Journal of clinical & experimental pathology最新文献

{"title":"CYANOCRYLATE ADHESIVES IN FORMATION OF COLORECTAL ANASTOMOSIS","authors":"R. V. Senyutovych, O. Ivashchuk, V. Bodyaka, Y. Chuprovska, I. A. Malishevskyi, I. B. Khalaturnic, S. L. Hovornian, P. S. Vatamaniuk","doi":"10.24061/1727-4338.XX.1.75.2021.14","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.14","url":null,"abstract":"Data of foreign literature concerning sutureless formation of the colorectal anastomosiswith the help of cyonocrylate adhesives are presented in the article. These are quick acting glues, available on the Ukrainian market, and may be used by Ukrainiansurgeons in implementation of their ideas as to the sutureless connection of organs in theexperimental and clinical investigations.12 different types of cyanocrylate adhesives as to their resistance to the rupture of theconnected by them large intestine segments, were studied. Questions of the technicalformation of the sutureless anastomoses were considered. When substantially newtechnical devices for gluing together the organs are absent, progress is hardly possible.Objective – to acquaint the domestic surgeons and oncologists with modern achievementsof foreign scientists in the field of sutureless colorectal anastomosis formation by meansof cyanocrylate adhesives.Conclusions. For some time past foreign surgeons the problems of colorectal anastomosesintensively develop the problems of colorectal. This is due to the fact that indices ofcolorectal anastomosis insufficiency remain on high levels. Unfortunately, the hopesthat the introduction of modern advanced stapler anastomotic techniques can radicallyreduce the frequency of this complication were not justified.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83889996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF PROTEOLYTIC AND FIBRINOLYTIC ACTIVITY OF BLOOD PLASMA IN COMORBID CHRONIC CORONARY SYNDROME, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, AND OBESE","authors":"I. Nemish, G. Stupnytska, O. Fediv","doi":"10.24061/1727-4338.XX.1.75.2021.10","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.10","url":null,"abstract":"The aim - to assess the proteolytic and fibrinolytic activity of blood plasma in comorbidchronic coronary syndrome (CCS), chronic obstructive pulmonary disease (COPD), andobese.Material and methods. The study involved 110 patients, who were divided into 5 clinicalgroups: G1 – 22 CCS and obese patients, G2 – 22 COPD and normal body weightpatients, G3 – 22 CCS, COPD and normal body mass index (BMI) subjects, G4 – 22CCS, COPD and overweight patients and G5 – 22 CCS, COPD and obese I, II degreepatients. The control group consisted of 20 healthy individuals. Proteolytic activityof blood plasma was assessed by the lysis of azoalbumin, azocasein, and azocol, andfibrinolytic – by the lysis of azofibrin.Results. There was a significant increase 50,5%, 43,3%, 43,8% (p<0,05) azoalbuminlysis in the fifth participant’s group compared with the 1st, 2nd, and 4th groups. An increasein azocasein lysis 38,08% was observed (p<0,05) in CCS, COPD, and obese patientscompared with CCS, and obese patients. Azocol lysis was significantly higher 41,7%,13,8%, and 22,06% (p<0,05) in CCS, COP, and obese patients compared with the first,second, and fourth groups. Total fibrinolytic activity (TFA) of blood plasma was 17,7%,14,89%, 21,27% (p<0,05) lower in the 3rd, 4th, and 5th patients’ groups compared withthe 1st one. Enzymatic fibrinolytic activity (EFA) of blood plasma was 28,29%, 22,19%,35,85% (p<0,05) lower in the 3rd, 4th, and 5th patients groups compared with the 1st one.EFA level decrease 23,77% (p<0,05) was observed in the fifth group compared with thesecond one.Conclusions. The most pronounced changes in proteolytic (increased azoalbumin,azocasein, and azocol lysis) and fibrinolytic (decreased total and enzymatic) activitiesof the blood plasma in comorbid chronic сoronary syndrome, chronic obstructivepulmonary disease, and obese patients.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86503852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNTHESIS AND INVESTIGATION OF ANTIMICROBIAL ACTIVITY OF THE NEW CLASS OF ACYLHYDROSONES (QUINOLIN-8-YL) OF GLYCOLIC ACID","authors":"V. Chornous, A. M. Grosav, M. Bratenko, S. Deineka, О.І. Gavrilyuk","doi":"10.24061/1727-4338.XIX.4.74.2020.13","DOIUrl":"https://doi.org/10.24061/1727-4338.XIX.4.74.2020.13","url":null,"abstract":"Antibiotic resistance of pathogenic strains of microorganisms is one of the most difficultproblems of modern medicine. An effective way to solve it is the synthesis of new classesof antibacterial and antifungal drugs with a wide spectrum of antiseptic action.Purpose of the research – synthesis of the new types of glycolic acid acylhydrazones(quinolin-8-yl)and investigation of their antimicrobe activity.Material and methods. The analysis of their antibacterial and antifungal activity wascarried out and the dependence of the antimicrobial action of the synthesized drugson the structure of the molecule, the type of heterocyclic fragment and the type ofmicroorganisms was investigated.Results. It was proposed a convenient method for the synthesis of new types of acylhydrosones (quinolin-8-yl) glycolic acid, which is realized by condensation ofhydrozides (quinolin-8-yl) of glycolic acid with a series of heterocyclic aldehydes.Conclusion. The results obtained indicate that this class of compounds is promising aspotential antimicrobial drugs.