Neuroembryology and aging最新文献

{"title":"Author and Subject Index Vol. 3, No. 4, 2004–05","authors":"","doi":"10.1159/000097374","DOIUrl":"https://doi.org/10.1159/000097374","url":null,"abstract":"","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"249 - 249"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000097374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64374516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Index Vol. 3, 2004–05","authors":"","doi":"10.1159/000097375","DOIUrl":"https://doi.org/10.1159/000097375","url":null,"abstract":"","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"250 - 250"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000097375","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64374734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subject Index Vol. 3, 2004–05","authors":"M. Malmierca, C. Waele, C. Huetz, J. Edeline, Jufang He, S. Newlands, D. Angelaki, J. M. Paterson, J. Menzies, I. Curthoys, P. Vidal, H. Straka, Lee E. Moore, N. Vibert, Yc Tse, D. Shum, Y. Chan, F. Bergquist, M. Dutia, C. Lai, Zhuo Zhang","doi":"10.1159/000097376","DOIUrl":"https://doi.org/10.1159/000097376","url":null,"abstract":"","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"251 - 252"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000097376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64374290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents Vol. 3, 2004–05","authors":"M. Malmierca, C. Waele, C. Huetz, J. Edeline, Jufang He, S. Newlands, D. Angelaki, J. M. Paterson, J. Menzies, I. Curthoys, P. Vidal, H. Straka, Lee E. Moore, N. Vibert, Yc Tse, D. Shum, Y. Chan, F. Bergquist, M. Dutia, C. Lai, Zhuo Zhang","doi":"10.1159/000097377","DOIUrl":"https://doi.org/10.1159/000097377","url":null,"abstract":"","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"253 - 254"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000097377","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64374352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page / Table of Contents","authors":"","doi":"10.1159/000097373","DOIUrl":"https://doi.org/10.1159/000097373","url":null,"abstract":"","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"3 1","pages":"157 - 159"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000097373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64374388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Overview","authors":"Y. Chan, Jufang He","doi":"10.1159/000096793","DOIUrl":"https://doi.org/10.1159/000096793","url":null,"abstract":"tibular compensation. Plastic changes in the membrane properties of medial vestibular neurons parallel the recovery of vestibulo-ocular reflexes. The correlation of findings from animal studies with observations from vestibular patients offers a perspective on the clinical impact of vestibular disorders. Curthoys’ [pp 207–214] article on vestibular responses to sound strategically bridges the foregoing articles on the vestibular system and the following three articles covering the auditory system. Evidence derived from animal studies which revealed the activation of vestibular receptors by sound has been translated into a new clinical test of human vestibular function using sound as the test stimulus. Malmierca’s [pp 215–229] article summarizes the anatomical and physiological features of the inferior colliculus. This article has put emphasis on the convergence of ascending and descending information. The article of Huetz and Edeline [pp 230–238] focuses on the thalamocortical system. It addresses the information relay system from the perspective of receptive field dynamics and the rate of signal transmission. The article by Zhang et al. [pp 239– 248] summarizes the thalamocortical and corticothalamic interaction in the auditory system. They propose a model in which the corticothalamic system serves as the executive filter for selective attention. The trend of future research in systems neuroscience is highlighted by the last three articles in which specific relay stations are explored as integral parts of a sensory system. With review articles on cognate disciplines in vestibular and auditory research, this special issue portrays the synergism that is necessary for future consolidation of vestibulo-auditory neurobiology. The vestibular system and auditory system utilize a common form of mechanosensitive hair cells located in the fluid-filled inner ear. Activation of these mechanoreceptors by appropriate stimuli triggers a cascade of neural events along distinctive pathways thereby providing the brain with the senses of balance and hearing. The review articles collected in this special issue summarize the latest progress of research in these two systems spanning from the dynamics of development to plasticity in adult circuitry. They also explore current advances in cellular mechanism, signal processing and clinical application. The first article by Lai et al. [pp 162–170] outlines the prenatal and postnatal developmental profiles of vestibular neural circuits. Emphasis is placed on the postnatal maturation of central vestibular neurons, including the role of glutamatergic transmission and the coding of gravity-related spatial information. The article of Newlands and Angelaki [pp 171–182] provides an overview on the compensatory processes of the primate oculomotor system following manipulations of the peripheral vestibular apparatus. Focus is placed on the plasticity of otolith/canal interaction and eye-head coordination especially during function","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"35 1","pages":"161 - 161"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64365802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Migration of Sacral Neural Crest Cells in Mouse Embryos","authors":"M. Dong, X. Wang, A. K. Chan, A. Burns, W. Chan","doi":"10.1159/000118929","DOIUrl":"https://doi.org/10.1159/000118929","url":null,"abstract":"Background: Neural crest cells (NCCs) are a group of multipotent embryonic cells which originate from the neural tube (developing central nervous system) and are capable of migrating to different locations within the embryo to form a variety of derivatives. In the avian, NCCs in the sacral region (sacral NCCs) have been shown to be able to give rise to neurons and glia of the hindgut. By using quail-chick chimeras, the complete migratory pathway of sacral NCCs from their origin to their final locations in the hindgut has been mapped. However, in mammals, information on