SYNTHESIS AND INVESTIGATION OF ANTIMICROBIAL ACTIVITY OF THE NEW CLASS OF ACYLHYDROSONES (QUINOLIN-8-YL) OF GLYCOLIC ACID

Abstract

Antibiotic resistance of pathogenic strains of microorganisms is one of the most difficultproblems of modern medicine. An effective way to solve it is the synthesis of new classesof antibacterial and antifungal drugs with a wide spectrum of antiseptic action.Purpose of the research – synthesis of the new types of glycolic acid acylhydrazones(quinolin-8-yl)and investigation of their antimicrobe activity.Material and methods. The analysis of their antibacterial and antifungal activity wascarried out and the dependence of the antimicrobial action of the synthesized drugson the structure of the molecule, the type of heterocyclic fragment and the type ofmicroorganisms was investigated.Results. It was proposed a convenient method for the synthesis of new types of acylhydrosones (quinolin-8-yl) glycolic acid, which is realized by condensation ofhydrozides (quinolin-8-yl) of glycolic acid with a series of heterocyclic aldehydes.Conclusion. The results obtained indicate that this class of compounds is promising aspotential antimicrobial drugs.