ISRN gastroenterology最新文献_第10页

DNase1: No Association with Crohn's Disease in a New Zealand Population. dna e1:新西兰人群与克罗恩病无关联

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-04 DOI: 10.5402/2012/826323

Angharad R Morgan, Wen-Jiun Lam, Dug-Yeo Han, Alan G Fraser, Lynnette R Ferguson

引用次数: 1

Eosinophilic gastrointestinal diseases: review and update. 嗜酸性粒细胞性胃肠道疾病:综述与最新进展。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-25 DOI: 10.5402/2012/463689

Mahreema Jawairia, Ghulamullah Shahzad, Paul Mustacchia

引用次数: 32

Virologic Outcome of Using Tenofovir/Emtricitabine to Treat Hepatitis B in HIV-Coinfected Patients. 替诺福韦/恩曲他滨治疗hiv合并感染患者乙型肝炎的病毒学结果

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2011-06-13 DOI: 10.5402/2011/405390

Christian A Engell, Vinh Philip Pham, Robert S Holzman, Judith A Aberg

{"title":"Virologic Outcome of Using Tenofovir/Emtricitabine to Treat Hepatitis B in HIV-Coinfected Patients.","authors":"Christian A Engell, Vinh Philip Pham, Robert S Holzman, Judith A Aberg","doi":"10.5402/2011/405390","DOIUrl":"https://doi.org/10.5402/2011/405390","url":null,"abstract":"Goal. To study the effect of combination antiviral therapy with tenofovir and emtricitabine or lamivudine with and without prior monotherapy with lamivudine. Study. We reviewed charts of 31 HIV-/HBV-coinfected patients. Twelve 3TC-naïve patients initially received tenofovir plus emtricitabine. Nineteen epivir experienced patients who had previously failed epivir were given tenofovir plus emtricitabine. Results. Baseline median HBV DNA was similar in the epivir-naïve (5.8×10(7) copies/mL) and experienced group (7.3×10(7) copies/mL, P = .65). The median time to complete suppression of HBV was 466 days in the naïve group and 877 days in the experienced (P = .001). After 12 months, 6/10 (60%) naïve patients and 3/14 (21%) experienced patients had HBV DNA below the detectionlimit (P = .067). After 24 months, 5/5 (100%) naïve patients and 4/13 (31%) experienced patients had an undetectable HBV DNA level (P = .015). Conclusions. The median time to suppression of HBV DNA was significantly shorter among treatment naïve patients. There was a significantly greater proportion of naïve patients with suppressed HBV DNA at 24 months. Our results support using initial dual therapy in those with HIV/HBV coinfection.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"405390"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/405390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30057446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Barrett's Esophagus in an Area with an Exceptionally Low Prevalence of Helicobacter pylori Infection. Barrett食管幽门螺杆菌感染发生率极低的地区。

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2011-06-26 DOI: 10.5402/2011/394734

Yeong Yeh Lee, Sharifah Emilia Tuan Sharif, Syed Hassan Syed Abd Aziz, S Mahendra Raj

引用次数: 10

Long-term followup with evaluation of the surgical and functional results of the ileal pouch reservoir in restorative proctocolectomy for ulcerative colitis. 溃疡性结肠炎恢复性直结肠切除术中回肠袋贮液的手术和功能效果的长期随访评价。

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2011-06-16 DOI: 10.5402/2011/625842

Ola Røkke, Knut Iversen, Torill Olsen, Sølvi-Mai Ristesund, Geir Egil Eide, Gitta Erika Turowski

{"title":"Long-term followup with evaluation of the surgical and functional results of the ileal pouch reservoir in restorative proctocolectomy for ulcerative colitis.","authors":"Ola Røkke, Knut Iversen, Torill Olsen, Sølvi-Mai Ristesund, Geir Egil Eide, Gitta Erika Turowski","doi":"10.5402/2011/625842","DOIUrl":"https://doi.org/10.5402/2011/625842","url":null,"abstract":"Aims. Evaluate the early and long term surgical and functional results of the ileal pouch-reservoir (IPAA) in patients with intractable ulcerative colitis. Material and Methods. Followup of 134 consecutive patients with W-or J-ileal pouch by diseases-specific and general health (SF-36) questionnaire. In the first 44 patients, early and late followup was performed. Results. Followup was performed 7.4 years (0.5-17 years) after construction of W (n = 9) and J (n = 125) ileal pouch, which had similar results. There were 14.9% early and 43.6% late complications with 12.7% early and 19.5% late reoperations. Protecting loop-ileostomy used in 54 patients (43.9%), did not protect against complications. Thirteen reservoirs (9.8%) were resected (n = 8) or deactivated (n = 5) due to functional failure. Operation time, postoperative complications and pouchitis were determinators for reservoir failure and reduced quality of life. The functional results at followup of 44 patients at 2.5 years (0.8-6.7 years) and 11.5 years (8.2-19.2 years) were remarkably similar. Conclusions. IPAA is a good option for most patients when medication fails. 10% experience failure with inferior quality of life. Protective stoma will not reduce failure rates. After an initial time period, reservoir function will not change over time.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"625842"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/625842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30200408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Diagnosis and therapy of microscopic colitis with presence of foamy macrophages in children. 儿童出现泡沫巨噬细胞的微小结肠炎的诊断和治疗。

