ISRN oncology最新文献_第4页

The role of magnetic resonance imaging in preoperative planning for patients undergoing therapeutic mammoplasty. 磁共振成像在治疗性乳房整形术患者术前规划中的作用。

ISRN oncology Pub Date : 2013-12-17 DOI: 10.1155/2013/260260

Gareth Hicks, Philip Turton, Sree Rajan, April Nunn, Nisha Sharma, Raj Achuthan

{"title":"The role of magnetic resonance imaging in preoperative planning for patients undergoing therapeutic mammoplasty.","authors":"Gareth Hicks, Philip Turton, Sree Rajan, April Nunn, Nisha Sharma, Raj Achuthan","doi":"10.1155/2013/260260","DOIUrl":"10.1155/2013/260260","url":null,"abstract":"Background. Assessment of the ratio between tumour volume and breast volume in therapeutic mammoplasty is paramount. Traditionally based on clinical assessment and conventional breast imaging, the role of breast magnetic resonance imaging (MRI) in this context has not been established. Methods. Data was collected from all women undergoing therapeutic mammoplasty (TM) between 2006 and 2011. Each case was discussed at an MDT where MRI was considered to facilitate surgical planning. The contribution of MRI to disease assessment and surgical outcome was then reviewed. Results. 35 women underwent TM, 15 of whom had additional MRI. 33% of patients within the MRI subgroup had abnormalities not seen on either mammography or USS. Of those undergoing MRI, 1/15 patients required completion mastectomy versus 3 patients requiring completion mastectomy and 1 patient requiring further wide local excision (4/20) in the conventional imaging group. No statistical difference was seen between size on MRI and size on mammography versus final histological size, but a general trend for greater correlation between size on MRI and final histological size was seen. Conclusion. MRI should be considered in selected patients undergoing therapeutic mammoplasty. Careful planning can identify those who are most likely to benefit from MRI, potentially reducing the need for further surgery. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"260260"},"PeriodicalIF":0.0,"publicationDate":"2013-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32055541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and prognosis of paraneoplastic syndromes in hepatocellular carcinoma. 肝细胞癌副肿瘤综合征的流行病学及预后。

ISRN oncology Pub Date : 2013-12-11 eCollection Date: 2013-01-01 DOI: 10.1155/2013/684026

Pik Eu Chang, Wai Choung Ong, Hock Foong Lui, Chee Kiat Tan

{"title":"Epidemiology and prognosis of paraneoplastic syndromes in hepatocellular carcinoma.","authors":"Pik Eu Chang, Wai Choung Ong, Hock Foong Lui, Chee Kiat Tan","doi":"10.1155/2013/684026","DOIUrl":"https://doi.org/10.1155/2013/684026","url":null,"abstract":"Background. Paraneoplastic syndromes (PNS) such as hypercalcaemia, hypercholesterolaemia, and erythrocytosis have been described in hepatocellular carcinoma (HCC). Aims. (1) To examine the prevalence, clinical characteristics, and survival of PNS in HCC patients and (2) to evaluate the extent to which each individual PNS impacts on patient survival. Methods. We prospectively evaluated the prevalence, clinical characteristics, and survival of PNS among 457 consecutive HCC patients seen in our department over a 10-year period and compared them with HCC patients without PNS. Results. PNS were present in 127 patients (27.8%). The prevalence of paraneoplastic hypercholesterolemia, hypercalcemia, and erythrocytosis 24.5%, 5.3%, and 3.9%, respectively. Patients with PNS had significantly higher alpha-fetoprotein levels, more advanced TNM stage, and shorter survival. Among the individual PNS, hypercalcemia and hypercholesterolemia were associated with more advanced disease and reduced survival but not erythrocytosis. On multivariate analysis, the presence of PNS was not found to be an independent prognostic factor for reduced HCC survival. Conclusion. PNS are not uncommon in HCC and are associated with poor prognosis and reduced survival due to their association with increased tumor burden. However, they do not independently predict poor survival. Individual PNS impact differently on HCC outcome; paraneoplastic hypercalcemia in particular is associated with poor outcome. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"684026"},"PeriodicalIF":0.0,"publicationDate":"2013-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/684026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32005898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Differential prognostic indicators for locoregional recurrence, distant recurrence, and death of breast cancer. 乳腺癌局部复发、远处复发和死亡的鉴别预后指标

