ISRN gastroenterology最新文献_第8页

Special considerations for endoscopists on PEG indications in older patients. 内窥镜医师对老年患者PEG适应症的特殊考虑。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-11-25 DOI: 10.5402/2012/607149

Fabrizio Cardin

{"title":"Special considerations for endoscopists on PEG indications in older patients.","authors":"Fabrizio Cardin","doi":"10.5402/2012/607149","DOIUrl":"10.5402/2012/607149","url":null,"abstract":"Undernutrition in frail elderly people is a pathological condition that needs to be recognized and addressed early. Neurological dysphagia is among the most frequent causes of this condition in the elderly but should be considered a terminal event in Alzheimer-type dementias. Tube feeding is an important resource for facilitating metabolic recovery in cachectic patients and is particularly successful in \"bridging\" and stabilizing therapies prior to major treatment able to cure the patient. Clinical management of tube feeding in \"incurable\" conditions is complex and becomes part of the palliative care and comfort provided in the terminal stages of illness. Non-specialized physicians are often unfamiliar with the theory and practice of end-of-life interventions, and the resulting decisions are in many cases actually contrary to patient comfort. These problems deserve to be more carefully addressed when the patient is unable to cooperate or express his/her preferences and needs. The success of percutaneous endoscopic gastrostomy has led to increasingly frequent referrals for placement in critically ill elderly patients. Endoscopists therefore become a key figure in stimulating rational, correct treatment of these patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"607149"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/607149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31111465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

What really causes necrotising enterocolitis? 导致坏死性小肠结肠炎的真正原因是什么？

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-12-17 DOI: 10.5402/2012/628317

Thomas Peter Fox, Charles Godavitarne

{"title":"What really causes necrotising enterocolitis?","authors":"Thomas Peter Fox, Charles Godavitarne","doi":"10.5402/2012/628317","DOIUrl":"10.5402/2012/628317","url":null,"abstract":"Background. One of the most serious gastrointestinal disorders occurring in neonates is necrotising enterocolitis (NEC). It is recognised as the most common intra-abdominal emergency and is the leading cause of short bowel syndrome. With extremely high mortality and morbidity, this enigmatic disease remains a challenge for neonatologists around the world as its definite aetiology has yet to be determined. As current medical knowledge stands, there is no single well-defined cause of NEC. Instead, there are nearly 20 risk factors that are proposed to increase the likelihood of developing NEC. Aims and Objectives. The aim of this project was to conduct a comprehensive literature review around the 20 or so well-documented and less well-documented risk factors for necrotising enterocolitis. Materials and Methods. Searches of the Medline, Embase, and Science direct databases were conducted using the words \"necrotising enterocolitis + the risk factor in question\" for example, \"necrotising enterocolitis + dehydration.\" Search results were ordered by relevance with bias given to more recent publications. Conclusion. This literature review has demonstrated the complexity of necrotising enterocolitis and emphasised the likely multifactorial aetiology. Further research is needed to investigate the extent to which each risk factor is implicated in necrotising enterocolitis.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"628317"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31158974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of antioxidant treatment on fibrogenesis in rats with carbon tetrachloride-induced cirrhosis. 抗氧化治疗对四氯化碳肝硬化大鼠纤维化的影响。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-04-02 DOI: 10.5402/2012/762920

Silvia Bona, Lidiane Isabel Filippin, Fábio Cangeri Di Naso, Cintia de David, Bruna Valiatti, Maximiliano Isoppo Schaun, Ricardo Machado Xavier, Norma Possa Marroni

