ISRN gastroenterology最新文献_第7页

POEMS Syndrome: A Report of 14 Cases and Review of the Literature. POEMS综合征14例报告及文献复习。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-04-01 DOI: 10.5402/2012/584287

Zong Fei Ji, Dan Ying Zhang, Shu Qiang Weng, Xi Zhong Shen, Hou Yu Liu, Ling Dong

{"title":"POEMS Syndrome: A Report of 14 Cases and Review of the Literature.","authors":"Zong Fei Ji, Dan Ying Zhang, Shu Qiang Weng, Xi Zhong Shen, Hou Yu Liu, Ling Dong","doi":"10.5402/2012/584287","DOIUrl":"https://doi.org/10.5402/2012/584287","url":null,"abstract":"POEMS syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia presenting polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. This study reviewed the clinical characteristics of 14 POEMS patients in Zhongshan hospital. The ratio of male to female was 9 : 5, and the average age was 47.1 years. The clinical manifestations were various, including motorial symptoms (weakness), sensory symptoms (numbness), lymphadenopathy, edema, abdominal distention, and skin hyperpigmentation. Imaging studies and laboratory tests also exhibited hepatomegaly, splenomegaly, thrombocytosis, endocrinopathy, and positive serum immunofixation in most patients. In addition, increased plasma cells in bone marrow and Castleman Disease were found in bone marrow and lymph nodes biopsies. All the eight follow-up patients were treated with alkylator-based combination chemotherapy or corticosteroids and thalidomide, with or without autologous stem cell transplantation. Unfortunately, two patients died three or four years after diagnosis of POEMS syndrome. The others showed response to therapy to some extent, but not completely remission. Currently, treatments for POEMS include radiation to the plasmacytoma, and systemic therapy is indicated. Low-dose alkylators with or without corticosteroids are effective in some patients. However, high-dose chemotherapy with auto-SCT dramatically improved symptoms and outcomes for POEMS patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":" ","pages":"584287"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/584287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40191851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Eradication Treatment of Helicobacter pylori Infection: Its Importance and Possible Relationship in Preventing the Development of Gastric Cancer. 幽门螺杆菌感染的根除治疗：幽门螺杆菌感染：其重要性及其与预防胃癌发展的可能关系

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-13 DOI: 10.5402/2012/935410

Bruna Maria Roesler, Sandra Cecília Botelho Costa, José Murilo Robilotta Zeitune

引用次数: 0

Parenteral nutrition combined with enteral nutrition for severe acute pancreatitis. 肠外营养联合肠内营养治疗重症急性胰腺炎。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-12-11 DOI: 10.5402/2012/791383

Akanand Singh, Ming Chen, Tao Li, Xiao-Li Yang, Jin-Zheng Li, Jian-Ping Gong

{"title":"Parenteral nutrition combined with enteral nutrition for severe acute pancreatitis.","authors":"Akanand Singh, Ming Chen, Tao Li, Xiao-Li Yang, Jin-Zheng Li, Jian-Ping Gong","doi":"10.5402/2012/791383","DOIUrl":"https://doi.org/10.5402/2012/791383","url":null,"abstract":"Background and Aims. Nutritional support in severe acute pancreatitis (SAP) is controversial concerning the merits of enteral or parenteral nutrition in the management of patients with severe acute pancreatitis. Here, we assess the therapeutic efficacy of gradually combined treatment of parenteral nutrition (PN) with enteral nutrition (EN) for SAP. Methods. The clinical data of 130 cases of SAP were analyzed retrospectively. Of them, 59 cases were treated by general method of nutritional support (Group I) and the other 71 cases were treated by PN gradually combined with EN (Group II). Results. The APACHE II score and the level of IL-6 in Group II were significantly lower than Group I (P < 0.05). Complications, mortality, mean hospital stay, and the cost of hospitalization in Group II were 39.4 percent, 12.7 percent, 32 ± 9 days, and 30869.4 ± 12794.6 Chinese Yuan, respectively, which were significantly lower than those in Group I. The cure rate of Group II was 81.7 percent which is obviously higher than that of 59.3% in Group I (P < 0.05). Conclusions. This study indicates that the combination of PN with EN not only can improve the natural history of pancreatitis but also can reduce the incidence of complication and mortality.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"791383"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/791383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Clinical diagnostic clues in Crohn's disease: a 41-year experience. 克罗恩病的临床诊断线索:41年的经验。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-11-19 DOI: 10.5402/2012/285475

C Quintana, L Galleguillos, E Benavides, J C Quintana, A Zúñiga, I Duarte, J Klaassen, M Kolbach, R M Soto, S Iacobelli, M Alvarez, A O'Brien

