Hepatocellular Carcinoma More Than 3 cm in Diameter: A Systematic Review of Transcatheter Arterial Chemoembolization Plus Percutaneous Ethanol Injection versus Transcatheter Arterial Chemoembolization Alone.
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引用次数: 10
Abstract
Objective. To identify the efficiency and safety of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol (PEI) for patients with hepatocellular carcinoma (HCC) more than 3 cm in diameter in comparison with those of transcatheter arterial chemoembolization monotherapy. Methods. All databases were searched up to February 22, 2013. The literature retrieval was conducted through Pubmed, Web of Science, and Cochrane Library. We also searched Chinese databases, including Chinese National Knowledge Infrastructure (CNKI), Chinese Biology Medicine (CBM), Wanfang database, and VIP Database for Chinese Technical Periodicals without language limitations. Results. Based on the criteria, we found 12 RCTs including 825 patients. Our results showed that TACE combined with PEI therapy compared with TACE monotherapy improved overall survival and tumor response. Conclusion. The combination of TACE and PEI compared with TACE monotherapy improved overall survival rates and tumor response of patients with large HCC. Besides, larger and more methodologically rigorous clinical trials are needed to confirm this outcome.
目标。目的探讨经导管动脉化疗栓塞(TACE)联合经皮乙醇(PEI)治疗直径大于3cm的肝细胞癌(HCC)与经导管动脉化疗栓塞单药治疗的疗效和安全性。方法。所有的数据库被检索到2013年2月22日。文献检索通过Pubmed、Web of Science和Cochrane Library进行。我们还检索了中文数据库，包括中国知网(CNKI)、中国生物医学数据库(CBM)、万方数据库和维普数据库(VIP)，没有语言限制。结果。根据标准，我们找到12项随机对照试验，包括825例患者。我们的研究结果显示，与TACE单药治疗相比，TACE联合PEI治疗提高了总生存期和肿瘤反应。结论。与TACE单药治疗相比，TACE联合PEI可提高大肝癌患者的总生存率和肿瘤反应。此外，还需要更大规模、更严谨的临床试验来证实这一结果。
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