Biomolecules最新文献_第7页

Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum. 综合辐射：跨辐射谱的混合照射的生物效应。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091282

Orfeas Parousis-Paraskevas, Angeliki Gkikoudi, Amer Al-Qaaod, Spyridon N Vasilopoulos, Gina Manda, Christina Beinke, Siamak Haghdoost, Georgia I Terzoudi, Faton Krasniqi, Alexandros G Georgakilas

{"title":"Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum.","authors":"Orfeas Parousis-Paraskevas, Angeliki Gkikoudi, Amer Al-Qaaod, Spyridon N Vasilopoulos, Gina Manda, Christina Beinke, Siamak Haghdoost, Georgia I Terzoudi, Faton Krasniqi, Alexandros G Georgakilas","doi":"10.3390/biom15091282","DOIUrl":"10.3390/biom15091282","url":null,"abstract":"Combined radiation exposures-pairings of ionizing and non-ionizing radiation-are increasingly relevant in medical, spaceflight, and environmental contexts. This systematic review evaluates their radiobiological effects and therapeutic applications, focusing on synergistic interactions and underlying biological mechanisms. A comprehensive search of PubMed, Google Scholar, Semantic Scholar, bioRxiv, and Europe PMC identified studies published from the 1960s through 2025. Eligible studies assessed biological responses to different radiation types applied either simultaneously or within 24 h, with minor exceptions. A total of 172 studies were included and categorized into radiobiological, therapeutic, and space radiation domains. Due to the predominance of mechanistic research, no formal risk-of-bias tool was applied; methodological limitations were assessed qualitatively. Findings were synthesized narratively by radiation type and domain. Synergistic and additive effects were frequently observed, with responses influenced by dose, sequence, radiation type, and DNA repair dynamics. Therapeutic combinations often enhanced efficacy, while space radiation studies revealed multifaceted biological damage. This review provides a consolidated reference for advancing research and applications involving combined radiation exposures, emphasizing the need for mechanistic insight and standardized protocols in therapy, radiation protection, and spaceflight. This study was funded by project 21GRD02 BIOSPHERE (European Partnership on Metrology, Horizon Europe) and reported per PRISMA 2020 guidelines; no protocol was registered.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optogenetics: A Novel Therapeutic Avenue for Age-Related Macular Degeneration. 光遗传学：老年性黄斑变性的新治疗途径。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091286

Pier Luigi Grenga, Chiara Ciancimino, Alessandro Meduri, Serena Fragiotta

引用次数: 0

The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe? 胰高血糖素样肽-1受体激动剂对勃起功能的影响：是敌是友？

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091284

Dimitris Kounatidis, Natalia G Vallianou, Eleni Rebelos, Kalliopi Vallianou, Evanthia Diakoumopoulou, Konstantinos Makrilakis, Nikolaos Tentolouris

{"title":"The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe?","authors":"Dimitris Kounatidis, Natalia G Vallianou, Eleni Rebelos, Kalliopi Vallianou, Evanthia Diakoumopoulou, Konstantinos Makrilakis, Nikolaos Tentolouris","doi":"10.3390/biom15091284","DOIUrl":"10.3390/biom15091284","url":null,"abstract":"Erectile dysfunction (ED) is a common yet frequently underrecognized microvascular complication of diabetes, affecting up to three out of four individuals. Key contributing factors include advancing age, long-standing disease duration, and suboptimal glycemic control, as well as insulin resistance and androgen deficiency-the latter being particularly common in men with type 2 diabetes (T2D) and obesity. While numerous studies have investigated the effects of various antidiabetic therapies on diabetes-related ED, the results remain inconsistent, limiting definitive conclusions. In recent years, increasing attention has focused on a novel class of antidiabetic medications, namely glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These agents have become central to the treatment of T2D due to their potent glucose-lowering properties and well-documented benefits on cardiovascular outcomes, and weight loss. Given these pleiotropic effects, GLP-1 RAs have been presumed to positively influence erectile function-a hypothesis supported by a growing body of experimental and clinical research. However, preliminary reports have also raised concerns about a possible association between GLP-1 RA use and ED. This narrative review aims to synthesize current evidence regarding the impact of GLP-1 RAs on erectile function, providing a platform for future research in this evolving field.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Synthesis of Bacterial Cellulose-Supported CoAl-Layered Double Hydroxide as a Peroxymonosulfate Activator for Enhancing the Removal of Tetracycline. 原位合成细菌纤维素负载煤层双氢氧化物促进四环素脱除的过氧单硫酸盐活化剂。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091283