{"title":"Effect of antioxidant treatment on fibrogenesis in rats with carbon tetrachloride-induced cirrhosis.","authors":"Silvia Bona, Lidiane Isabel Filippin, Fábio Cangeri Di Naso, Cintia de David, Bruna Valiatti, Maximiliano Isoppo Schaun, Ricardo Machado Xavier, Norma Possa Marroni","doi":"10.5402/2012/762920","DOIUrl":"https://doi.org/10.5402/2012/762920","url":null,"abstract":"Aim. This study aimed to assess the antioxidant activity of quercetin (Q) in an experimental model of cirrhosis induced by CCl(4) inhalation. Materials and Methods. We used 25 male Wistar rats (250 g) that were divided into 3 groups: control (CO), CCl(4), and CCl(4) + Q. The rats were subjected to CCl(4) inhalation (2x/week) for 16 weeks, and they received phenobarbital in their drinking water at a dose of 0.3 g/dL as a P450 enzyme inducer. Q (50 mg/Kg) was initiated intraperitoneally at 10 weeks of inhalation and lasted until the end of the experiment. Statistical analysis was by ANOVA Student Newman-Keuls (mean ± SEM), and differences were considered statistically significant when P < 0.05. Results. After treatment with quercetin, we observed an improvement in liver complications, decreased fibrosis, as analyzed by picrosirius for the quantification of collagen, and decreased levels of matrix metalloproteinase 2 (MMP-2) compared with the CCl(4) group. It also reduced oxidative stress, as confirmed by the decrease of substances reacting to thiobarbituric acid (TBARS), the increased activity of antioxidant enzymes, and the reduced glutathione ratio and glutathione disulfide (GSH/GSSG). Conclusion. We suggest that the use of quercetin might be promising as an antioxidant therapy in liver fibrosis.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"762920"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/762920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30610821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Subclinical cardiac dysfunction in children with coeliac disease: is the gluten-free diet effective? 乳糜泻患儿的亚临床心功能障碍:无麸质饮食有效吗?

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-11-14 DOI: 10.5402/2012/706937

Berna Saylan, Ayhan Cevik, Ceyda Tuna Kirsaclioglu, Filiz Ekici, Ozgur Tosun, Gonca Ustundag

{"title":"Subclinical cardiac dysfunction in children with coeliac disease: is the gluten-free diet effective?","authors":"Berna Saylan, Ayhan Cevik, Ceyda Tuna Kirsaclioglu, Filiz Ekici, Ozgur Tosun, Gonca Ustundag","doi":"10.5402/2012/706937","DOIUrl":"https://doi.org/10.5402/2012/706937","url":null,"abstract":"Objectives. The aim of this study is to investigate the effects of coeliac disease on cardiac function in children using conventional transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Methods. Coeliac disease patients were evaluated in two different groups based on serum endomysial antibody (EmA) titers (EmA (+) and EmA (-)), and the data obtained by conventional and TDE studies were compared between the patient groups and healthy controls. Results. There was no significant difference between EmA (+) and EmA (-) groups in terms of the conventional TTE parameters, including ejection fraction (EF), fractional shortening (FS), and left ventricle end diastolic diameter (LVEDD), that show the left ventricular systolic function (P = 0.727, P = 0.317, P = 0.118). TDE showed a significant difference in left ventricle (LV) isovolumic relaxation time (LV IVRT) and LV myocardial performance index (LV MPI) parameters between EmA (+) and EmA (-) patient groups (P < 0.0001). Conclusion. The measurement of LV MPI and LV IVRT parameters by TDE would be beneficial in early determination of the cardiac involvement and establishing appropriate treatment and followup of patients with coeliac disease as well as in making distinction between EmA (+) and EmA (-) patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"706937"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/706937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31096907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Transcatheter arterial chemoembolization: history for more than 30 years. 经导管动脉化疗栓塞:已有30多年的历史。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-08-26 DOI: 10.5402/2012/480650

Yong-Song Guan, Qing He, Ming-Quan Wang

引用次数: 57

Evaluation of the appropriate age range of colorectal cancer screening based on the changing epidemiology in the past 20 years in taiwan. 台湾近20年来流行病学变化对结直肠癌筛检适龄的评估。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-08-30 DOI: 10.5402/2012/960867

Huan-Cheng Chang, Jorng-Tzong Horng, Wen-Chu Lin, Hsin-Wen Lai, Cheng-Wei Chang, Tzu-An Chen

