BMC Infectious Diseases最新文献

{"title":"Early prediction of bloodstream infections in ICU patients using machine learning methods based on routine laboratory parameters.","authors":"Yanying Chen, Ziru Chen, Dongyun Xu, Shibing Li, Feixiong Chen, Xufa Yu, Shutao Cai, Cuilan Zeng, Xueyan Ye, Jie Yang, Jun Liu, Jianmei Lin, Siyu Xiao","doi":"10.1186/s12879-025-11580-4","DOIUrl":"10.1186/s12879-025-11580-4","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1196"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of charcot's triad and Tokyo guidelines 2018 as a diagnostic tool for acute ascending cholangitis secondary to a liver cystic echinococcosis.","authors":"Mohamed Ali Chaouch, Mohamed Wejih Dougaz, Mohamed Maher Bergaoui, Aymen Trigui, Salah Boujelbene, Faouzi Noomen, Ramzi Nouira, Chadli Dziri","doi":"10.1186/s12879-025-11644-5","DOIUrl":"10.1186/s12879-025-11644-5","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the diagnostic accuracy of Charcot's triad (CT) and the Tokyo Guidelines 2018 (TG18) for acute ascending cholangitis (AAC) secondary to liver cystic echinococcosis (LEC) rupture in the biliary tree.</p><p><strong>Methods: </strong>This retrospective multicenter study was conducted between January 2016 and December 2021. The diagnostic performance of CT and TG18 was evaluated using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the ROC curve.</p><p><strong>Results: </strong>Among 1643 patients, 133 were diagnosed with AAC (8.1%). Concerning CT, the analytical study showed that the incomplete form had a sensitivity of 28.6%, specificity of 91.9%, PPV of 36%, and NPV of 89%. The complete form had a sensitivity, specificity, PPV, and NPV of 25.4%, 97.5%, 61.5%, and 89.1%, respectively. For TG18, the suspected/definite form had a sensitivity, specificity, PPV, and NPV of 74.6%, 68.2%, 22.1%, and 93.5%, respectively. The definite form had a sensitivity, specificity, PPV, and NPV of 65.1%, 88.4%, 47.1%, and 94.1%, respectively. The Suspected form was estimated at an AUC of 0.447, with a non-significant p-value.</p><p><strong>Conclusions: </strong>This research emphasizes the complexity of AAC diagnosis and the limitations of current diagnostic tools. TG18, especially in its definite form, can effectively rule out AAC, whereas CT, despite its low sensitivity, remains useful due to its high specificity. The findings advocate further research to refine the existing diagnostic methods and develop new tools.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1201"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance and bacterial co-infections in COVID-19 patients in Iran: a systematic review and meta-analysis of hospitalized and non-hospitalized cases.","authors":"Zahra Najafi-Olya, Zahra Heydarifard, Mehdi Azizmohammad Looha, Akram Sadat Ahmadi, Neda Yarhamadi, Moslem Safaei","doi":"10.1186/s12879-025-11643-6","DOIUrl":"10.1186/s12879-025-11643-6","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1197"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infections of chlamydia trachomatis, mycoplasma genitalium and neisseria gonorrhoeae among the outpatients of reproductive medicine center in Chongqing, China: a retrospective study.","authors":"Xing Luo, Xia Chen, Yubing Liang, Wenhong Chen, Guoning Huang, Yezhou Xiang, Ke Chen","doi":"10.1186/s12879-025-11671-2","DOIUrl":"10.1186/s12879-025-11671-2","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1216"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria and soil transmitted helminth infection and associated factors among pregnant women attending public health facilities in Dilla town, South Ethiopia: cross sectional study design.","authors":"Samuel Tefera, Alayu Bogale, Adamu Kassie, Abera Abreham, Andualem Bayih, Musa Mohammed Ali","doi":"10.1186/s12879-025-11642-7","DOIUrl":"10.1186/s12879-025-11642-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Malaria and soil transmitted helminth (STH) are co-endemic and major public health problems in Ethiopia including study area. Understanding the burden and co-occurrence of these infections is crucial for informing effective antenatal interventions. This study aimed to assess the prevalence of malaria, STH infections, and malaria-STH co-infection, as well as identify associated risk factors among pregnant women attending antenatal care services in public health facilities in Dilla town, Gedeo Zone, Southern Ethiopia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A facility-based cross-sectional study was conducted using a systematic random sampling of 331 pregnant women attending antenatal care at public health facilities in Dilla town between April 1 and June 24, 2023. Data were collected through face-to-face interviews using structured questionnaires. Faecal specimens were examined using both the direct wet mount and formol-ether concentration techniques. Thick and thin blood films were analyzed using microscopy. The collected data were entered into Epi-Data version 4.6 and subsequently exported to SPSS version 25 for analysis. A logistic regression model was used to assess the association between independent variables and the outcome variable. Variables with p ≤ 0.25 in bivariate analysis were included in multivariable logistic regression; p &lt; 0.05 was considered statistically significant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Result: &lt;/strong&gt;The overall prevalence of STH, malaria, and malaria-STH co-infection was 60/331 (18.1%) [95% CI: 13.9-22.3], 29/331 (8.8%) [95% CI: 5.7-12.1], and 19/331 (5.7%) [95% CI: 3.3-8.5] respectively. Ascaris lumbricoides (45/331, 13.6%) was the predominant STH, followed by hookworms (8/331, 2.4%). Plasmodium vivax and Plasmodium falciparum