Biomolecules最新文献_第7页

Morphological Characterization, Polyphenolic Profile, and Bioactive Properties of Limoncella, an Ancient Mediterranean Variety of Sweet Citrus. 一种古老的地中海甜柑橘品种柠檬的形态特征、多酚特征和生物活性特性。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101275

Lucia Potenza, Roberta Saltarelli, Francesco Palma, Laura Di Patria, Giosuè Annibalini, Sabrina Burattini, Pietro Gobbi, Laura Valentini, Giovanni Caprioli, Agnese Santanatoglia, Sauro Vittori, Elena Barbieri

{"title":"Morphological Characterization, Polyphenolic Profile, and Bioactive Properties of Limoncella, an Ancient Mediterranean Variety of Sweet Citrus.","authors":"Lucia Potenza, Roberta Saltarelli, Francesco Palma, Laura Di Patria, Giosuè Annibalini, Sabrina Burattini, Pietro Gobbi, Laura Valentini, Giovanni Caprioli, Agnese Santanatoglia, Sauro Vittori, Elena Barbieri","doi":"10.3390/biom14101275","DOIUrl":"https://doi.org/10.3390/biom14101275","url":null,"abstract":"Limoncella of Mattinata, a rare and ancient Mediterranean citrus fruit, was investigated by sequence analysis of the ribosomal internal transcribed spacer regions, which assigns it as a variety of Citrus medica L. Morphological, chemical, and biomolecular approaches, including light and electron microscopy, HPLC-ESI-MS/MS, and antioxidant and anti-inflammatory assays, were used to characterize the flavedo and albedo parts, usually rich in bioactive compounds. The morphological findings showed albedo and flavedo cellular structures as \"reservoirs\" of nutritional components. Both albedo and flavedo hydroalcoholic extracts were rich in polyphenols, but they were different in compounds and quantity. The flavedo is rich in p-coumaric acid and rutin, whereas the albedo contains high levels of hesperidin and quercitrin. Antioxidant, anti-inflammatory, and genoprotective effects for albedo and flavedo were found. The results confirmed the health properties of flavedo and highlighted that albedo is also a rich source of antioxidants. Moreover, this study valorizes Limoncella of Mattinata's nutritional properties, cueing its crops' repopulation.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice. 术后电针促进小鼠腹腔手术后认知功能的恢复

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101274

Yuen-Shan Ho, Wai-Yin Cheng, Michael Siu-Lun Lai, Chi-Fai Lau, Gordon Tin-Chun Wong, Wing-Fai Yeung, Raymond Chuen-Chung Chang

{"title":"Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice.","authors":"Yuen-Shan Ho, Wai-Yin Cheng, Michael Siu-Lun Lai, Chi-Fai Lau, Gordon Tin-Chun Wong, Wing-Fai Yeung, Raymond Chuen-Chung Chang","doi":"10.3390/biom14101274","DOIUrl":"https://doi.org/10.3390/biom14101274","url":null,"abstract":"Postoperative cognitive dysfunction (POCD) is a common complication that affects memory, executive function, and processing speed postoperatively. The pathogenesis of POCD is linked to excessive neuroinflammation and pre-existing Alzheimer's disease (AD) pathology. Previous studies have shown that acupuncture improves cognition in the early phase of POCD. However, POCD can last for longer periods (up to weeks and years). The long-term effects of acupuncture are unknown. In this study, we hypothesized that electroacupuncture (EA) could reduce inflammation and cognitive dysfunction induced by laparotomy over a longer period. We characterized the effects of postoperative EA on cognitive changes and investigated the underlying molecular mechanisms in mice. Laparotomy was performed in 3-month-old mice followed by daily EA treatment for 2 weeks. Our data indicated that laparotomy induced prolonged impairment in memory and executive functions, which were mitigated by postoperative EA. EA also reduced tau phosphorylation and suppressed the activation of tau-related kinases and glia, with effects comparable to ibuprofen. These findings demonstrate the beneficial effects of EA in a mouse model of POCD, suggesting that EA's ability to suppress neuroinflammation may contribute to its protective effects. In conclusion, EA may be a viable non-pharmacological intervention for managing POCD in different phases of the medical condition.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Otoconin-90 and Otolin-1 Concentrations in Benign Paroxysmal Positional Vertigo. 良性阵发性位置性眩晕的血清耳鸣素-90 和耳鸣素-1 浓度。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101279

Demet Aygun, Seyma Dumur, Mehmet Nuri Elgormus, Mehmet Serkan Alpaslan, Hafize Uzun

