ISRN oncology最新文献_第5页

PKC ε Phosphorylates and Mediates the Cell Membrane Localization of RhoA. PKC ε磷酸化并介导RhoA的细胞膜定位。

ISRN oncology Pub Date : 2013-09-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/329063

Tizhi Su, Samuel Straight, Liwei Bao, Xiujie Xie, Caryn L Lehner, Greg S Cavey, Theodoros N Teknos, Quintin Pan

{"title":"PKC ε Phosphorylates and Mediates the Cell Membrane Localization of RhoA.","authors":"Tizhi Su, Samuel Straight, Liwei Bao, Xiujie Xie, Caryn L Lehner, Greg S Cavey, Theodoros N Teknos, Quintin Pan","doi":"10.1155/2013/329063","DOIUrl":"https://doi.org/10.1155/2013/329063","url":null,"abstract":"Protein kinase C ε (PKC ε ) signals through RhoA to modulate cell invasion and motility. In this study, the multifaceted interaction between PKC ε and RhoA was defined. Phosphopeptide mapping revealed that PKC ε phosphorylates RhoA at T127 and S188. Recombinant PKC ε bound to recombinant RhoA in the absence of ATP indicating that the association between PKC ε and RhoA does not require an active ATP-docked PKC ε conformation. Activation of PKC ε resulted in a dramatic coordinated translocation of PKC ε and RhoA from the cytoplasm to the cell membrane using time-lapse fluorescence microscopy. Stoichiometric FRET analysis revealed that the molecular interaction between PKC ε and RhoA is a biphasic event, an initial peak at the cytoplasm and a gradual prolonged increase at the cell membrane for the entire time-course (12.5 minutes). These results suggest that the PKC ε -RhoA complex is assembled in the cytoplasm and subsequently recruited to the cell membrane. Kinase inactive (K437R) PKC ε is able to recruit RhoA to the cell membrane indicating that the association between PKC ε and RhoA is proximal to the active catalytic site and perhaps independent of a PKC ε -RhoA phosphorylation event. This work demonstrates, for the first time, that PKC ε phosphorylates and modulates the cell membrane translocation of RhoA. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"329063"},"PeriodicalIF":0.0,"publicationDate":"2013-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/329063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31832148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evolving concepts: how diet and the intestinal microbiome act as modulators of breast malignancy. 不断演变的概念：饮食和肠道微生物群如何调节乳腺恶性肿瘤。

ISRN oncology Pub Date : 2013-09-25 DOI: 10.1155/2013/693920

Iuliana Shapira, Keith Sultan, Annette Lee, Emanuela Taioli

{"title":"Evolving concepts: how diet and the intestinal microbiome act as modulators of breast malignancy.","authors":"Iuliana Shapira, Keith Sultan, Annette Lee, Emanuela Taioli","doi":"10.1155/2013/693920","DOIUrl":"10.1155/2013/693920","url":null,"abstract":"The intestinal microbiome plays an important role in human physiology. Next-generation sequencing technologies, knockout and gnotobiotic mouse models, fecal transplant data and epidemiologic studies have accelerated our understanding of microbiome abnormalities seen in immune diseases and malignancies. Dysbiosis is the disturbed microbiome ecology secondary to external pressures such as host diseases, medications, diet and genetic conditions often leading to abnormalities of the host immune system. Specifically dysbiosis has been shown to lower circulating lymphocytes, and increase neutrophil to lymphocyte ratio, a finding which has been associated with a decreased survival in women with breast cancers. Dysbiosis also plays a role in the recycling of estrogens via the entero-hepatic circulation, increasing estrogenic potency in the host, which is another leading cause of breast malignancy. Non-modifiable factors such as age and genetic mutations disrupt the microbiome, but modifiable factors such as diet may also lead to profound disruptions as well. A better understanding of dietary factors and how they disrupt the microbiome may lead to beneficial nutritional interventions for breast cancer patients. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"693920"},"PeriodicalIF":0.0,"publicationDate":"2013-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31830794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive value of cystatin C in monitoring of B non-hodgkin lymphomas: relation to biochemical and clinical parameters. 胱抑素C在监测B型非霍奇金淋巴瘤中的预测价值:与生化和临床参数的关系。