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2011-07-06 DOI: 10.5402/2011/756292

Jan Józefczuk, Bogdan Marian Woźniewicz

{"title":"Diagnosis and therapy of microscopic colitis with presence of foamy macrophages in children.","authors":"Jan Józefczuk, Bogdan Marian Woźniewicz","doi":"10.5402/2011/756292","DOIUrl":"10.5402/2011/756292","url":null,"abstract":"We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of microscopic colitis with presence of foamy macrophages. A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin and eosin-stained specimens collected from the large intestine, reviewed under ×200 or ×320 magnification. No statistically significant improvement was found following the use of 5-amino-2-dihydroxybenzoic acid in therapy of the disease. The use of Saccharomyces boulardii was associated with statistically significant improvement in clinical, endoscopic, and histopathological condition. Use of magnesium caused a histological, statistically significant improvement but failed to have any effect on the clinical and endoscopic presentation. In the group of children in whom no therapeutic intervention was provided, a statistically significant spontaneous clinical improvement was observed, but no statistically significant changes in endoscopic and microscopic condition were found.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"756292"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30200921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of amlodipine alone and in combination with atenolol on bowel habit in patients with hypertension: an observation. 氨氯地平单用与阿替洛尔联用对高血压患者排便习惯的影响。

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2010-11-07 DOI: 10.5402/2011/757141

Lekha Saha, Chander Shekhar Gautam

{"title":"The effect of amlodipine alone and in combination with atenolol on bowel habit in patients with hypertension: an observation.","authors":"Lekha Saha, Chander Shekhar Gautam","doi":"10.5402/2011/757141","DOIUrl":"https://doi.org/10.5402/2011/757141","url":null,"abstract":"The prevalence of hypertension increases with advancing age. The management of hypertension especially in the elderly has its own limitations. Verapamil is not recommended in the elderly on account of high incidences of troublesome constipation. Amlodipine has become very popular with the cardiologists and general physicians. Survey of literature has not yielded any citation where the troublesome effect of amlodipine on the gastrointestinal tract has been reported. In an experimental study on isolated rabbit intestine we have demonstrated that amlodipine dose-dependently inhibit the spontaneous activity of the intestinal tract. With this background the present observational study was planned. A total of 100 hypertensive patients were included in the present study. Fifty patients were on amlodipine alone and 50 patients on combination of amlodipine and atenolol. The main parameter analyzed was the frequency and consistency of stool before and after intake of drug. The relative risk (RR) of developing constipation was 4.00 with 95% CI 0.8930 to 17.917 in amlodipine alone group. From this study it can be concluded that the relative risk of developing constipation is 4 times more in patients who are taking amlodipine alone as compared to those patients who are on combination of amlodipine and atenolol.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"757141"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/757141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30200922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Esophagitis in children with celiac disease. 乳糜泻患儿的食管炎

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2011-07-13 DOI: 10.5402/2011/489065

