Development of polyps and cancer in patients with a negative colonoscopy: a follow-up study of more than 20 years.

ISRN gastroenterology Pub Date : 2014-03-04 eCollection Date: 2014-01-01 DOI:10.1155/2014/261302
R J L F Loffeld
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Abstract

Background. Adenomas are missed during colonoscopy. Aim. Assess the occurrence of colorectal cancer (CRC) and polyps in patients with a negative index colonoscopy (IC). Patients and Methods. All patients with a IC in 1992-1994, aged 40 and 60 years, were included. Exclusion criterion was presence of abnormalities, a family history, or surveillance. At the end of 2013 all records were studied in order to gather follow-up information. Results. 394 patients were included in four groups: group 1 patients who died, group 2 patients who were not in the hospital systems anymore, group 3 patients still visiting the hospital but not the department of gastroenterology, and group 4 patients undergoing new colonoscopies. In group 1, 2 patients died of CRC and 4 developed a polyp. No data were available from the patients in group 2. Patients in group 3 visited the outpatient clinics but did not undergo new colonoscopy. Patients in group 4 underwent additional colonoscopies. The yield was 35 patients polyps and three CRCs. Five patients (1.3%) developed CRC, and 39 (9%) developed a polyp. Conclusion. Given these results the number of potentially missed adenomas in IC is very low and the consequences of missed adenomas are highly exaggerated.

结肠镜检查阴性患者息肉和癌症的发展:超过20年的随访研究。
背景。结肠镜检查时遗漏腺瘤。的目标。评估阴性结肠镜检查(IC)患者结直肠癌(CRC)和息肉的发生率。患者和方法。所有1992-1994年间40岁和60岁的IC患者纳入研究。排除标准为存在异常、家族史或监测。2013年底,为了收集后续信息,对所有记录进行了研究。结果:394例患者分为4组:第1组患者死亡,第2组患者不在医院系统,第3组患者仍在医院就诊但未到消化内科就诊,第4组患者新行结肠镜检查。1组2例死于结直肠癌,4例发生息肉。2组患者无资料。第三组患者到门诊就诊,但没有进行新的结肠镜检查。第4组患者接受了额外的结肠镜检查。结果为35例息肉和3例crc。5名患者(1.3%)发展为结直肠癌,39名患者(9%)发展为息肉。结论。鉴于这些结果,IC中潜在漏诊腺瘤的数量非常低,漏诊腺瘤的后果被高度夸大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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