Biomedical Journal最新文献

{"title":"Multidisciplinary Team Approach to Pelvic Floor Disorders: A Systematic Review.","authors":"Tzong-Yun Tsai, Shu-Huan Huang, Chun-Kai Liao, Kun-Yu Tsai, Pao-Shiu Hsieh, Sum-Fu Chiang, Osamu Hiraike","doi":"10.1016/j.bj.2025.100912","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100912","url":null,"abstract":"<p><strong>Background: </strong>Pelvic floor disorders (PFDs) severely and negatively impact on quality of life, affecting physical, psychological, and social well-being. Historically, PFDs have been managed within single-specialty frameworks, yet the complexity of these conditions often necessitates a comprehensive, multidisciplinary team (MDT) approach. This systematic review assesses the effectiveness of MDT strategies in improving outcomes for individuals with PFDs, aiming to identify the benefits and potential advantages of integrated, multi-specialty care for these complex conditions.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a systematic search of PubMed, EMBASE, and Cochrane CENTRAL was conducted through September 25, 2024. Inclusion criteria were studies of adult patients with PFDs in which MDT protocols were integrated for diagnosis, treatment, or rehabilitation. Eligible studies included comparisons between MDT and non-MDT care, as well as studies without a comparison group. Outcomes of interest were patient-reported outcomes, therapy adherence, complication rates, and recurrence rates. Three independent reviewers screened titles and abstracts for eligibility, with discrepancies resolved through discussion to reach a consensus. Data extraction was independently performed by two reviewers, and any discrepancies were adjudicated by a third reviewer.</p><p><strong>Results: </strong>In total, 24 studies conducted across various countries were included, comprising 21 retrospective cohort studies, 2 prospective cohort studies, and 1 randomized controlled trial (RCT), with sample sizes ranging from 36 to 3,600 patients. The findings generally indicate favorable outcomes with an MDT approach, including enhanced surgical results, greater symptom relief, reduced recurrence and complication rates following surgical interventions, improved treatment adherence, and high patient satisfaction.</p><p><strong>Conclusions: </strong>An MDT approach offers benefits for PFD management, improving patient-reported outcomes, treatment adherence, and quality of life. This review supports the broader adoption of MDT approaches for comprehensive PFD management. Further research is warranted to confirm long-term effectiveness and standardize MDT protocols.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100912"},"PeriodicalIF":4.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of PAI-1 in the progression and treatment resistance of non-small cell lung cancer.","authors":"Takeshi Masuda, Noboru Hattori","doi":"10.1016/j.bj.2025.100911","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100911","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is the leading cause of cancer-related mortality worldwide. Although immune checkpoint inhibitors (ICIs), chemotherapy, and molecular targeted therapies have improved survival rates, therapeutic resistance remains a major barrier to curative outcomes. Recently, plasminogen activator inhibitor-1 (PAI-1) has been implicated in lung cancer progression and treatment resistance.</p><p><strong>Material and methods: </strong>This review summarizes the recent evidence from preclinical and clinical studies on the Role of PAI-1 in the progression and treatment resistance in lung cancer, focusing on its contribution to tumor aggressiveness and resistance to therapy. As limited evidence is available regarding its role in small cell lung cancer, this review focuses on the findings reported to date for non-small cell lung cancer (NSCLC).</p><p><strong>Results: </strong>PAI-1 promoted tumor invasion, angiogenesis, and epithelial-mesenchymal transition (EMT), thereby facilitating cancer progression. Elevated PAI-1 expression in tumor tissues and plasma is correlated with advanced disease stages and poor prognosis. Genetic polymorphisms such as A15T, which affect PAI-1 stability, are also associated with unfavorable outcomes. PAI-1 contributes to radiotherapy resistance through the hypoxia-induced upregulation of AKT/ERK signaling, chemotherapy by activating cancer-associated fibroblasts, and targeted therapies via integrin-mediated EMT. Moreover, it enhances immune evasion by promoting programmed cell death-ligand 1 expression and creating an immunosuppressive tumor microenvironment.</p><p><strong>Conclusions: </strong>PAI-1 is a key regulator of tumor progression and therapeutic resistance in NSCLC. Targeting PAI-1 may offer a novel strategy to overcome resistance to multiple treatment modalities, and future research should focus on developing PAI-1-based biomarkers and therapeutic combinations for both NSCLC.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100911"},"PeriodicalIF":4.