proportions were (16/331, 4.8%) and (13/331, 4.0%), respectively. Study participants who resided in rural areas, lived near stagnant water, and did not use insecticide-treated nets (ITNs) had 2.66, 3.09, and 3.67 times the odds of being infected with malaria, respectively. Study participants who resided in rural areas, did not practice handwashing with soap and water before meals, did not wash their hands after using the toilet, and ate raw vegetables had 2.22, 3.93, 3.23, and 2.23-times odds of being infected with STHs, respectively. Additionally, living near stagnant water, not practicing handwashing with soap and water before meals, and the habit of eating soil were associated with 3.76, 3.82, and 9.45-times odds of acquiring malaria-STH co-infection, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study highlights the prevalence of malaria, STH, and malaria-STH co-infections among pregnant women in Dilla town. In the study area, intestinal parasites, malaria, and their co-infection remain a health concern. To improve preventive and early intervention among pregnant women, prenatal care services should include routine screening and integrated diagnosis for STH infections an","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1194"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of preoperative and postoperative HPV infection dynamics in patients with cervical intraepithelial neoplasia and cervical cancer: implications for screening and management.","authors":"Tongbao Feng, Wuwen Zhang, Ting Zhao, Siyuan Zhou, Ping Zhang, Liming Tang","doi":"10.1186/s12879-025-11591-1","DOIUrl":"10.1186/s12879-025-11591-1","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) transmission poses significant health risks, particularly in women. This study aims to detail the prevalence and characteristics of HPV infections both before and after surgical treatment in patients with cervical intraepithelial neoplasia (CIN) and cervical cancer.</p><p><strong>Methods: </strong>We recruited 370 patients diagnosed with CIN or cervical cancer. The study first assessed the overall prevalence of preoperative HPV infections, analyzing variations across different age groups and histological diagnoses. We then investigated the relationships between postoperative HPV positivity rates and various factors including age, histological diagnoses, HPV genotypes, and the presence of multiple HPV infections. A comparative analysis was also conducted to observe the dynamics of HPV infections before and after cervical operations.</p><p><strong>Results: </strong>An overall HPV positivity rate of 97.0% was observed in patients diagnosed with CIN or cervical cancer, with HPV16, HPV52, HPV58, HPV33, HPV51, and HPV18 being the most prevalent genotypes. The distribution of HPV infection varied significantly by age and histological diagnosis. Notably, the prevalence of HPV16 showed significant differences across age and histological diagnoses groups. Among the 282 patients who underwent surgical treatment, 40.1% remained HPV positive postoperatively, with those aged ≥ 60 years and those with multiple HPV infections showing higher rates of postoperative HPV positivity.</p><p><strong>Conclusions: </strong>The findings confirm the strong association between high-risk HPV infection and the development of CIN and cervical cancer. They also highlight the need for tailored approaches in the postoperative management of HPV to prevent recurrence, offering new insights for improving screening and treatment strategies.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1195"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specialty and age-based differences in awareness and attitudes towards antibiotic stewardship: a cross-sectional online survey on Japanese clinic physicians.","authors":"Yoshiaki Gu, An Dang Do, Yumiko Fujitomo, Fumio Ohtake","doi":"10.1186/s12879-025-11583-1","DOIUrl":"10.1186/s12879-025-11583-1","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) is a critical global health issue, with inconsistent adherence to antimicrobial stewardship contributing to its worsening. This study aims to assess physicians' awareness and attitudes towards AMR and appropriate antimicrobial use across different medical specialties in Japan.</p><p><strong>Methods: </strong>An online cross-sectional survey was conducted from January 31 to February 5, 2024, among 280 physicians from three specialties (internal medicine, pediatrics, and otorhinolaryngology) who were working in outpatient clinics in Japan. Participants were asked about their familiarity with the National Action Plan (NAP) on AMR and the manuals of Ministry of Health and Labor Welfare (MHLW) on prudent antimicrobial use. Their opinions on AMR facts and antibiotic use were also surveyed using five-point Likert scales. Data were analyzed using descriptive statistics, multilevel mixed-effects ordered logistic regression and generalized linear models to examine factors influencing NAP/manuals adherence.</p><p><strong>Results: </strong>Most respondents were male (85%) and predominantly aged 50 and above (73.9%), Familiarity with the AMR Action Plan varied, with 36.4% of respondents reported understanding its content, while 37.5% only knew its name. Similarly, 27.1% of respondents used the MHLW manuals, whereas 48.6% were aware of them but did not use them. Internal medicine physicians showed the highest adherence to antimicrobial stewardship and most concern about AMR facts, while pediatricians demonstrated the highest adherence to MHLW manuals (AOR = 2.4, p = 0.000 compared to internal medicine doctors). Otorhinolaryngologists reported higher awareness of NAP (AOR = 2.6, p = 0.006 compared to internal medicine doctors) but had the lowest adherence to NAP and MHLW manuals. Younger physicians (< 50 years) were more proactive in addressing AMR and adhering to antimicrobial stewardship than older physicians. Messages emphasizing the prevention of drug resistance and societal impacts of AMR were most associated with positive attitudes from physicians in outpatient clinics.