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Role of pentoxifylline and sparfloxacin in prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. 己酮茶碱和斯帕沙星在肝硬化患者自发性细菌性腹膜炎预防中的作用。
ISRN gastroenterology Pub Date : 2014-03-06 eCollection Date: 2014-01-01 DOI: 10.1155/2014/595213
Tarek Mohammed Mostafa, Osama Mohamed Ibrahim, Gamal Abd El-Khalek Badra, Mahmoud Samy Abdallah
{"title":"Role of pentoxifylline and sparfloxacin in prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients.","authors":"Tarek Mohammed Mostafa,&nbsp;Osama Mohamed Ibrahim,&nbsp;Gamal Abd El-Khalek Badra,&nbsp;Mahmoud Samy Abdallah","doi":"10.1155/2014/595213","DOIUrl":"https://doi.org/10.1155/2014/595213","url":null,"abstract":"<p><p>This study was directed to evaluate the role of sparfloxacin and pentoxifylline in the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. Forty cirrhotic patients with ascites were included in the study. Patients were randomized into four groups in a blind fashion; each group consists of ten patients. Group one received ciprofloxacin (control group), group two received sparfloxacin, group three received pentoxifylline, and group four received a combination of sparfloxacin and pentoxifylline. Treatment duration was six months. Serum TNF- α level was the primary inflammatory marker of the study to evaluate the effect of the used medications. In group two, TNF- α level showed a statistically significant decrease in comparison with group one (P = 0.001), while in group three, TNF- α level showed nonsignificant difference in comparison with the control group (P > 0.05). In addition, group four showed a statistically significant decrease in TNF- α level compared to the other three groups (P < 0.05). The finding from our study indicates that sparfloxacin as well as pentoxifylline could be used in prophylaxis of spontaneous bacterial peritonitis. Combination of sparfloxacin and pentoxifylline showed some of synergism which may be useful in decreasing emergence of resistant strains. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2014 ","pages":"595213"},"PeriodicalIF":0.0,"publicationDate":"2014-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/595213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32261093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Development of polyps and cancer in patients with a negative colonoscopy: a follow-up study of more than 20 years. 结肠镜检查阴性患者息肉和癌症的发展:超过20年的随访研究。
ISRN gastroenterology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/261302
R J L F Loffeld
{"title":"Development of polyps and cancer in patients with a negative colonoscopy: a follow-up study of more than 20 years.","authors":"R J L F Loffeld","doi":"10.1155/2014/261302","DOIUrl":"https://doi.org/10.1155/2014/261302","url":null,"abstract":"<p><p>Background. Adenomas are missed during colonoscopy. Aim. Assess the occurrence of colorectal cancer (CRC) and polyps in patients with a negative index colonoscopy (IC). Patients and Methods. All patients with a IC in 1992-1994, aged 40 and 60 years, were included. Exclusion criterion was presence of abnormalities, a family history, or surveillance. At the end of 2013 all records were studied in order to gather follow-up information. Results. 394 patients were included in four groups: group 1 patients who died, group 2 patients who were not in the hospital systems anymore, group 3 patients still visiting the hospital but not the department of gastroenterology, and group 4 patients undergoing new colonoscopies. In group 1, 2 patients died of CRC and 4 developed a polyp. No data were available from the patients in group 2. Patients in group 3 visited the outpatient clinics but did not undergo new colonoscopy. Patients in group 4 underwent additional colonoscopies. The yield was 35 patients polyps and three CRCs. Five patients (1.3%) developed CRC, and 39 (9%) developed a polyp. Conclusion. Given these results the number of potentially missed adenomas in IC is very low and the consequences of missed adenomas are highly exaggerated. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2014 ","pages":"261302"},"PeriodicalIF":0.0,"publicationDate":"2014-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/261302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32261672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Cavity as an Extragastric Reservoir of Helicobacter pylori. 口腔是幽门螺杆菌的胃外储存库。
