ISRN gastroenterology最新文献_第6页

Colorectal cancer in northwestern iran. 伊朗西北部的结直肠癌。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-12 DOI: 10.5402/2012/968560

Rahim Mahmodlou, Payvand Mohammadi, Nariman Sepehrvand

{"title":"Colorectal cancer in northwestern iran.","authors":"Rahim Mahmodlou, Payvand Mohammadi, Nariman Sepehrvand","doi":"10.5402/2012/968560","DOIUrl":"https://doi.org/10.5402/2012/968560","url":null,"abstract":"Background. Colorectal cancer is the third most prevalent cancer worldwide, which is less common in the Middle East; its prevalence demonstrated to be 7 persons per 100,000 populations in Iran. In this study, we aimed to investigate the clinicopathologic features of CRC patients in West Azerbaijan province of Iran. Methods. In this crosssectional study, 546 patients who underwent surgical procedures with the pathologic diagnosis of colorectal cancer in both academic and private hospitals of Urmia were enrolled. Results. The mean age at diagnosis was 55.2 ± 11.5 years. 23% had an age lower than forty years old. Rectal bleeding (26%), abdominal pain (25%), and large bowel obstruction (23%) were three most common presenting symptoms. 26% of patients presented with acute abdomen. 95% of tumors were adenocarcinoma, 4% were lymphoma, and 1% was other rare tumors. Regarding the stage of cancer according to TNM staging system, 6% of patients were in stage I, followed by 37% in stage II, 33% in stage III, and 24% in stage IV. In 44.5% of patients, the tumor was located in rectum. Conclusion. In west Azerbaijan province of Iran, patients with colorectal cancer present in younger age and more advanced stages in comparison with the developed countries.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"968560"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/968560","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30735068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

In Crohn's Disease, Anti-TNF-α Treatment Changes the Balance between Mucosal IL-17, FOXP3, and CD4 Cells. 在克罗恩病中，抗tnf -α治疗改变粘膜IL-17、FOXP3和CD4细胞之间的平衡

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-14 DOI: 10.5402/2012/505432

Veera Hölttä, Taina Sipponen, Mia Westerholm-Ormio, Harri M Salo, Kaija-Leena Kolho, Martti Färkkilä, Erkki Savilahti, Outi Vaarala, Paula Klemetti

{"title":"In Crohn's Disease, Anti-TNF-α Treatment Changes the Balance between Mucosal IL-17, FOXP3, and CD4 Cells.","authors":"Veera Hölttä, Taina Sipponen, Mia Westerholm-Ormio, Harri M Salo, Kaija-Leena Kolho, Martti Färkkilä, Erkki Savilahti, Outi Vaarala, Paula Klemetti","doi":"10.5402/2012/505432","DOIUrl":"https://doi.org/10.5402/2012/505432","url":null,"abstract":"Aim. In Crohn's disease (CD), anti-TNF-α treatment is a potent medication. We aimed to characterize the effect of anti-TNF-α treatment on T effector and regulatory cells. Material and Methods. We studied T-effector and regulatory cells on cellular and mRNA levels in intestinal biopsy samples from 13 Crohn's disease patient. Biopsies were obtained at baseline and 3 months after anti-TNF-α treatment, and from 14 inflammation-free control subjects. Results. Patients had higher numbers of ileal IL-17(+) and forkhead box P3 (FOXP3)(+) cells than did control subjects, both before ( P ≤ 0.001 and P ≤ 0.05, resp.) and after the anti-TNF-α treatment (P ≤ 0.01, P ≤ 0.01). Intestinal interferon-γ and IL-17 mRNA expression was higher in Crohn's disease and remained elevated after anti-TNF-α treatment. The ratio of IL-17(+) cells to CD4(+) cells decreased (P ≤ 0.05) and compared to baseline the ratio of IL-17(+) cells to FOXP3(+) was lower after treatment (P ≤ 0.05). Conclusions. TNF-α-blocking agents improved intestinal balance between IL-17(+) T-effector and regulatory T cells, although intestinal IL-17 upregulation remained elevated.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"505432"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/505432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30750052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Lipid droplet binding of hepatitis C virus core protein genotype 3. 丙型肝炎病毒核心蛋白基因型3的脂滴结合。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-07-11 DOI: 10.5402/2012/176728

