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Diabetic nephropathy : DN最新文献

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The multifaceted contributions of long noncoding RNAs on mitochondrial dysfunction in diabetic nephropathy. 长链非编码rna对糖尿病肾病线粒体功能障碍的多方面贡献。
Diabetic nephropathy : DN Pub Date : 2021-06-01 Epub Date: 2021-08-24 DOI: 10.2478/dine-2021-0003
Li Li, Lin Sun, Farhad R Danesh
{"title":"The multifaceted contributions of long noncoding RNAs on mitochondrial dysfunction in diabetic nephropathy.","authors":"Li Li, Lin Sun, Farhad R Danesh","doi":"10.2478/dine-2021-0003","DOIUrl":"https://doi.org/10.2478/dine-2021-0003","url":null,"abstract":"Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) and end-stage renal disease worldwide [1]. Consensus guidelines for the management of CKD in patients with diabetes recommend control of hyperglycemia and hypertension as well as the use of renin-angiotensin system blockers, and, more recently, sodium-glucose cotransporter 2 inhibitor [2, 3]. Nonetheless, despite extensive studies on the pathogenesis and development of DKD over the past three decades, a significant risk of DKD progression remains, and hence novel approaches and therapies are needed to prevent its occurrence.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"1 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536200/pdf/nihms-1748093.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39551850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of dapagliflozin-induced expression profile of long noncoding RNAs in proximal tubular epithelial cells of diabetic kidney disease 达格列净诱导的糖尿病肾病近端小管上皮细胞长链非编码rna表达谱分析
Diabetic nephropathy : DN Pub Date : 2021-06-01 DOI: 10.2478/dine-2022-0004
Yi Song, F. Guo, Fengjuan Huang, Yanyan Zhao, Xiaojun Ma, Lina Wu, G. Qin
{"title":"Analysis of dapagliflozin-induced expression profile of long noncoding RNAs in proximal tubular epithelial cells of diabetic kidney disease","authors":"Yi Song, F. Guo, Fengjuan Huang, Yanyan Zhao, Xiaojun Ma, Lina Wu, G. Qin","doi":"10.2478/dine-2022-0004","DOIUrl":"https://doi.org/10.2478/dine-2022-0004","url":null,"abstract":"Abstract Background Accumulating evidence indicates that long noncoding RNAs (lncRNAs) play an important role in diabetic kidney disease (DKD). Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, exerts protective effects against DKD, but the underlying mechanism remains unclear. Methods In this study, we performed RNA microarray analysis to investigate differentially expressed lncRNAs and mRNAs in human proximal tubular epithelial cells (HK-2 cells) cultured with normal glucose (Ng), high glucose (Hg), and Hg plus DAPA, and conducted bioinformatic analyses to investigate their functions. Results Compared with the Ng group, 6761 lncRNAs and 3162 mRNAs were differentially expressed in the Hg group. Expression levels of 714 and 259 lncRNAs were up- and down-regulated, respectively, whereas those of 138 and 127 mRNAs were up- and down-regulated, respectively, after DAPA treatment (fold change ≥2, P < 0.05). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted to assess the biological functions of lncRNAs and potential target genes. According to GO analysis, dysregulated mRNAs were primarily enriched in the cell cycle, whereas DAPA-induced mRNAs were enriched in collagen biosynthesis and regulation of programmed cell death. Type I diabetes mellitus and cell cycle signaling were the main KEGG pathways in the Hg group. However, cancer and signal transduction pathways were related to DAPA treatment. Conclusions Finally, we established protein–protein interaction (PPI) networks, as well as lncRNA–mRNA and lncRNA–miRNA–mRNA networks, and identified five potentially important lncRNAs whose expression levels were altered by DAPA treatment. Our findings suggest that lncRNAs are potential targets for DKD treatment.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"22 1","pages":"77 - 89"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75209827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetic Nephropathy Foreword 糖尿病肾病
Diabetic nephropathy : DN Pub Date : 2021-06-01 DOI: 10.2478/dine-2021-0001
Jianghua Chen
{"title":"Diabetic Nephropathy Foreword","authors":"Jianghua Chen","doi":"10.2478/dine-2021-0001","DOIUrl":"https://doi.org/10.2478/dine-2021-0001","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"123 1","pages":"1 - 2"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79481730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key profibrotic and pro-inflammatory pathways in the pathogenesis of diabetic kidney disease 糖尿病肾病发病过程中关键的促纤维化和促炎途径
Diabetic nephropathy : DN Pub Date : 2021-06-01 DOI: 10.2478/dine-2021-0005
Devang M Patel, Yuxin Yang, Kexin Shi, Tieqiao Wu, M. Cooper, Z. Chai