</p><p><strong>Conclusions: </strong>This study highlights significant variability in AMR awareness and adherence across specialties and age groups. Internal medicine physicians showed the highest adherence, while pediatricians were the most familiar with AMR manuals. Otorhinolaryngologists demonstrated strong awareness but lower adherence. Targeted educational interventions, particularly focusing on older physicians and specific specialties, are needed to improve antimicrobial use and combat the growing threat of resistance.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1186"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal analysis and risk prediction of foodborne diseases based on meteorological risk factors: a case study of Wuxi city, China.","authors":"Ke Qin, Xiaoting Dai, Linhai Wu, Minguo Gao","doi":"10.1186/s12879-025-11686-9","DOIUrl":"10.1186/s12879-025-11686-9","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1206"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV Dolutegravir resistance and multiclass failure in Mozambique: findings from a real-world cohort.","authors":"Fausto Ciccacci, Anna Maria Doro Altan, Noorjehan Majid, Stefano Orlando, Elton Uamusse, Marcia Rafael, Zita Sidumo, Paola Germano, Giovanni Guidotti, Carlo Federico Perno","doi":"10.1186/s12879-025-11639-2","DOIUrl":"10.1186/s12879-025-11639-2","url":null,"abstract":"<p><strong>Background: </strong>Dolutegravir (DTG) is the anchor drug of the first-line agent for HIV treatment globally, including low- and middle-income countries. Although clinical trials report low rates of integrase inhibitor resistance, real-world data from sub-Saharan Africa suggest a different scenario. We aimed to assess the prevalence and patterns of DTG resistance in Mozambique, building on prior preliminary findings with an expanded cohort and extended observation period.</p><p><strong>Methods: </strong>We conducted a retrospective observational study in five DREAM centers in Mozambique. HIV-positive individuals on DTG-based antiretroviral therapy (ART) with confirmed virological failure (HIV RNA > 1000 copies/mL) between July 2022 and December 2024 were included. Participants underwent genotypic resistance testing after six months of enhanced adherence support. Resistance mutations were identified via Sanger sequencing and interpreted using the Stanford HIV Drug Resistance Database.</p><p><strong>Results: </strong>Of 28 individual tested, 13 (46.4%) exhibited DTG resistance (12/13 with intermediate or high-level resistance); 92.3% harboured HIV-1 subtype C. Frequently observed mutations included G118R (43.8%), E138K (43.8%), L74M (31.3%), and R263K (25.0%), often in combination. All DTG-resistant individuals who underwent testing for other drug classes (n = 9) also showed co-resistance to NRTIs and/or NNRTIs. Notably, high-level resistance emerged also in 6 failing participants having shifted to DTG while virologically suppressed.</p><p><strong>Conclusions: </strong>This study reports the presence of DTG resistance and multiclass failure in Mozambique, suggesting potential limitations of current strategies. Sentinel surveillance and expanded access to resistance testing are important to preserve the efficacy of DTG-based regimens and inform future deployment of long-acting therapies in sub-Saharan Africa.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1210"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling COVID-19 pneumonia and COVID-associated pulmonary aspergillosis: sensitivity analysis and optimal control.","authors":"Mallela Ankamma Rao, Emad K Jaradat, Medisetty Padma Devi, Prasantha Bharathi Dhandapani, Rebecca Muhumuza Nalule, Mohannad Al-Hmoud","doi":"10.1186/s12879-025-11606-x","DOIUrl":"10.1186/s12879-025-11606-x","url":null,"abstract":"<p><p>Severe cases of COVID-19 can progress to pneumonia and, in some patients, to COVID-19-associated pulmonary aspergillosis (CAPA), a fungal co-infection linked to high mortality. Most existing models address COVID-19 transmission alone, without explicitly capturing the sequential progression to pneumonia and CAPA. To address this gap, we develop a novel compartmental model (SII_cpI_caHR) that integrates the co-dynamics of COVID-19 pneumonia and CAPA, incorporating both disease progression pathways and hospitalisation processes. The model is calibrated using cumulative COVID-19 case data from India, and analysed through stability theory, sensitivity analysis, and an optimal control framework. Sensitivity indices and Partial Rank Correlation Coefficients identify key parameters influencing transmission and severity. We evaluate time-dependent intervention strategies-vaccination, early hospitalisation, and enhanced treatment-individually and in combination, using Pontryagin's Maximum Principle and numerical simulation. Results show that while each single measure reduces disease burden, combined application of all three significantly minimises pneumonia and CAPA prevalence, lowers hospitalisation needs, and is cost-effective within realistic constraints. These findings emphasise the importance of integrated public health strategies that couple pharmaceutical and clinical interventions to curb severe COVID-19 outcomes and associated fungal complications.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1192"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}