{"title":"Clinical diagnostic clues in Crohn's disease: a 41-year experience.","authors":"C Quintana, L Galleguillos, E Benavides, J C Quintana, A Zúñiga, I Duarte, J Klaassen, M Kolbach, R M Soto, S Iacobelli, M Alvarez, A O'Brien","doi":"10.5402/2012/285475","DOIUrl":"https://doi.org/10.5402/2012/285475","url":null,"abstract":"Determining the diagnosis of Crohn's disease has been highly difficult mainly during the first years of this study carried out at the Pontificia Universidad Catolica (PUC) Clinical Hospital. For instance, it has been frequently confused with Irritable bowel syndrome and sometimes misdiagnosed as ulcerative colitis, infectious colitis or enterocolitis, intestinal lymphoma, or coeliac disease. Consequently, it seems advisable to characterize what the most relevant clinical features are, in order to establish a clear concept of Crohn's disease. This difficulty may still be a problem at other medical centers in developing countries. Thus, sharing this information may contribute to a better understanding of this disease. Based on the clinical experience gained between 1963 and 2004 and reported herein, the main clinical characteristics of the disease are long-lasting day and night abdominal pain, which becomes more intense after eating and diarrhoea, sometimes associated to a mass in the abdomen, anal lesions, and other additional digestive and nondigestive clinical features. Nevertheless, the main aim of this work has been the following: is it possible to make, in an early stage, the diagnosis of Crohn's disease with a high degree of certainty exclusively with clinical data?","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"285475"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/285475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31100497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Ultrasonographic evaluation of bowel wall thickness and intramural blood flow in ulcerative colitis. 溃疡性结肠炎肠壁厚度及壁内血流的超声评价。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-05-09 DOI: 10.5402/2012/370495

Abolhassan Shakeri Bavil, Mohommad Hossein Somi, Masoud Nemati, Batool Seyfi Nadergoli, Kamyar Ghabili, Reshad Mirnour, Hamideh Ashrafi

{"title":"Ultrasonographic evaluation of bowel wall thickness and intramural blood flow in ulcerative colitis.","authors":"Abolhassan Shakeri Bavil, Mohommad Hossein Somi, Masoud Nemati, Batool Seyfi Nadergoli, Kamyar Ghabili, Reshad Mirnour, Hamideh Ashrafi","doi":"10.5402/2012/370495","DOIUrl":"https://doi.org/10.5402/2012/370495","url":null,"abstract":"Aim. This study aimed at assessing Doppler ultrasonographic findings of gut wall vessels and thickness in active and quiescent ulcerative colitis. Methods. Fifty patients with ulcerative colitis were studied using transabdominal grayscale and Doppler sonography of sigmoid, distal and middle parts of descending colon in different stages of the disease. Thickness of colon wall in the most involved site, number of color signals in each box, resistive index (RI), and pulsatility index (PI) were evaluated. Results. The median thickness of the colon wall in the most involved sites was 4.3 mm in acute phase and 4.4 mm in the inactive phase (P = 0.47). The median number of the color signals in the active phase at the most involved site, distal part of descending colon and sigmoid was higher than that of the color signals in the inactive phase (P = 0.0001). In the most involved site, the PI and RI were undetectable in the inactive phase. The median PI was 1.4 in the mild phase, 1.3 in the moderate phase, and 1.1 in the severe phase (P = 0.002). Conclusion. In contrast to the colon wall thickness, increased intramural blood flow reflected the clinical severity in ulcerative colitis patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"370495"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/370495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30656223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Functional abdominal bloating with distention. 功能性腹胀伴腹胀。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-19 DOI: 10.5402/2012/721820

Stephen Norman Sullivan

引用次数: 21

Endoscopic Submucosal Dissection for Treatment of Patients Aged 75 Years and over with Esophageal Cancer. 内镜下粘膜剥离术治疗75岁及以上食管癌。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-06-17 DOI: 10.5402/2012/671324

Osamu Kikuchi, Hirokazu Mouri, Kazuhiro Matsueda, Hiroshi Yamamoto

{"title":"Endoscopic Submucosal Dissection for Treatment of Patients Aged 75 Years and over with Esophageal Cancer.","authors":"Osamu Kikuchi, Hirokazu Mouri, Kazuhiro Matsueda, Hiroshi Yamamoto","doi":"10.5402/2012/671324","DOIUrl":"https://doi.org/10.5402/2012/671324","url":null,"abstract":"Background. Although many reports concerning the use of endoscopic submucosal dissection (ESD) for esophageal cancer have been published, the feasibility of ESD in elderly patients has not been reported. Therefore, we evaluated the efficacy and safety of ESD for treating early esophageal cancer in elderly patients. Methods. A total of 62 cases (52 men, 10 women; mean age ± standard deviation, 66.5 ± 10.5 years) for which the first resection (first treatment) of esophageal cancer was performed by ESD were identified from 77 consecutive esophageal epithelial cancers in 67 patients treated at our institution from January 2005 to March 2011. Patient characteristics, clinical findings, and outcomes were retrospectively assessed for patients separated into older (aged 75 years and older) and younger (aged under 75 years) groups. Results. No significant differences in specimen size, procedure time, median length of the hospital stay (8 versus 9 days; P = 0.252) or procedure-associated complications (8% versus 27%; P = 0.264) were observed between the older (n = 13) and younger (n = 49) groups. Lesions were completely resected in 12 patients and 44 patients, in the younger and older groups, respectively, and the curative resection rate was 77% and 59%, respectively. There were no deaths attributable to procedure-associated complications. Conclusions. ESD is an effective treatment for early esophageal cancer and is well tolerated by elderly patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"671324"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/671324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30750051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Short-term effects and early complications of balloon-occluded retrograde transvenous obliteration for gastric varices. 球囊闭塞经静脉逆行静脉闭塞术治疗胃底静脉曲张的近期疗效及早期并发症。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-12-05 DOI: 10.5402/2012/919371