{"title":"Key profibrotic and pro-inflammatory pathways in the pathogenesis of diabetic kidney disease","authors":"Devang M Patel, Yuxin Yang, Kexin Shi, Tieqiao Wu, M. Cooper, Z. Chai","doi":"10.2478/dine-2021-0005","DOIUrl":"https://doi.org/10.2478/dine-2021-0005","url":null,"abstract":"Abstract Diabetes is a noncommunicable disease and arguably represents the greatest pandemic in human history. Diabetic kidney disease (DKD) is seen in both type 1 and type 2 diabetes and can be detected in up to 30–50% of diabetic subjects. DKD is a progressive chronic kidney disease (CKD) and is a leading cause of mortality and morbidity in patients with diabetes. Renal fibrosis and inflammation are the major pathological features of DKD. There are a large number of independent and overlapping profibrotic and pro-inflammatory pathways involved in the pathogenesis and progression of DKD. Among these pathways, the transforming growth factor-β (TGF-β) pathway plays a key pathological role by promoting fibrosis. Sirtuin-1 (SIRT1) is a protein deacetylase that has been shown to be renoprotective with an anti-inflammatory effect. It is postulated that a reduction in renal SIRT1 levels could play a key role in the pathogenesis of DKD and that restoration of SIRT1 will attenuate DKD. Cell division autoantigen 1 (CDA1) synergistically enhances the profibrotic effect of TGF-β in DKD by regulating the expression of the TGF-β type I receptor (TβRI). CDA1 has also been found to be an inhibitor of SIRT1 in the DNA damage response. Indeed, targeting CDA1 in experimental DKD not only attenuates diabetes-associated renal fibrosis but also attenuates the expression of key pro-inflammatory genes such as tumor necrosis factor-α (TNF-α) and Monocyte Che moattractant Protein-1 (MCP-1). In conclusion, there is a large body of experimental data to support the view that targeting CDA1 is a superior approach to directly targeting TGF-β in DKD since it is not only safe but also efficacious in retarding both fibrosis and inflammation.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"16 1","pages":"15 - 26"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72729254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Insulin therapy in diabetic kidney disease 胰岛素治疗糖尿病肾病
Diabetic nephropathy : DN Pub Date : 2021-06-01 DOI: 10.2478/dine-2022-0006
Yan Liu, Chanyue Zhao, Xiao-fen Xiong, Ming Yang, Lin Sun
{"title":"Insulin therapy in diabetic kidney disease","authors":"Yan Liu, Chanyue Zhao, Xiao-fen Xiong, Ming Yang, Lin Sun","doi":"10.2478/dine-2022-0006","DOIUrl":"https://doi.org/10.2478/dine-2022-0006","url":null,"abstract":"Abstract Diabetic kidney disease (DKD) is the main cause of end-stage renal disease (ESRD). The use of insulin represents a challenge in patients with DKD due to the patient and medication issues. Insulin regimens, insulin dosing, and titration need to be individualized based on the patient's age, renal function, and comorbidities to improve glycemic control and reduce the risk of hypoglycemia. Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) and DKD. For patients with type 2 diabetes mellitus (T2DM) and early stage of DKD, basal insulin combined with oral antidiabetic drugs (OADs) is recommended. In patients with middle and advanced DKD, it is necessary to adjust the dose of insulin according to stages of DKD, and the use of insulin analogs is recommended. In particular, elderly patients with DKD can simplify their insulin regimen to reduce the risk of hypoglycemia. In pregnant women with DKD, insulin requirements also vary based on parity and the stage of pregnancy.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"09 1","pages":"67 - 76"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86047449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal biopsy in patients with diabetes: Yesterday, today, and tomorrow 糖尿病患者的肾活检:昨天，今天和明天
Diabetic nephropathy : DN Pub Date : 2021-06-01 DOI: 10.2478/dine-2022-0001
W. Hiser, Xinjin Zhou
{"title":"Renal biopsy in patients with diabetes: Yesterday, today, and tomorrow","authors":"W. Hiser, Xinjin Zhou","doi":"10.2478/dine-2022-0001","DOIUrl":"https://doi.org/10.2478/dine-2022-0001","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"22 1","pages":"59 - 62"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74114882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous membranous nephropathy and diabetic nephropathy occurrence in a patient: A case report 膜性肾病和糖尿病肾病同时发生1例报告
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2478/dine-2021-0009
Binyao Tian, Nan Liu, Tianhua Xu, Xiaodan Liu, L. Yao
{"title":"Simultaneous membranous nephropathy and diabetic nephropathy occurrence in a patient: A case report","authors":"Binyao Tian, Nan Liu, Tianhua Xu, Xiaodan Liu, L. Yao","doi":"10.2478/dine-2021-0009","DOIUrl":"https://doi.org/10.2478/dine-2021-0009","url":null,"abstract":"Abstract Membranous nephropathy (MN) is the most common glomerular disease in adults and is constantly associated with the occurrence of nephrotic syndrome. While diabetic kidney disease (DKD) and diabetic nephropathy (DN), which often occur in diabetic patients, are considered as the major causes of end-stage kidney disease. Actually, MN often occurs in patients with diabetes mellitus (DM), but to obtain a clear differential diagnosis without a renal biopsy has become difficult. Here we report the case of a female diabetic patient who developed both MN and DN simultaneously.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"11 1","pages":"51 - 54"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89460990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis of diabetic kidney disease 糖尿病肾病的发病机制
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2478/dine-2021-0004
S. Tang, Anthony Chan, W. Yiu, K. Lai