ISRN gastroenterology Pub Date : 2014-02-20 eCollection Date: 2014-01-01 DOI: 10.1155/2014/261369
Arwa Al Sayed, Pradeep S Anand, Kavitha P Kamath, Shankargouda Patil, R S Preethanath, Sukumaran Anil
{"title":"Oral Cavity as an Extragastric Reservoir of Helicobacter pylori.","authors":"Arwa Al Sayed,&nbsp;Pradeep S Anand,&nbsp;Kavitha P Kamath,&nbsp;Shankargouda Patil,&nbsp;R S Preethanath,&nbsp;Sukumaran Anil","doi":"10.1155/2014/261369","DOIUrl":"https://doi.org/10.1155/2014/261369","url":null,"abstract":"<p><p>Background. Several studies were reported on the prevalence, and relationship between the existence of Helicobacter pylori (H. pylori) in oral cavity and in stomach of patients. The purpose of this study was to systematically review the existing literature on the presence of H. pylori in the oral cavity and its link to gastric infection, the existence of coinfection, and the impact of anti-H. pylori therapy on the dental plaque and vice versa. Method. Two authors independently searched the Medline, EMBASE, Cochrane Library, Web of Science, Google Scholar, and Scopus databases for relevant studies. The articles were analyzed critically and all qualified studies were included. The search was carried out by using a combined text and the MeSH search strategies: using the key words Helicobacter, Helicobacter pylori, and H. pylori in combination with dental plaque, periodontitis, and oral hygiene. Results. The data was presented in 8 tables and each topic separately discussed. Conclusion. Based on the systematic review of the available literature on H. pylori infection and its presence in the oral cavity, it can be concluded that dental plaque can act as a reservoir, and proper oral hygiene maintenance is essential to prevent reinfection. Due to the diversified methods and population groups involved in the available literature, no concrete evidence can be laid down. Further studies are necessary to establish the role of H. pylori in the oral cavity and its eradication on preventing the gastroduodenal infection. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2014 ","pages":"261369"},"PeriodicalIF":0.0,"publicationDate":"2014-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/261369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32234713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
Is CT Angiogram of the Abdominal Vessels Needed following the Diagnosis of Ischemic Colitis? A Multicenter Community Study. 缺血性结肠炎诊断后是否需要腹部血管CT造影?多中心社区研究。
ISRN gastroenterology Pub Date : 2014-02-12 eCollection Date: 2014-01-01 DOI: 10.1155/2014/756926
Muhammed Sherid, Salih Samo, Samian Sulaiman, Husein Husein, Sankara N Sethuraman, John A Vainder
{"title":"Is CT Angiogram of the Abdominal Vessels Needed following the Diagnosis of Ischemic Colitis? A Multicenter Community Study.","authors":"Muhammed Sherid,&nbsp;Salih Samo,&nbsp;Samian Sulaiman,&nbsp;Husein Husein,&nbsp;Sankara N Sethuraman,&nbsp;John A Vainder","doi":"10.1155/2014/756926","DOIUrl":"https://doi.org/10.1155/2014/756926","url":null,"abstract":"<p><p>Background. CT angiogram is frequently obtained after diagnosis of ischemic colitis (IC). Aims. To investigate the vascular findings of CT angiogram as compared to contrast-enhanced CT scan and whether this modality changes the management or prognosis of IC. Methods. We conducted a retrospective analysis of patients with IC from 2007 to 2013. Results. CT angiogram was performed in 34 patients (28.81%), whereas contrast-enhanced CT scan was performed in 54 patients (45.76%). In CT angiogram group, 8 patients (23.5%) had atherosclerotic changes. Stenosis was found in 12 patients (35.3%) (9: celiac trunk, 3: SMA). Among this group, one patient underwent colectomy and another underwent angioplasty of the celiac trunk who died within 30 days. Among contrast-enhanced CT scan group, 5 patients (9.3%) had atherosclerotic changes. Stenosis was found in 5 patients (9.3%) (3: celiac trunk, 1: SMA, and 1: IMA). Among this group, 3 patients had colectomy and one died within 30 days. There was no statistical difference between both groups in all vascular findings except the stenosis which was higher in CT angiogram group (P = 0.0025). Neither the need for surgery nor all-cause mortality was different between both groups. Conclusion. CT angiogram did not provide any useful findings that altered the management or the prognosis of IC. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2014 ","pages":"756926"},"PeriodicalIF":0.0,"publicationDate":"2014-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/756926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32557972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Preliminary Study on the Expression and the Clinical Significance of CD133 in Peripheral Blood of Patients with Gastric Adenocarcinoma. 胃腺癌患者外周血CD133表达及临床意义的初步研究。
ISRN gastroenterology Pub Date : 2014-02-06 eCollection Date: 2014-01-01 DOI: 10.1155/2014/245329
Ju-Gang Wu, Ji-Wei Yu, Rui-Qi Lu, Shou-Lian Wang, Xiao-Chun Ni, Lin-Hai Zheng, Bo-Jian Jiang
{"title":"Preliminary Study on the Expression and the Clinical Significance of CD133 in Peripheral Blood of Patients with Gastric Adenocarcinoma.","authors":"Ju-Gang Wu,&nbsp;Ji-Wei Yu,&nbsp;Rui-Qi Lu,&nbsp;Shou-Lian Wang,&nbsp;Xiao-Chun Ni,&nbsp;Lin-Hai Zheng,&nbsp;Bo-Jian Jiang","doi":"10.1155/2014/245329","DOIUrl":"https://doi.org/10.1155/2014/245329","url":null,"abstract":"<p><p>Background. Significances of CD133 mRNA in peripheral blood mononuclear cells (PBMCs) of gastric adenocarcinoma (GC) patients were investigated. Methods. Correlations of CD133 mRNA expression in PBMCs on clinicopathological parameters or CD133 protein expression were analyzed. Receiver operating characteristic curve according to bright scale value (BSV) of CD133 mRNA was used to group patients for prognosis analysis. Results. BSV of preoperative CD133 mRNA in PBMCs in GC was significantly higher than that in volunteers or in GU. Invasive depth or metastatic lymph node number for higher BSV of preoperative CD133 mRNA and invasive depth or lymphatic vessel invasion for higher BSV of postoperative CD133 mRNA in the PBMCs were identified. Patients with CD133(+) expression in primary lesion had a significantly higher expression of preoperative CD133 mRNA in the PBMCs. The expression of preoperative or postoperative CD133 mRNA in PBMCs related positively to CD133 mRNA expression in primary lesion. Patients with higher expression of preoperative or postoperative CD133 mRNA shared significantly shorter survival compared with that in lower expression group. Conclusion. Higher levels of preoperative or postoperative CD133 mRNA in PBMCs of GC correlated positively to the lymphatic metastasis and the BSV of CD133 mRNA in primary lesion, indicating the poorer survival. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2014 ","pages":"245329"},"PeriodicalIF":0.0,"publicationDate":"2014-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/245329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32197028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Association of symptoms of gastroesophageal reflux with metabolic syndrome parameters in patients with endocrine disease. 内分泌疾病患者胃食管反流症状与代谢综合征参数的关系
ISRN gastroenterology Pub Date : 2014-01-30 eCollection Date: 2014-01-01 DOI: 10.1155/2014/863206
Masatoshi Nomura, Naotaka Tashiro, Tetsuhiro Watanabe, Akie Hirata, Ichiro Abe, Taijiro Okabe, Ryoichi Takayanagi
{"title":"Association of symptoms of gastroesophageal reflux with metabolic syndrome parameters in patients with endocrine disease.","authors":"Masatoshi Nomura,&nbsp;Naotaka Tashiro,&nbsp;Tetsuhiro Watanabe,&nbsp;Akie Hirata,&nbsp;Ichiro Abe,&nbsp;Taijiro Okabe,&nbsp;Ryoichi Takayanagi","doi":"10.1155/2014/863206","DOIUrl":"https://doi.org/10.1155/2014/863206","url":null,"abstract":"<p><p>Background. Metabolic syndrome (MetS) and obesity are known risk factors for gastroesophageal reflux disease (GERD), which is often found in patients with endocrine disorders, such as thyroid dysfunction and hypopituitarism. To clarify the relationship of endocrine disease with GERD, we investigated the symptoms of GERD in patients with various endocrine diseases. Methods. Patients with various endocrine disorders who visited