Manabu Watanabe, Kazue Shiozawa, Takashi Ikehara, Shigeru Nakano, Michio Kougame, Takafumi Otsuka, Yoshinori Kikuchi, Koji Ishii, Yoshinori Igarashi, Yasukiyo Sumino

{"title":"Short-term effects and early complications of balloon-occluded retrograde transvenous obliteration for gastric varices.","authors":"Manabu Watanabe, Kazue Shiozawa, Takashi Ikehara, Shigeru Nakano, Michio Kougame, Takafumi Otsuka, Yoshinori Kikuchi, Koji Ishii, Yoshinori Igarashi, Yasukiyo Sumino","doi":"10.5402/2012/919371","DOIUrl":"https://doi.org/10.5402/2012/919371","url":null,"abstract":"The short-term effects of balloon-occluded retrograde transvenous obliteration (BRTO) to treat gastric varices were evaluated by using computed tomography (CT) and gastroscopy (GF). The subjects were 77 patients who underwent BRTO to treat gastric varices. The short-term effects of BRTO were investigated with regard to ascites, pleural effusion, venous thrombus, and esophageal varices by comparing the findings of CT and GF performed within one month before and after BRTO. The mean duration of followup was 960.1 days. Ascites and pleural effusion were exacerbated after BRTO in 26 (33.8%) and 31 (40.3%), respectively. A significant difference in ascites exacerbation was noted in patients with hypoalbuminemia and a high Child-Pugh score, and a significant difference in exacerbation of pleural effusion was noted in patients with hypoalbuminemia. Venous thrombus was noted in 7 patients (9.1%). Esophageal varices were exacerbated in 14 (21.2%) of the 66 patients. The 2-year survival rate was 720 days, and significant differences were noted in the Child-Pugh classification and the concomitance of hepatocellular carcinoma (HCC) on multivariate analysis of prognosis-related factors. Conclusion. The frequencies of exacerbation of ascites, pleural effusion, and esophageal varices after BRTO were high but these may not be related to survival.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"919371"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/919371","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Improving hepatitis B vaccine efficacy in end-stage renal diseases patients and role of adjuvants. 提高终末期肾病患者的乙型肝炎疫苗疗效及佐剂的作用。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-09-18 DOI: 10.5402/2012/960413

Mohammad Hossein Somi, Babak Hajipour

{"title":"Improving hepatitis B vaccine efficacy in end-stage renal diseases patients and role of adjuvants.","authors":"Mohammad Hossein Somi, Babak Hajipour","doi":"10.5402/2012/960413","DOIUrl":"10.5402/2012/960413","url":null,"abstract":"Hepatitis B virus (HBV) infection is a serious global health problem.The prevalence of viral hepatitis is higher in dialysis patients than in the general population because of the opportunity for exposure during the dialysis procedure. Immunization is the most effective way to prevent transmission of hepatitis B virus (HBV) and hence the development of acute or chronic hepatitis B. It is well established that patients with end-stage renal disease including dialysis-dependent patients, have an impaired immune response to hepatitis B vaccine. End stage renal diseases (ESRD) patients have lower seroconversion rates compared with the subjects with intact renal function. Moreover, even after the completion of vaccination schedule anti-hepatitis B (anti-HBs) titers of responder dialysis, patients are low and decline logarithmically with time. The impaired efficacy of HBV vaccine in patients with ESRD has been attributed to numerous factors such as immune compromise because of uremia and some other factors. One approach to improve the immunogenicity of existing HBV vaccines is adjuvantation, and it's very important to find more effective adjutants for improving HBV vaccine efficacy. In this paper we have a brief review on recently known new ways for improving HBV vaccine efficacy.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"960413"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30947519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards universal screening for colon cancer: a cheap, reliable, noninvasive test using gene expression analysis of rectal swabs. 迈向结肠癌的普遍筛查:一种使用直肠拭子基因表达分析的廉价、可靠、无创测试。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-01-29 DOI: 10.5402/2012/170210

Andrew P Smith, Yanek S Y Chiu, Nancy M Lee

引用次数: 5