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophages in the male genital tract.","authors":"María Sol Martinez, Rubén Darío Motrich","doi":"10.1016/j.bj.2025.100910","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100910","url":null,"abstract":"<p><p>Macrophages play essential roles in maintaining immune defence and tissue homeostasis within the male genital tract, which is essential for reproductive health. Since their initial discovery in the testes, macrophages have been established as highly adaptable immune cells that perform diverse functions ranging from immune surveillance to tissue repair. In the testes, macrophages play a crucial role in maintaining immune privilege and tissue homeostasis by regulating inflammatory responses and supporting steroidogenesis and spermatogenesis via intricate crosstalk with Leydig and Sertoli cells. In the epididymis, macrophages maintain a balance between immune tolerance and pathogen defence, ensuring the integrity of maturing sperm. Moreover, recent evidence has begun to reveal the complex and unique characteristics of prostate tissue-resident macrophages and their roles in homeostasis and disease. Notably, these cells exhibit dual functions in pathological conditions, contributing both to chronic inflammation in prostatitis and to the modulation of tumour dynamics in prostate cancer. Remarkably, dysregulation of macrophage function has been implicated in several prevalent male urological diseases and male infertility. This review integrates historical perspectives with recent advances in the immunobiology of macrophages in the male genital tract, highlighting their role as pivotal regulators of reproductive tract homeostasis.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100910"},"PeriodicalIF":4.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro axotomy models regulated by ROCK inhibitor for studying neuroregeneration and growth cone morphology.","authors":"Fang Fang, Dan Xu, Shuang Dou, Shaoqin Zhan, Yingjuan Fan, Yuehong Zhuang, Weihong Xu, Zixing Xu","doi":"10.1016/j.bj.2025.100908","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100908","url":null,"abstract":"<p><p>Current complex models of human nerve injury hinder the identification of cellular responses and the screening of therapies. As a solution, simpler in vitro axotomy models utilizing embryonic rat dorsal root ganglion (DRG) and spinal motor neuron aggregates (SMNAs) have been introduced. To ensure model consistency, DRG or SMNA was placed in a cross-shaped channel for axotomy, performed microscopically with a razor. Afterward, the expression of four regeneration-associated genes (RAGs) and regulatory genes was assessed, along with quantifying axon outgrowth and growth cone changes in response to ROCK inhibitor Y27632. Additionally, a mouse perforator flap model was created to evaluate Y27632's effect on DRG axon reinnervation. It turned out that complete and consistent severance of the axons from the DRGs and SMNAs could be easily achieved, with significantly increased expressions of the four RAGs, Rho A and ROCK2. Y27632 could significantly augment axon regeneration in DRGs with axotomy in vitro and in the flap model but showed no impact on DRG axon outgrowth without axotomy. In comparison, Y27632 could slightly increase axon outgrowth from SMNAs without axotomy but drastically boost the axon regeneration from SMNAs with axotomy. The growth cones of DRGs and SMNAs drastically shrunk after axotomy, which could be significantly expanded by Y27632. In contrast, no impact on the growth cones of DRG and SMNAs without axotomy by Y27632 could be observed. The novel in vitro axotomy models regulated by ROCK inhibitors can be used to optimize studies on peripheral nerve injury-related drug screening by observing neuroregeneration and growth cone changes.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100908"},"PeriodicalIF":4.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occlusal disharmony attenuates inhibitory synaptic transmission in the medial prefrontal cortex and contributes to anxiety.","authors":"Juan Li, Jiayao Zhang, Ming Xu, Qi Zhang, Weicai Liu","doi":"10.1016/j.bj.2025.100909","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100909","url":null,"abstract":"<p><strong>Background: </strong>It has been well-validated that Occlusal Disharmony (OD) induces negative emotions, especially anxiety. While it leads to considerable frustration for both doctors and patients, its underlying mechanisms remain unclear, and effective treatment has been lacking. The present study aims to explore the pathological mechanisms of OD induced anxiety and to find a straightforward yet effective treatment strategy for this ostensibly intricate clinical phenomenon.</p><p><strong>Material and methods: </strong>OD mice were established through binding a metal tube to their right mandibular incisor. Then, the mental state of the mice was assessed by various behavioral experiments. Additionally, the mood of OD mice was also evaluated similarly before and after the injection of mifepristone. Furthermore, neuronal excitability in the mPFC was examined by immunofluorescence and electrophysiology, with the potential mechanisms investigated through Western blotting.