Biomedical Journal最新文献

Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism. 自噬诱导的成骨细胞来源的外泌体通过重塑肠道微生物代谢来维持骨形成和预防骨质疏松症。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-05-06 DOI: 10.1016/j.bj.2025.100870

Lin Chen, Liesheng Lu, Chunyi Fan, Xiaonan Zhu, Ling Pan, Shanshan Tang, Yufan Wang, Yongde Peng, Li You

{"title":"Autophagy-induced osteoblast-derived exosomes maintain bone formation and prevent osteoporosis by remodeling gut microbiota-metabolism.","authors":"Lin Chen, Liesheng Lu, Chunyi Fan, Xiaonan Zhu, Ling Pan, Shanshan Tang, Yufan Wang, Yongde Peng, Li You","doi":"10.1016/j.bj.2025.100870","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100870","url":null,"abstract":"Background: Osteoporosis is a chronic disease of bone metabolism with high incidence rates. Recently, exosome therapy has emerged as a promising avenue for the treatment of osteoporosis. However, the role of autophagy-induced osteoblast-derived exosomes (Auto-exo) in osteoporosis has yet to be elucidated.Methods: The effect of Auto-exo in bone formation was assessed in vivo. The composition of gut microbiota was determined through 16S rDNA sequencing, and metabolite profiles were analyzed using liquid chromatography-mass spectrometry (LC-MS). Cell experiments were conducted to explore the role of bilirubin in bone formation.Results: Auto-exo were successfully isolated and identified. Auto-exo promoted bone formation and alleviated osteoporosis progression in a mouse model of osteoporosis. 16S rDNA sequencing revealed that Auto-exo changed diversity and composition of gut microbiota in osteoporotic mice, with a notable increase in Lactobacillus and a decrease in Dubosiella and Faecalibaculum. LC-MS analysis indicated that Auto-exo treatment reduced the elevated levels of bilirubin in osteoporotic mice. Cell experiments uncovered that bilirubin remarkably inhibited osteoblast differentiation. Furthermore, Auto-exo promoted osteoblast differentiation via inhibiting bilirubin production.Conclusions: Our findings demonstrated that Auto-exo promoted bone formation by modulating the gut microbiota-metabolites bilirubin axis, thereby alleviating osteoporosis progression. This discovery provides a novel perspective on the mechanisms underlying the therapeutic effects of Auto-exo in osteoporosis.","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100870"},"PeriodicalIF":4.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SLC7A11-HSPB1 Axis: A Novel Mechanism for Hepatocellular Carcinoma Progression and Ferroptosis Regulation. SLC7A11-HSPB1轴：肝细胞癌进展和铁下垂调控的新机制

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-05-06 DOI: 10.1016/j.bj.2025.100869

Yan An, Weilong Liu, Yuliang Deng, Wanqiu Huang, Jian Huang

{"title":"SLC7A11-HSPB1 Axis: A Novel Mechanism for Hepatocellular Carcinoma Progression and Ferroptosis Regulation.","authors":"Yan An, Weilong Liu, Yuliang Deng, Wanqiu Huang, Jian Huang","doi":"10.1016/j.bj.2025.100869","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100869","url":null,"abstract":"Background: SLC7A11, a plasma membrane protein, has been implicated as an oncogene in various cancers, including hepatocellular carcinoma (HCC). Its role in HCC pathogenesis, particularly in relation to ferroptosis, is not well understood. This study aims to investigate the function of SLC7A11 with ferroptosis and its interaction in development of HCC.Methods and material: Clinical HCC tissue samples were used to analyze the expression of SLC7A11 by RT-PCR. The impact of SLC7A11 on HCC cell viability, proliferation, and migration was assessed by CCK-8, AlamarBlue and Transwell. Protein-protein interactions were explored using co-immunoprecipitation and immunofluorescence. The effect of SLC7A11 on ferroptosis was evaluated by iron levels, ROS, and GSH. The impact of sorafenib and doxorubicin (DOX) on HCC cells was analyzed using cell viability assay.Results: SLC7A11 was found to be highly expressed in HCC tissues and was correlated with tumor size and poor prognosis. Overexpression of SLC7A11 in HCC cells promoted cell viability, proliferation, and migration. Additionally, SLC7A11 overexpression mitigated erastin-induced ferroptosis, as evidenced by decreased ROS levels and increased GSH levels. We also discovered that SLC7A11 interacted with HSPB1. HSPB1 inhibited erastin-induced ferroptosis. Furthermore, a portion of the cell death induced by sorafenib and DOX is attributed to ferroptosis, with HSPB1 and SLC7A11 inhibiting the death induced by the two drugs, respectively.Conclusions: SLC7A11 plays a significant role in HCC progression by inhibiting ferroptosis, and its interaction with HSPB1 is a critical pathway in this process. Targeting the SLC7A11-HSPB1 axis may provide a novel therapeutic strategy for HCC treatment, highlighting the importance of understanding the mechanisms of ferroptosis in cancer cells.","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100869"},"PeriodicalIF":4.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles and Potential of Large Language Models in Healthcare: A Comprehensive Review. 大型语言模型在医疗保健中的作用和潜力：一个全面的综述。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-29 DOI: 10.1016/j.bj.2025.100868