Guan Qiang, Ravi Jhaveri

引用次数: 8

Necrotizing enterocolitis in very low birth weight infants: a systemic review. 极低出生体重儿的坏死性小肠结肠炎:一项系统综述。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-09-10 DOI: 10.5402/2012/562594

Bhoomika K Patel, Jigna S Shah

引用次数: 67

CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11. CCN1通过整合素α11诱导食管鳞状细胞癌中β-Catenin易位

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-05-31 DOI: 10.5402/2012/207235

Jianyuan Chai, Cristina Modak, Yi Ouyang, Sing-Yung Wu, M Mazen Jamal

{"title":"CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11.","authors":"Jianyuan Chai, Cristina Modak, Yi Ouyang, Sing-Yung Wu, M Mazen Jamal","doi":"10.5402/2012/207235","DOIUrl":"https://doi.org/10.5402/2012/207235","url":null,"abstract":"Aims. Nuclear translocation of β-catenin is common in many cancers including esophageal squamous cell carcinoma (ESCC). As a mediator of Wnt signaling pathway, nuclear β-catenin can activate many growth-related genes including CCN1, which in turn can induce β-catenin translocation. CCN1, a matricellular protein, signals through various integrin receptors in a cell-dependent manner to regulate cell adhesion, proliferation, and survival. Its elevation has been reported in ESCC as well as other esophageal abnormalities such as Barrett's esophagus. The aim of this study is to examine the relationship between CCN1 and β-catenin in ESCC. Methods and Results. The expression and correlation between CCN1 and β-catenin in ESCC tissue were examined through immunohistochemistry and further analyzed in both normal esophageal epithelial cells and ESCC cells through microarray, functional blocking and in situ protein ligation. We found that nuclear translocation of β-catenin in ESCC cells required high level of CCN1 as knockdown of CCN1 in ESCC cells reduced β-catenin expression and translocation. Furthermore, we found that integrin α(11) was highly expressed in ESCC tumor tissue and functional blocking integrin α(11) diminished CCN1-induced β-catenin elevation and translocation. Conclusions. Integrin α(11) mediated the effect of CCN1 on β-catenin in esophageal epithelial cells.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"207235"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/207235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30693182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Helicobacter pylori Eradication Therapy: Current Availabilities. 幽门螺杆菌根除疗法:目前的可用性。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-07-29 DOI: 10.5402/2012/186734

M Gasparetto, M Pescarin, G Guariso

{"title":"Helicobacter pylori Eradication Therapy: Current Availabilities.","authors":"M Gasparetto, M Pescarin, G Guariso","doi":"10.5402/2012/186734","DOIUrl":"https://doi.org/10.5402/2012/186734","url":null,"abstract":"Background. Though Helicobacter pylori (HP) infections have progressively declined throughout most of the industrialized countries, a gradual increase in failure of HP eradication treatments is observed. Aim. To critically review evidence on the efficacy of the therapeutic availabilities for HP eradication, as yet. Methods. A selection of Clinical Trials, Systematic Reviews and Meta-analyses within the time period 2010-2012, was performed through a Medline search. Previous references were included when basically supporting the first selection. Results. An increasing rise in HP resistance rates for antimicrobial agents is currently observed. Further causes of HP treatment failure include polymorphisms of the CYP 2C19, an increased body mass index (BMI), smoking, poor compliance and re-infections. Alternative recent approaches to standard triple therapy have been attempted to increase the eradication rate, including bismuth-containing quadruple therapy, non-bismuth containing quadruple therapy, sequential therapy and levofloxacin-containing regimens. Conclusions. The main current aims should be the maintenance of a high eradication rate (>85%) of HP and the prevention of any increase in antimicrobial resistance. In the next future, the perspective of a tailored therapy could optimize eradication regimens within the different countries.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"186734"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/186734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30840219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Thyroid and Hepatic Haemodynamic Alterations among Egyptian Children with Liver Cirrhosis. 埃及肝硬化儿童甲状腺和肝脏血流动力学的改变。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-07-30 DOI: 10.5402/2012/595734