{"title":"Serum Otoconin-90 and Otolin-1 Concentrations in Benign Paroxysmal Positional Vertigo.","authors":"Demet Aygun, Seyma Dumur, Mehmet Nuri Elgormus, Mehmet Serkan Alpaslan, Hafize Uzun","doi":"10.3390/biom14101279","DOIUrl":"10.3390/biom14101279","url":null,"abstract":"Objective: The aim was to evaluate the value of otolith-associated protein otoconin-90 (OC90) and otolin-1 in the pathogenesis research and clinical treatment of benign paroxysmal positional vertigo (BPPV).Material and method: The study included 50 patients with BPPV admitted to neurology and otorhinolaryngology departments and 30 healthy subjects with no history of dizziness as a control group.Results: BPPV and controls were similar in terms of gender and age. Otolin-1 concentration was significantly greater in the BPPV group than in the controls (710.44 [584.35-837.39] vs 280.45 [212.7-419.61]; p < 0.001). No statistical significance was found, although OC90 was higher in the BPPV group than in the controls. There was a strong positive correlation between otolin-1 and OC90, a moderate negative correlation between otolin-1 and vitamin D, and a strong negative correlation between OC90 and vitamin D in the BPPV patient group. Otolin-1 had high specificity and AUC values for BPPV (AUC: 0.933; 95% CI: 0.881-0.986, 79.2% sensitivity, 100% specificity with a cutoff greater than 525).Conclusions: High serum concentrations of otolin-1 were associated with an increased risk of BPPV, but high concentrations of OC90 were not. Serum concentrations of otolin-1 can potentially be used as a biomarker for the acute onset of inner ear disorders due to the significant increase in patients with BPPV. Vitamin D has high specificity and sensitivity in patients with BPPV. It also provides evidence that BPPV patients with vitamin D deficiency may improve their symptoms with replacement therapy. More large-scale prospective studies are required to confirm these associations and clarify the exact mechanisms.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[¹⁸F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders. 将[18F]NaF PET/CT 作为渐进性骨纤维增生症的标记物：从骨疾病的分子机制到临床应用。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101276

Jolien Zwama, Neeltje M Rosenberg, Vincent A Verheij, Pieter G H M Raijmakers, Maqsood Yaqub, Esmée Botman, Ruben D de Ruiter, Mark R Garrelfs, Arend Bökenkamp, Dimitra Micha, Lothar A Schwarte, Bernd P Teunissen, Adriaan A Lammertsma, Ronald Boellaard, Elisabeth M W Eekhoff

{"title":"[18F]NaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders.","authors":"Jolien Zwama, Neeltje M Rosenberg, Vincent A Verheij, Pieter G H M Raijmakers, Maqsood Yaqub, Esmée Botman, Ruben D de Ruiter, Mark R Garrelfs, Arend Bökenkamp, Dimitra Micha, Lothar A Schwarte, Bernd P Teunissen, Adriaan A Lammertsma, Ronald Boellaard, Elisabeth M W Eekhoff","doi":"10.3390/biom14101276","DOIUrl":"https://doi.org/10.3390/biom14101276","url":null,"abstract":"Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies. 主动和被动应对策略的雌性大鼠的多巴胺累积反应不同

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101280

Vsevolod V Nemets, Ekaterina P Vinogradova, Vladislav Zavialov, Vladimir P Grinevich, Evgeny A Budygin, Raul R Gainetdinov

{"title":"Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies.","authors":"Vsevolod V Nemets, Ekaterina P Vinogradova, Vladislav Zavialov, Vladimir P Grinevich, Evgeny A Budygin, Raul R Gainetdinov","doi":"10.3390/biom14101280","DOIUrl":"https://doi.org/10.3390/biom14101280","url":null,"abstract":"There is a gap in existing knowledge of stress-triggered neurochemical and behavioral adaptations in females. This study was designed to explore the short-term consequences of a single social defeat (SD) on accumbal dopamine (DA) dynamics and related behaviors in female Wistar rats. During the SD procedure, rats demonstrated different stress-handling strategies, which were defined as active and passive coping. The \"active\" subjects expressed a significantly higher level of activity directed toward handling stress experience, while the \"passive\" ones showed an escalated freezing pattern. Remarkably, these opposite behavioral manifestations were negatively correlated. Twenty-four hours following the SD exposure, decreased immobility latency in the Porsolt test and cognitive augmentation in the new object recognition evaluation were evident, along with an increase in electrically evoked mesolimbic DA release in passive coping rats. Rats exhibiting an active pattern of responses showed insignificant changes in immobility and cognitive performance as well as in evoked mesolimbic DA response. Furthermore, the dynamics of the decline and recovery of DA efflux under the depletion protocol were significantly altered in the passive but not active female rats. Taken together, these data suggest that female rats with a passive coping strategy are more susceptible to developing behavioral and neurochemical alterations within 24 h after stress exposure. This observation may represent both maladaptive and protective responses of an organism on a short timescale.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and Dynamical Properties of Nucleic Acid Hairpins Implicated in Trinucleotide Repeat Expansion Diseases. 涉及三核苷酸重复扩增疾病的核酸发夹的结构和动力学特性

