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Diabetic nephropathy : DN最新文献

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A point mutation of mitochondrial genes in diabetes and deafness with focal segmental glomerular sclerosis 糖尿病和耳聋伴局灶节段性肾小球硬化的线粒体基因点突变
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2478/dine-2021-0010
Jin Zhang, Yan Wang, Yong-gui Wu
{"title":"A point mutation of mitochondrial genes in diabetes and deafness with focal segmental glomerular sclerosis","authors":"Jin Zhang, Yan Wang, Yong-gui Wu","doi":"10.2478/dine-2021-0010","DOIUrl":"https://doi.org/10.2478/dine-2021-0010","url":null,"abstract":"Abstract Deafness, diabetes and proteinuria are typically understood to be an uncommon combination. Here, we reported a 26-year-old woman with a history of persistent deafness, diabetes mellitus, and proteinuria. The diagnosis mainly depends on clinical symptoms, but the cause of the disease should be examined. The histological finding in renal biopsy showed secondary focal segmental glomerular sclerosis (FSGS), but not classic diabetic nephropathy. Further pathogeny was found. Subsequently, a 3243A>G mutation in the mitochondrial DNA was found. Thus, the diagnosis of maternally inherited deafness and diabetes (MIDD) was considered. Ineffective and unnecessary immunosuppression can be avoided through timely diagnosis. Long-term treatment of CoQ10 can be useful in MIDD patients.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"1 1","pages":"55 - 58"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90157551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sitagliptin ameliorates ER stress in diabetic kidney disease through upregulation of SIRT1 西格列汀通过上调SIRT1改善糖尿病肾病内质网应激
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2478/dine-2021-0007
Qunzi Zhang, J. Jia, Li He, Ying Fan, Niansong Wang
{"title":"Sitagliptin ameliorates ER stress in diabetic kidney disease through upregulation of SIRT1","authors":"Qunzi Zhang, J. Jia, Li He, Ying Fan, Niansong Wang","doi":"10.2478/dine-2021-0007","DOIUrl":"https://doi.org/10.2478/dine-2021-0007","url":null,"abstract":"Abstract Objectives Endoplasmic reticulum (ER) stress plays a significant role in the progression of diabetic kidney disease (DKD), and dipeptidyl peptidase-4 (DPP4) inhibitors are widely used antihyperglycemic agents, exerting renal beneficial effects in DKD. Here, we investigated the role of DPP4 inhibitor Sitagliptin (Sita) in ER homeostasis in the kidneys of diabetic DBA2/J (D2) mice and in albumin-stimulated HK-2 cells. Methods and Results ER stress was observed both in vivo and in vitro, as reflected by notably increased glucose-regulated protein of 78 kDa (GRP78), CHOP, high phosphorylation of PERK (p-PERK), and cleaved caspase3 (c-CASP3), whereas Sita effectively attenuated these disorders. Meanwhile, Sita increased the expression of SIRT1 both in vivo and in vitro. To further validate the potential effects of SIRT1 in regulating ER stress, we regulated SIRT1 by siRNA and overexpressed plasmids in albumin-overloaded HK-2 cells. Elevated SIRT1 alleviated albumin-induced ER stress, while decreased SIRT1 further aggravated ER stress in albumin-treated HK-2 cells. Conclusion The results suggest that a novel mechanism links the DPP4 enzyme to ER stress during tubular injury in DKD and highlight that SIRT1 may be a potential target for managing DKD.","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"19 1","pages":"33 - 41"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89309952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Inaugural Statement 就职声明
Diabetic nephropathy : DN Pub Date : 2021-01-01 DOI: 10.2753/csa0009-4625230191
Zhangsuo Liu
{"title":"Inaugural Statement","authors":"Zhangsuo Liu","doi":"10.2753/csa0009-4625230191","DOIUrl":"https://doi.org/10.2753/csa0009-4625230191","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"58 1","pages":"3 - 4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73920670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, Regional, and Ethnic Differences in Diabetic Nephropathy 糖尿病肾病的全球、地区和种族差异
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_3
O. Ameh, I. Okpechi, C. Agyemang, A. Kengne
{"title":"Global, Regional, and Ethnic Differences in Diabetic Nephropathy","authors":"O. Ameh, I. Okpechi, C. Agyemang, A. Kengne","doi":"10.1007/978-3-319-93521-8_3","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_3","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76730603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Atherosclerosis and Diabetic Nephropathy 动脉粥样硬化和糖尿病肾病
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_22
R. Duivenvoorden
{"title":"Atherosclerosis and Diabetic Nephropathy","authors":"R. Duivenvoorden","doi":"10.1007/978-3-319-93521-8_22","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_22","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76545787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diabetic Nephropathy in Children and Adolescents 儿童和青少年糖尿病肾病
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_4
P. Bjornstad
{"title":"Diabetic Nephropathy in Children and Adolescents","authors":"P. Bjornstad","doi":"10.1007/978-3-319-93521-8_4","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_4","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"401 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77858975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Clinical Features and Natural Course of Diabetic Nephropathy 糖尿病肾病的临床特点及自然病程
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_2
P. Rossing, M. Frimodt-Møller
{"title":"Clinical Features and Natural Course of Diabetic Nephropathy","authors":"P. Rossing, M. Frimodt-Møller","doi":"10.1007/978-3-319-93521-8_2","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_2","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"10 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75215264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Future and Novel Compounds in the Treatment of Diabetic Nephropathy 未来和新的化合物在糖尿病肾病的治疗
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_29
Nienke M A Idzerda, M. Pena, D. Zeeuw, H. Heerspink
{"title":"Future and Novel Compounds in the Treatment of Diabetic Nephropathy","authors":"Nienke M A Idzerda, M. Pena, D. Zeeuw, H. Heerspink","doi":"10.1007/978-3-319-93521-8_29","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_29","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81450598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Animal Models of Diabetic Kidney Disease 糖尿病肾病的动物模型
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_23
Isabel T N Nguyen, A. Koppen, J. Joles
{"title":"Animal Models of Diabetic Kidney Disease","authors":"Isabel T N Nguyen, A. Koppen, J. Joles","doi":"10.1007/978-3-319-93521-8_23","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_23","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74937367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hypertension in Diabetic Kidney Disease 糖尿病肾病中的高血压
Diabetic nephropathy : DN Pub Date : 2018-10-30 DOI: 10.1007/978-3-319-93521-8_20
G. Ruiz‐Hurtado, L. Ruilope
{"title":"Hypertension in Diabetic Kidney Disease","authors":"G. Ruiz‐Hurtado, L. Ruilope","doi":"10.1007/978-3-319-93521-8_20","DOIUrl":"https://doi.org/10.1007/978-3-319-93521-8_20","url":null,"abstract":"","PeriodicalId":89356,"journal":{"name":"Diabetic nephropathy : DN","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80142580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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