Biomedical Journal最新文献

Associations with Lip Cant and Facial Midline Correction Following Bimaxillary Surgery in Class III Asymmetry: A CBCT-Based Analysis. 双颌III类不对称手术后唇斜和面部中线矫正的相关性：基于cbct的分析。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-12 DOI: 10.1016/j.bj.2025.100877

Chih-Ling Lin, Yun-Fang Chen, Ying-An Chen, Chuan-Fong Yao, Tong Xi, Yu-Fang Liao, Yu-Ray Chen

{"title":"Associations with Lip Cant and Facial Midline Correction Following Bimaxillary Surgery in Class III Asymmetry: A CBCT-Based Analysis.","authors":"Chih-Ling Lin, Yun-Fang Chen, Ying-An Chen, Chuan-Fong Yao, Tong Xi, Yu-Fang Liao, Yu-Ray Chen","doi":"10.1016/j.bj.2025.100877","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100877","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the outcomes of bimaxillary surgery for class III asymmetry and lip cant, and identified factors associated with lip cant and facial midline correction.</p><p><strong>Materials and methods: </strong>Fifty adult patients (22 females, 28 males; mean age: 24.8 ± 5.1 years) with class III asymmetry and lip cant who underwent bimaxillary surgery were prospectively and consecutively analyzed. Cone-beam computed tomography (CBCT) scans obtained preoperatively and at postoperative follow-up were superimposed to assess surgical jaw movements in six degrees of freedom and their effects on lip cant and facial midline symmetry.</p><p><strong>Results: </strong>Significant reductions were observed in lip cant (1.6 ± 1.6 mm), lower lip deviation (2.4 ± 1.7 mm), chin deviation (5.8 ± 4.2 mm), and facial midline deviation (9.7 ± 7.2 mm). Multiple linear regression analysis identified mandibular roll correction (β = 0.456, P < 0.01) and pre-treatment lip cant severity (β = 0.394, P < 0.01) as significant factors of lip cant reduction. Additionally, chin shift (β = 0.495, P < 0.01) and mandibular shift (β = 0.461, P < 0.01) were significant factors of facial midline correction.</p><p><strong>Conclusion: </strong>Bimaxillary surgery significantly improved lip cant and facial midline deviation in patients with class III asymmetry and lip cant. Mandibular roll correction and pre-treatment lip cant severity were key factors associated with lip cant correction, while chin and mandibular shift correction were associated with facial midline improvement.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100877"},"PeriodicalIF":4.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models. 针刺扭转参数对AA大鼠肥大细胞介导的镇痛作用的影响。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-04 DOI: 10.1016/j.bj.2025.100876

Yi Yu, Yi-Xuan Wang, Xuan Qiao, Ying-Chen Li, Yu-Hang Liu, Zouqin Huang, Wei Yao

{"title":"Influence of acupuncture twisting parameters on analgesic effects mediated by mast cells in AA rat models.","authors":"Yi Yu, Yi-Xuan Wang, Xuan Qiao, Ying-Chen Li, Yu-Hang Liu, Zouqin Huang, Wei Yao","doi":"10.1016/j.bj.2025.100876","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100876","url":null,"abstract":"<p><p>Acupuncture has been recognized for its potential effectiveness in pain relief without the side effects commonly associated with pharmaceutical treatments. This study investigates the effects of various acupuncture twisting parameters on analgesia using an acute adjuvant-induced arthritis (AA) rat model, focusing on the roles of mast cell activation, histamine (HIS) release, and local neural pathways. Utilizing robot-assisted acupuncture, we varied rotation angles (60°-360°) and frequencies (0.5-2.5 Hz) to evaluate their influence on pain modulation. The pain threshold recovery ratio (PTRR) was used to quantify the analgesic effect. The optimal combination of a 180° rotation angle and 1.0 Hz frequency resulted in the strongest analgesic effect, as indicated by increased PTRR and elevated mast cell degranulation rates (MCdR). Additionally, local HIS injections replicated the analgesic effects of acupuncture, whereas administration of an H1 receptor antagonist and lidocaine reduced these effects, highlighting the essential roles of HIS and local nerve conduction in acupuncture-induced analgesia. This study demonstrates the existence of optimal acupuncture parameters for achieving maximal analgesic effects in rat models, and elucidates the critical role of mast cell-mediated neural pathways, thus providing insights into optimizing acupunctire's clinical application in pain management.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100876"},"PeriodicalIF":4.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IRE1-Mediated Endoplasmic Reticulum Stress Response Regulates Oxidative Damage in CYP4V2 Deficient Human Retinal Pigment Epithelial Cells. ire1介导的内质网应激反应调节CYP4V2缺陷人视网膜色素上皮细胞的氧化损伤