</p><p><strong>Results: </strong>OD mice exhibited anxiety-like behavior, and the administration of mifepristone, an anxiolytic drug, could alleviate it. Subsequently, an increase in n[1]euronal excitability was observed, accompanied by a reduction in the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs) in the medial prefrontal cortex (mPFC). In addition, the expression of erb-b2 receptor tyrosine kinase 4 (ERBB4) and neuregulin 1 (NRG1), proteins associated with inhibitory neurotransmitter release, were found to be significantly downregulated in the mPFC.</p><p><strong>Conclusion: </strong>OD attenuates GABAergic synaptic transmission in the mPFC, which may be the neural mechanism of anxiety caused by OD. But this phenomenon could be effectively alleviated by anti-anxiety treatment.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100909"},"PeriodicalIF":4.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila.","authors":"Peng-Shiuan Lee, Meng-Hsuan Chiang, Tony Wu, Chia-Lin Wu","doi":"10.1016/j.bj.2025.100907","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100907","url":null,"abstract":"<p><strong>Background: </strong>Thirst and hunger are fundamental survival drives that modulate various aspects of animal behavior through specific neural circuits. Previous studies have demonstrated that dopaminergic neurons (DANs) innervating the mushroom body (MB) in the Drosophila brain play essential roles in innate and learned thirst- and hunger-dependent behaviors, with most experiments focusing on acute water or food deprivation. However, it is unclear whether acute water or food deprivation alters dopamine production and neural activity in MB-innervating DANs.</p><p><strong>Material and methods: </strong>We genetically expressed green fluorescent protein (GFP) in MB-innervating DANs using broadly and specifically labeled GAL4 lines under satiety, thirst, and hunger states. The brains were immunostained with anti-tyrosine hydroxylase (TH) to assess dopamine biosynthesis. Additionally, the transcriptional reporter of intracellular Ca²⁺ (TRIC) was expressed in these DANs using the same GAL4 lines to monitor neural activity under different internal states. Normalized anti-TH and TRIC signals in specific MB compartments were compared between the satiety and thirst groups and between the satiety and hunger groups using unpaired two-tailed t-tests.</p><p><strong>Results: </strong>Neither TH levels nor neural activity in the 13 subtypes of MB-innervating DANs exhibited significant differences during the satiety, thirst, and hunger conditions.</p><p><strong>Conclusion: </strong>This study suggests that 16-hour water deprivation or 24-hour food deprivation does not significantly alter dopamine production and neural activity in MB-innervating DANs. These findings offer insights into the independence of baseline dopaminergic activity from internal states in thirst- or hunger-related behaviors.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100907"},"PeriodicalIF":4.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Radiotherapy with Tyrosine Kinase Inhibitors Might Benefit Survival in Hepatoma Patients with Portal Vein Tumor Thrombosis.","authors":"Hui-Ling Huang, Wei-Ming Lin, Chia-Hsuan Lai, Te-Sheng Chang, Sheng-Nan Lu","doi":"10.1016/j.bj.2025.100904","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100904","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is associated with a poor prognosis, and current treatment options yield suboptimal results. This article aims to share our treatment outcomes for PVTT using tyrosine kinase inhibitors (TKIs), radiation therapy (RT), and their combination.</p><p><strong>Methods: </strong>From 2010 to 2021, a total of 160 Child-Pugh class A HCC patients with PVTT, but without extrahepatic spread, were enrolled. Among them, 26, 10, 81, and 43 patients underwent no treatment, RT, TKIs, and combination therapy, respectively.</p><p><strong>Results: </strong>Compared to the no treatment group (median survival: 2 months), the RT group (4.5 months, p=0.034), TKIs group (5.0 months, p=0.0017), and combination group (15.0 months, p<0.001) all demonstrated a survival benefit. The multivariate Cox model showed adjusted hazard ratios and 95% confidence intervals of 0.35 (0.16-0.78), 0.40 (0.25-0.63) and 0.26 (0.15-0.44) for RT, TKIs, combination groups, respectively. From clinical observation of patients who survived for two years, we found that 20% of RT patients achieved good local control, and the RT group had longer durations of TKI use.</p><p><strong>Conclusions: </strong>In this series, 26.9% (43/160) of HCC patients with PVTT underwent combination treatment with TKIs and RT, achieving a median survival of 15.0 months. The contributions of RT were 20% disease control rate and may extend the duration of TKIs use. Therefore, all candidates without contraindications should be considered for combination treatment.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100904"},"PeriodicalIF":4.