ISRN gastroenterology最新文献_第3页

Enhanced blood lymphocytes apoptosis in children with inflammatory bowel disease. 炎症性肠病患儿血液淋巴细胞凋亡增高

ISRN gastroenterology Pub Date : 2013-08-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/415417

M A El-Hodhod, R H Aly, S R Youssef, S I Mohamed

{"title":"Enhanced blood lymphocytes apoptosis in children with inflammatory bowel disease.","authors":"M A El-Hodhod, R H Aly, S R Youssef, S I Mohamed","doi":"10.1155/2013/415417","DOIUrl":"10.1155/2013/415417","url":null,"abstract":"The aim of this work was to measure peripheral lymphocyte apoptosis during IBD flare and remission. Subjects and Methods. Flow-cytometric assessment of apoptosis of peripheral blood lymphocytes (PBL) was assessed in 30 children with IBD (16 with ulcerative colitis and 14 with Crohn's disease) compared to 22, age and sex matched, healthy children. This was carried out during a flare, whether in newly diagnosed or relapsing patients, and after achievement of remission. Clinical findings, complete blood count, liver transaminases, and kidney functions were assessed. Results. Early apoptotic and late apoptotic/necrotic lymphocytes were significantly higher during IBD flare compared to controls (P ≤ 0.01 and <0.01, resp., in ulcerative colitis and P ≤ 0.01 and <0.01, resp., in Crohn's disease patients). Remission values were significantly decreased but did not come back to the control levels. Early apoptotic values were significantly related to joint involvement in IBD patients (P < 0.0001). Conclusions. We can speculate a systemic nature of IBD as evident by enhanced peripheral lymphocyte apoptosis. This is related, to a great extent, to the disease process as it is more deranged in flare than in remission. Relation of this derangement to extraintestinal manifestations needs a special attention. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"415417"},"PeriodicalIF":0.0,"publicationDate":"2013-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/415417","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31764751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Scientific evaluation of edible fruits and spices used for the treatment of peptic ulcer in traditional Iranian medicine. 对伊朗传统医学中用于治疗消化性溃疡的食用水果和香料进行科学评估。

ISRN gastroenterology Pub Date : 2013-08-26 DOI: 10.1155/2013/136932

Mohammad Hosein Farzaei, Mohammad Reza Shams-Ardekani, Zahra Abbasabadi, Roja Rahimi

{"title":"Scientific evaluation of edible fruits and spices used for the treatment of peptic ulcer in traditional Iranian medicine.","authors":"Mohammad Hosein Farzaei, Mohammad Reza Shams-Ardekani, Zahra Abbasabadi, Roja Rahimi","doi":"10.1155/2013/136932","DOIUrl":"10.1155/2013/136932","url":null,"abstract":"In traditional Iranian medicine (TIM), several edible fruits and spices are thought to have protective and healing effects on peptic ulcer (PU). The present study was conducted to verify anti-PU activity of these remedies. For this purpose, edible fruits and spices proposed for the management of PU in TIM were collected from TIM sources, and they were searched in modern medical databases to find studies that confirmed their efficacy. Findings from modern investigations support the claims of TIM about the efficacy of many fruits and spices in PU. The fruit of Phyllanthus emblica as a beneficial remedy for PU in TIM has been demonstrated to have antioxidant, wound healing, angiogenic, anti-H. pylori, cytoprotective, antisecretory, and anti-inflammatory properties. The fruit of Vitis vinifera has been found to be anti-H. pylori, anti-inflammatory, wound healing, angiogenic, cytoprotective, and antioxidant. The fruit and aril of seed from Myristica fragrans exert their beneficial effects in PU by increasing prostaglandin, modulation of nitric oxide and inflammatory mediators, wound healing, antisecretory, antacid, antioxidant, and anti-H. pylori activities, and improving angiogenesis. Pharmacological and clinical studies for evaluation of efficacy of all TIM fruits and spices in PU and their possible mechanisms of action are recommended. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"136932"},"PeriodicalIF":0.0,"publicationDate":"2013-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31758977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and therapeutic value of ERCP in acute cholangitis. ERCP对急性胆管炎的诊断和治疗价值。

