS) program, involving 120,000 adults aged ≥18 years. Descriptive statistics were used to calculate prevalence rates, and multivariable logistic regression analyzed associations with age, sex, BMI, smoking, alcohol consumption, and physical inactivity.</p><p><strong>Results: </strong>Hypertension prevalence increased significantly from 18.9% (2002) to 29.6% (2019) (P<0.001). The sharpest rise occurred among adults aged 18-44 years, tripling from 5.3% to 12.8%. By 2019, prevalence was higher in men (34.2%) than women (25.4%), with the western regions showing the highest rates (32.9%). Key risk factors included aging (OR=1.72), elevated BMI (OR=1.85), smoking (OR=1.32), alcohol use (OR=1.28), and physical inactivity (OR=1.18) (P<0.05 for all).</p><p><strong>Conclusions: </strong>Hypertension prevalence in China has surged over two decades, disproportionately affecting younger adults and men. Regional disparities and modifiable lifestyle factors underscore the urgency for tailored prevention strategies targeting high-risk populations. Future research should explore mechanisms driving these trends and optimize integrated interventions to curb this public health burden.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2468172"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-03-31DOI: 10.1080/08037051.2025.2480608
Sverre E Kjeldsen, Mattias Brunström, Michel Burnier, Brent Egan, Krzysztof Narkiewicz, Reinhold Kreutz, Giuseppe Mancia
{"title":"Management of 'Elevated' blood pressure according to the 2024 European Society of Cardiology Guidelines: lack of supportive evidence and high risk of excessive treatment.","authors":"Sverre E Kjeldsen, Mattias Brunström, Michel Burnier, Brent Egan, Krzysztof Narkiewicz, Reinhold Kreutz, Giuseppe Mancia","doi":"10.1080/08037051.2025.2480608","DOIUrl":"10.1080/08037051.2025.2480608","url":null,"abstract":"","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2480608"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-02-05DOI: 10.1080/08037051.2025.2457698
Mateusz Gaczoł, Marek Rajzer, Wiktoria Wojciechowska
{"title":"Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions.","authors":"Mateusz Gaczoł, Marek Rajzer, Wiktoria Wojciechowska","doi":"10.1080/08037051.2025.2457698","DOIUrl":"10.1080/08037051.2025.2457698","url":null,"abstract":"<p><strong>Purpose: </strong>Ventricular-arterial coupling (VAC) is a crucial concept in cardiovascular physiology, representing the dynamic interaction between the left ventricle and the arterial system. This comprehensive literature review explores the changes in VAC with ageing and various cardiovascular diseases (CVDs).</p><p><strong>Materials and methods: </strong>This literature review covers studies on changes in VAC with age and common CVDs, such as arterial hypertension, atrial fibrillation (AF) and heart failure with preserved and reduced ejection fraction and aortic stenosis (AS). The review discusses traditional measures of VAC, including arterial elastance (Ea) and ventricular elastance (Ees), as well as emerging parameters, such as global longitudinal strain (GLS) and pulse wave velocity (PWV). The review introduces the PWV/GLS ratio as a novel method for assessing VAC.</p><p><strong>Results: </strong>With ageing, both Ea and Ees increase, while the Ea/Ees ratio remains relatively stable, reflecting balanced arterial and ventricular adaptations. Novel measures, such as PWV/GLS ratio, show greater impairment in older adults and provide a comprehensive evaluation of VAC.</p><p><strong>Conclusions: </strong>Ageing disrupts VAC through arterial stiffening and reduced heart function, often exacerbated by CVDs. Novel metrics like PWV/GLS may improve VAC assessment, helping clinicians manage age-related cardiovascular issues by identifying risks earlier and guiding treatment to support efficient heart-artery interaction.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2457698"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-02-25DOI: 10.1080/08037051.2025.2469264
Bihua Chen, Guorong Chen, Hong Jiang, Ya Sun, Jie Chen, Dan Wang, Mingzhi Chen, Jia Shi, Yan Peng, Yimin Cheng, Cheng Yang, Yuanyuan Ding, Jin Su, Ming Liu, Fulai Shen, Yicheng Qiu, Yi Shen, Qiyun Cao, Jiayu Su
