ISRN gastroenterology最新文献_第5页

Esophageal sarcoidosis: a review of cases and an update. 食道结节病:病例回顾及最新进展。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-03-05 DOI: 10.1155/2013/836203

Albin Abraham, Rabab Hajar, Ravi Virdi, Jaspreet Singh, Paul Mustacchia

引用次数: 22

Changes in plasma ghrelin and serum leptin levels after Cisplatin-based transcatheter arterial infusion chemotherapy for hepatocellular carcinoma. 以顺铂为基础的肝细胞癌经导管动脉输注化疗后血浆胃饥饿素和血清瘦素水平的变化。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-03-07 DOI: 10.1155/2013/415450

Tomoaki Matsumura, Makoto Arai, Masaharu Yoshikawa, Kentaro Sudo, Kazuyoshi Nakamura, Tatsuro Katsuno, Fumihiko Kanai, Taketo Yamaguchi, Osamu Yokosuka

{"title":"Changes in plasma ghrelin and serum leptin levels after Cisplatin-based transcatheter arterial infusion chemotherapy for hepatocellular carcinoma.","authors":"Tomoaki Matsumura, Makoto Arai, Masaharu Yoshikawa, Kentaro Sudo, Kazuyoshi Nakamura, Tatsuro Katsuno, Fumihiko Kanai, Taketo Yamaguchi, Osamu Yokosuka","doi":"10.1155/2013/415450","DOIUrl":"https://doi.org/10.1155/2013/415450","url":null,"abstract":"Background and Objective. Cisplatin-based chemotherapy is widely recognized to cause severe gastrointestinal disorders like nausea, vomiting, and appetite loss. The aim of this study was to assess whether cisplatin-based transcatheter arterial infusion (TAI) chemotherapy reduces plasma ghrelin levels and food intake in hepatocellular carcinoma (HCC) patients. Methods. Seventeen patients with HCC who underwent cisplatin-based TAI chemotherapy (80-100 mg/body) were enrolled in this study. Changes in peptide hormones, including ghrelin and leptin, as well as cytokines, were measured before and after chemotherapy. Appetite was evaluated by visual analog scale (VAS) and food intake was scored by eleven stages (0-10). Results. Appetite and food intake were significantly decreased after chemotherapy (P < 0.05). Plasma acylated ghrelin levels before therapy and at day 1, day 7, and day 14 after chemotherapy were 10.4 ± 7.2, 4.7 ± 4.7, 11.7 ± 8.9, and 9.3 ± 6.6 fmol/mL, respectively. The level on day 1 was decreased significantly (P < 0.05). In contrast, the levels of leptin, granulocyte colony-stimulating factor (G-CSF), and monocyte chemotactic protein-1 (MCP-1) on day 1 were increased significantly (P < 0.05). Conclusions. TAI for HCC reduced plasma acylated ghrelin levels, appetite, and food intake significantly. In addition, it increased serum leptin levels.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":" ","pages":"415450"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/415450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Gastroesophageal reflux in critically ill children: a review. 危重儿童胃食管反流的研究进展

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-01-31 DOI: 10.1155/2013/824320

Maria José Solana García, Jesús López-Herce Cid, César Sánchez Sánchez

{"title":"Gastroesophageal reflux in critically ill children: a review.","authors":"Maria José Solana García, Jesús López-Herce Cid, César Sánchez Sánchez","doi":"10.1155/2013/824320","DOIUrl":"https://doi.org/10.1155/2013/824320","url":null,"abstract":"Gastroesophageal reflux (GER) is very common in children due to immaturity of the antireflux barrier. In critically ill patients there is also a high incidence due to a partial or complete loss of pressure of the lower esophageal sphincter though other factors, such as the use of nasogastric tubes, treatment with adrenergic agonists, bronchodilators, or opiates and mechanical ventilation, can further increase the risk of GER. Vomiting and regurgitation are the most common manifestations in infants and are considered pathological when they have repercussions on the nutritional status. In critically ill children, damage to the esophageal mucosa predisposes to digestive tract hemorrhage and nosocomial pneumonia secondary to repeated microaspiration. GER is mainly alkaline in children, as is also the case in critically ill pediatric patients. pH-metry combined with multichannel intraluminal impedance is therefore the technique of choice for diagnosis. The proton pump inhibitors are the drugs of choice for the treatment of GER because they have a greater effect, longer duration of action, and a good safety profile.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"824320"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/824320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31257127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection. 乙型肝炎表面抗原可能参与乙型肝炎病毒感染的免疫发病机制。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-01-16 DOI: 10.1155/2013/935295

