结直肠癌的发病率在荷兰zaanstreek地区的老年队列中正在下降:年龄队列效应。

ISRN gastroenterology Pub Date : 2013-07-07 Print Date: 2013-01-01 DOI:10.1155/2013/871308
R J L F Loffeld, P E P Dekkers, M Flens
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引用次数: 5

摘要

介绍。结直肠癌(CRC)发病率高。切除腺瘤,即前体病变,可能有助于预防癌症。的目标。目的:调查连续几年结直肠癌的年发病率。患者和方法。研究对象为1990年至2010年间诊断为结直肠癌的所有患者。评估诊断日期、诊断时的年龄、性别和肿瘤的位置。结果。共有1575例结直肠癌确诊病例,其中男性865例(55%),女性710例(45%)。结直肠癌多见于男性。随着时间的推移,结直肠癌的发病率有所增加。排除直肠癌后,结肠近端癌的百分比呈逐年上升趋势。在连续的20年里,Zaanstreek地区的人口从130.000增加到145.330。在这20年间,51-70岁年龄组的结直肠癌发病率显著增加,而71岁以上年龄组的癌症发病率显著下降。结论。71岁以上年龄组结直肠癌发病率的下降可能间接反映了由于这些年龄组在生命早期切除腺瘤而产生的年龄队列效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect.

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect.

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect.

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect.

Introduction. Colorectal cancer (CRC) has a high incidence. Removal of adenomas, the precursor lesion, could be helpful in the prevention of cancer. Aim. To investigate the yearly incidence of CRC in consecutive years. Patients and Methods. All patients diagnosed with CRC in the years 1990 till 2010 were studied. Date of diagnosis, age at time of diagnosis, gender, and localisation of the tumour were assessed. Results. A total of 1575 incident CRC were diagnosed, 865 men (55%) and 710 women (45%). CRC occurred more often in men. In the course of the years, the occurrence of CRC increased. After exclusion of rectal cancer, the percentage of proximal cancer in the colon shows a trend towards increase in the consecutive years. In the twenty consecutive years, the population of the Zaanstreek region increased from 130.000 to 145.330. There was a significant increase of CRC in the age cohort 51-70 in the period of twenty years, while a significant decreasing incidence of cancer was seen in patients above 71 years. Conclusion. The decreasing incidence of colorectal cancer in the age cohorts above 71 years possibly reflects indirect evidence of an age-cohort effect due to removal of adenomas in these age cohorts earlier in life.

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