Zeinab A El-Kabbany, Rasha T Hamza, Ahmed S Abd El Hakim, Lamis M Tawfik

{"title":"Thyroid and Hepatic Haemodynamic Alterations among Egyptian Children with Liver Cirrhosis.","authors":"Zeinab A El-Kabbany, Rasha T Hamza, Ahmed S Abd El Hakim, Lamis M Tawfik","doi":"10.5402/2012/595734","DOIUrl":"https://doi.org/10.5402/2012/595734","url":null,"abstract":"Background. Alterations in thyroid hormones regulation and metabolism are frequently observed in patients with cirrhosis. Aims. To assess alterations in thyroid volume (TV), haemodynamics, and hormones in patients with cirrhosis and their relation to hepatic arterial haemodynamics, and disease severity. Methods. Forty cirrhotic patients were compared to 30 healthy subjects regarding TV, free triiodiothyronine (fT(3)), free tetraiodothyronine (fT(4)), thyroid stimulating hormone (TSH), and pulsatility and resistance indices in the inferior thyroid and hepatic arteries. Results. TV (P = 0.042), thyroid volume standard deviation score (TVSDS, P = 0.001), Inferior Thyroid Artery Pulsatility Index (ITAPI, P = 0.001), Inferior Thyroid Artery Resistance Index (ITARI, P = 0.041), Hepatic Artery Pulsatility Index (HAPI, P = 0.029) and Hepatic Artery Resistance Index (HARI, P = 0.035) were higher among cases being highest in Child-C patients. FT(3) was lower in patients than controls (P = 0.001) and correlated negatively with ITAPI (r = -0.71, P = 0.021) and ITARI (r = -0.79, P = 0.011). ITAPI and ITARI correlated directly with HAPI and HARI (r = 0.62, P = 0.03, and r = 0.42, P = 0.04, resp.). Conclusions. Thyroid is involved in the haemodynamic alterations of cirrhosis. Routine study of thyroid by Doppler and assessment of thyroid functions should be performed in patients with cirrhosis to offer proper treatment if needed.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"595734"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/595734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30856178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents. COX2和p53在十二指肠内容物反流诱导大鼠食管癌中的表达

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-01-05 DOI: 10.5402/2012/914824

Naoki Hashimoto

{"title":"Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents.","authors":"Naoki Hashimoto","doi":"10.5402/2012/914824","DOIUrl":"https://doi.org/10.5402/2012/914824","url":null,"abstract":"Aim. Reflux of duodenal contents can induce mucosal injury, stimulate cell proliferation, and promote tumorigenesis. We examined the expression of COX2 and p53 in rat esophageal lesions induced by duodenal content reflux. Methods. Thirty 8-week-old male Wistar rats were exposed to duodenal content esophageal reflux. All animals underwent an esophagoduodenal anastomosis (EDA) with total gastrectomy in order to produce chronic esophagitis. Ten rats were the sham. Control. They were sacrificed at the 40th week. Their esophagi were examined for HE, COX2, p53, and proliferating cell nuclear antigen (PCNA). Results. After 40 weeks of reflux, dysplasia, squamous cell carcinoma (SCC), and adenocarcinoma (ADC) were found. PCNA labeling index was higher in dysplastic and cancer tissue than that in normal. Overexpression of COX2 was shown in ADC and SCC. Wild-type p53 accumulation was found in ADC, and not in SCC. Conclusion. Reflux of duodenal contents into the esophagus led to ADC and SCC in rats. COX2 may play an important role in esophageal cancer by duodenal content reflux. Our present results suggest an association between wild-type p53 accumulation and COX2 expression in ADC, with no such relation seen in SCC.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"914824"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/914824","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30408654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Primary sclerosing cholangitis associated with elevated immunoglobulin-g4: a preliminary study. 原发性硬化性胆管炎与免疫球蛋白g4升高相关的初步研究

