Biomolecules最新文献_第7页

Advances in the Synthesis and Biological Applications of Enoxacin-Based Compounds. 依诺沙星类化合物的合成和生物应用进展。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-07 DOI: 10.3390/biom14111419

Garba Suleiman, Nabil El Brahmi, Gérald Guillaumet, Saïd El Kazzouli

{"title":"Advances in the Synthesis and Biological Applications of Enoxacin-Based Compounds.","authors":"Garba Suleiman, Nabil El Brahmi, Gérald Guillaumet, Saïd El Kazzouli","doi":"10.3390/biom14111419","DOIUrl":"10.3390/biom14111419","url":null,"abstract":"A comprehensive review of advances in the synthesis and biological applications of enoxacin (1, referred to as ENX)-based compounds is presented. ENX, a second-generation fluoroquinolone (FQ), is a prominent 1,8-naphthyridine containing compounds studied in medicinal chemistry. Quinolones, a class of synthetic antibiotics, are crucial building blocks for designing multi-biological libraries due to their inhibitory properties against DNA replication. Chemical modifications at positions 3 and 7 of the quinolone structure can transform antibacterial FQs into anticancer analogs. ENX and its derivatives have been examined for various therapeutic applications, including anticancer, antiviral, and potential treatment against COVID-19. Several synthetic methodologies have been devised for the efficient and versatile synthesis of ENX and its derivatives. This review emphasizes all-inclusive developments in the synthesis of ENX derivatives, focusing on modifications at C3 (carboxylic acid, Part A), C7 (piperazinyl, Part B), and other modifications (Parts A and B). The reactions considered were chosen based on their reproducibility, ease of execution, accessibility, and the availability of the methodology reported in the literature. This review provides valuable insights into the medicinal properties of these compounds, highlighting their potential as therapeutic agents in various fields.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11592230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanide and Cyanogenic Compounds-Toxicity, Molecular Targets, and Therapeutic Agents. 氰化物和氰基化合物--毒性、分子靶标和治疗剂。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-07 DOI: 10.3390/biom14111420

Joanna Izabela Lachowicz, Jan Alexander, Jan O Aaseth

引用次数: 0

How Does Physical Activity Modulate Hormone Responses? 体育锻炼如何调节激素反应？

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-07 DOI: 10.3390/biom14111418

Cristina Mennitti, Gabriele Farina, Antonio Imperatore, Giulia De Fonzo, Alessandro Gentile, Evelina La Civita, Gianluigi Carbone, Rosa Redenta De Simone, Maria Rosaria Di Iorio, Nadia Tinto, Giulia Frisso, Valeria D'Argenio, Barbara Lombardo, Daniela Terracciano, Clara Crescioli, Olga Scudiero

{"title":"How Does Physical Activity Modulate Hormone Responses?","authors":"Cristina Mennitti, Gabriele Farina, Antonio Imperatore, Giulia De Fonzo, Alessandro Gentile, Evelina La Civita, Gianluigi Carbone, Rosa Redenta De Simone, Maria Rosaria Di Iorio, Nadia Tinto, Giulia Frisso, Valeria D'Argenio, Barbara Lombardo, Daniela Terracciano, Clara Crescioli, Olga Scudiero","doi":"10.3390/biom14111418","DOIUrl":"10.3390/biom14111418","url":null,"abstract":"Physical activity highly impacts the neuroendocrine system and hormonal secretion. Numerous variables, both those related to the individual, including genetics, age, sex, biological rhythms, nutritional status, level of training, intake of drugs or supplements, and previous or current pathologies, and those related to the physical activity in terms of type, intensity, and duration of exercise, or environmental conditions can shape the hormonal response to physical exercise. The aim of this review is to provide an overview of the effects of physical exercise on hormonal levels in the human body, focusing on changes in concentrations of hormones such as cortisol, testosterone, and insulin in response to different types and intensities of physical activity. Regular monitoring of hormonal responses in athletes could be a potential tool to design individual training programs and prevent overtraining syndrome.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction Between Nitric Oxide and Silicon on Leghaemoglobin and S-Nitrosothiol Levels in Soybean Nodules. 一氧化氮和硅对大豆结节中血红蛋白和 S-亚硝硫醇水平的影响

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-07 DOI: 10.3390/biom14111417