ISRN oncology Pub Date : 2013-11-26 eCollection Date: 2013-01-01 DOI: 10.1155/2013/946945

Rungnapa Chairat, Adisorn Puttisri, Asani Pamarapa, Jirause Moollaor, Chamaiporn Tawichasri, Jayanton Patumanond

{"title":"Differential prognostic indicators for locoregional recurrence, distant recurrence, and death of breast cancer.","authors":"Rungnapa Chairat, Adisorn Puttisri, Asani Pamarapa, Jirause Moollaor, Chamaiporn Tawichasri, Jayanton Patumanond","doi":"10.1155/2013/946945","DOIUrl":"https://doi.org/10.1155/2013/946945","url":null,"abstract":"Objective. To explore prognostic characteristics for locoregional recurrence, distant recurrence, and mortality in patients with breast cancer. Methods. A 5-year retrospective review of patients was conducted in two university affiliated hospitals in the north of Thailand. Prognostic characteristics and clinical outcomes were retrieved from medical registry. Death was verified by the civil database from the Ministry of Interior, direct telephone contact, or by prepaid postcard. Data were analyzed by stratified Cox's regression proposed by Lunn & McNeil, in which multiple-typed outcomes were analyzed in a single multivariable model. Results. The assembled cohort comprised 829 patients. Under the multivariable analysis, 7 prognostic characteristics were significant prognostic indicators. Positive axillary lymph nodes >3 and presence of lymphovascular invasion (LVI) increased locoregional recurrence, while disease stage 3, positive axillary lymph nodes >3, and radiotherapy increase distant recurrence. Hormonal therapy reduced the distant recurrence. Pathological tumor size >2 cm, disease stage 3, positive axillary lymph nodes >3, and presence of LVI increased, while hormonal therapy and chemotherapy reduced death. Conclusions. Clinical characteristic reflecting tumor invasions increased locoregional recurrence, distant recurrence, or death, while hormonal therapy and chemotherapy reduced such risks. The effect of radiation remained inconclusive but may increase the risk of distant recurrence. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"946945"},"PeriodicalIF":0.0,"publicationDate":"2013-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/946945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31988810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Chromosome aberrations in cells infected with bovine papillomavirus: comparing cutaneous papilloma, esophagus papilloma, and urinary bladder lesion cells. 牛乳头瘤病毒感染细胞中的染色体畸变:比较皮肤乳头瘤、食道乳头瘤和膀胱病变细胞。

ISRN oncology Pub Date : 2013-11-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/910849

S R C Campos, T C Melo, S Assaf, R P Araldi, J Mazzuchelli-de-Souza, M P Sircili, R F Carvalho, F Roperto, W Beçak, R C Stocco

{"title":"Chromosome aberrations in cells infected with bovine papillomavirus: comparing cutaneous papilloma, esophagus papilloma, and urinary bladder lesion cells.","authors":"S R C Campos, T C Melo, S Assaf, R P Araldi, J Mazzuchelli-de-Souza, M P Sircili, R F Carvalho, F Roperto, W Beçak, R C Stocco","doi":"10.1155/2013/910849","DOIUrl":"https://doi.org/10.1155/2013/910849","url":null,"abstract":"THE MAJORITY OF MALIGNANT CELLS PRESENT GENETIC INSTABILITY WITH CHROMOSOME NUMBER CHANGES PLUS SEGMENTAL DEFECTS: these changes involve intact chromosomes and breakage-induced alterations. Some pathways of chromosomal instability have been proposed as random breakage, telomere fusion, and centromere fission. Chromosome alterations in tumor cells have been described in animal models and in vitro experiments. One important question is about possible discrepancies between animal models, in vitro studies, and the real events in cancer cells in vivo. Papillomaviruses are relevant agents in oncogenic processes related to action on host genome. Recently, many reports have discussed the presence of virus DNA in peripheral blood, in humans and in animals infected by papillomaviruses. The meaning of this event is of controversy: possible product of apoptosis occurring in cancer cells, metastasized cancer cells, or active DNA sequences circulating in bloodstream. This study compares chromosome aberrations detected in bovine cells, in peripheral blood cells, and in BPV lesion cells: the literature is poor in this type of study. Comparing chromosome aberrations described in the different cells, a common mechanism in their origin, can be suggested. Furthermore blood cells can be evaluated as an effective way of virus transmission. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"910849"},"PeriodicalIF":0.0,"publicationDate":"2013-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/910849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31919643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins. 活化的Ras作为治疗靶点:直接靶向Ras亚型和野生型与突变蛋白的限制。