ISRN oncology Pub Date : 2013-09-16 eCollection Date: 2013-01-01 DOI: 10.1155/2013/752792

A Softić, L Begić, A Halilbašić, T Vižin, J Kos

{"title":"The predictive value of cystatin C in monitoring of B non-hodgkin lymphomas: relation to biochemical and clinical parameters.","authors":"A Softić, L Begić, A Halilbašić, T Vižin, J Kos","doi":"10.1155/2013/752792","DOIUrl":"https://doi.org/10.1155/2013/752792","url":null,"abstract":"The predictive value of cystatin C as a marker of course of the disease has been evaluated. Fifty-two pairs of serum samples of patients with B non-Hodgkin lymphoma have been collected at the time of diagnosis and before fourth cycle of chemotherapy. The levels of cystatin C, CRP, β 2M, LDH, and IL-6 in samples have been measured, and clinical parameters of course of the disease (B symptoms, clinical stage, patients' age, and IPI) have been noted. In total patient's group cystatin C levels correlated with β 2M and IPI. In aggressive lymphomas, the inhibitor levels correlated with clinical stage of disease and were significantly higher in patients with elevated LDH activity. In aggressive nodal lymphomas its levels correlated with β 2M, IPI, and clinical stage of disease. The cystatin C level was significantly increased in total group of patients over 60 years old, while in particular types of lymphoma, no statistical significance has been obtained. Our results indicate that cystatin C should be taken into consideration in disease monitoring. However, we expect that the disease-free and overall survival analysis will give the definitive answer about the reliability of cystatin C as an indicator of course of aggressive lymphomas. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":" ","pages":"752792"},"PeriodicalIF":0.0,"publicationDate":"2013-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/752792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40273722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Evaluation of the benefit of routine intraoperative frozen section analysis of sentinel lymph nodes in breast cancer. 乳腺癌前哨淋巴结术中常规冰冻切片分析的效果评价。

ISRN oncology Pub Date : 2013-09-16 eCollection Date: 2013-01-01 DOI: 10.1155/2013/843793

C M T P Francissen, R F D van la Parra, A H Mulder, A M Bosch, W K de Roos

{"title":"Evaluation of the benefit of routine intraoperative frozen section analysis of sentinel lymph nodes in breast cancer.","authors":"C M T P Francissen, R F D van la Parra, A H Mulder, A M Bosch, W K de Roos","doi":"10.1155/2013/843793","DOIUrl":"https://doi.org/10.1155/2013/843793","url":null,"abstract":"Aims. Intraoperative analysis of the sentinel lymph node (SLN) by frozen section (FS) allows for immediate axillary lymph node dissection (ALND) in case of metastatic disease in patients with breast cancer. The aim of this study is to evaluate the benefit of intraoperative FS, with regard to false negative rate (FNR) and influence on operation time. Materials and Methods. Intraoperative analysis of the SLN by FS was performed on 628 patients between January 2005 and October 2009. Patients were retrospectively studied. Results. FS accurately predicted axillary status in 525 patients (83.6%). There were 78 true positive findings (12.4%), of which there are 66 macrometastases (84.6%), 2 false positive findings (0.3%), and 101 false negative findings (16.1%), of which there are 65 micrometastases and isolated tumour cells (64.4%) resulting in an FNR of 56.4%. Additional operation time of a secondary ALND after wide local excision and SLNB is 17 minutes, in case of ablative surgery 35 minutes. The SLN was negative in 449 patients (71.5%), making their scheduled operation time unnecessary. Conclusions. FS was associated with a high false negative rate (FNR) in our population, and the use of telepathology caused an increase in this rate. Only 12.4% of the patients benefited from intraoperative FS, as secondary ALND could be avoided, so FS may be indicated for a selected group of patients. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":" ","pages":"843793"},"PeriodicalIF":0.0,"publicationDate":"2013-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/843793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40273723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Radiographic parameters in predicting outcome of patients with hepatocellular carcinoma treated with yttrium-90 microsphere radioembolization. 放射学参数在预测肝细胞癌患者用钇-90微球放射栓塞治疗预后中的作用。

