Depressed-Type Colonic Lesions and "De Novo" Cancer in Familial Adenomatous Polyposis: A Colonoscopist's Viewpoint.

ISRN gastroenterology Pub Date : 2013-01-01 Epub Date: 2013-02-27 DOI:10.1155/2013/838134
Shin-Ei Kudo, Yuusaku Sugihara, Hiroyuki Kida, Fumio Ishida, Hideyuki Miyachi, Yuichi Mori, Masashi Misawa, Tomokazu Hisayuki, Kenta Kodama, Kunihiko Wakamura, Takemasa Hayashi, Yoshiki Wada, Shigeharu Hamatani
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引用次数: 8

Abstract

Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome. Almost all patients with FAP will develop colorectal cancer if their FAP is not identified and treated at an early stage. Although there are many reports about polypoid lesions and colorectal cancers in FAP patients, little information is available concerning depressed lesions in FAP patients. Several reports suggested that depressed-type lesions are characteristic of FAP and important in the light of their rapid growth and high malignancy. Here, we describe the occurrence of depressed-type lesions in FAP patients treated at our institution. Between April 2001 and March 2010, eight of 18 FAP patients had colorectal cancers. Depressed-type colorectal cancer was found in three patients. It should be kept in mind that depressed-type lesions occur even in FAP.

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家族性腺瘤性息肉病的凹陷型结肠病变和“新生”癌:结肠镜医师的观点。
家族性腺瘤性息肉病(FAP)是最常见的遗传性息肉病综合征。如果FAP不能在早期识别和治疗,几乎所有的FAP患者都会发展为结直肠癌癌症。尽管有许多关于FAP患者息肉样病变和结直肠癌的报道,但关于FAP病人抑郁性病变的信息很少。一些报告表明,凹陷型病变是FAP的特征,并且由于其快速生长和高度恶性而具有重要意义。在这里,我们描述了在我们机构接受治疗的FAP患者中抑郁型病变的发生。2001年4月至2010年3月,18名FAP患者中有8人患有结直肠癌。在3例患者中发现了抑郁症型癌症。应该记住,即使在FAP中也会出现抑郁型病变。
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