ISRN oncology Pub Date : 2013-10-31 eCollection Date: 2013-01-01 DOI: 10.1155/2013/536529

Raymond R Mattingly

{"title":"Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins.","authors":"Raymond R Mattingly","doi":"10.1155/2013/536529","DOIUrl":"https://doi.org/10.1155/2013/536529","url":null,"abstract":"The ability to selectively and directly target activated Ras would provide immense utility for treatment of the numerous cancers that are driven by oncogenic Ras mutations. Patients with disorders driven by overactivated wild-type Ras proteins, such as type 1 neurofibromatosis, might also benefit from progress made in that context. Activated Ras is an extremely challenging direct drug target due to the inherent difficulties in disrupting the protein:protein interactions that underlie its activation and function. Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. Likely reasons for this disappointing outcome include the significant and underappreciated differences in the isoforms of Ras. It is still plausible that inhibition of farnesyl transferase will prove effective for disease that is driven by activated H-Ras. The principal current focus of drugs entering clinic trial is inhibition of pathways downstream of activated Ras, for example, trametinib, a first-in-class MEK inhibitor. The complexity of signaling that is driven by activated Ras indicates that effective inhibition of oncogenic transduction through this approach will be difficult, with resistance being likely to emerge through switch to parallel pathways. Durable disease responses will probably require combinatorial block of several downstream targets. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"536529"},"PeriodicalIF":0.0,"publicationDate":"2013-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/536529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31917526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

The Chemokine CXCL8 in Carcinogenesis and Drug Response. 趋化因子CXCL8在癌变和药物反应中的作用。

ISRN oncology Pub Date : 2013-10-09 DOI: 10.1155/2013/859154

Dominique Gales, Clarence Clark, Upender Manne, Temesgen Samuel

{"title":"The Chemokine CXCL8 in Carcinogenesis and Drug Response.","authors":"Dominique Gales, Clarence Clark, Upender Manne, Temesgen Samuel","doi":"10.1155/2013/859154","DOIUrl":"https://doi.org/10.1155/2013/859154","url":null,"abstract":"Although the functions of chemokines in the regulation of immune processes have been studied in some detail, the role of these biomolecules in cancer is not fully understood. Chemokines mediate migration of immune cells and other functions related to immunity. They are also involved in oncogenesis and in tumor progression, invasion, and metastasis through mechanisms similar to their roles in immune functions. Various chemokines also promote cell proliferation and resistance to apoptosis of stressed cells. Consequently, chemokines and their receptors present potential therapeutic targets for anticancer drugs. The chemokine CXCL8, also known as interleukin-8 (IL8), is a proinflammatory molecule that has functions within the tumor microenvironment. Due to its potent angiogenic effects and the activity of the chemokine and its receptors in the promotion of invasion and metastasis, CXCL8 and its receptors are now considered as attractive targets for cancer therapy. This review relates the current understanding of the regulation, signaling, and functions of CXCL8 that contribute to tumor growth and metastasis, and of its role in drug response. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"859154"},"PeriodicalIF":0.0,"publicationDate":"2013-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/859154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31860016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 92

Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines. 锰基金属单体配合物对KG-1A和K562细胞系的抗白血病作用

ISRN oncology Pub Date : 2013-10-08 eCollection Date: 2013-01-01 DOI: 10.1155/2013/709269