ISRN oncology Pub Date : 2013-09-15 eCollection Date: 2013-01-01 DOI: 10.1155/2013/538376

Mohamed E Salem, Nitin Jain, Gregory Dyson, Stephanie Taylor, Sherif M El-Refai, Minsig Choi, Anthony F Shields, Jeffery Critchfield, Philip A Philip

{"title":"Radiographic parameters in predicting outcome of patients with hepatocellular carcinoma treated with yttrium-90 microsphere radioembolization.","authors":"Mohamed E Salem, Nitin Jain, Gregory Dyson, Stephanie Taylor, Sherif M El-Refai, Minsig Choi, Anthony F Shields, Jeffery Critchfield, Philip A Philip","doi":"10.1155/2013/538376","DOIUrl":"https://doi.org/10.1155/2013/538376","url":null,"abstract":"Background. In patients with hepatocellular carcinoma, selection criteria for transarterial hepatic selective internal radiotherapy are imprecise. Additionally, radiographic parameters to predict outcome of transarterial hepatic selective internal radiotherapy have not been fully characterized. Patients and methods. Computed tomography (CT) scans of 23 patients with unresectable primary hepatocellular carcinoma before and after transarterial hepatic selective internal radiotherapy with yttrium-90 microspheres were retrospectively reviewed. Selected radiographic parameters were evaluated and correlated with progression-free survival and overall survival. Response to treatment was assessed with Response RECIST 1.1 and Morphology, Attenuation, Size, and Structure (MASS) criteria. Results. On the post-SIRT CT, 68% of tumors demonstrated decreased size (median decrease of 0.8 cm, P = 0.3); 64% had decreased attenuation (median decrease 5.7 HU, P = 0.06), and 48% demonstrated increased tumor necrosis (P < 0.001). RECIST-defined partial response was seen in 10% patients, stable disease in 80%, and 10% had disease progression. Median progression-free survival was 3.9 months (range, 3.3 to 7.3), and median overall survival was 11.2 months (7.1 to 31.1). Pretreatment lower hepatopulmonary shunt fraction, central hypervascularity, and well-defined tumor margins were associated with improved progression-free survival. Conclusion. In patients with unresectable hepatocellular carcinoma, pretreatment CT parameters may predict favorable response to SIRT and improve patient selection. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":" ","pages":"538376"},"PeriodicalIF":0.0,"publicationDate":"2013-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/538376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40274361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

From radical mastectomy to breast-conserving therapy and oncoplastic breast surgery: a narrative review comparing oncological result, cosmetic outcome, quality of life, and health economy. 从根治性乳房切除术到保乳治疗和乳房肿瘤整形手术:比较肿瘤结果、美容结果、生活质量和健康经济的叙述性回顾。

ISRN oncology Pub Date : 2013-09-12 DOI: 10.1155/2013/742462

Ahmad Kaviani, Nassim Sodagari, Sara Sheikhbahaei, Vahid Eslami, Nima Hafezi-Nejad, Amin Safavi, Maryam Noparast, Alfred Fitoussi