Chihung Lin, Chang-Fu Kuo

{"title":"Roles and Potential of Large Language Models in Healthcare: A Comprehensive Review.","authors":"Chihung Lin, Chang-Fu Kuo","doi":"10.1016/j.bj.2025.100868","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100868","url":null,"abstract":"Large Language Models (LLMs) are capable of transforming healthcare by demonstrating remarkable capabilities in language understanding and generation. They have matched or surpassed human performance in standardized medical examinations and assisted in diagnostics across specialties like dermatology, radiology, and ophthalmology. LLMs can enhance patient education by providing accurate, readable, and empathetic responses, and they can streamline clinical workflows through efficient information extraction from unstructured data such as clinical notes. Integrating LLM into clinical practice involves user interface design, clinician training, and effective collaboration between Artificial Intelligence (AI) systems and healthcare professionals. Users must possess a solid understanding of generative AI and domain knowledge to assess the generated content critically. Ethical considerations to ensure patient privacy, data security, mitigating biases, and maintaining transparency are critical for responsible deployment. Future directions for LLMs in healthcare include interdisciplinary collaboration, developing new benchmarks that incorporate safety and ethical measures, advancing multimodal LLMs that integrate text and imaging data, creating LLM-based medical agents capable of complex decision-making, addressing underrepresented specialties like rare diseases, and integrating LLMs with robotic systems to enhance precision in procedures. Emphasizing patient safety, ethical integrity, and human-centered implementation is essential for maximizing the benefits of LLMs, while mitigating potential risks, thereby helping to ensure that these AI tools enhance rather than replace human expertise and compassion in healthcare.","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100868"},"PeriodicalIF":4.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage Regulation of Hypothalamic-Pituitary-Adrenal and Gonadal Axis Homeostasis and Hormonal Output. 巨噬细胞调节下丘脑-垂体-肾上腺和性腺轴稳态和激素输出。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-27 DOI: 10.1016/j.bj.2025.100866

Conan J O O'Brien

{"title":"Macrophage Regulation of Hypothalamic-Pituitary-Adrenal and Gonadal Axis Homeostasis and Hormonal Output.","authors":"Conan J O O'Brien","doi":"10.1016/j.bj.2025.100866","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100866","url":null,"abstract":"Macrophages are critical immune cells present in virtually every tissue, where they contribute to tissue homeostasis beyond their traditional immune roles. Past and recent evidence highlights their involvement in endocrine regulation, particularly within the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes. This review explores the ontogeny and function of macrophages residing in the hypothalamus, pituitary, adrenals, and gonads, emphasizing their contributions to hormonal output and endocrine homeostasis. Macrophages in the hypothalamus and pituitary modulate neuroendocrine signalling, impacting stress and reproductive hormone production. In the adrenal glands, distinct macrophage subsets regulate glucocorticoid and mineralocorticoid synthesis, influencing systemic metabolism and blood pressure. Gonadal macrophages contribute to steroidogenesis and fertility, with roles in testosterone production, ovarian folliculogenesis, and corpus luteum maintenance. The emerging understanding of macrophage regulation of endocrine function may seed novel therapeutic approaches for endocrine disorders. Future research should further elucidate the molecular mechanisms underlying macrophage regulation of hormone production and explore their implications for metabolic, immune, and reproductive health.","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100866"},"PeriodicalIF":4.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophages of the Heart: Homeostasis and Disease. 心脏巨噬细胞：稳态与疾病。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-27 DOI: 10.1016/j.bj.2025.100867