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-02 DOI: 10.1016/j.bj.2025.100875

Yu-Ting Hsiao, Chang-Chun Hsiao, Jong-Jer Lee

{"title":"IRE1-Mediated Endoplasmic Reticulum Stress Response Regulates Oxidative Damage in CYP4V2 Deficient Human Retinal Pigment Epithelial Cells.","authors":"Yu-Ting Hsiao, Chang-Chun Hsiao, Jong-Jer Lee","doi":"10.1016/j.bj.2025.100875","DOIUrl":"https://doi.org/10.1016/j.bj.2025.100875","url":null,"abstract":"<p><strong>Background: </strong>Given the role of polyunsaturated fatty acid (PUFA) overload and mitochondrial dysfunction in retinal pigment epithelium (RPE) cells in causing retinal degeneration in Bietti crystalline dystrophy (BCD), we aimed to identify the pathways responsible for intracellular oxidative stress and mitochondrial damage in CYP4V2-deficient RPE cells.</p><p><strong>Materials and methods: </strong>Proteomic analysis of control and CYP4V2-knockdown (KD) ARPE-19 cells revealed that endoplasmic reticulum (ER) stress was the most enriched pathway. The effects of CYP4V2 deficiency on intracellular reactive oxygen species, mitochondrial integrity, and ATP production were assessed.</p><p><strong>Results: </strong>Inositol-requiring enzyme 1 α (IRE1α) inhibitors suppressed upregulation of endoplasmic reticulum oxidoreductase 1 alpha (ERO1-Lα) protein expression, which contributed to ER-associated oxidative stress. Loss of mitochondrial transmembrane potential and reduced ATP production were mitigated with IRE1α inhibitor in CYP4V2-KD ARPE-19 cells.</p><p><strong>Conclusions: </strong>Our findings reveal a novel regulatory mechanism involving potential reduction in PUFA utilization, IRE1α signaling mediated ER oxidative stress, and mitochondrial dysfunction in BCD, potentially offering future therapeutic avenues.</p>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":" ","pages":"100875"},"PeriodicalIF":4.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pentoxifylline use and diabetic retinopathy in patients with type 2 diabetes mellitus and chronic kidney disease: A multi-institutional cohort study 2 型糖尿病合并慢性肾脏病患者使用五氧嘧啶与糖尿病视网膜病变之间的关系：一项多机构队列研究。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100771

Tzu-Yi Lin , Eugene Yu-Chuan Kang , Nan-Kai Wang , Je-Ho Kang , Kuan-Jen Chen , Wei-Chi Wu , Chi-Chun Lai , Yih-Shiou Hwang

{"title":"Association between pentoxifylline use and diabetic retinopathy in patients with type 2 diabetes mellitus and chronic kidney disease: A multi-institutional cohort study","authors":"Tzu-Yi Lin , Eugene Yu-Chuan Kang , Nan-Kai Wang , Je-Ho Kang , Kuan-Jen Chen , Wei-Chi Wu , Chi-Chun Lai , Yih-Shiou Hwang","doi":"10.1016/j.bj.2024.100771","DOIUrl":"10.1016/j.bj.2024.100771","url":null,"abstract":"<div><h3>Background</h3><div>Pentoxifylline is administered to improve the hemodynamics of patients with chronic kidney disease (CKD). Despite the improvement of capillary blood flow velocity in the retina after pentoxifylline use, no evidence has been provided to prove the protective effect against diabetic retinopathy (DR). Therefore, this study aimed to assess the risk of DR in pentoxifylline users with CKD and diabetes mellitus (DM).</div></div><div><h3>Material and methods</h3><div>In this retrospective cohort study, the Chang Gung Research Database, which includes the data of patients with CKD and DM from 2003 to 2019, was used. Each calendar year was divided into 4 data units with 3 months each for every patient and every year during the follow-up. The ocular outcomes were new-onset DR, DR-related complications, and vitreoretinal interventions.</div></div><div><h3>Results</h3><div>A total of 56,439 patients without preexisting DR and 5039 patients with preexisting DR were included in this study. Exposure to pentoxifylline was associated with an elevated risk of new-onset DR (adjusted hazard ratio = 1.24, 95% confidence interval = 1.13–1.36) in patients without preexisting DR. Additionally, exposure to pentoxifylline was associated with an elevated risk of DR-related complications and vitreoretinal interventions in patients with or without preexisting DR.</div></div><div><h3>Conclusions</h3><div>Exposure to pentoxifylline is associated with an elevated risk of DR, regardless of whether patients have preexisting DR.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100771"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management miRNA 介导的男性和女性结直肠癌患者时钟基因表达调控及对疾病管理的可能影响。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100784