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79855091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF IONOREGULATORY RENAL FUNCTION OF RATS IN THE DYNAMICS OF EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT WITH UNDERLYING PHARMACOLOGICAL BLOCADE OF RENIN-ANGIOTENSINALDOSTERONE SYSTEM","authors":"О. Olenovych","doi":"10.24061/1727-4338.XIX.4.74.2020.7","DOIUrl":"https://doi.org/10.24061/1727-4338.XIX.4.74.2020.7","url":null,"abstract":"The aim of the study – to explore the role of the renin-angiotensin-aldosteronesystem (RAAS) in the disturbance of ionoregulatory renal function in alloxan-inducedexperimental diabetes mellitus (EDM).Material and methods. The experiments were carried out on 78 white non-linearmature male rats with 11-, 26- and 46-day long alloxan-induced EDM with underlyingpharmacological blockade of RAAS by administration of kaptopril. The study ofionoregulating function of the kidneys was provided by the clearance method under thecondition of water 2-hour diuresis.Results. Pharmacological blockade of RAAS in rats with alloxan-induced EDM causedan intensification of natriuresis at all stages of the experiment: increased urinaryconcentration of sodium ions, its excretion and clearance. On the 11th day of EDM, thesodium filtration charge increased with the development of hyponatremia, proximal anddistal sodium reabsorption standardized in volume of glomerular filtrate (GF) decreased,kaliuresis was suppressed, and sodium-free water clearance elevated. In case of 26-daylong EDM, the sodium filtration charge decreased, its absolute and relative reabsorption,the distal sodium reabsorption standardized by GF increased. Kaliuresis increased. In46-day long EDM, the sodium filtration charge decreased, and hyponatremia enhanced.Absolute and relative sodium reabsorption reduced due to both – proximal and distal.Kaliuresis augmented, the clearance of sodium-free water declined.Conclusions. The increase in urinary sodium loss during the 11-day EDM is stipulatedby glomerular hyperfiltration, causing a functional weakening of the tubulotubularbalance and relative dysfunction of the distal segment of the nephron, emphasizing therenoprotective effect of RAAS on ionoregulatory function of the kidneys. The decrease inthe total reabsorption potential of the tubular segment of the nephron in the dynamics ofEDM development reflects on the proximal tubules, and preserved tubulotubular balancecertifies functional intactness of the distal tubules in 26-day long EDM. RAAS pathologicalactivation and attenuation of the renal blood flow autoregulation by tubuloglomerularfeedback may serve as an initiating factor in the development of tubular disorders in 26-day long alloxan diabetes with following progression in 46-day long EDM.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82341362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CASE OF TREATMENT OF AN ANTERIOR ABDOMINAL WALL ABSCESS CAUSED BY LARGE BOWEL FISTULA","authors":"N. Gnatyuk, S. Shevchenko, D. Y. Krivoruchko, V. Bodyaka, Yu. P. Petruk, S. Raychuk, N. V. Lyanskorunsky, Y. Chuprovskaya, V. P. Unguryan, S. L. Govornyan","doi":"10.24061/1727-4338.xix.3.73.2020.29","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.3.73.2020.29","url":null,"abstract":"У статті представлено клінічний випадок лікування абсцесу передньої черевної стінки, який виник внаслідок формування зовнішньої нориці сигмоподібної кишки при перфорації дивертикулу останньої. Пацієнту виконано лапаротомію, комбіновану лівобічну геміколектомію з резекцією тонкої кишки, висічення товстокишкової нориці передньої черевної стінки, санацію та дренування черевної порожнини. Післяопераційний період перебігав без ускладнень, рана загоїлася первинним натягом. Пацієнта на 17-ту добу у задовільному стані виписано з лікарні. Висновок. При лікуванні гнійно-запальних захворювань передньої черевної стінки необхідно звертати увагу на причину їх виникнення, а також виключити хірургічні захворювання черевної порожнини. Ключові слова: зовнішня нориця, абсцес, сигмоподібна кишка.