Koketso C Mabatha, Pheletso Letuka, Olukayode Aremu, Michael Z Zulu

{"title":"Macrophages of the Heart: Homeostasis and Disease.","authors":"Koketso C Mabatha, Pheletso Letuka, Olukayode Aremu, Michael Z Zulu","doi":"10.1016/j.bj.2025.100867","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100867","url":null,"abstract":"Cardiac macrophages (CMs) are the most abundant immune cell type in the heart. They are critical for maintaining cardiac homeostasis and in the orchestration of immune responses to ischemic and non-ischemic cardiomyopathies. Their functions are highly heterogeneous and regulated by their tissue microenvironment. CMs have high plasticity, which allows them to perform various functions in the myocardium to bring about homeostasis within the cardiovascular system (CVS). CMs also play critical roles in coronary development and angiogenesis, tissue repair and remodeling, cardiac conduction and in the clearance of necrotic and apoptotic cells. However, there is a paucity of studies on the biology of cardiac macrophages in both steady state and disease, especially, in humans. In this review, we discuss the multifaceted roles of CMs in the heart, focusing on their ontogeny, homeostatic functions and immunological responses during inflammation and reparative processes post-injury. We highlight the heterogeneity of CMs in their ontogeny, phenotypes and functions as well as their roles in the pathogenesis of pathological conditions such as myocarditis, myocardial fibrosis and heart failure. Understanding the unique characteristics of cardiac macrophages in the cardiac milieu is critical for the development of macrophage-specific therapeutic interventions to alleviate the global burden of cardiovascular disease (CVD). Therefore, future studies should focus on further improving the understanding of the biology of cardiac macrophages to harness their potential as therapeutic targets for cardiovascular disorders.","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100867"},"PeriodicalIF":4.1,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additional insights on SARS-CoV-2 spike protein variants and red blood cells biology. 关于SARS-CoV-2刺突蛋白变异和红细胞生物学的其他见解。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-25 DOI: 10.1016/j.bj.2025.100856

Francesco Dima, Gian Luca Salvagno, Giuseppe Lippi

引用次数: 0

Effect of SARS-CoV2 S protein on red blood cells parameters. Some comments. SARS-CoV2 S蛋白对红细胞参数的影响一些评论。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-22 DOI: 10.1016/j.bj.2025.100857

Geir Bjørklund, Umberto Tirelli, Salvatore Chirumbolo, Luigi Valdenassi

引用次数: 0

Circadian rhythmicity and human health. 昼夜节律与人类健康。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-21 DOI: 10.1016/j.bj.2025.100855

Jan Martel, David M Ojcius, John D Young

引用次数: 0

PAI-1, hematopoietic stem cell, and chronic myeloid leukemia. PAI-1，造血干细胞和慢性髓性白血病。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-18 DOI: 10.1016/j.bj.2025.100854

Naoto Takahashi, Hideo Harigae

引用次数: 0

Navigating AI in Cardiology: A Scoping Review of Integration through Clinical Decision Support Systems for Acute Coronary Syndrome. 在心脏病学中导航人工智能：急性冠状动脉综合征临床决策支持系统整合的范围审查。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-04-15 DOI: 10.1016/j.bj.2025.100853

Shu-Hui Chen, Chin-Chieh Wu, Kuan-Fu Chen

{"title":"Navigating AI in Cardiology: A Scoping Review of Integration through Clinical Decision Support Systems for Acute Coronary Syndrome.","authors":"Shu-Hui Chen, Chin-Chieh Wu, Kuan-Fu Chen","doi":"10.1016/j.bj.2025.100853","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100853","url":null,"abstract":"Background: The integration of AI in diagnosing and managing ACS shows increasing promise, yet challenges remain in translating AI-CDSS into clinical practice. This study evaluates the advancements and limitations of AI for ACS over the past three years, purpose of understanding the scope, limitations, and potential of AI-CDSS in ACS.Materials and methods: We conducted a systematic review of recent literature, adhering to guidelines for systematic reviews. We applied QUADAS-2 and PROBAST tools for quality assessment, focusing on biases in study designs. Ten studies about AI-CDSS in ACS management underwent critical analysis, emphasizing the strength of their research methods and the thoroughness of their prospective validation to ensure theoretical integrity and practical reliability.Results: Our research reveals that while discourse around AI-CDSS in ACS management intensifies, obstacles hinder efficacy in practical settings. These challenges include biases in tests and unrepresentative patient selection, pointing to the need for rigorous and inclusive samples. The lack of sufficient external and prospective validation in studies also raises concerns clinical utility of AI-CDSS. The result is the gap between the potential benefits of AI-CDSS and the actual impact of improving diagnostic accuracy and outcomes for ACS limitations identified.Conclusions: While AI-CDSS shows promise for improving diagnostic accuracy, treatment efficacy, and workflows in ACS, this study highlights the imperative to enhance model validation, including prospective validation, and address lingering diagnostic gaps. Improving study design and mitigating biases remain crucial for the acceptance and effectiveness of AI-CDSS in acute cardiac care settings.","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100853"},"PeriodicalIF":4.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0