{"title":"From radical mastectomy to breast-conserving therapy and oncoplastic breast surgery: a narrative review comparing oncological result, cosmetic outcome, quality of life, and health economy.","authors":"Ahmad Kaviani, Nassim Sodagari, Sara Sheikhbahaei, Vahid Eslami, Nima Hafezi-Nejad, Amin Safavi, Maryam Noparast, Alfred Fitoussi","doi":"10.1155/2013/742462","DOIUrl":"https://doi.org/10.1155/2013/742462","url":null,"abstract":"Surgical management of breast cancer has evolved considerably over the last two decades. There has been a major shift toward less-invasive local treatments, from radical mastectomy to breast-conserving therapy (BCT) and oncoplastic breast surgery (OBS). In order to investigate the efficacy of each of the three abovementioned methods, a literature review was conducted for measurable outcomes including local recurrence, survival, cosmetic outcome, quality of life (QOL), and health economy. From the point of view of oncological result, there is no difference between mastectomy and BCT in local recurrence rate and survival. Long-term results for OBS are not available. The items assessed in the QOL sound a better score for OBS in comparison with mastectomy or BCT. OBS is also associated with a better cosmetic outcome. Although having low income seems to be associated with lower BCT and OBS utilization, prognosis of breast cancer is worse in these women as well. Thus, health economy is the matter that should be studied seriously. OBS is an innovative, progressive, and complicated subspeciality that lacks published randomized clinical trials comparing surgical techniques and objective measures of outcome, especially from oncologic and health economy points of view. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":" ","pages":"742462"},"PeriodicalIF":0.0,"publicationDate":"2013-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/742462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40273721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Beyond the limits of oxygen: effects of hypoxia in a hormone-independent prostate cancer cell line. 超越氧的限制:缺氧对激素不依赖型前列腺癌细胞系的影响。

ISRN oncology Pub Date : 2013-09-12 eCollection Date: 2013-01-01 DOI: 10.1155/2013/918207

A C Mamede, A M Abrantes, L Pedrosa, J E Casalta-Lopes, A S Pires, R J Teixo, A C Gonçalves, A B Sarmento-Ribeiro, C J Maia, M F Botelho

引用次数: 13

Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? RECIST标准在预测头颈部肿瘤诱导后化疗的病理反应方面存在局限性吗?

ISRN oncology Pub Date : 2013-09-11 eCollection Date: 2013-01-01 DOI: 10.1155/2013/259154

V Patil, V Noronha, A Joshi, Vamshi Muddu Krishna, S Juvekar, Gauri Pantvaidya, Pankaj Chaturvedi, D Chaukar, Supreeta Arya, Aswari Patil, B Bhosale, A Dongre, A K Dcruz, K Prabhash

{"title":"Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy?","authors":"V Patil, V Noronha, A Joshi, Vamshi Muddu Krishna, S Juvekar, Gauri Pantvaidya, Pankaj Chaturvedi, D Chaukar, Supreeta Arya, Aswari Patil, B Bhosale, A Dongre, A K Dcruz, K Prabhash","doi":"10.1155/2013/259154","DOIUrl":"https://doi.org/10.1155/2013/259154","url":null,"abstract":"This study studied the coorelation between radiological response to induction chemotherapy and acheivement of pCR or near pCR. It was a retrospective analysis in which all patients who received NACT from 2008 till april 2012 were subjected to inclusion criteria. Coorelation analysis was performed between CR + PR and acheivement of pCR or near pCR. Twenty four patients were identified.The primary site of tumor was oral cavity in 19 patients (79.2%), maxilla in 2 patients (4.2%), laryngopharynx in 2 patients (4.2%) and oropharynx in 1 patient (4.2%). The clinical stage was stage IVA in 16 patients ( 66.7%) and IVB in 8 patients (33.3%). The overall response rates ie a combination of CR and PR was seen in 11patients (45.8%). The pCR was seen in 15 patients (62.5%) and rest had near pCR. There was no linear coorelation between radiological size decrement and tumor response. On coorelation analysis the spearman correlation coefficent was −0.039 (P = 0.857). This suggest that presently used radiological response criterias for response assesment in head and neck cancers severly limit our ability to identify patients who would have pCR or near pCR.","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"259154"},"PeriodicalIF":0.0,"publicationDate":"2013-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/259154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31792472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis. UGT2B17 多态性与前列腺癌风险：一项元分析

ISRN oncology Pub Date : 2013-09-09 DOI: 10.1155/2013/465916

Marce-Amara Kpoghomou, Joella Eldie Soatiana, Fatch W Kalembo, Ghose Bishwajit, Wei Sheng