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"307 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78259697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIHELMINTIC PROPERTIES OF MEDICINAL PLANTS","authors":"S. Dubinin, O. Klepets, O. B. Riabushko, A. Vatsenko, N. Ulanovska-Tsyba, N. Perederii","doi":"10.24061/1727-4338.xix.3.73.2020.25","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.3.73.2020.25","url":null,"abstract":"Objective: to study the anthelmintic properties of medicinal plants from the literatureand make a list of such plants (wild and cultivated) that are common in Ukraine.Material and methods. The material was Domestic and foreign scientific publications,processed using the methods of analysis, synthesis, comparison, systematization andgeneralization, served as the material of studying.. The lists of plants with anthelminticproperties are compiled on the basis of an analysis of reference information fromspecial pharmacognostic reports.Results. The anthelmintic activity of medicinal plants is due to the presence of terpenes, phenols, nitrogen-containing compounds in their composition, that can negatively affectthe functioning of the integument, the digestion of parasitic worms, their mobility, growthand reproduction. The natural and cultivated flora of Ukraine has more than 50 speciesof medicinal plants with an anthelmintic effect.Conclusions. Herbal preparations with an anthelmintic effect have a number ofadvantages over synthetic ones (effectiveness, relative safety, availability, low cost),however, experimental studies of such drugs are needed for their possible negative effectson the human body.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76418462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TEACHING OF MEDICAL PARASITOLOGY TO THE STUDENTS OF “NURSING” SPECIALTY OF MEDICAL COLLEGES DURING TRADITIONAL AND ON LINE STUDYING","authors":"R. Bulyk, Yu.V. Karavan, K. Tymchuk, V. Voloshyn","doi":"10.24061/1727-4338.xix.3.73.2020.21","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.3.73.2020.21","url":null,"abstract":"","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89831540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADVANTAGES AND DISADVANTAGES OF MEDICAL PARASITOLOGY TEACHING UNDER CONDITIONS OF DISTANCE EDUCATION","authors":"R. Bulyk, K. Vlasova, M. Kryvchanska, O. Vlasova, V. Voloshyn, V. Yosypenko","doi":"10.24061/1727-4338.xix.3.73.2020.20","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.3.73.2020.20","url":null,"abstract":"The development of the education system under modern conditions requires changesin many directions: information, methodological, technological, organizational ect.The article deals with the distance education advantages and disadvantages, as well as highlights own experience of implementing online technologies in the educationalprocess of the medical students.The objective of the article is to analyze the features of distance studies and determine itsadvantages and disadvantages.Conclusions. Distance/online/electronic education has already taken one of the leadingpositions in higher educational system of many universities, but not in the medical ones.The transition to enforced distance/electronic methods of education in 2020 hasmodernized all stages of teaching and perception of the medical education. Yes, thisextraordinary time requires the adaptation of training and control materials. Habitualclasses are irreplaceable, but the development of the digital space creates excellentalternative opportunities for the studies and development of up-to-date students andfuture specialists during quarantine.Distance education is a separate type of teaching, it is philosophy, methodology,psychology of studies and teaching. Everything must be studied and developedthoroughly, it is necessary to improve presentation of the material constantly, as well asmeans of assistance and self-control. However, distance/online studies are definitely a bigadvantage during a global pandemia.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77969312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USE OF VISUALIZATION TOOLS IN THE EDUCATIONAL PROCESS","authors":"R.Ye, O. V. Bulyk, Kushniryk","doi":"10.24061/1727-4338.xix.3.73.2020.22","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.3.73.2020.22","url":null,"abstract":"An article integrates data on visualization tools used in the educational process of highschool students, particularly in the field of medicine. The role of visualization in theformation of professional competencies of students is also shown in the paper.Objective – analysis of scientific papers that describe the possible visualization toolsin the educational process during the explanation of new material, generalization,systematization and testing of knowledge and prove their role as the acquisition ofknowledge, skills and abilities of students.Conclusions. There is a significant choice of teaching methods and tools in the arsenalof a high school teacher now, that considerably facilitates the perception of educationalmaterial by the students and contributes to its better acquisition. One of such effectivemethods is visualization by means of multimedia presentations, videos and interactivetechnologies. This approach will contribute to the better formation of the students’professional competencies, ability to analyze and think critically.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85446147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPREADING OF DERMACENTOR RETICULATUS TICKS IN UKRAINE","authors":"L. Fedonyuk, S. Podobivskiy","doi":"10.24061/1727-4338.xix.3.73.2020.18","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.3.73.2020.18","url":null,"abstract":"","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85797428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}