sacral NCC migration is still scarce. Aims: In the present study, we used in situ cell labeling with wheat germ agglutinin gold conjugates or DiI as cell markers, whole embryo culture and histochemical staining to determine the early spatiotemporal migration of sacral NCCs in normal mouse embryos. Results and Conclusions: It was found that most of the sacral NCCs at the neuraxis caudal to the 24th somite (postumbilical level) started migration from the dorsal part of the neural tube at E9.5 and then migrated dorsoventrally in the pelvic mesenchyme between the neural tube and the somite. Many of the sacral NCCs resided in the region of the dorsal root ganglia on each side of the neural tube, while some of them continued to migrate dorsoventrally to reach the region around the dorsal aorta by E11.0. Hence, sacral NCCs enter the hindgut well after E11.0. Further studies will be carried out to find out the entire migratory pathway of sacral NCCs in the mouse prior to their entry to the hindgut.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"14 1","pages":"189 - 201"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000118929","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64563188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Aging Expression of Cystathionine-Beta Synthase in the Temporal Lobe and Cerebellum of Down Syndrome Patients","authors":"T. Kanaumi, A. Ichinohe, Hideo Kimura, H. Iwasaki, S. Hirose, S. Takashima","doi":"10.1159/000118930","DOIUrl":"https://doi.org/10.1159/000118930","url":null,"abstract":"Down’s syndrome (DS) is characterized by intellectual disabilities and Alzheimer-type dementia. Cystathionine-β synthase (CBS) plays a role in the production of hydrogen sulfide (H2S) in the brain and is encoded by a gene which is localized in the DS critical region of chromosome 21. The expression of CBS was compared during development and aging. Therefore, cerebri (temporal lobe) and cerebelli from fetuses and adults were studied in 22 normal controls and 21 DS patients using immunohistochemical methods. During normal development, CBS-positive astrocytes appeared in the cortical layer at 14 weeks of gestation (GW), remained elevated until 34 GW and decreased slightly during the infantile period (1–11 months of age). A few CBS-positive neurons were transiently found in the deep cortical layer only at 35 GW. In the cerebellum, CBS-positive Bergmann glial cells were found from 26 GW to adulthood in both controls and DS patients. In DS, there were greater numbers of CBS-positive astrocytes, situated predominantly in granular cell layers II and IV, compared to the controls. In addition, CBS-positive astrocytes were also increased around senile plaques in adults with DS. The high level of CBS in the granular cell layers in DS may be related to an abnormal development of inhibitory neurons and may be responsible for the pathogenesis of intellectual disability, while the increased CBS observed in adult DS may be related to the pathogenesis of Alzheimer-type dementia.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"4 1","pages":"202 - 207"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000118930","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64563241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postnatal Developmental Changes of Vitreous and Lens Volumes in Sprague-Dawley Rats","authors":"O. Sha, W. Kwong","doi":"10.1159/000118928","DOIUrl":"https://doi.org/10.1159/000118928","url":null,"abstract":"Purpose: To study the postnatal changes in the vitreous and lens volumes in Sprague-Dawley rats. Methods: Six eyes from Sprague-Dawley rats at each age (postnatal days 1, 6, 12, 21, 30 and 120) were obtained and cryosectioned without fixation. The areas of vitreous, lens and intraocular cavity in the sections were measured separately and their volumes calculated. The percentages of vitreous and lens volumes in the intraocular cavity of each eye were also calculated. Results: The rat vitreous volumes (means ± SE) were 5.2 ± 0.5 µl on day 1, 13.4 ± 0.6 µl on day 6, 22.2 ± 1.0 µl on day 12, 27.8 ± 0.6 µl on day 21, 33.3 ± 1.3 µl on day 30 and 52.4 ± 1.9 µl on day 120. The lens volumes were 3.5 ± 0.2 µl, 7.7 ± 0.4 µl, 10.6 ± 0.4 µl, 15.1 ± 0.5 µl, 19.6 ± 0.8 µl and 43.0 ± 1.3 µl, respectively, in each time group. The vitreous and lens measurements revealed different growth rates and trends. Conclusion: Our systematic data quantify the postnatal development of the lens and the vitreous, and also provide a reference for the ocular volumes of rats at specific postnatal ages.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"4 1","pages":"183 - 188"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000118928","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64563180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurogenesis in Human Hippocampus: Implications for Alzheimer Disease Pathogenesis","authors":"R. Castellani, Xiongwei Zhu, Hyoung-Gon Lee, George Perry, Mark A. Smith, G. Casadesus","doi":"10.1159/000118927","DOIUrl":"https://doi.org/10.1159/000118927","url":null,"abstract":"Hippocampal neurogenesis, the innate capacity of stem cells in the hippocampus to generate new neurons throughout life, is attracting interest in neurodegenerative disease research as an indicator of neuroplasticity and therefore treatment. Conditions that improve cognitive output and increase neurogenesis are associated with a decreased incidence of Alzheimer disease (AD), and conditions that lead to reduced cognition and neurogenesis are associated with increases in the incidence of AD. Therefore, hippocampal neurogenesis may be of particular relevance in the development of AD, and the modulation of this process can afford an important therapeutic avenue. Nevertheless, apparent contradictions across studies examining all factors of hippocampal neurogenesis in AD have led to a confusing state of affairs regarding the role of this process in the disease, as aberrant cell cycle activation has been advanced as an early pathogenic factor in the development of AD. The objective of this review is to critically examine these contradicting reports and provide additional and alternative insights into the function of hippocampal neurogenesis in AD.","PeriodicalId":89607,"journal":{"name":"Neuroembryology and aging","volume":"4 1","pages":"175 - 182"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000118927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64563120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}