Angharad R Morgan, Wen-Jiun Lam, Dug-Yeo Han, Alan G Fraser, Lynnette R Ferguson
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引用次数: 1
Abstract
DNase1 has been implicated in a number of immune disorders and is an excellent candidate gene for Crohn's disease (CD). We investigated whether DNase1 SNPs rs1053874 and rs8176938 were associated with CD in a well-characterized New Zealand dataset consisting of 447 cases and 716 controls. Furthermore, we measured serum DNase1 activity levels in a number of CD patients and controls. We did not find any evidence of association for either DNase1 genetic variation or DNase1 activity levels with CD. The lack of association indicates that DNase1 does not play a significant role in predisposing to CD in the New Zealand population.
DNase1与许多免疫疾病有关，是克罗恩病(CD)的优秀候选基因。我们在一个由447例病例和716例对照组成的特征良好的新西兰数据集中研究了DNase1 snp rs1053874和rs8176938是否与CD相关。此外，我们测量了许多乳糜泻患者和对照组的血清DNase1活性水平。我们没有发现DNase1遗传变异或DNase1活性水平与CD相关的任何证据。缺乏相关性表明DNase1在新西兰人群中对CD易感性没有显著作用。
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