Xiuzhi Bai, Yongsheng Du, Zhongxiang Liu, Jing Cheng, Jie Yang, Ying Li

{"title":"In Situ Synthesis of Bacterial Cellulose-Supported CoAl-Layered Double Hydroxide as a Peroxymonosulfate Activator for Enhancing the Removal of Tetracycline.","authors":"Xiuzhi Bai, Yongsheng Du, Zhongxiang Liu, Jing Cheng, Jie Yang, Ying Li","doi":"10.3390/biom15091283","DOIUrl":"10.3390/biom15091283","url":null,"abstract":"This study employed the hydrothermal coprecipitation method to grow CoAl-layered double hydroxide (LDH) onto bacterial cellulose (BC) in situ, successfully preparing the CoAl-LDH@BC composite. This composite was then used to activate peroxymonosulfate (PMS) for tetracycline (TC) degradation. According to the results, the CoAl-LDH@BC/PMS system demonstrated a remarkable removal efficiency of 99.9% for TC within 15 min. Moreover, the influencing factors of catalyst dosage, PMS dosage, TC concentration, reaction temperature, initial pH, and inorganic ions were evaluated. Notably, the system demonstrated broad-spectrum contaminant removal capabilities, which could simultaneously eliminate more than 99.7% of oxytetracycline hydrochloride (TCH) and 87.9% of ciprofloxacin (CFX) within 20 min. Additionally, the removal rates for several dyes reached more than 95.7% in 20 min. Phytotoxicity assessment (using mung bean seeds) confirmed a significant reduction in the biotoxicity of post-treatment TC solutions. The identification of TC degradation intermediates was enabled, alongside the subsequent proposal of plausible degradation pathways. Furthermore, mechanistic investigations based on radical quenching experiments revealed the coexistence of dual radical (•OH and SO4-•) and non-radical (1O2) oxidation pathways in the reaction of the CoAl-LDH@BC/PMS system. Overall, this research broadens the potential applications of bacterial cellulose-based porous materials and provides an innovative insight into antibiotic wastewater treatment.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Stem Cell-Based Embryo Models in Implantation Research: Regulation, Consistency and Potential. 人类干细胞胚胎模型在着床研究中的应用：调控、一致性和潜力。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091287

Søren Holm

引用次数: 0

Postmortem Stability Analysis of Lipids and Polar Metabolites in Human, Rat, and Mouse Brains. 人、大鼠和小鼠大脑中脂质和极性代谢物的死后稳定性分析。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091288

Marina Zavolskova, Dmitry Senko, Olga Bukato, Sergey Troshin, Elena Stekolshchikova, Mark Kachanovski, Anna Akulova, Maria Afonina, Olga Efimova, Daria Petrova, Maria Osetrova, Philipp Khaitovich

{"title":"Postmortem Stability Analysis of Lipids and Polar Metabolites in Human, Rat, and Mouse Brains.","authors":"Marina Zavolskova, Dmitry Senko, Olga Bukato, Sergey Troshin, Elena Stekolshchikova, Mark Kachanovski, Anna Akulova, Maria Afonina, Olga Efimova, Daria Petrova, Maria Osetrova, Philipp Khaitovich","doi":"10.3390/biom15091288","DOIUrl":"10.3390/biom15091288","url":null,"abstract":"Lipids and polar metabolites are emerging as promising indicators of the brain's molecular phenotype in both clinical and fundamental research. However, the impact of postmortem delay on these compounds, unavoidable in human brain studies, remains insufficiently understood. In this study, we examined the postmortem stability of lipids and polar metabolites over a 48-h interval in the brains of three species: humans, rats, and mice. We show that the abundance levels of 23% of the 867 studied lipids and 75% of the 104 studied polar metabolites were affected significantly by postmortem delay in at least one species. The postmortem effects correlated positively and significantly among the species, while showing an approximately tenfold slower rate in humans compared to rodents. The only exception to the postmortem rates deceleration was a group of oxidized fatty acids, which accumulated at similar speed in both humans and rodents. These findings provide valuable insights for improving reproducibility and refining the interpretation of human and rodent brain lipidome and metabolome data in future studies.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Bioevaluation of Chalcones as Broad-Spectrum Antiviral Compounds Against Single-Stranded RNA Viruses. 查尔酮作为单链RNA病毒广谱抗病毒化合物的合成及生物评价。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-05 DOI: 10.3390/biom15091285