Yasuteru Kondo, Masashi Ninomiya, Eiji Kakazu, Osamu Kimura, Tooru Shimosegawa

{"title":"Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection.","authors":"Yasuteru Kondo, Masashi Ninomiya, Eiji Kakazu, Osamu Kimura, Tooru Shimosegawa","doi":"10.1155/2013/935295","DOIUrl":"https://doi.org/10.1155/2013/935295","url":null,"abstract":"Various findings concerning the clinical significance of quantitative changes in hepatitis B surface antigen (HBsAg) during the acute and chronic phase of hepatitis B virus (HBV) infection have been reported. In addition to being a biomarker of HBV-replication activity, it has been reported that HBsAg could contribute to the immunopathogenesis of HBV persistent infection. Moreover, HBsAg could become an attractive target for immune therapy, since the cellular and humeral immune response against HBsAg might be able to control the HBV replication and life cycle. However, several reports have described the immune suppressive function of HBsAg. HBsAg might suppress monocytes, dendritic cells (DCs), natural killer (NK), and natural killer T (NK-T) cells by direct interaction. On the other hand, cytotoxic T lymphocytes (CTLs) and helper T (Th) cells were exhausted by high amounts of HBsAg. In this paper, we focused on the immunological aspects of HBsAg, since better understanding of the interaction between HBsAg and immune cells could contribute to the development of an immune therapy as well as a biomarker of the state of HBV persistent infection.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"935295"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/935295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31324085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77

Examination of the Anti-Inflammatory, Antioxidant, and Xenobiotic-Inducing Potential of Broccoli Extract and Various Essential Oils during a Mild DSS-Induced Colitis in Rats. 西兰花提取物和各种精油在轻度dss诱导大鼠结肠炎中的抗炎、抗氧化和诱导异种生物潜能的研究

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-02-28 DOI: 10.1155/2013/710856

Kristin Mueller, Nicole Michaela Blum, Andreas Stefan Mueller

{"title":"Examination of the Anti-Inflammatory, Antioxidant, and Xenobiotic-Inducing Potential of Broccoli Extract and Various Essential Oils during a Mild DSS-Induced Colitis in Rats.","authors":"Kristin Mueller, Nicole Michaela Blum, Andreas Stefan Mueller","doi":"10.1155/2013/710856","DOIUrl":"https://doi.org/10.1155/2013/710856","url":null,"abstract":"Phytogenic compounds with antioxidant and anti-inflammatory properties are currently discussed as promising complementary agents in prevention and treatment of inflammatory bowel disease (IBD). Our study aimed to evaluate possible protective and curative effects of broccoli extract (BE) and of the essential oils of turmeric (Cuo), thyme (To), and rosemary (Ro) in a rat model with a mild dextran sulphate sodium- (DSS-) induced colitis. Therefore Wistar rats were fed a diet without an additive (Con) or diets with the addition of BE, Cuo, To, and Ro during the whole experiment. Pretreatment with Ro, Cuo, and To increased the expression of the tight junction protein Cldn3. All additives reduced mRNA of VCAM-1 which plays a crucial role in the first state of inflammatory response. Only Ro pretreatment affected the expression of the antioxidant enzymes HO1, GPx2, and of glutathione-S-transferases. All additives counteracted the DSS-induced rise in COX2 and VCAM-1 expression. Colonic IL-10 was increased by Cuo, To, and Ro. During the recovery phase DSS pretreatment increased NF κ B, VCAM-1, and MCP-1: This response was counter-regulated by all additives. We conclude that the phytogenic additives tested have a promising anti-inflammatory potential in vivo and a particular role in the prevention of IBD.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":" ","pages":"710856"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/710856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Exploring anorectal manometry as a method to study the effect of locally administered ropivacaine in patients with ulcerative colitis. 探讨用肛门直肠测压法研究局部给药罗哌卡因对溃疡性结肠炎患者的影响。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-02-17 DOI: 10.1155/2013/656921