{"title":"Evaluation of the appropriate age range of colorectal cancer screening based on the changing epidemiology in the past 20 years in taiwan.","authors":"Huan-Cheng Chang, Jorng-Tzong Horng, Wen-Chu Lin, Hsin-Wen Lai, Cheng-Wei Chang, Tzu-An Chen","doi":"10.5402/2012/960867","DOIUrl":"https://doi.org/10.5402/2012/960867","url":null,"abstract":"Introduction. According to the recommendation of the United States Preventative Services Task Force, most countries provide average-risk screening for colorectal cancers (CRCs) between the ages of 50 and 75 years. However, the age range of screening should be modified because of an increasing life span. Methods. Totally 124,314 CRC cases were registered in Taiwan Cancer Registry from 1988 to 2007. The 20-year study period was divided into four 5-year increments. We divided the patients into four age groups (under age 50, age 50-74, age 74-84, and over age 85) in each increment to determine whether there were changes in the age distribution. Results. In the subgroup of patients under age 50, the number of CRC cases increased, but they accounted for a decreasing proportion of the total CRCs. In the 50-74 age group, the proportion of CRC cases also dropped. In contrast, the proportion increased in the 75-84 age group. Therefore, 43.63% of CRC patients would not be delegated to screen in the period of 2003-2007 if the CRC screening were restricted in the 50-74 age group. Conclusions. CRC screening for healthy individuals aged over 75 years is necessary.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"960867"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/960867","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30899206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Effect of Echium amoenum Fisch. et Mey a Traditional Iranian Herbal Remedy in an Experimental Model of Acute Pancreatitis. 刺青的作用。伊朗传统草药对急性胰腺炎实验模型的影响。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-09-13 DOI: 10.5402/2012/141548

Alireza Abed, Mohsen Minaiyan, Alireza Ghannadi, Parvin Mahzouni, Mohammad Reza Babavalian

{"title":"Effect of Echium amoenum Fisch. et Mey a Traditional Iranian Herbal Remedy in an Experimental Model of Acute Pancreatitis.","authors":"Alireza Abed, Mohsen Minaiyan, Alireza Ghannadi, Parvin Mahzouni, Mohammad Reza Babavalian","doi":"10.5402/2012/141548","DOIUrl":"https://doi.org/10.5402/2012/141548","url":null,"abstract":"Acute pancreatitis is a morbid inflammatory condition of pancreas with limited specific therapy. Enhanced oxidative stress plays an important role in induction and progression of acute pancreatitis. So reducing oxidative stress may relieve this pathogenic process. Echium amoenum Fisch. and Mey has been implemented in Iranian folk medicine for several centuries. Antioxidant, analgesic, immunomodulatory, and anxiolytic properties of E. amoenum suggest that this plant may have beneficial effects in the management of acute pancreatitis. The aim of this study was to evaluate the protective effect of petals of E. amoenum extract (EAE) on a murine model of pancreatitis. Acute pancreatitis was induced by five intraperitoneal (i.p.) injection of cerulein (50 μg/kg) with 1h intervals which was characterized by pancreatic inflammation and increase in the serum level of digestive enzymes, in comparison to normal mice. EAE (100, 200, and 400 mg/kg) was administered i.p., 30 minutes before induction of pancreatitis. Pretreatment with EAE (400 mg/kg) reduced significantly the inflammatory response of cerulein-induced acute pancreatitis by ameliorating pancreatic edema, amylase and lipase serum levels, proinflammatory cytokines, myeloperoxidase activity, lipid peroxidation and pathological alteration. These results show that EAE attenuates the severity of cerulein-induced acute pancreatitis with an anti-inflammatory, immunomodulatory and antioxidant effects.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"141548"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/141548","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30930217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Long-term outcome after resection rectopexy for internal rectal intussusception. 直肠内肠套叠切除术后的远期疗效。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-12-30 DOI: 10.5402/2012/824671