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101278

Feng Pan, Pengning Xu, Christopher Roland, Celeste Sagui, Keith Weninger

{"title":"Structural and Dynamical Properties of Nucleic Acid Hairpins Implicated in Trinucleotide Repeat Expansion Diseases.","authors":"Feng Pan, Pengning Xu, Christopher Roland, Celeste Sagui, Keith Weninger","doi":"10.3390/biom14101278","DOIUrl":"https://doi.org/10.3390/biom14101278","url":null,"abstract":"Dynamic mutations in some human genes containing trinucleotide repeats are associated with severe neurodegenerative and neuromuscular disorders-known as Trinucleotide (or Triplet) Repeat Expansion Diseases (TREDs)-which arise when the repeat number of triplets expands beyond a critical threshold. While the mechanisms causing the DNA triplet expansion are complex and remain largely unknown, it is now recognized that the expandable repeats lead to the formation of nucleotide configurations with atypical structural characteristics that play a crucial role in TREDs. These nonstandard nucleic acid forms include single-stranded hairpins, Z-DNA, triplex structures, G-quartets and slipped-stranded duplexes. Of these, hairpin structures are the most prolific and are associated with the largest number of TREDs and have therefore been the focus of recent single-molecule FRET experiments and molecular dynamics investigations. Here, we review the structural and dynamical properties of nucleic acid hairpins that have emerged from these studies and the implications for repeat expansion mechanisms. The focus will be on CAG, GAC, CTG and GTC hairpins and their stems, their atomistic structures, their stability, and the important role played by structural interrupts.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparing a Phytosome for Promoting Delivery Efficiency and Biological Activities of Methyl Jasmonate-Treated Dendropanax morbifera Adventitious Root Extract (DMARE). 制备植物胶囊以提高茉莉酸甲酯处理过的Dendropanax morbifera不定根提取物（DMARE）的输送效率和生物活性。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101273

Fengjiao Xu, Shican Xu, Li Yang, Aili Qu, Dongbin Li, Minfen Yu, Yongping Wu, Shaojian Zheng, Xiao Ruan, Qiang Wang

{"title":"Preparing a Phytosome for Promoting Delivery Efficiency and Biological Activities of Methyl Jasmonate-Treated Dendropanax morbifera Adventitious Root Extract (DMARE).","authors":"Fengjiao Xu, Shican Xu, Li Yang, Aili Qu, Dongbin Li, Minfen Yu, Yongping Wu, Shaojian Zheng, Xiao Ruan, Qiang Wang","doi":"10.3390/biom14101273","DOIUrl":"https://doi.org/10.3390/biom14101273","url":null,"abstract":"(1) Background: Methyl jasmonate-treated D. morbifera adventitious root extract (MeJA-DMARE), enriched with phenolics, has enhanced bioactivities. However, phenolics possess low stability and bioavailability. Substantial evidence indicates that plant extract-phospholipid complex assemblies, known as phytosomes, represent an innovative drug delivery system. (2) Methods: The phytosome complex was created by combining MeJA-DMARE with Soy-L-α-phosphatidylcholine (PC) using three different ratios through two distinct methods (co-solvency method: A1, A2, and A3; thin-layer film method: B1, B2, and B3). (3) Results: Initial evaluation based on UV-Vis, entrapment efficiency (EE%), and loading content (LC%) indicated that B2 exhibited the highest EE% (79.98 ± 1.45) and LC% (69.17 ± 0.14). The phytosome displayed a spherical morphology with a particle size of 210 nm, a notably low polydispersity index of 0.16, and a superior zeta potential value at -25.19 mV. The synthesized phytosome exhibited superior anti-inflammatory activities by inhibiting NO and ROS production (reduced to 8.9% and 55.1% at 250 μg/mL) in RAW cells and adjusting the expression of related inflammatory cytokines; they also slowed lung tumor cell migration (only 2.3% of A549 cells migrated after treatment with phytosomes at 250 μg/mL), promoting ROS generation in A549 cell lines (123.7% compared to control) and stimulating apoptosis of lung cancer-related genes. (4) Conclusions: In conclusion, the MeJA-DMARE phytosome offers stable, economically efficient, and environmentally friendly nanoparticles with superior inflammation and lung tumor inhibition properties. Thus, the MeJA-DMARE phytosome holds promise as an applicable and favorable creation for drug delivery and lung cancer treatment.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11505992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular and Molecular Mechanisms of Hypertrophy of Ligamentum Flavum. 黄韧带肥大的细胞和分子机制

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-10 DOI: 10.3390/biom14101277

Prashanta Silwal, Allison M Nguyen-Thai, Peter G Alexander, Gwendolyn A Sowa, Nam V Vo, Joon Y Lee