ISRN gastroenterology Pub Date : 2013-08-13 eCollection Date: 2013-01-01 DOI: 10.1155/2013/191729

Kenan Buyukasik, Ahmet Burak Toros, Hasan Bektas, Aziz Ari, Mehmet Mehdi Deniz

引用次数: 27

ERCP features and outcome in patients with periampullary duodenal diverticulum. 壶腹周围十二指肠憩室的ERCP特征及预后。

ISRN gastroenterology Pub Date : 2013-07-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/217261

Amir Houshang Mohammad Alizadeh, Esmaeil Shamsi Afzali, Anahita Shahnazi, Mirhadi Mousavi, Siavash Zafar Doagoo, Dariush Mirsattari, Mohammad Reza Zali

{"title":"ERCP features and outcome in patients with periampullary duodenal diverticulum.","authors":"Amir Houshang Mohammad Alizadeh, Esmaeil Shamsi Afzali, Anahita Shahnazi, Mirhadi Mousavi, Siavash Zafar Doagoo, Dariush Mirsattari, Mohammad Reza Zali","doi":"10.1155/2013/217261","DOIUrl":"https://doi.org/10.1155/2013/217261","url":null,"abstract":"Background. Although periampullary diverticulum is usually asymptomatic and discovered incidentally in patients during endoscopic retrograde cholangiopancreatography (ERCP), it may lead to post-ERCP morbidity. We compared baseline characteristics and clinical data as well as ERCP results in patients with and without periampullary diverticulum. Methods. Clinical, laboratory, and ERCP data of 780 patients referred to the Taleghani Hospital, as a great referral endoscopy center, in Iran were prospectively analyzed. Results. The periampullary diverticulum was identified in 44 patients (5.6%). Cannulation of common bile duct was more failed in patients with diverticulum compared to others (35.5% versus 11.5, P < 0.001). Patients with diverticulum had eight times more often common bile duct stone compared to patients without diverticulum (54.5% versus 12.2%, P < 0.001). Post-ERCP complications were observed in 2.3% and 4.2% of patients with and without diverticulum, respectively, which did not significantly differ in both groups. Conclusion. Because of more failure cannulation in the presence of periampullary diverticulum, ERCP requires more skills in these patients. Prevalence of common bile duct stone was notably higher in patients with diverticulum; therefore, more assessment of bile stone and its complications in these patients is persistently recommended. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"217261"},"PeriodicalIF":0.0,"publicationDate":"2013-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/217261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31689602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Effect of diazepam on severity of acute pancreatitis: possible involvement of peripheral benzodiazepine receptors. 地西泮对急性胰腺炎严重程度的影响:可能涉及外周苯二氮卓受体。

ISRN gastroenterology Pub Date : 2013-07-17 eCollection Date: 2013-01-01 DOI: 10.1155/2013/484128