Da-Sol Lee, Ashim Kumar Das, Nusrat Jahan Methela, Byung-Wook Yun

{"title":"Interaction Between Nitric Oxide and Silicon on Leghaemoglobin and S-Nitrosothiol Levels in Soybean Nodules.","authors":"Da-Sol Lee, Ashim Kumar Das, Nusrat Jahan Methela, Byung-Wook Yun","doi":"10.3390/biom14111417","DOIUrl":"10.3390/biom14111417","url":null,"abstract":"Nitrogen fixation in legume nodules is crucial for plant growth and development. Therefore, this study aims to investigate the effects of nitric oxide [S-nitrosoglutathione (GSNO)] and silicon [sodium metasilicate (Si)], both individually and in combination, on soybean growth, nodule formation, leghaemoglobin (Lb) synthesis, and potential post-translational modifications. At the V1 stage, soybean plants were treated for 2 weeks with 150 µM GSNO, and Si at concentrations of 1 mM, 2 mM, and 4 mM. The results showed that NO and Si enhance the nodulation process by increasing phenylalanine ammonia-lyase activity and Nod factors (NIP2-1), attracting rhizobia and accelerating nodule formation. This leads to a greater number and larger diameter of nodules. Individually, NO and Si support the synthesis of Lb and leghaemoglobin protein (Lba) expression, ferric leghaemoglobin reductases (FLbRs), and S-nitrosoglutathione reductase (GSNOR). However, when used in combination, NO and Si inhibit these processes, leading to elevated levels of S-nitrosothiols in the roots and nodules. This combined inhibition may potentially induce post-translational modifications in FLbRs, pivotal for the reduction of Lb3+ to Lb2+. These findings underscore the critical role of NO and Si in the nodulation process and provide insight into their combined effects on this essential plant function.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11592487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Overnight Storage of Human Atrial Myocytes on Intracellular Calcium Homeostasis and Electrophysiological Utility. 隔夜储存人类心房肌细胞对细胞内钙平衡和电生理效用的影响

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-07 DOI: 10.3390/biom14111415

Cristina Aceituno, David Revuelta, Verónica Jiménez-Sábado, Antonino Ginel, Cristina E Molina, Leif Hove-Madsen

{"title":"Impact of Overnight Storage of Human Atrial Myocytes on Intracellular Calcium Homeostasis and Electrophysiological Utility.","authors":"Cristina Aceituno, David Revuelta, Verónica Jiménez-Sábado, Antonino Ginel, Cristina E Molina, Leif Hove-Madsen","doi":"10.3390/biom14111415","DOIUrl":"10.3390/biom14111415","url":null,"abstract":"Human atrial myocytes afford an attractive experimental model to investigate mechanisms underlying electrophysiological alterations in cardiovascular disease. However, this model presents limitations, such as the availability of human atrial tissue and a variable yield of myocytes isolation. Therefore, we aimed to determine whether overnight storage can increase the time window where the electrophysiological properties of human atrial myocytes can be determined. To address this issue, human atrial myocytes isolated from patients undergoing cardiac surgery were used for patch-clamp experiments on the day of cell isolation (Day 1) and the following day (Day 2). The shape of the current-voltage (I-V) relationship for the calcium current (ICa) depended on the access resistance and the cell capacitance, with large cells (>75 pF) requiring a lower access resistance (<15 MΩ) than small cells (<40 pF) to avoid distortion of the I-V curve. Importantly, overnight storage did not significantly affect (1) the ICa amplitude or properties, (2) sarcoplasmic reticulum calcium homeostasis or (3) the frequency-dependency of the beat-to-beat response. In conclusion, overnight storage of isolated human atrial myocytes at 4 °C does not affect essential features of intracellular calcium homeostasis and, therefore, affords a simple protocol to extend the experimental lifetime of human atrial myocytes.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restored Collagen VI Microfilaments Network in the Extracellular Matrix of CRISPR-Edited Ullrich Congenital Muscular Dystrophy Fibroblasts. CRISPR 改造的乌利希先天性肌肉萎缩症成纤维细胞细胞外基质中胶原 VI 微丝网络的恢复。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-06 DOI: 10.3390/biom14111412

Daniela Benati, Eleonora Cattin, Federico Corradi, Tommaso Ferrari, Eleonora Pedrazzoli, Clarissa Patrizi, Matteo Marchionni, Roberto Bertorelli, Veronica De Sanctis, Luciano Merlini, Alessandra Ferlini, Patrizia Sabatelli, Francesca Gualandi, Alessandra Recchia