Egil Johnson, Kristin Kjellevold, Hans-Olaf Johannessen, Anders Drolsum

{"title":"Long-term outcome after resection rectopexy for internal rectal intussusception.","authors":"Egil Johnson, Kristin Kjellevold, Hans-Olaf Johannessen, Anders Drolsum","doi":"10.5402/2012/824671","DOIUrl":"https://doi.org/10.5402/2012/824671","url":null,"abstract":"Background and Aims. The optimal treatment of patients with internal rectal intussusception (IRI) is unresolved. The aim was to study the short- and long-term outcome of resection rectopexy in these patients. Methods. An observational and mainly prospective study of 48 patients (44 women) with IRI who had ligament-preserving suture rectopexy by laparoscopic (n = 25) or open (n = 23) technique. Outcome measures were morbidity, scores for constipation and anal incontinence, patients' report, and health-related quality of life (HRQoL). Results. From preoperatively to a median of 6 months and 76 months postoperatively, constipation scores were reduced from a mean of (95% CI) 13.20 (11.41 to 15.00) to 6.91 (5.29 to 8.54) and 6.35 (4.94 to 7.76) (P < 0.0001). The number of constipated patients was reduced from 35 to eleven and eight, respectively, and none became constipated. Nine of ten symptoms of constipation improved. Corresponding scores for anal incontinence were 4.7 (2.4-7.0), 4.0 (2.4-5.7), and 4.1 (2.3-5.8), respectively. HRQoL at long-term followup compared to the general Norwegian population was reduced in four out of eight dimensions concerning physical factors. The patient-reported outcome at short- and long-term followup was improved by 85.4% and 75.0%, respectively. Conclusions. Resection rectopexy for IRI improved the outcome. HRQoL was reduced compared with the general population.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"824671"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/824671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31185229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Critical analysis of esophageal multichannel intraluminal impedance monitoring 20 years later. 20年后食管多通道腔内阻抗监测的关键分析。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-10-24 DOI: 10.5402/2012/903240

Fernando A M Herbella

引用次数: 18

Nutritional status assessment in cirrhotic patients after protein supplementation. 肝硬化患者补充蛋白质后的营养状况评估。

ISRN gastroenterology Pub Date : 2012-01-01 Epub Date: 2012-12-04 DOI: 10.5402/2012/690402

Supanee Putadechakum, Theerawut Klangjareonchai, Arpussanee Soponsaritsuk, Chulaporn Roongpisuthipong

{"title":"Nutritional status assessment in cirrhotic patients after protein supplementation.","authors":"Supanee Putadechakum, Theerawut Klangjareonchai, Arpussanee Soponsaritsuk, Chulaporn Roongpisuthipong","doi":"10.5402/2012/690402","DOIUrl":"https://doi.org/10.5402/2012/690402","url":null,"abstract":"Background. Protein supplementation has been shown to be effective for the treatment of malnourished patients with liver cirrhosis. The parameters used to assess nutritional improvement in cirrhotic patients for such treatment are important. Objective. To evaluate the parameters for assessment of nutritional status in patients with liver cirrhosis after protein supplementation. Material and Method. A cross-sectional, prospective clinical trial with 22 cirrhotic patients was performed. Data from anthropometry, bioelectrical impedance, subjective global assessment (SGA), and visceral protein were gathered and analyzed to assess nutritional improvement after protein supplementation. Results. Twenty-two cirrhotic patients (mean age 52.9 ± 12.8 years; 54.5% male; 63.6% alcoholic cirrhosis; 63.6% Child-Pugh C) were recruited. After protein supplementation, a significant improvement was demonstrated in the SGA class A from 10 patients (45.5%) to 16 (72.7%) and 18 (81.8%) at the 4th and 8th weeks, respectively. Body weight, body mass index, and lean muscle mass were significantly increased from baseline at the 8th week. No significant change in other nutritional parameters was observed. Conclusions. The SGA and lean muscle mass were significant parameters in order to assess nutritional status in cirrhotic patients after protein supplementation.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2012 ","pages":"690402"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/690402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16