{"title":"Validating the accuracy of Omron J760 electronic blood pressure monitor in the general population according to AAMI/ESH/ISO (ISO 81060-2:2018) + AMD1:2020.","authors":"Bihua Chen, Guorong Chen, Hong Jiang, Ya Sun, Jie Chen, Dan Wang, Mingzhi Chen, Jia Shi, Yan Peng, Yimin Cheng, Cheng Yang, Yuanyuan Ding, Jin Su, Ming Liu, Fulai Shen, Yicheng Qiu, Yi Shen, Qiyun Cao, Jiayu Su","doi":"10.1080/08037051.2025.2469264","DOIUrl":"10.1080/08037051.2025.2469264","url":null,"abstract":"<p><strong>Purpose: </strong>The accuracy of the Omron J760 electronic blood pressure (BP) monitor for upper arm BP measurement in the adult general population was validated following the AAMI/ESH/ISO (ISO 81060-2:2018) + Amd1:2020 protocol. We expect that this device can be used for home blood pressure monitoring, with its measurements serving as a clinical reference.</p><p><strong>Methods: </strong>Subjects meeting the age, gender, BP, and cuff distribution criteria as specified by the AAMI/ESH/ISO (ISO 81060-2:2018) + Amd1:2020 were recruited. BP measurements were conducted using the same-arm sequential method. The test device cuff was suitable for arm circumferences ranging from 22.0 cm to 42.0 cm.</p><p><strong>Results: </strong>Eighty-nine participants were initially recruited, 85 were evaluated after excluding 4 participants. The mean age of the participants was 48.5 ± 15.17 years. For validation criterion 1, the mean ± standard deviation (SD) of the differences between the test device and the reference BP measurements were 0.2 ± 5.74 mmHg for systolic BP and -0.9 ± 4.69 mmHg for diastolic BP. These results met the AAMI/ESH/ISO (ISO 81060-2:2018)+Amd1:2020 standard, which requires differences of ≤5 ± ≤8 mmHg. For validation criterion 2, the mean differences between the test device and the reference device were 0.2 ± 5.10 mmHg for systolic BP and -0.9 ± 4.30 mmHg for diastolic BP. This criterion was satisfied with criterion 2 of ≤6.95 mmHg for systolic BP and ≤6.88 mmHg for diastolic BP.</p><p><strong>Conclusion: </strong>The Omron J760 electronic BP monitor meets the requirements of the AAMI/ESH/ISO (ISO 81060-2:2018)+Amd 1:2020 validation standard.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2469264"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-05-28DOI: 10.1080/08037051.2025.2511212
I Ivanko, Ž Dika, I Ćelap, V Vukosav, P Gaćina, J Josipović
{"title":"'It does not end with delivery?' Pregnancy-associated thrombotic microangiopathy in the setting of postpartum preeclampsia/eclampsia - case report.","authors":"I Ivanko, Ž Dika, I Ćelap, V Vukosav, P Gaćina, J Josipović","doi":"10.1080/08037051.2025.2511212","DOIUrl":"10.1080/08037051.2025.2511212","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnancy-associated thrombotic microangiopathy (TMA) is potentially life-threatening disorder which refers to endothelial injury as the main culprit. Our case demonstrates true severity of pregnancy-associated TMA in postpartum period and diagnostic challenges in obtaining correct diagnosis.</p><p><strong>Case presentation: </strong>The 32-year-old woman, with no previous record of gestational hypertension, underwent C-section in 30<sup>th</sup> week of 1<sup>st</sup> pregnancy due to preeclampsia. Postpartum period was complicated with TMA and continuous need for antihypertensive therapy. Due to suspicion of thrombotic thrombocytopenic purpura (TTP), plasmapheresis was started. After dismissing TTP diagnosis, plasmapheresis was continued while perusing other possible pregnancy-associated TMAs. After a period of stabilisation, anaemia and thrombocytopenia worsened with signs of renal impairment and the patient experienced hypertensive crisis, culminating with grand mal epileptic seizure. She was sedated and treated with intravenous antihypertensive therapy in the Intensive care unit setting. Anti-complement therapy was obtained due to high suspicion of atypical haemolytic uraemic syndrome (aHUS) but ultimately was not delivered due to the rapid improvement in clinical and laboratory findings. No high-risk polymorphism for aHUS were detected, rather multiple common risk variants for complement mediated TMA. The patient experienced full clinical recovery with minimal residual renal impairment.</p><p><strong>Conclusion: </strong>this case is an example of pregnancy-associated TMA in the setting of preeclampsia in postpartum period which progressed to eclampsia due to the uncontrolled arterial hypertension. Upon vigorous blood pressure management, signs of TMA fully subsided.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2511212"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-04-03DOI: 10.1080/08037051.2025.2487592