Wael N Sayej, Razan Alkhouri, Robert D Baker, Raza Patel, Susan S Baker

{"title":"Esophagitis in children with celiac disease.","authors":"Wael N Sayej, Razan Alkhouri, Robert D Baker, Raza Patel, Susan S Baker","doi":"10.5402/2011/489065","DOIUrl":"https://doi.org/10.5402/2011/489065","url":null,"abstract":"Objectives. To our knowledge, the occurrence of esophagitis in children with celiac disease (CD) has never been evaluated. The aim of this study is to determine the prevalence of esophagitis in children with CD. Patients and Methods. Between 2003 and 2007, children with biopsy confirmed CD were retrospectively identified. Biopsy reports were reviewed for esophageal inflammation. Biopsy reports of 2218 endoscopies performed during the same period were also evaluated for inflammation. Results. Forty-nine children diagnosed with CD (47% boys). Nineteen of 49 (39%) patients with CD had esophagitis (95% CI 0.23-0.5). Thirty percent of boys and 46% of girls with CD had esophagitis (95% CI 0.12-0.40). Overall, 45% of patients who underwent upper endoscopy had esophagitis. The prevalence of esophagitis in CD (39%) compared to the prevalence of esophagitis (45%) in our practice was not significantly different, P = 0.2526. Conclusion. There was no difference in the prevalence of esophagitis between children diagnosed with CD at the time of their diagnostic EGD and the prevalence of esophagitis in children without CD. A prospective study to determine whether the esophagitis should be treated with acid suppression or whether the esophagitis heals with the gluten-free diet is warranted.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"489065"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/489065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30202761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Registration of health-related quality of life in a cohort of patients undergoing cholecystectomy. 一组胆囊切除术患者健康相关生活质量的登记

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2011-06-21 DOI: 10.5402/2011/507389

Simon Henry Pålsson, Ib Rasmussen, Patrik Lundström, Johanna Osterberg, Gabriel Sandblom

{"title":"Registration of health-related quality of life in a cohort of patients undergoing cholecystectomy.","authors":"Simon Henry Pålsson, Ib Rasmussen, Patrik Lundström, Johanna Osterberg, Gabriel Sandblom","doi":"10.5402/2011/507389","DOIUrl":"https://doi.org/10.5402/2011/507389","url":null,"abstract":"Background. Assessment of gallstone surgery's impact on quality of life (QoL) requires a reliable instrument with sufficient responsiveness. The instrument should also enable estimation of each individual's expected condition in an unaffected state. Materials and Methods. The Swedish Register for Gallstone Surgery and ERCP (GallRiks) registers indications, complications, results, and QoL-outcome of gallstone surgery. In 2008, 68 hospitals were registered in GallRiks. Between 2007 and 2008, SF-36 (a short form health survey) was filled in 1-2 weeks pre- and 6-9 months postoperatively at five of the units. Expected scores were determined from an age- and gender-matched Swedish population (AGMSP). Results. Of the 330 patients, 212 responded to SF36 pre- and postoperatively (RR = 64%; 212/330). Standardized response means ranged from 0.20 to 0.93 for the SF-36 subscores. Highest responsiveness was seen for bodily pain. Preoperatively, all subscores were significantly lower than in the AGMSP (all P < .05). Six months postoperatively, there was no significant difference between any of the observed and expected quality of life subscales. Conclusion. SF-36 is a useful instrument for measuring the impact of gallstone surgery on QoL. The postinterventional health status equalled or even exceeded the AGMSP for all subscales.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"507389"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/507389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30202762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life. 芦荟对肠易激综合征患者的随机、交叉、安慰剂对照研究：对患者生活质量的影响

ISRN gastroenterology Pub Date : 2011-01-01 Epub Date: 2010-10-11 DOI: 10.5402/2011/206103

H A Hutchings, K Wareham, J N Baxter, P Atherton, J G C Kingham, P Duane, L Thomas, M Thomas, C L Ch'ng, J G Williams

{"title":"A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Patient Quality of Life.","authors":"H A Hutchings, K Wareham, J N Baxter, P Atherton, J G C Kingham, P Duane, L Thomas, M Thomas, C L Ch'ng, J G Williams","doi":"10.5402/2011/206103","DOIUrl":"10.5402/2011/206103","url":null,"abstract":"Background. Irritable bowel syndrome (IBS) is a chronic, difficult to treat condition. The efficacy of Aloe vera in treating IBS symptoms is not yet proven. The purpose of this study was to determine if Aloe vera is effective in improving quality of life. Methods. A multicentre, randomised, double-blind, cross-over placebo controlled study design. Patients were randomised to Aloe vera, wash-out, placebo or placebo, washout, Aloe vera. Each preparation (60 mL) was taken orally twice a day. Patient quality of life was measured using the Gastrointestinal Symptoms Rating Score, Irritable Bowel Syndrome Quality of Life, EuroQol and the Short-Form-12 at baseline and treatment periods 1 and 2. Results. A total of 110 patients were randomised, but only 47 completed all questionnaires and both study arms. Statistical analysis showed no difference between the placebo and Aloe vera treatment in quality of life. Discussion. This study was unable to show that Aloe vera was superior to placebo in improving quality of life. Drop outs and other confounding factors may have impacted on the power of the study to detect a clinically important difference. Conclusion. This study failed to find Aloe vera superior to placebo in improving quality of life proven Irritable Bowel Syndrome patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2011 ","pages":"206103"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30056914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0