Alireza Abed, Mohsen Minaiyan, Azadeh Safaei, Diana Taheri

{"title":"Effect of diazepam on severity of acute pancreatitis: possible involvement of peripheral benzodiazepine receptors.","authors":"Alireza Abed, Mohsen Minaiyan, Azadeh Safaei, Diana Taheri","doi":"10.1155/2013/484128","DOIUrl":"https://doi.org/10.1155/2013/484128","url":null,"abstract":"Acute pancreatitis is a lethal inflammatory condition of pancreas with high mortality rate. There is a pressing need for research to explore active agents and novel mechanisms involving in the treatment of pancreatitis. Clinical studies have shown after the initial acinar cell injury plasma levels of pro-inflammatory cytokines are elevated in patients with acute pancreatitis and the degree of cytokine elevation correlates with disease severity. Diazepam may decrease interleukin release from macrophages, suppress neutrophil activities, and exhibit anti-inflammatory effects. So it is expected that in vivo pretreatment of acute pancreatitis with different doses of diazepam can attenuate its severity. Thus, we evaluated the effects of diazepam, intraperitoneally (5, 10, and 20 mg/kg i.p.), intracerebroventricularly (ICV 10 μ g), and concurrently with flumazenil (1 mg/kg) on cerulein-induced acute pancreatitis in mice. Interestingly, the pretreatment with diazepam (5 mg/kg i.p.) reduced significantly the inflammatory response of acute pancreatitis by ameliorating pancreatic edema, amylase and lipase serum levels, myeloperoxidase activity, pancreatic TNF-alpha, and pathological alteration compared to control group. Diazepam i.c.v. was ineffective, suggesting that central benzodiazepine receptors have no significant role in this property. These results demonstrate that pretreatment with diazepam exhibits anti-inflammatory property in cerulein-induced acute pancreatitis possibly through peripheral benzodiazepine receptors. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"484128"},"PeriodicalIF":0.0,"publicationDate":"2013-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/484128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31666757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect. 结直肠癌的发病率在荷兰zaanstreek地区的老年队列中正在下降:年龄队列效应。

ISRN gastroenterology Pub Date : 2013-07-07 Print Date: 2013-01-01 DOI: 10.1155/2013/871308

R J L F Loffeld, P E P Dekkers, M Flens

{"title":"The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect.","authors":"R J L F Loffeld, P E P Dekkers, M Flens","doi":"10.1155/2013/871308","DOIUrl":"https://doi.org/10.1155/2013/871308","url":null,"abstract":"Introduction. Colorectal cancer (CRC) has a high incidence. Removal of adenomas, the precursor lesion, could be helpful in the prevention of cancer. Aim. To investigate the yearly incidence of CRC in consecutive years. Patients and Methods. All patients diagnosed with CRC in the years 1990 till 2010 were studied. Date of diagnosis, age at time of diagnosis, gender, and localisation of the tumour were assessed. Results. A total of 1575 incident CRC were diagnosed, 865 men (55%) and 710 women (45%). CRC occurred more often in men. In the course of the years, the occurrence of CRC increased. After exclusion of rectal cancer, the percentage of proximal cancer in the colon shows a trend towards increase in the consecutive years. In the twenty consecutive years, the population of the Zaanstreek region increased from 130.000 to 145.330. There was a significant increase of CRC in the age cohort 51-70 in the period of twenty years, while a significant decreasing incidence of cancer was seen in patients above 71 years. Conclusion. The decreasing incidence of colorectal cancer in the age cohorts above 71 years possibly reflects indirect evidence of an age-cohort effect due to removal of adenomas in these age cohorts earlier in life. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"871308"},"PeriodicalIF":0.0,"publicationDate":"2013-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/871308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31650538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hepatocellular Carcinoma More Than 3 cm in Diameter: A Systematic Review of Transcatheter Arterial Chemoembolization Plus Percutaneous Ethanol Injection versus Transcatheter Arterial Chemoembolization Alone. 直径大于3cm的肝细胞癌:经导管动脉化疗栓塞加经皮乙醇注射与单独经导管动脉化疗栓塞的系统评价。

ISRN gastroenterology Pub Date : 2013-07-01 Print Date: 2013-01-01 DOI: 10.1155/2013/526024