János Nemcsik, Enrique Rodilla, Fabiolucio Albini, Michael Doumas, Jean-Marc Boivin, Helga Gyöngyösi, Reinhold Kreutz, Rosa de Pinho
{"title":"Implementation of hypertension guidelines by general practitioner societies and the use of single pill combinations in Europe-results of the survey of the general practitioner nucleus of European society of hypertension.","authors":"János Nemcsik, Enrique Rodilla, Fabiolucio Albini, Michael Doumas, Jean-Marc Boivin, Helga Gyöngyösi, Reinhold Kreutz, Rosa de Pinho","doi":"10.1080/08037051.2025.2487592","DOIUrl":"10.1080/08037051.2025.2487592","url":null,"abstract":"<p><strong>Purpose: </strong>The implementation of hypertension guidelines into the everyday practice of general practitioners (GPs) have an outmost importance to provide optimal care for patients. The aim of our study was, on the one hand to gain insight about the relationship between hypertension societies and GP societies, and on the other hand, to get feedback about the use of single pill combinations (SPC) in each country, as an indicator of guideline implementation.</p><p><strong>Materials and methods: </strong>The European Society of Hypertension (ESH) GP Nucleus initiated a survey containing 17 questions about the existence and number of national hypertension and GP societies, the relationship between them and with pharmacists and nurse associations, the authors of national guidelines and the availability of SPCs. The survey was sent to the national hypertension society representatives of ESH. Additionally, data about the number of SPCs sold yearly was also checked using IQVIA database.</p><p><strong>Results: </strong>Responses were collected from 25 European countries. In most of the countries there is only one hypertension society (23/25) and one GP society (18/25), most of which having a relationship with each other (22/25). Of the countries with national hypertension guidelines most of them are written by the national hypertension society (45%) followed by the GP society (27%) or by public administration (27%). Two thirds of the national hypertension societies (16/25) have relationship with nurse societies and half of them (12/25) with pharmacists. In 65% (15/23) of the guidelines dual SPC therapy is recommended for treatment initiation however, marked differences are present in the number of yearly sold SPCs in different countries.</p><p><strong>Conclusions: </strong>National hypertension societies have remarkable impact on GPs for the management of hypertensive patients. However, improvement is needed in the collaboration with nurse and pharmacist societies and in some countries in the use of SPCs for hypertension therapy.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":" ","pages":"2487592"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postoperative systemic arterial hypertension in infants with congenital heart diseases: prevalence and risk factors.","authors":"Xiaohong Chen, Yanling Chen, Lijie Zhao, Ruikun Zou, Yuan Ren, Xin Sun, Xinmeng Zhang, Haiyun Yuan, Yifei Wang","doi":"10.1080/08037051.2024.2436385","DOIUrl":"https://doi.org/10.1080/08037051.2024.2436385","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence rate and risk factors for systemic arterial hypertension in infants with congenital heart diseases.</p><p><strong>Methods: </strong>A retrospective cohort study of postoperative systemic arterial hypertension incidence in infants who underwent cardiac surgery was conducted. The primary diagnosis was retrieved. The general characteristics, surgical information, and blood pressure data at five periods were also collected. The five periods were at admission, 48 hours after cardiac surgery (postoperative), at discharge, at full-time, and at any time during hospitalisation. The risk factors for postoperative hypertension and hypertension at discharge were determined by multivariate logistic regression.