Eva Arlander, Robert Löfberg, Leif Törkvist, Ulrik Lindforss

{"title":"Exploring anorectal manometry as a method to study the effect of locally administered ropivacaine in patients with ulcerative colitis.","authors":"Eva Arlander, Robert Löfberg, Leif Törkvist, Ulrik Lindforss","doi":"10.1155/2013/656921","DOIUrl":"https://doi.org/10.1155/2013/656921","url":null,"abstract":"The symptoms of distal ulcerative colitis have been related to changes in rectal sensitivity and capacity due to inflammation, altered gastrointestinal motility, and sensory perception. With the use of anorectal manometry, the function was measured in seven patients with active distal proctitis during local treatment with ropivacaine. Seven healthy subjects were studied in the same way for comparison with normal conditions. The anal resting pressure and squeezing pressure were similar in all groups. Significantly lower rectal distention volumes were required for rectal sensation, critical volume, and to induce rectal contractility in patients with active disease compared to controls. Rectal compliance was significantly reduced in patients with active and quiescent disease. The increased rectal sensitivity and contractility in patients with active colitis appear to be related to active mucosal inflammation and ulceration. The frequency and urgency of defecation and the fecal incontinence may be due to a hypersensitive, hyperactive, and poorly compliant rectum. The findings in our study indicate that the inflammatory damage to the rectal wall with poor compliance is unaffected by local anaesthetics such as ropivacaine. The symptomatic relief and reduction in clinical symptoms following treatment are not reflected in the anorectal manometric findings.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"656921"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/656921","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31295124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Depressed-Type Colonic Lesions and "De Novo" Cancer in Familial Adenomatous Polyposis: A Colonoscopist's Viewpoint. 家族性腺瘤性息肉病的凹陷型结肠病变和“新生”癌:结肠镜医师的观点。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-02-27 DOI: 10.1155/2013/838134

Shin-Ei Kudo, Yuusaku Sugihara, Hiroyuki Kida, Fumio Ishida, Hideyuki Miyachi, Yuichi Mori, Masashi Misawa, Tomokazu Hisayuki, Kenta Kodama, Kunihiko Wakamura, Takemasa Hayashi, Yoshiki Wada, Shigeharu Hamatani

引用次数: 8

Gastric electrical stimulation for the treatment of obesity: from entrainment to bezoars-a functional review. 胃电刺激治疗肥胖:从夹带到牛粪——功能综述。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-02-07 DOI: 10.1155/2013/434706

Martin P Mintchev

{"title":"Gastric electrical stimulation for the treatment of obesity: from entrainment to bezoars-a functional review.","authors":"Martin P Mintchev","doi":"10.1155/2013/434706","DOIUrl":"https://doi.org/10.1155/2013/434706","url":null,"abstract":"GROWING WORLDWIDE OBESITY EPIDEMIC HAS PROMPTED THE DEVELOPMENT OF TWO MAIN TREATMENT STREAMS: (a) conservative approaches and (b) invasive techniques. However, only invasive surgical methods have delivered significant and sustainable benefits. Therefore, contemporary research exploration has focused on the development of minimally invasive gastric manipulation methods featuring a safe but reliable and long-term sustainable weight loss effect similar to the one delivered by bariatric surgeries. This antiobesity approach is based on placing external devices in the stomach ranging from electrodes for gastric electrical stimulation to temporary intraluminal bezoars for gastric volume displacement for a predetermined amount of time. The present paper examines the evolution of these techniques from invasively implantable units to completely noninvasive patient-controllable implements, from a functional, rather than from the traditional, parametric point of view. Comparative discussion over the available pilot and clinical studies related to gastric electrical stimulation outlines the promises and the fallacies of this concept as a reliable alternative anti-obesity strategy.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"434706"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/434706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31295125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis. 儿童溃疡性结肠炎的粪便钙保护蛋白与临床疾病活动性。