Shiying Wang, Liping Zhuang, Zhiqiang Meng

{"title":"Hepatocellular Carcinoma More Than 3 cm in Diameter: A Systematic Review of Transcatheter Arterial Chemoembolization Plus Percutaneous Ethanol Injection versus Transcatheter Arterial Chemoembolization Alone.","authors":"Shiying Wang, Liping Zhuang, Zhiqiang Meng","doi":"10.1155/2013/526024","DOIUrl":"https://doi.org/10.1155/2013/526024","url":null,"abstract":"Objective. To identify the efficiency and safety of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol (PEI) for patients with hepatocellular carcinoma (HCC) more than 3 cm in diameter in comparison with those of transcatheter arterial chemoembolization monotherapy. Methods. All databases were searched up to February 22, 2013. The literature retrieval was conducted through Pubmed, Web of Science, and Cochrane Library. We also searched Chinese databases, including Chinese National Knowledge Infrastructure (CNKI), Chinese Biology Medicine (CBM), Wanfang database, and VIP Database for Chinese Technical Periodicals without language limitations. Results. Based on the criteria, we found 12 RCTs including 825 patients. Our results showed that TACE combined with PEI therapy compared with TACE monotherapy improved overall survival and tumor response. Conclusion. The combination of TACE and PEI compared with TACE monotherapy improved overall survival rates and tumor response of patients with large HCC. Besides, larger and more methodologically rigorous clinical trials are needed to confirm this outcome. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"526024"},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/526024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31650536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo. 血红素和原卟啉锌IX对格拉司琼体内外便秘作用的影响

ISRN gastroenterology Pub Date : 2013-06-20 Print Date: 2013-01-01 DOI: 10.1155/2013/612037

Addolorata Zigrino, Valentina Leo, Giuseppe Renna, Monica Montagnani, Maria Antonietta De Salvia

{"title":"Hemin and Zinc Protoporphyrin IX Affect Granisetron Constipating Effects In Vitro and In Vivo.","authors":"Addolorata Zigrino, Valentina Leo, Giuseppe Renna, Monica Montagnani, Maria Antonietta De Salvia","doi":"10.1155/2013/612037","DOIUrl":"https://doi.org/10.1155/2013/612037","url":null,"abstract":"Granisetron is a 5-HT3 receptors antagonist used in the management of emesis associated with anticancer chemotherapy. It affects intestinal motility with constipating effect. Since the pathway heme oxygenase/carbon monoxide (HO/CO) is involved in gastrointestinal motility, we evaluated the possible interplay between granisetron and agents affecting HO/CO pathways such as zinc protoporphyrin IX (ZnPPIX), an HO inhibitor, or hemin, an HO-1 inducer. ZnPPIX (10 µM) or hemin (10 µM), but not granisetron (0.1, 0.3, 1 µM), affected spontaneous basal activity recorded in rat duodenal strips, in noncholinergic nonadrenergic conditions. Granisetron restored spontaneous basal activity after ZnPPIX, but not after hemin. ZnPPIX decreased and hemin increased the inhibition of activity after electrical field stimulation (EFS), but they did not affect the contraction that follows the relaxation induced by EFS called off contraction. Granisetron did not alter the response to EFS per se but abolished both ZnPPIX and hemin effect when coadministered. In vivo study showed constipating effect of granisetron (25, 50, 75 µg/kg/sc) but no effect of either ZnPPIX (50 µg/kg/i.p.) or hemin (50 µM/kg/i.p.). When coadministered, granisetron effect was abolished by ZnPPIX and increased by hemin. Specimens from rats treated in vivo with hemin (50 µM/kg/i.p.) showed increased HO-1 protein levels. In conclusion, granisetron seems to interact with agents affecting HO/CO pathway both in vitro and in vivo. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"612037"},"PeriodicalIF":0.0,"publicationDate":"2013-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/612037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31588600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Factors Influencing Survival in Stage IV Colorectal Cancer: The Influence of DNA Ploidy. 影响IV期结直肠癌生存的因素:DNA倍性的影响。

ISRN gastroenterology Pub Date : 2013-06-04 Print Date: 2013-01-01 DOI: 10.1155/2013/490578

Ioannis D Xynos, Nicolaos Kavantzas, Smaro Tsaousi, Michalis Zacharakis, George Agrogiannis, Christos Kosmas, Andreas Lazaris, John Sarantonis, Stavros Sougioultzis, Dimitrios Tzivras, Aris Polyzos, Efstratios S Patsouris, Nikolas Tsavaris