Kyushu University Hospital were included. GERD symptoms were examined using a self-administered questionnaire, the frequency scale for the symptoms of GERD (FSSG). Metabolic parameters, including body-mass index (BMI), waist circumference, blood pressure, hemoglobin A1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides, and values of endocrine function, including thyroid stimulating hormone, free thyroxin, cortisol, and insulin-like growth factor-1, were assessed. Results. A total of 111 consecutive patients were recruited for the study. Among these, 18 (16.2%) patients were considered to have GERD. Among the parameters, BMI (P = 0.03) and triglycerides (P = 0.001) showed a positive association and HDL-C (P = 0.0007) showed an inverse association with the FSSG score. However, none of the endocrine values were associated with the FSSG score. Conclusion. Symptoms of GERD in patients with endocrine disorders might be attributed to MetS as comorbidity. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":" ","pages":"863206"},"PeriodicalIF":0.0,"publicationDate":"2014-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/863206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40305310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Parameters associated with significant liver histological changes in patients with chronic hepatitis B. 慢性乙型肝炎患者肝脏组织学改变的相关参数
ISRN gastroenterology Pub Date : 2014-01-28 eCollection Date: 2014-01-01 DOI: 10.1155/2014/913890
Li Xiao, Jianchun Xian, Yang Li, Aiwen Geng, Xiuzhen Yang, Libin Han, Hongtao Xu
{"title":"Parameters associated with significant liver histological changes in patients with chronic hepatitis B.","authors":"Li Xiao,&nbsp;Jianchun Xian,&nbsp;Yang Li,&nbsp;Aiwen Geng,&nbsp;Xiuzhen Yang,&nbsp;Libin Han,&nbsp;Hongtao Xu","doi":"10.1155/2014/913890","DOIUrl":"https://doi.org/10.1155/2014/913890","url":null,"abstract":"<p><p>This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":" ","pages":"913890"},"PeriodicalIF":0.0,"publicationDate":"2014-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/913890","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40300047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Practical medical management of Crohn's disease. 克罗恩病的实用医疗管理。
ISRN gastroenterology Pub Date : 2013-11-07 DOI: 10.1155/2013/208073
Bulent Baran, Cetin Karaca
{"title":"Practical medical management of Crohn's disease.","authors":"Bulent Baran,&nbsp;Cetin Karaca","doi":"10.1155/2013/208073","DOIUrl":"https://doi.org/10.1155/2013/208073","url":null,"abstract":"<p><p>Crohn's disease is a chronic inflammatory disease of diagnostic and therapeutic challenges. After proper diagnosis, treatment decisions must be made on precise clinical judgment. During the course of the disease there are variable clinical features, so each case must be managed individually. Physicians who care for patients with Crohn's disease should be prepared for treatment options in different states of the disease and possible complications of both the disease and medications. This paper will focus on the management of Crohn's disease. We aim to discuss current treatment options in different presentations of the disease and to provide algorithmic management strategy. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"208073"},"PeriodicalIF":0.0,"publicationDate":"2013-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/208073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31927800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Epidemiology of gastric cancer in the gangetic areas of west bengal. 西孟加拉邦恒河地区胃癌流行病学。
ISRN gastroenterology Pub Date : 2013-10-23 eCollection Date: 2013-01-01 DOI: 10.1155/2013/823483
Ashis Kumar Saha, Somnath Maitra, Subhas Chandra Hazra