{"title":"Pathogenesis of diabetic kidney disease","authors":"S. Tang, Anthony Chan, W. Yiu, K. Lai","doi":"10.2478/dine-2021-0004","DOIUrl":"https://doi.org/10.2478/dine-2021-0004","url":null,"abstract":"Abstract Diabetic kidney disease (DKD) is characterized by an accumulation of extracellular matrix proteins such as collagen and fibronectin in the kidney, resulting in tubulointerstitial fibrosis, glomerular mesangial hypertrophy and expansion, thickening of the glomerular basement membrane, podocyte foot process effacement, and inflammation due to the infiltration of monocytes and macrophages. All of these factors contribute to kidney function loss and can ultimately lead to progressive chronic kidney disease and kidney failure. In the review, we summarize the current state of knowledge in the pathogenesis of diabetic kidney disease to include the impact of genetic and environmental factors, hemodynamic changes, glycemic control, inflammation, proteinuria and novel mechanisms such as non-coding RNAs and lipotoxicity.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"6 1","pages":"9 - 13"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89850684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NRF2: A potential target for the treatment of diabetic nephropathy NRF2:治疗糖尿病肾病的潜在靶点
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2478/dine-2021-0006
Jiahui Zhang, Fnu Anshul, Joshua D. Breidenbach, Jing Liu, James Shaffner
{"title":"NRF2: A potential target for the treatment of diabetic nephropathy","authors":"Jiahui Zhang, Fnu Anshul, Joshua D. Breidenbach, Jing Liu, James Shaffner","doi":"10.2478/dine-2021-0006","DOIUrl":"https://doi.org/10.2478/dine-2021-0006","url":null,"abstract":"Abstract One of the major complications of diabetes mellitus is diabetic nephropathy (DN), the pathogenesis of which is primarily driven by oxidative stress. As a major regulator of antioxidant responses, the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has recently attracted much interest. NRF2 is a primary defense mechanism against the cytotoxic effects of oxidative stress, involving heterogeneous detoxification, the production of antioxidants and anti-inflammatory molecules, DNA repair, nuclear chaperones, and proteasome systems. A myriad of studies in pre-clinical models of DN have consistently demonstrated a beneficial effect of NRF2 activation, suggesting that NRF2 is likely a promising target for treating DN. This has been further supported by findings from clinical trials of bardoxolone methyl, an activator of NRF2, despite the unexpected adverse cardiovascular effects. This review summarizes the support for therapeutic targeting of NRF2 in DN and emphasizes the need for the optimization of NRF2-based treatment with the minimization of potential adverse effects.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"11 1","pages":"27 - 32"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85489103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expression of POMC and AgRP in brain and kidney tissues at different stages of diabetic nephropathy rats 糖尿病肾病不同阶段大鼠脑、肾组织中POMC和AgRP的表达
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2478/dine-2021-0008
Shasha Liu, J. Da, Jiayu Li, R. Dong, J. Yuan, Y. Zha
{"title":"The expression of POMC and AgRP in brain and kidney tissues at different stages of diabetic nephropathy rats","authors":"Shasha Liu, J. Da, Jiayu Li, R. Dong, J. Yuan, Y. Zha","doi":"10.2478/dine-2021-0008","DOIUrl":"https://doi.org/10.2478/dine-2021-0008","url":null,"abstract":"Abstract Objective To explore the changes of proopiomelanocortin (POMC) and Agouti-Related Peptide (AgRP) expression in brain and kidney tissues under insulin intervention at different stages of diabetic nephropathy (DN) rats. Methods The male Sprague-Dawley (SD) rats of DN were treated with high-fat diet for 8 weeks and induced by intraperitoneally injection of streptozotocin (30 mg/kg) for one time. Then DN rats were also injected insulin subcutaneously at 2–5 U/(kg·24 h) from initiation of the streptozotocin. Kidney tissue, blood sample, and 24 h-urine were collected to detect the ratio of kidney/body weight, blood glucose and 24-h urinary albumin excretion rate at different stages (4, 8, 12, and 16 weeks). Immunohistochemistry assay was used to measure the expression of POMC and AgRP at different stages of DN rats. Results The DN rats were established successfully. With the progression of DN, blood glucose, 24-h urinary albumin excretion rate and kidney body weight ratio increased significantly, while decreased when insulin was injected. Immunohistochemistry showed that the expression levels of POMC were decreased gradually in brain and kidney tissues. Conversely, the expression of AgRP in kidney was highest at week 8 and then decreased gradually. The effect of insulin on normalizing POMC and AgRP expression in brain and renal tissues was also observed in DKD rats. Conclusion With the progression of DN, the expression of POMC and AgRP in kidney tissues was observed at different stages of disease, and their expressions were significantly normalized by insulin. The mechanism of in situ expression of POMC and AGRP in kidney to the progression of DN needs further investigations.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"2 5 1","pages":"43 - 49"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72515487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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