Lorael K M Kirton, Nasser N Yousef, Griffith D Parks, Otto Phanstiel

{"title":"Synthesis and Bioevaluation of Chalcones as Broad-Spectrum Antiviral Compounds Against Single-Stranded RNA Viruses.","authors":"Lorael K M Kirton, Nasser N Yousef, Griffith D Parks, Otto Phanstiel","doi":"10.3390/biom15091285","DOIUrl":"10.3390/biom15091285","url":null,"abstract":"Chalcones are flavonoid compounds containing an α,β-unsaturated ketone core that are often found in plants and have diverse biological activities including antiviral activity. For example, chalcone 8o was previously shown to have antiviral activity against human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV); two viruses that use a nuclear phase to complete their growth cycle. Here, we synthesized ten new derivatives of 8o and tested them for antiviral activity against four RNA viruses that replicate exclusively in the cytoplasm, including prototype members of the paramyxovirus, flavivirus, bunyavirus, and coronavirus families. For example, chalcones 8o and 8p showed potent inhibition of PIV5 replication with minimal cytotoxicity in human fibroblast cultures. Time-of-addition studies showed that these chalcones inhibit an early stage of viral replication and prevent viral spread through cell cultures. Most importantly, our top performing chalcones showed potent in vitro antiviral activity against Zika virus, La Crosse Virus, and the coronavirus OC43. These studies offer mechanistic insight into chalcone-mediated inhibition of viral replication, demonstrate the influence of functional group changes of chalcone scaffolds on their efficacy as antivirals, and support the development of chalcones as broad-spectrum antiviral compounds.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Culture System for Inhibiting In Vitro Differentiation of Ovine Granulosa Cells. 抑制绵羊颗粒细胞体外分化的新型培养体系。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-04 DOI: 10.3390/biom15091280

Yufen Zhao, Haijiang Liu, Zhe Mu, Haijun Li, Wangmei Qi

{"title":"A Novel Culture System for Inhibiting In Vitro Differentiation of Ovine Granulosa Cells.","authors":"Yufen Zhao, Haijiang Liu, Zhe Mu, Haijun Li, Wangmei Qi","doi":"10.3390/biom15091280","DOIUrl":"10.3390/biom15091280","url":null,"abstract":"The in vitro granulosa cell (GC) model presents a valuable tool to explore antral follicle development. A full understanding of the reasons and blocking methods that occur during in vitro luteinization of sheep GCs, stimulated by serum culture, is a complex goal that has not been completely achieved. Herein, the phenomenon and causes of GC differentiation, as well as the methods for inhibiting luteinization in an in vitro culture system, were investigated by immunofluorescence, Western blot, RT-qPCR, and ELISA techniques. The results reveal that, when compared to fresh GCs, FSHR protein levels in primary GCs significantly decreased in serum-containing media, while STAR protein levels significantly increased, implying that sheep GCs can differentiate in serum-containing media. LH concentrations were significantly greater in serum-containing media compared to serum-free media. The LH receptor (LHR) mRNA expression in primary-generation GCs steadily increased with longer culture times, indicating that LH-LHR signaling leads to GC luteinization in vitro. In primary and second-generation GCs, 180 nmol/L BAY-899, an LHR-specific antagonist, significantly increased FSHR protein expression, reduced STAR protein synthesis, and inhibited P4 secretion within 48 h of in vitro culture compared to controls. BAY-899 showed no adverse effects on fifth-generation GCs growth, implying that BAY-899 can inhibit GC luteinization while not affecting cell proliferation. In conclusion, this study found that the LHR antagonist BAY-899 can preserve the features of sheep GCs in vitro by suppressing the spontaneous luteinization process caused by LH-LHR signaling, which has a key methodological implication for studying the mechanics of antral follicle formation in vivo.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and Computational Studies Reveal That Per- and Polyfluoroalkyl Substances Can Impair Protamine-DNA Interaction, Potentially Inducing DNA Damage. 分子和计算研究表明，全氟烷基和多氟烷基物质可以损害蛋白蛋白-DNA相互作用，潜在地诱导DNA损伤。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-04 DOI: 10.3390/biom15091279

Federica Musella, Maria Grazia Guarnieri, Simona Amore, Luigi Montano, Francesco Bertola, Salvatore Micali, Francesco Paolo Busardò, Carmen Di Giovanni, Gennaro Lettieri, Marina Piscopo