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-09-04 DOI: 10.5402/2012/325743

Baran Parhizkar, Amir Houshang Mohammad Alizadeh, Hamid Asadzadeh Aghdaee, Habib Malekpour, Amir Hossein Entezari

{"title":"Primary sclerosing cholangitis associated with elevated immunoglobulin-g4: a preliminary study.","authors":"Baran Parhizkar, Amir Houshang Mohammad Alizadeh, Hamid Asadzadeh Aghdaee, Habib Malekpour, Amir Hossein Entezari","doi":"10.5402/2012/325743","DOIUrl":"https://doi.org/10.5402/2012/325743","url":null,"abstract":"Background. Immunoglobulin IgG4-associated cholangitis (IAC) disease is a systemic disease histologically characterized by extensive T lymphocytes and IgG4 positive plasma cell infiltration in various organs. Prevalence of IAC in PSC patients was reported to be between 7% and 11.6% in a few previous studies. This study was carried out to evaluate frequency of serum IgG4 level in PSC patient referred to the gastroenterology ward of Taleghani educational hospital in Tehran, Iran. Material and Methods. This study was a prospective analytical cross-sectional study. Clinical presentation, laboratory values, imaging changes, inflammatory bowel disease (IBD), esophageal varices, ascites, and child score in newly PSC patients with elevated IgG4 were determined and compared with PSC patients with normal levels of IgG4. Data was analyzed by using SPSS software. The frequency and standard deviations were calculated. Differences among groups were evaluated by using the chi-square, fisher exact, and Mann-Whitney U tests. Results. 34 patients with PSC were examined in the study period, of which 9 cases (26.5%) had high IgG4 levels. Most of the patients were male, 23 cases (67.6%) and nonsmoker, 26 cases (76.5%). Patient average age was 47 years old (range 21-67 years). There was not any significant relationship among patients with IAC and PSC patients in terms of variables such as age, smoking, presence of IBD, ascites, esophageal varices, child score, and imaging findings (P > 0.05). Conclusion. IAC should be suspected in cases of unexplained biliary strictures with increased serum IgG4. Testing PSC patients for IgG4 and treating those who have high levels with corticosteroids in clinical trials should be considered in future studies.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"325743"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/325743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30913809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Current trends in the management of gastroesophageal reflux disease: a review. 当前胃食管反流病的治疗趋势综述。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-07-11 DOI: 10.5402/2012/391631

Sylvester Chuks Nwokediuko

{"title":"Current trends in the management of gastroesophageal reflux disease: a review.","authors":"Sylvester Chuks Nwokediuko","doi":"10.5402/2012/391631","DOIUrl":"https://doi.org/10.5402/2012/391631","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is a chronic disorder of the upper gastrointestinal tract with global distribution. The incidence is on the increase in different parts of the world. In the last 30 to 40 years, research findings have given rise to a more robust understanding of its pathophysiology, clinical presentation, and management. The current definition of GERD (The Montreal definition, 2006) is not only symptom-based and patient-driven, but also encompasses esophageal and extraesophageal manifestations of the disease. The implication is that the disease can be confidently diagnosed based on symptoms alone. Nonerosive reflux disease (NERD) remains the predominant form of GERD. Current thinking is that NERD and erosive reflux disease (ERD) are distinct phenotypes of GERD rather than the old concept which regarded them as components of a disease spectrum. Non erosive reflux disease is a very heterogeneous group with significant overlap with other functional gastrointestinal disorders. There is no gold standard for the diagnosis of GERD. Esophageal pH monitoring and intraluminal impedance monitoring have thrown some light on the heterogeneity of NERD. A substantial proportion of GERD patients continue to have symptoms despite optimal PPI therapy, and this has necessitated research into the development of new drugs. Several safety concerns have been raised about chronic use of proton pump inhibitors but these are yet to be substantiated in controlled studies. The debate about efficacy of long-term medical treatment compared to surgery continues, however, recent data indicate that modern surgical techniques and long-term PPI therapy have comparable efficacy. These and other issues are subjects of further research.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"391631"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/391631","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75