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-02-26 DOI: 10.1155/2013/179024

Kaija-Leena Kolho, Dan Turner

{"title":"Fecal calprotectin and clinical disease activity in pediatric ulcerative colitis.","authors":"Kaija-Leena Kolho, Dan Turner","doi":"10.1155/2013/179024","DOIUrl":"https://doi.org/10.1155/2013/179024","url":null,"abstract":"Objective. To explore fecal calprotectin levels in pediatric ulcerative colitis (UC) in relation with the validated clinical activity index PUCAI. Methods. This study included all 37 children (median age 14 years) with UC who had calprotectin measured (PhiCal ELISA Test) by the time of PUCAI assessment at the Children's Hospital of Helsinki in a total of 62 visits. Calprotectin values <100 μ g/g of stool were considered as normal. The best cut-off value of each measure to predict 3-month clinical outcome was derived by maximizing sensitivity and specificity. Results. In clinically active disease (PUCAI ≥ 10), calprotectin was elevated in 29/32 patients (91% sensitivity). When in clinical remission, 26% (8/30) of the children had normal calprotectin but 7 (23%) had an exceedingly high level (>1000 μ g/g). The best cut-off value for calprotectin for predicting poor outcome was 800 μ g/g (sensitivity 73%, specificity 72%; area under the ROC curve being 0.71 (95%CI 0.57-0.85)) and for the PUCAI best cut-off values >10 (sensitivity 62%, specificity 64%; area under the ROC curve 0.714 (95%CI 0.58-0.85)). Conclusion. The clinical relevance of somewhat elevated calprotectin during clinical remission in pediatric UC is not known and, until further evidence accumulates, does not indicate therapy escalation.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":" ","pages":"179024"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/179024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40229080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Minimization of Radiation Exposure due to Computed Tomography in Inflammatory Bowel Disease. 炎症性肠病计算机断层扫描辐射暴露的最小化。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-04-10 DOI: 10.5402/2012/790279

Patrick D Mc Laughlin, Owen J O'Connor, Siobhán B O'Neill, Fergus Shanahan, Michael M Maher

{"title":"Minimization of Radiation Exposure due to Computed Tomography in Inflammatory Bowel Disease.","authors":"Patrick D Mc Laughlin, Owen J O'Connor, Siobhán B O'Neill, Fergus Shanahan, Michael M Maher","doi":"10.5402/2012/790279","DOIUrl":"https://doi.org/10.5402/2012/790279","url":null,"abstract":"Patient awareness and concern regarding the potential health risks from ionizing radiation have peaked recently (Coakley et al., 2011) following widespread press and media coverage of the projected cancer risks from the increasing use of computed tomography (CT) (Berrington et al., 2007). The typical young and educated patient with inflammatory bowel disease (IBD) may in particular be conscious of his/her exposure to ionising radiation as a result of diagnostic imaging. Cumulative effective doses (CEDs) in patients with IBD have been reported as being high and are rising, primarily due to the more widespread and repeated use of CT (Desmond et al., 2008). Radiologists, technologists, and referring physicians have a responsibility to firstly counsel their patients accurately regarding the actual risks of ionizing radiation exposure; secondly to limit the use of those imaging modalities which involve ionising radiation to clinical situations where they are likely to change management; thirdly to ensure that a diagnostic quality imaging examination is acquired with lowest possible radiation exposure. In this paper, we synopsize available evidence related to radiation exposure and risk and we report advances in low-dose CT technology and examine the role for alternative imaging modalities such as ultrasonography or magnetic resonance imaging which avoid radiation exposure.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"790279"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/790279","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30610822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23