{"title":"Restored Collagen VI Microfilaments Network in the Extracellular Matrix of CRISPR-Edited Ullrich Congenital Muscular Dystrophy Fibroblasts.","authors":"Daniela Benati, Eleonora Cattin, Federico Corradi, Tommaso Ferrari, Eleonora Pedrazzoli, Clarissa Patrizi, Matteo Marchionni, Roberto Bertorelli, Veronica De Sanctis, Luciano Merlini, Alessandra Ferlini, Patrizia Sabatelli, Francesca Gualandi, Alessandra Recchia","doi":"10.3390/biom14111412","DOIUrl":"10.3390/biom14111412","url":null,"abstract":"Collagen VI is an essential component of the extracellular matrix (ECM) composed by α1, α2 and α3 chains and encoded by COL6A1, COL6A2 and COL6A3 genes. Dominant negative pathogenic variants in COL6A genes result in defects in collagen VI protein and are implicated in the pathogenesis of muscular diseases, including Ullrich congenital muscular dystrophy (UCMD). Here, we designed a CRISPR genome editing strategy to tackle a dominant heterozygous deletion c.824_838del in exon 9 of the COL6A1 gene, causing a lack of secreted collagen VI in a patient's dermal fibroblasts. The evaluation of efficiency and specificity of gene editing in treating patient's fibroblasts revealed the 32% efficiency of editing the mutated allele but negligible editing of the wild-type allele. CRISPR-treated UCMD skin fibroblasts rescued the secretion of collagen VI in the ECM, which restored the ultrastructure of the collagen VI microfibril network. By using normal melanocytes as surrogates of muscle cells, we found that collagen VI secreted by the corrected patient's skin fibroblasts recovered the anchorage to the cell surface, pointing to a functional improvement of the protein properties. These results support the application of the CRISPR editing approach to knock out COL6A1 mutated alleles and rescue the UCMD phenotype in patient-derived fibroblasts.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics. 接受包括家庭锻炼、支链氨基酸和益生菌在内的多因素干预的晚期慢性肝病患者的虚弱生物标志物

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-06 DOI: 10.3390/biom14111410

Luca Laghi, Maria Àngels Ortiz, Giacomo Rossi, Eva Román, Carlo Mengucci, Elisabet Cantó, Lucia Biagini, Elisabet Sánchez, Maria Mulet, Álvaro García-Osuna, Eulàlia Urgell, Naujot Kaur, Maria Poca, Josep Padrós, Maria Josep Nadal, Berta Cuyàs, Edilmar Alvarado, Silvia Vidal, Elena Juanes, Andreu Ferrero-Gregori, Àngels Escorsell, German Soriano

{"title":"Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics.","authors":"Luca Laghi, Maria Àngels Ortiz, Giacomo Rossi, Eva Román, Carlo Mengucci, Elisabet Cantó, Lucia Biagini, Elisabet Sánchez, Maria Mulet, Álvaro García-Osuna, Eulàlia Urgell, Naujot Kaur, Maria Poca, Josep Padrós, Maria Josep Nadal, Berta Cuyàs, Edilmar Alvarado, Silvia Vidal, Elena Juanes, Andreu Ferrero-Gregori, Àngels Escorsell, German Soriano","doi":"10.3390/biom14111410","DOIUrl":"10.3390/biom14111410","url":null,"abstract":"Frailty in cirrhosis or advanced chronic liver disease (ACLD) is a relevant prognostic factor. In the present study, we aimed to analyze potential biomarkers associated with frailty and its improvement in patients with ACLD. We analyzed the serum of outpatients with ACLD who participated in a previous study (Román, Hepatol Commun 2024) in which frailty was assessed using the liver frailty index (LFI), and patients who were frail or prefrail were randomized to a multifactorial intervention (home exercise, branched-chain amino acids, and probiotics) or control for 12 months. We determined a biomarker battery of inflammation, bacterial translocation, and liver damage in blood and urine and blood metabolomics by 1H-NMR. Thirty-seven patients were included. According to the LFI, 32 patients were frail or prefrail, and 5 were robust. At baseline, LFI correlated with LBP, sCD163, mtDNA, FGF-21, urinary NGAL, urinary claudin-3, and the metabolites mannose, ethanol, and isoleucine. During the study, patients in the intervention group showed an improvement in LFI and a decrease in CRP, LBP, sCD163, and ccK18 compared to the control group. Metabolomics showed a decrease in dimethyl sulfone and creatinine and an increase in malonate, ornithine, isoleucine, and valine in the intervention group. We conclude that frailty in patients with ACLD is associated with biomarkers of systemic inflammation, bacterial translocation, and liver damage, and alterations of amino acid and short-chain fatty acid metabolism.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11592179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Analytical Characterization, and Human CB₁ Receptor Binding Studies of the Chloroindole Analogues of the Synthetic Cannabinoid MDMB-CHMICA. 合成大麻素 MDMB-CHMICA 的氯吲哚类似物的合成、分析表征和人类 CB1 受体结合研究。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-06 DOI: 10.3390/biom14111414

Sascha Münster-Müller, Steven Hansen, Tobias Lucas, Arianna Giorgetti, Lukas Mogler, Svenja Fischmann, Folker Westphal, Volker Auwärter, Michael Pütz, Till Opatz