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma systemic treatment update: From early to advanced stage","authors":"Wei Teng ,&nbsp;Tai-Chi Wu ,&nbsp;Shi-Ming Lin","doi":"10.1016/j.bj.2024.100815","DOIUrl":"10.1016/j.bj.2024.100815","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) ranks the sixth most common malignancy but the third leading cause of cancer-related mortality in the world. Significant breakthroughs have been made in systemic treatment for HCC over the past two decades, which have improved treatment outcomes. In addition to multiple tyrosine kinase inhibitors (mTKIs), immune checkpoint inhibitors (ICIs) and antiangiogenic drugs are increasingly being applied. The combination of ICI and antiangiogenic or dual ICIs has become the new standard of care due to remarkable response rates. However, currently available systemic regimens are primarily reserved for certain patients in the intermediate and advanced stages who will not benefit from locoregional treatments. Evidence supporting the use of systemic treatment as neoadjuvant or adjuvant therapies in patients with early-stage HCC, especially the high risk of recurrence after curative treatments, remains limited. This review identified recent developments in systemic therapy, including mTKIs and ICIs, considering results on first- and second-line treatment, role of neoadjuvant and adjuvant settings, and combination with loco-regional therapy. Various ongoing clinical trials regarding the role of systemic therapies and potential novel targets in patients with early-, intermediate-, and advanced-stage HCC were also summarized and revealed that systemic therapy is no longer limited to advanced-stage HCC. Moreover, the introduction of T-cell redirecting strategies, including bispecific antibodies and chimeric antigen receptor T cells, has revolutionized the treatment landscape for HCC. Future research should focus on an in-depth exploration of the mechanisms governing the establishment of tumor barriers.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100815"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geography, genes, and germs: An evolutionary entanglement","authors":"Aila Akosua Kattner","doi":"10.1016/j.bj.2025.100888","DOIUrl":"10.1016/j.bj.2025.100888","url":null,"abstract":"<div><div>This journal issue presents an article on genomic surveillance and phylogenetic analysis for monitoring SARS-CoV-2, alongside reviews of recent advances in the treatment of hepatocellular carcinoma and gastric cancer, and current insights into mpox. It includes a perspective on the role of extended reality techniques in pediatric neurosurgery, as well as updates on cleft care and the relationship between mitochondrial bioenergetics and iron. Further contributions explore the link between metastatic potential and cytidine deaminase, miRNA targets involved in hypertrophy and fibrosis during cardiac remodeling, and new deep-learning models for predicting response to cardiac resynchronization therapy. The expression of connexin gap junction proteins in atrial fibrillation is examined in detail, along with a retrospective study on enteral autonomy in pediatric short bowel syndrome. The issue concludes with novel insights into the rare genetic disorder Bietti crystalline dystrophy.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100888"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vertical Facial Patterns on Three-Dimensional Surgical Outcomes and Stability in Skeletal Class II Malocclusion.","authors":"Wasuthorn Poolsin, Ellen Wen-Ching Ko, Carol Yi-Hsuan Chen, Cheng-Hui Lin","doi":"10.1016/j.bj.2025.100894","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100894","url":null,"abstract":"<p><strong>Background: </strong>The surgical outcomes and stability of patients with skeletal Class II malocclusion determine the success of treatment. Variations in surgical interventions, patient responsiveness, and growth patterns across vertical facial morphologies result in varying treatment outcomes and postoperative stability.</p><p><strong>Methods: </strong>This retrospective study recruited 52 adults diagnosed with skeletal Class II malocclusion treated with bimaxillary surgery; these adults were divided into two groups according to their vertical facial patterns. Cone-beam computed tomography images were collected before surgery (T0), after surgery (T1), and after orthodontic treatment (T2). Reconstructed three-dimensional images were used for cephalometric measurements and analysis.</p><p><strong>Results: </strong>From T0 to T1, the Frankfort-mandibular plane angle decreased in the high-angle group but increased in the low-medium-angle group. The mandible advanced 9.02 and 6.21 mm in the high-angle and low-medium-angle groups, respectively. From T1 to T2, significant changes were observed in the anterior mandible horizontal movement of the high-angle group (-1.91 ± 3.63 mm) compared with the low-medium-angle group (-0.57 ± 1.04 mm). There were more patients exhibit clinically significant relapse (> 2 mm) in the high-angle group (44%) than in the low-medium-angle group (20%).</p><p><strong>Conclusion: </strong>The relapse patterns in the two groups were similarly upward and backward. However, the high angle group exhibited greater average postoperative changes. The proportion of patients who exhibited a clinically significant relapse was higher in the high angle group.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100894"},"PeriodicalIF":4.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}