{"title":"Cellular and Molecular Mechanisms of Hypertrophy of Ligamentum Flavum.","authors":"Prashanta Silwal, Allison M Nguyen-Thai, Peter G Alexander, Gwendolyn A Sowa, Nam V Vo, Joon Y Lee","doi":"10.3390/biom14101277","DOIUrl":"https://doi.org/10.3390/biom14101277","url":null,"abstract":"Hypertrophy of the ligamentum flavum (HLF) is a common contributor to lumbar spinal stenosis (LSS). Fibrosis is a core pathological factor of HLF resulting in degenerative LSS and associated low back pain. Although progress has been made in HLF research, the specific molecular mechanisms that promote HLF remain to be defined. The molecular factors involved in the onset of HLF include increases in inflammatory cytokines such as transforming growth factor (TGF)-β, matrix metalloproteinases, and pro-fibrotic growth factors. In this review, we discuss the current understanding of the mechanisms involved in HLF with a particular emphasis on aging and mechanical stress. We also discuss in detail how several pathomechanisms such as fibrosis, proliferation and apoptosis, macrophage infiltration, and autophagy, in addition to several molecular pathways involving TGF-β1, mitogen-activated protein kinase (MAPKs), and nuclear factor-κB (NF-κB) signaling, PI3K/AKT signaling, Wnt signaling, micro-RNAs, extracellular matrix proteins, reactive oxygen species (ROS), etc. are involved in fibrosis leading to HLF. We also present a summary of the current advancements in preclinical animal models for HLF research. In addition, we update the current and potential therapeutic targets/agents against HLF. An improved understanding of the molecular processes behind HLF and a novel animal model are key to developing effective LSS prevention and treatment strategies.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Thumbprints: Biological Signatures That Measure Loss of Identity. 分子拇指印：衡量身份丧失的生物特征。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-09 DOI: 10.3390/biom14101271

Pallavi R Devchand, Michael Dicay, John L Wallace

{"title":"Molecular Thumbprints: Biological Signatures That Measure Loss of Identity.","authors":"Pallavi R Devchand, Michael Dicay, John L Wallace","doi":"10.3390/biom14101271","DOIUrl":"https://doi.org/10.3390/biom14101271","url":null,"abstract":"Each life is challenged to adapt to an ever-changing environment with integrity-simply put, to maintain identity. We hypothesize that this mission statement of adaptive homeostasis is particularly poignant in an adaptive response, like inflammation. A maladaptive response of unresolved inflammation can seed chronic disease over a lifetime. We propose the concept of a molecular thumbprint: a biological signature of loss of identity as a measure of incomplete return to homeostasis after an inflammatory response. Over time, personal molecular thumbprints can measure dynamic and precise trajectories to chronic inflammatory diseases and further loss of self to cancer. Why is this important? Because the phenotypes and molecular signatures of established complex inflammatory diseases are a far cry from the root of the complex problem, let alone the initial seed. Understanding the science behind key germinating seeds of disease helps to identify molecular factors of susceptibility, resilience, and early dietary or drug intervention. We pilot this hypothesis in a rat colitis model that is well-established for understanding molecular mechanisms of colonic health, disease, and transition of colitis to cancer.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications. 细胞死亡调控中的丝裂噬：细胞死亡调控中的有丝分裂：机理和对疾病的影响。

IF 4.8 2区生物学

Biomolecules Pub Date : 2024-10-09 DOI: 10.3390/biom14101270

Jiani Lin, Xinyao Chen, Yuyang Du, Jiapeng Li, Tingting Guo, Sai Luo

{"title":"Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications.","authors":"Jiani Lin, Xinyao Chen, Yuyang Du, Jiapeng Li, Tingting Guo, Sai Luo","doi":"10.3390/biom14101270","DOIUrl":"https://doi.org/10.3390/biom14101270","url":null,"abstract":"Mitophagy, a selective form of autophagy, plays a crucial role in maintaining optimal mitochondrial populations, normal function, and intracellular homeostasis by monitoring and removing damaged or excess mitochondria. Furthermore, mitophagy promotes mitochondrial degradation via the lysosomal pathway, and not only eliminates damaged mitochondria but also regulates programmed cell death-associated genes, thus preventing cell death. The interaction between mitophagy and various forms of cell death has recently gained increasing attention in relation to the pathogenesis of clinical diseases, such as cancers and osteoarthritis, neurodegenerative, cardiovascular, and renal diseases. However, despite the abundant literature on this subject, there is a lack of understanding regarding the interaction between mitophagy and cell death. In this review, we discuss the main pathways of mitophagy, those related to cell death mechanisms (including apoptosis, ferroptosis, and pyroptosis), and the relationship between mitophagy and cell death uncovered in recent years. Our study offers potential directions for therapeutic intervention and disease diagnosis, and contributes to understanding the molecular mechanism of mitophagy.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0