{"title":"Synthesis, Analytical Characterization, and Human CB1 Receptor Binding Studies of the Chloroindole Analogues of the Synthetic Cannabinoid MDMB-CHMICA.","authors":"Sascha Münster-Müller, Steven Hansen, Tobias Lucas, Arianna Giorgetti, Lukas Mogler, Svenja Fischmann, Folker Westphal, Volker Auwärter, Michael Pütz, Till Opatz","doi":"10.3390/biom14111414","DOIUrl":"10.3390/biom14111414","url":null,"abstract":"Synthetic cannabinoids (SCs) are one of the largest groups of new psychoactive substances (NPSs). However, the relationship between their chemical structure and the affinity to human CB1 receptors (hCB1), which mediates their psychotropic activity, is not well understood. Herein, the synthesis of the 2-, 4-, 5-, 6- and 7-chloroindole analogues of the synthetic cannabimimetic MDMB-CHMICA, along with their analytical characterization via ultraviolet-visible (UV/VIS), infrared (IR), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry, is described. Furthermore, all five derivatives of MDMB-CHMICA were analyzed for their hCB1 binding affinities. Chlorination at position 4 and 5 of the indole core reduced the binding affinity compared to MDMB-CHMICA, while the test compounds chlorinated in positions 2, 6, and 7 largely retained their binding affinities relative to the non-chlorinated parent compound.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11592078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Engineering Approaches for the Microbial Production of Vanillin. 微生物生产香兰素的基因工程方法。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-06 DOI: 10.3390/biom14111413

Luísa D F Santos, Sylvie Lautru, Jean-Luc Pernodet

{"title":"Genetic Engineering Approaches for the Microbial Production of Vanillin.","authors":"Luísa D F Santos, Sylvie Lautru, Jean-Luc Pernodet","doi":"10.3390/biom14111413","DOIUrl":"10.3390/biom14111413","url":null,"abstract":"Vanilla flavour is widely used in various industries and is the most broadly used flavouring agent in the food industry. The demand for this flavour is, therefore, extremely high, yet vanilla bean extracts can only meet about 1% of the overall demand. Vanillin, the main constituent of vanilla flavour, can easily be obtained through chemical synthesis. Nonetheless, consumer demands for natural products and environmentally friendly industrial processes drive the development of biotechnological approaches for its production. Some microorganisms can naturally produce vanillin when fed with various substrates, including eugenol, isoeugenol, and ferulic acid. The characterisation of the genes and enzymes involved in these bioconversion pathways, as well as progress in the understanding of vanillin biosynthesis in Vanilla orchids, allowed the development of genetic engineering and synthetic biology approaches to increase vanillin production in naturally vanillin-producing microorganisms, or to implement novel vanillin biosynthetic pathways in microbial chassis. This review summarises and discusses these genetic engineering and synthetic biology approaches for the microbial production of vanillin.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KnowVID-19: A Knowledge-Based System to Extract Targeted COVID-19 Information from Online Medical Repositories. KnowVID-19：基于知识的系统，从在线医学资料库中提取有针对性的 COVID-19 信息。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-11-06 DOI: 10.3390/biom14111411

Muzzamil Aziz, Ioana Popa, Amjad Zia, Andreas Fischer, Sabih Ahmed Khan, Amirreza Fazely Hamedani, Abdul R Asif

{"title":"KnowVID-19: A Knowledge-Based System to Extract Targeted COVID-19 Information from Online Medical Repositories.","authors":"Muzzamil Aziz, Ioana Popa, Amjad Zia, Andreas Fischer, Sabih Ahmed Khan, Amirreza Fazely Hamedani, Abdul R Asif","doi":"10.3390/biom14111411","DOIUrl":"10.3390/biom14111411","url":null,"abstract":"We present KnowVID-19, a knowledge-based system that assists medical researchers and scientists in extracting targeted information quickly and efficiently from online medical literature repositories, such as PubMed, PubMed Central, and other biomedical sources. The system utilizes various open-source machine learning tools, such as GROBID, S2ORC, and BioC to streamline the processes of data extraction and data mining. Central to the functionality of KnowVID-19 is its keyword-based text classification process, which plays a pivotal role in organizing and categorizing the extracted information. By employing machine learning techniques for keyword extraction-specifically RAKE, YAKE, and KeyBERT-KnowVID-19 systematically categorizes publication data into distinct topics and subtopics. This topic structuring enhances the system's ability to match user queries with relevant research, improving both the accuracy and efficiency of the search results. In addition, KnowVID-19 leverages the NetworkX Python library to construct networks of the most relevant terms within publications. These networks are then visualized using Cytoscape software, providing a graphical representation of the relationships between key terms. This network visualization allows researchers to easily track emerging trends and developments related to COVID-19, long COVID, and associated topics, facilitating more informed and user-centered exploration of the scientific literature. KnowVID-19 also provides an interactive web application with an intuitive, user-centered interface. This platform supports seamless keyword searching and filtering, as well as a visual network of term associations to help users quickly identify emerging research trends. The responsive design and network visualization enables efficient navigation and access to targeted COVID-19 literature, enhancing both the user experience and the accuracy of data-driven insights.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"14 11","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11592241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0