Sandeep Kumar Dash, Sourav Chattopadhyay, Totan Ghosh, Satyajit Tripathy, Sabyasachi Das, Debasis Das, Somenath Roy

{"title":"Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines.","authors":"Sandeep Kumar Dash, Sourav Chattopadhyay, Totan Ghosh, Satyajit Tripathy, Sabyasachi Das, Debasis Das, Somenath Roy","doi":"10.1155/2013/709269","DOIUrl":"https://doi.org/10.1155/2013/709269","url":null,"abstract":"Transitional metals and metal compounds have been used in versatile platforms for biomedical applications and therapeutic intervention. Severe side effects of anticancer drugs produce an urgent urge to develop new classes of anticancer agents with great potency as well as selectivity. In this background, recent studies demonstrate that monomeric manganese (MnII) thiocyanate complex (MMTC) holds great promise to exert effective antileukemic effects. MMTC was developed by a simple chemical reaction and characterized by elemental analyses, thermal analyses, and Fourier transform infrared (FTIR) spectroscopy. Anti-leukemic efficacy of the developed MMTC was estimated in KG-1A (AML) and K562 (CML) cell lines. Cell viability study, drug uptake assay, cellular redox balance (GSH and GSSG level), nitric oxide (NO) release level, reactive oxygen species (ROS) formation, alteration of mitochondrial membrane potential (MMP), and DNA fragmentation revealed that MMTC was able to produce significant antiproliferative effects on both cell lines at 25 μ g mL(-1) without showing any toxicological impact on normal lymphocytes. These findings will enlighten the biomedical application of manganese-based metal complexes as anti-leukemic agents. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"709269"},"PeriodicalIF":0.0,"publicationDate":"2013-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/709269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

The Practice of Medical Oncology in Morocco: The National Study of the Moroccan Group of Trialist in Medical Oncology (EVA-Onco). 摩洛哥肿瘤医学实践:摩洛哥肿瘤医学试验组(EVA-Onco)的国家研究。

ISRN oncology Pub Date : 2013-10-08 eCollection Date: 2013-01-01 DOI: 10.1155/2013/341565

Saber Boutayeb, Amina Taleb, Rizlane Belbaraka, Nabil Ismaili, Narjiss Berrada, Wafa Allam, Halima Abahsain, Naoufal Mellas, Saif Afkir, Omar Mesbahi, Mohammed Ichou, Hassan Errihani

{"title":"The Practice of Medical Oncology in Morocco: The National Study of the Moroccan Group of Trialist in Medical Oncology (EVA-Onco).","authors":"Saber Boutayeb, Amina Taleb, Rizlane Belbaraka, Nabil Ismaili, Narjiss Berrada, Wafa Allam, Halima Abahsain, Naoufal Mellas, Saif Afkir, Omar Mesbahi, Mohammed Ichou, Hassan Errihani","doi":"10.1155/2013/341565","DOIUrl":"https://doi.org/10.1155/2013/341565","url":null,"abstract":"Objective. To determine the current shortfall of medical oncologists (MOs) and the projected supply. Background. Morocco, the medical oncology (MO) is a relatively new specialty. Medical oncology was recognized as a separate specialty in 1994 but the real taking-off was done only since the 2000s after the creation of the chair of medical oncology in the University of Rabat. The GRIOMM (Moroccan group of trialist in medical oncology) was created in 2011 and conducted its first study, EVA-onco, concerning the practice of medical oncology in Morocco in 2011. Design. EVA-onco is a prospective study concerning the practice of medical oncology in Morocco in 2011. Results. The entire public cancer centers completed the survey. There were no missing data. The number of medical oncologist per 100000/habitants in Morocco was 0.09. The average number of new patients seen per medical oncologist was 718 patients (ranging by state from 97 to 1875). The shortfall of MOs was estimated at 26 at least in 2011 according to the national recommendations. Conclusions. Since 2010, a national strategy to increase the capacity of MO workforce existed. The current shortfall of MO is expected to disappear in the future. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"341565"},"PeriodicalIF":0.0,"publicationDate":"2013-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/341565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Better survival with three-dimensional conformal radiotherapy than with conventional radiotherapy for cervical cancer: a population-based study. 宫颈癌三维适形放疗比传统放疗生存率更高:一项基于人群的研究。