{"title":"Molecular and Computational Studies Reveal That Per- and Polyfluoroalkyl Substances Can Impair Protamine-DNA Interaction, Potentially Inducing DNA Damage.","authors":"Federica Musella, Maria Grazia Guarnieri, Simona Amore, Luigi Montano, Francesco Bertola, Salvatore Micali, Francesco Paolo Busardò, Carmen Di Giovanni, Gennaro Lettieri, Marina Piscopo","doi":"10.3390/biom15091279","DOIUrl":"10.3390/biom15091279","url":null,"abstract":"Interactions between protamines and DNA are essential for the correct structure of human sperm chromatin. Reproductive health can be adversely affected by environmental pollutants like per- and polyfluoroalkyl substances (PFAS). We previously reported that exposure to PFAS in the Veneto region causes alterations in sperm nuclear basic proteins (SNBP), along with reduced seminal antioxidant activity and increased lipoperoxides. This study analysed the protamine-to-histone ratio in SNBP and quantified the extent of DNA damage induced by SNBP in subjects in Veneto with serum perfluorooctanoic acid (PFOA) levels above the reference threshold. We found that all individuals with serum PFOA above the threshold exhibited grade three DNA damage, regardless of the protamine-histone ratio, which was generally altered but consistently shifted toward protamines. This indicate that exposure to PFAS can alter the protamine-histone ratio in these subjects. Moreover, SNBPs from these individuals showed reduced DNA-protective capacity under pro-oxidant conditions, suggesting a role in oxidative damage. To rationalize these effects, in this cross sectional study, we investigated the potential interactions between PFAS and human protamines by molecular docking analyses which showed that PFAS can form stable complexes with DNA through hydrophobic and polar interactions, especially with thymine pyrimidine rings. Further, docking analyses revealed that fluorine atoms in PFAS may interact with guanidinium groups in protamine P1 via electrostatic and van der Waals forces, competing with DNA for binding sites and potentially disrupting chromatin organisation. A ternary PFAS-DNA-protamine adduct may underpin the observed DNA damage. These results suggest that PFAS induce oxidative stress, which could affect male fertility.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target. 烟酰胺n -甲基转移酶在心血管疾病中的作用：代谢调节因子和新出现的治疗靶点。

IF 4.8 2区生物学

Biomolecules Pub Date : 2025-09-04 DOI: 10.3390/biom15091281

Jawaria, Yusra Zarlashat, Márton Philippovich, Edit Dósa

{"title":"Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target.","authors":"Jawaria, Yusra Zarlashat, Márton Philippovich, Edit Dósa","doi":"10.3390/biom15091281","DOIUrl":"10.3390/biom15091281","url":null,"abstract":"Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, arising from complex interactions among metabolic, genetic, and environmental factors. Nicotinamide N-methyltransferase (NNMT) has recently emerged as a key metabolic regulator in CVD pathogenesis. By consuming nicotinamide and methyl groups, NNMT perturbs epigenetic, metabolic, and redox pathways that are critical for cardiovascular health. NNMT-mediated NAD+ depletion impairs mitochondrial function, sirtuin (SIRT) activity, redox balance, and energy metabolism, thereby creating a pro-atherogenic environment. NNMT and its product 1-methylnicotinamide (1-MNA) show a complex duality: they modulate SIRT activity-particularly SIRT1 and SIRT3-to influence gluconeogenesis, cholesterol synthesis, lipogenesis, and mitochondrial antioxidant defenses. NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (e.g., TLR4-NF-κB and STAT3-IL-1β). Growing evidence links NNMT to major CVD risk factors, including hyperlipidemia, hypertension, diabetes mellitus, and obesity. Thus, NNMT has a multifaceted role in cardiovascular health: while its enzymatic activity is often pathogenic (via NAD+/SAM consumption and homocysteine production), its metabolite 1-MNA can exert protective effects (via NRF2 activation and anti-thrombotic mechanisms). This duality highlights the need to delineate the molecular processes that balance these opposing actions. Experimental studies using small-molecule NNMT inhibitors and RNA interference have shown promising cardiometabolic benefits in preclinical models, including improved insulin sensitivity, reduced atherosclerosis, and attenuated cardiac dysfunction. However, no clinical trials have yet targeted NNMT specifically in CVD. Future research should clarify the tissue-specific functions of NNMT and translate these insights into novel therapeutic strategies.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0