{"title":"Epidemiology of gastric cancer in the gangetic areas of west bengal.","authors":"Ashis Kumar Saha,&nbsp;Somnath Maitra,&nbsp;Subhas Chandra Hazra","doi":"10.1155/2013/823483","DOIUrl":"https://doi.org/10.1155/2013/823483","url":null,"abstract":"<p><p>There is marked geographical variation in the distribution and incidence of stomach cancer. We tried here to describe the pattern of relationships of age, sex, religion distribution, symptom profile, histological subtypes and Helicobacter pylori (H. pylori) infection with gastric cancer in Gangetic West Bengal. This study was done over a period of five years (2006-2010). The patients residing in the Gangetic areas of West Bengal presenting with upper gastrointestinal symptoms underwent UGI endoscopy. Among gastric cancer patients, demographic characteristics, symptomatology, macroscopic and histologic lesions and H. pylori status were analyzed. At confidence level 95%, \"Z\" and \"P\" value were calculated to find significance. Among 23851 patients underwent UGI endoscopy, 14106 were males, 9745 females, 17889 Hindus and 5962 Muslims. Among 462 gastric cancer patients, Male : Female 2.7 : 1, Hindus : Muslim 3 : 1, abdominal pain, indigestion, and weight-loss were commonest presentations. Antrum was the commonest site whereas ulceroproliferative type was commonest type. H. pylori positivity was 80.89% in adenocarcinoma with statistically significant relation with intestinal type. In future, our target will be to modify risk factors; it will need further demographic studies and analysis, so that we can detect it earliest. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"823483"},"PeriodicalIF":0.0,"publicationDate":"2013-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/823483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31881165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Loss of villin immunoexpression in colorectal carcinoma is associated with poor differentiation and survival. 结直肠癌中绒毛蛋白免疫表达的缺失与分化差和生存率低有关。
ISRN gastroenterology Pub Date : 2013-09-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/679724
Jaudah Al-Maghrabi, Wafaey Gomaa, Abdelbaset Buhmeida, Mohmmad Al-Qahtani, Mahmoud Al-Ahwal
{"title":"Loss of villin immunoexpression in colorectal carcinoma is associated with poor differentiation and survival.","authors":"Jaudah Al-Maghrabi,&nbsp;Wafaey Gomaa,&nbsp;Abdelbaset Buhmeida,&nbsp;Mohmmad Al-Qahtani,&nbsp;Mahmoud Al-Ahwal","doi":"10.1155/2013/679724","DOIUrl":"https://doi.org/10.1155/2013/679724","url":null,"abstract":"<p><p>Background and Aims. Villin is a highly specialised protein and is expressed in intestinal and renal proximal tubular epithelium. It was detected in colorectal carcinomas (CRC) and other nongastrointestinal tumours. The aim of the current study is to investigate the immunohistochemical expression of villin in a subset of primary CRC and determine its relation to tumour differentiation, invasion, nodal metastasis, recurrence, and disease-free survival. Patients and Methods. Paraffin blocks of 93 cases of CRC were retrieved constituting 93 primary CRC and 58 adjacent normal mucosa. Immunohistochemistry was performed using antivillin antibody. The extent (%) of villin immunoexpression was categorised for statistical analysis. Statistical tests were used to determine the association of villin with clinicopathological characteristics: age, sex, tumour location, tumour size, depth of invasion, tumour grade, nodal metastasis, lymphovascular invasion, margin status, recurrence, and survival. Results. Villin immunostaining results showed that villin is downregulated in CRC. Villin has no association with age, sex, tumour location, depth of invasion, nodal metastasis, lymphovascular invasion, margin status, and recurrence. However, villin is expressed in higher rate in CRC less than 5 cm, well- and moderately differentiated CRC. Poor survival was associated with tumour with low villin immunoexpression. Conclusion. Villin was downregulated in CRC. Villin immunoexpression in CRC is associated with better survival, well-differentiated tumours, and small-sized tumours. Villin has no significant association with disease recurrence or nodal metastasis. More in vivo and in vitro studies are required for further elucidation of how villin may be involved in CRC. </p>","PeriodicalId":89397,"journal":{"name":"ISRN gastroenterology","volume":"2013 ","pages":"679724"},"PeriodicalIF":0.0,"publicationDate":"2013-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/679724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31772997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
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