{"title":"UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis.","authors":"Marce-Amara Kpoghomou, Joella Eldie Soatiana, Fatch W Kalembo, Ghose Bishwajit, Wei Sheng","doi":"10.1155/2013/465916","DOIUrl":"10.1155/2013/465916","url":null,"abstract":"Objective. Recent studies on the association between uridine diphosphosglucuronosyltransferases (UGTs) 2B17 polymorphism and risk of prostate cancer (PCa) showed inconclusive results. To clarify this possible association, we conducted a meta-analysis of published studies. Methods. We searched the published literature from PubMed, Embase, Google Scholar, and China National Knowledge Infrastructure (CNKI). According to our inclusion criteria, studies that observed the association between UGT2B17 polymorphism and PCa risk were included. The principal outcome measure was the adjusted odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with UGT2B17 polymorphism. Results. A total of 6 studies with 7,029 subjects (3,839 cases and 3,190 controls) were eligible for inclusion in the meta-analysis. Overall, there was a significant association between UGT2B17 polymorphism and increased risk of prostate cancer (OR = 1.74, 95% CI 1.14-2.64, P < 0.001). Similar results were found in the subgroup analyses by ethnicity and types of controls. Conclusion. This meta-analysis demonstrates that UGT2B17 polymorphism is associated with prostate cancer susceptibility, and it contributes to the increased risk of prostate cancer. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"465916"},"PeriodicalIF":0.0,"publicationDate":"2013-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Midkine Mediates Intercellular Crosstalk between Drug-Resistant and Drug-Sensitive Neuroblastoma Cells In Vitro and In Vivo. 体外和体内Midkine介导耐药和药物敏感神经母细胞瘤细胞间的细胞间串扰。

ISRN oncology Pub Date : 2013-09-03 eCollection Date: 2013-01-01 DOI: 10.1155/2013/518637

Fei Chu, Jessica A Naiditch, Sandra Clark, Yi-Yong Qiu, Xin Zheng, Timothy B Lautz, Janette L Holub, Pauline M Chou, Michael Czurylo, Mary Beth Madonna

{"title":"Midkine Mediates Intercellular Crosstalk between Drug-Resistant and Drug-Sensitive Neuroblastoma Cells In Vitro and In Vivo.","authors":"Fei Chu, Jessica A Naiditch, Sandra Clark, Yi-Yong Qiu, Xin Zheng, Timothy B Lautz, Janette L Holub, Pauline M Chou, Michael Czurylo, Mary Beth Madonna","doi":"10.1155/2013/518637","DOIUrl":"https://doi.org/10.1155/2013/518637","url":null,"abstract":"Resistance to cytotoxic agents has long been known to be a major limitation in the treatment of human cancers. Although many mechanisms of drug resistance have been identified, chemotherapies targeting known mechanisms have failed to lead to effective reversal of drug resistance, suggesting that alternative mechanisms remain undiscovered. Previous work identified midkine (MK) as a novel putative survival molecule responsible for cytoprotective signaling between drug-resistant and drug-sensitive neuroblastoma, osteosarcoma and breast carcinoma cells in vitro. In the present study, we provide further in vitro and in vivo studies supporting the role of MK in neuroblastoma cytoprotection. MK overexpressing wild type neuroblastoma cells exhibit a cytoprotective effect on wild type cells when grown in a co-culture system, similar to that seen with doxorubicin resistant cells. siRNA knockdown of MK expression in doxorubicin resistant neuroblastoma and osteosarcoma cells ameliorates this protective effect. Overexpression of MK in wild type neuroblastoma cells leads to acquired drug resistance to doxorubicin and to the related drug etoposide. Mouse studies injecting various ratios of doxorubicin resistant or MK transfected cells with GFP transfected wild type cells confirm this cytoprotective effect in vivo. These findings provide additional evidence for the existence of intercellular cytoprotective signals mediated by MK which contribute to chemotherapy resistance in neuroblastoma. ","PeriodicalId":89399,"journal":{"name":"ISRN oncology","volume":"2013 ","pages":"518637"},"PeriodicalIF":0.0,"publicationDate":"2013-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/518637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31773000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7