</p><p><strong>Results: </strong>This study enrolled 1205 eligible infants. The age and weight at surgery were 27.0 (13.0, 59.0) days and 3.53 ± 0.96 kg, respectively. The prevalence rates of postoperative hypertension and hypertension at discharge were 12.8 (10.9-14.7)% and 6.9 (5.5-8.3)%, respectively. The incidence of postoperative hypertension varies greatly across different types of congenital heart diseases. A low weight <i>Z</i> score, preoperative hypertension, patent ductus arteriosus, and coarctation of the aorta were risk factors for postoperative hypertension, whereas transposition of the great arteries grouped with pulmonary atresia, pulmonary stenosis, and total anomalous pulmonary venous connection was a protective factor. The ventricular septal defect was a risk factor for postoperative hypertension but not for hypertension at discharge.</p><p><strong>Conclusions: </strong>The incidence of postoperative systemic arterial hypertension is high in infants after cardiac surgery. The prevalence of hypertension decreased at discharge. Prospective long-term follow-up studies are needed to delineate the natural history of hypertension in high-risk children.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":"34 1","pages":"2436385"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blood PressurePub Date : 2025-12-01Epub Date: 2025-04-28DOI: 10.1080/08037051.2025.2493828
Theresa J van Lith, Esther Janssen, Jan-Willem van Dalen, Hao Li, Mats Koeneman, Wouter M Sluis, Naomi T Wijers, Marieke J H Wermer, Menno V Huisman, H Bart van der Worp, Frederick J A Meijer, Anil M Tuladhar, Sebastian J H Bredie, Frank-Erik de Leeuw
{"title":"Higher blood pressure variability during hospitalisation is associated with lower cerebral white matter integrity in COVID-19 patients.","authors":"Theresa J van Lith, Esther Janssen, Jan-Willem van Dalen, Hao Li, Mats Koeneman, Wouter M Sluis, Naomi T Wijers, Marieke J H Wermer, Menno V Huisman, H Bart van der Worp, Frederick J A Meijer, Anil M Tuladhar, Sebastian J H Bredie, Frank-Erik de Leeuw","doi":"10.1080/08037051.2025.2493828","DOIUrl":"https://doi.org/10.1080/08037051.2025.2493828","url":null,"abstract":"<p><strong>Background: </strong>High blood pressure variability (BPV) is associated with cerebrovascular damage and dementia, but it is unknown whether short-term BPV during hospitalisation is also associated with cerebral white matter (WM) damage. We examined whether BPV, measured in-hospital using continuous monitoring, is associated with WM microstructural integrity in COVID-19 patients.</p><p><strong>Methods: </strong>We included hospitalised COVID-19 patients from the CORONavirus and Ischemic Stroke (CORONIS) study who underwent continuous vital signs monitoring using a wearable device during hospital admission and had an MRI shortly after discharge. Systolic BPV was calculated as Average Real Variability (ARV) and Coefficient of Variation (CV) with 1-, 5- and 20-minute intervals. We used diffusion tensor imaging to assess fractional anisotropy (FA) and peak width of skeletonised mean diffusivity (PSMD) as markers of WM integrity. Associations between BPV and WM integrity were examined with linear regression adjusted for age, mean systolic blood pressure (BP), number of BP measurements and type of respiratory support.</p><p><strong>Results: </strong>We included 47 COVID-19 patients (mean age: 59.6 years). BP was measured 6306 ± 4343 times per patient (median admission: 11 days (Interquartile Range [IQR] 7.5-15.0). Both higher ARV and CV were associated with lower WM microstructural integrity, reflected by lower FA (ARV: <i>β</i> = -0.40, <i>p</i> = .010; CV: <i>β</i> = -0.33, <i>p</i> = 0.026) and higher PSMD (CV: <i>β</i> = 0.28, <i>p</i> = .038) after adjustment for confounders. Correction for WM hyperintensities did not change these results.</p><p><strong>Conclusions: </strong>High BPV during hospitalisation is associated with lower WM integrity in COVID-19 patients, although causality needs to be demonstrated. Our findings need validation in hospitalised patients without COVID-19 to examine generalisability.</p>","PeriodicalId":9000,"journal":{"name":"Blood Pressure","volume":"34 1","pages":"2493828"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}