ISRN oncology Pub Date : 2013-10-02 eCollection Date: 2013-01-01 DOI: 10.1155/2013/729819

Chen-Hsi Hsieh, Shiang-Jiun Tsai, Wen-Yen Chiou, Moon-Sing Lee, Hon-Yi Lin, Shih-Kai Hung

{"title":"Better survival with three-dimensional conformal radiotherapy than with conventional radiotherapy for cervical cancer: a population-based study.","authors":"Chen-Hsi Hsieh, Shiang-Jiun Tsai, Wen-Yen Chiou, Moon-Sing Lee, Hon-Yi Lin, Shih-Kai Hung","doi":"10.1155/2013/729819","DOIUrl":"https://doi.org/10.1155/2013/729819","url":null,"abstract":"Three-dimensional conformal radiation therapy (3DCRT) has emerged as a preferred treatment for gynecologic malignancies. Yet its superiority to conventional radiotherapy (2-dimensional radiotherapy (2DRT)) for gynecologic malignancies has not been well established. Data from the 2005 to 2010 National Health Insurance Research Database (NHIRD) provided by the National Research Institutes in Taiwan were analyzed to address this issue. Patients were initially diagnosed as having cervical cancer according to the International Classification of Disease, Ninth Revision, Clinical Modification (ICD-9-CM) code 180, and this clinical diagnosis was confirmed histopathologically or cytologically. Kaplan-Meier method and Cox proportional hazards regression were used to analyze the reported data. Between January 2005 and December 2010, there were 776 patients with newly diagnosed cervical cancer without metastasis, local recurrence, or surgical treatment before RT and 132 and 644 patients, respectively, who received 2DRT and 3DCRT. After adjustment for age, diabetes mellitus, hypertension, coronary heart disease, hyperlipidemia, side effects, urbanization level, geographic region, and enrollee category in the 5-year follow-up period, the HR was 1.82 (95% CI, 1.16-2.85, P = 0.009). The 5-year survival rate in the 2DRT and 3DCRT groups was 73.0% and 82.3%, P = 0.007, respectively. Cervical cancer patients treated with 3DCRT had better overall survival. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"729819"},"PeriodicalIF":0.0,"publicationDate":"2013-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/729819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of β -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity. 大豆皂苷通过抑制β -葡糖醛酸酶活性和异常隐窝灶数量而非环氧化酶-2活性来抑制大鼠结肠癌的进展。

ISRN oncology Pub Date : 2013-10-02 eCollection Date: 2013-01-01 DOI: 10.1155/2013/645817

Yu-Wei Guo, Yue-Hwa Chen, Wan-Chun Chiu, Hsiang Liao, Shyh-Hsiang Lin

{"title":"Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of β -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity.","authors":"Yu-Wei Guo, Yue-Hwa Chen, Wan-Chun Chiu, Hsiang Liao, Shyh-Hsiang Lin","doi":"10.1155/2013/645817","DOIUrl":"https://doi.org/10.1155/2013/645817","url":null,"abstract":"Objective. The effect of extracted crude soybean saponins on preneoplastic lesions, aberrant crypt foci (ACF), and the related mechanism were investigated. Research Methods and Procedures. Rats were assigned into five groups according to different doses of extracted crude soybean saponins and received 1,2-dimethylhydrazine (DMH) injection in week 5. In week 15, all rats were sacrificed. The number of ACFs, the cyclooxygenase-2 (COX-2) protein expression, the level of prostaglandins E2 (PGE2), and the activity of β -glucuronidase were examined. Results. Results revealed that the consumption of extracted crude soybean saponins decreased the number of ACFs and the activity of β -glucuronidase in rats, while the expression of COX-2 protein and PGE2 level were not affected. Conclusions. Soybean saponins were effective in inhibiting colon cancer by downregulating the activity of β -glucuronidase in colonic mucosa but not the COX-2 protein expression and PGE2 level. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"645817"},"PeriodicalIF":0.0,"publicationDate":"2013-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/645817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12