{"title":"Factors Influencing Survival in Stage IV Colorectal Cancer: The Influence of DNA Ploidy.","authors":"Ioannis D Xynos, Nicolaos Kavantzas, Smaro Tsaousi, Michalis Zacharakis, George Agrogiannis, Christos Kosmas, Andreas Lazaris, John Sarantonis, Stavros Sougioultzis, Dimitrios Tzivras, Aris Polyzos, Efstratios S Patsouris, Nikolas Tsavaris","doi":"10.1155/2013/490578","DOIUrl":"https://doi.org/10.1155/2013/490578","url":null,"abstract":"Objective. To evaluate the prognostic significance of microscopically assessed DNA ploidy and other clinical and laboratory parameters in stage IV colorectal cancer (CRC). Methods. 541 patients with histologically proven stage IV CRC treated with palliative chemotherapy at our institution were included in this retrospective analysis, and 9 variables (gender, age, performance status, carcinoembryonic antigen, cancer antigen 19-9, C-Reactive Protein (CRP), anaemia, hypoalbuminaemia, and ploidy (DNA Index)) were assessed for their potential relationship to survival. Results. Mean survival time was 12.8 months (95% confidence interval (CI) 12.0-13.5). Multivariate analysis revealed that DNA indexes of 2.2-3.6 and >3.6 were associated with 2.94 and 4.98 times higher probability of death, respectively, compared to DNA index <2.2. CRP levels of >15 mg/dL and 5-15 mg/dL were associated with 2.52 and 1.72 times higher risk of death, respectively. Hazard ratios ranged from 1.29 in patients mild anaemia (Hb 12-13.5 g/dL) to 1.88 in patients with severe anaemia (Hb < 8.5 g/dL). Similarly, the presence of hypoalbuminaemia (albumin < 5 g/dL) was found to confer 1.41 times inferior survival capability. Conclusions. Our findings suggest that patients with stage IV CRC with low ploidy score and CRP levels, absent or mild anaemia, and normal albumin levels might derive greatest benefit from palliative chemotherapy. ","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"490578"},"PeriodicalIF":0.0,"publicationDate":"2013-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/490578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31568395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The effect of weight loss on pediatric nonalcoholic Fatty liver disease. 减肥对儿童非酒精性脂肪肝的影响

ISRN gastroenterology Pub Date : 2013-05-27 Print Date: 2013-01-01 DOI: 10.1155/2013/398297

David E St-Jules, Corilee A Watters, Ken Nagamori, Jeremy King

{"title":"The effect of weight loss on pediatric nonalcoholic Fatty liver disease.","authors":"David E St-Jules, Corilee A Watters, Ken Nagamori, Jeremy King","doi":"10.1155/2013/398297","DOIUrl":"https://doi.org/10.1155/2013/398297","url":null,"abstract":"This study evaluated the effect of weight loss on pediatric nonalcoholic fatty liver disease (NAFLD). Subjects included 81 overweight NAFLD patients referred to two pediatric gastroenterologists from 2000 to 2010. Data on subjects were obtained from review of medical charts. The effect of weight loss was assessed at 1-4 months, 5-8 months, 9-12 months, and beyond one year as the change in weight, BMI z-score (for age-and-sex), and alanine aminotransferase and the relationship between the change in body weight and BMI z-score, and the change in alanine aminotransferase. Subjects were mostly obese (99%), male (86%), and Asian (63%) and had median age of 14.1 (11.2-16.2) years and alanine aminotransferase of 105 (78-153) U/L at referral. Alanine aminotransferase decreased 32 ± 66 (P = 0.016), 30 ± 65 (P = 0.134), 37 ± 75 (P = 0.0157), and 45 ± 69 (P = 0.014) for subjects with follow-up data at 1-4 months (n = 47), 5-8 months (n = 26), 9-12 months (n = 19), and beyond one year (n = 19), respectively. During these time periods, neither was body weight (-0.2 to +7.1 kg) or BMI z-score (-0.12 to -0.05) significantly reduced, nor were changes in these variables associated with the change in alanine aminotransferase. These findings suggest that weight and BMI z-score may not be sufficient indicators of treatment response in pediatric NAFLD patients.","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"398297"},"PeriodicalIF":0.0,"publicationDate":"2013-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/398297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31518579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2