Iveta Herichová

{"title":"miRNA-mediated regulation of clock gene expression in men and women with colorectal cancer and possible consequences for disease management","authors":"Iveta Herichová","doi":"10.1016/j.bj.2024.100784","DOIUrl":"10.1016/j.bj.2024.100784","url":null,"abstract":"<div><h3>Background</h3><div>The incidence and mortality of colorectal cancer (CRC) are persistently higher in men than in women. CRC malignancy is strongly influenced by small non-coding RNAs (miRNAs). Moreover, deregulation of the circadian molecular oscillator has been associated with CRC facilitation. To analyse possible cumulative effects of the above-mentioned factors on CRC progression, we focused on functions of sex-biased miRNAs associated with the clock genes per2 and/or cry2, which are involved in the cell cycle control and DNA damage response.</div></div><div><h3>Major findings</h3><div>We identified miR-24, miR-92a, miR-181a, and miR-21 associated with per2 that are up-regulated in transformed colon tissue of men. miR-93, miR-17, miR-20a, and miR-24 with higher expression in males compared to females were linked to cry2. All these miRNAs possess oncogenic potential and exert their effects mainly via inhibition of the tumour suppressors phosphatase and tensin homolog (PTEN) and/or p53. Down-regulation of PTEN and p53 in men was further strengthened by inhibition of tumour suppressor per2. Oncogenic up-regulated miRNAs associated with per2 or cry2 in the transformed colon tissue of women were not detected.</div></div><div><h3>Conclusion</h3><div>We conclude that the cancer-promoting, sex-biased miRNAs miR-24, miR-92a, miR-181a, miR-93, miR-17, miR-20a, and miR-21 associated with clock genes per2 and/or cry2 can contribute to the sex-dependent development of CRC via inhibition of the PTEN and p53 pathways.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100784"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additional insights on SARS-CoV-2 spike protein variants and red blood cells biology 关于SARS-CoV-2刺突蛋白变异和红细胞生物学的其他见解。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100856

Francesco Dima, Gian Luca Salvagno, Giuseppe Lippi

引用次数: 0

Chronobioethics: Symphony of biological clocks observed by 7-day/24-h ambulatory blood pressure monitoring and cardiovascular health 时间生物伦理学：通过 7 天/24 小时动态血压监测观察到的生物钟交响乐与心血管健康。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100753

Kuniaki Otsuka , Larry A. Beaty , Madoka Sato , Kazunobu Shitakura , Tomoko Kikuchi , Kiyotaka Okajima , Shigehiko Terada , Germaine Cornelissen

{"title":"Chronobioethics: Symphony of biological clocks observed by 7-day/24-h ambulatory blood pressure monitoring and cardiovascular health","authors":"Kuniaki Otsuka , Larry A. Beaty , Madoka Sato , Kazunobu Shitakura , Tomoko Kikuchi , Kiyotaka Okajima , Shigehiko Terada , Germaine Cornelissen","doi":"10.1016/j.bj.2024.100753","DOIUrl":"10.1016/j.bj.2024.100753","url":null,"abstract":"<div><h3>Background</h3><div>The high prevalence of desynchronized biological rhythms is becoming a primary public health concern. We assess complex and diverse inter-modulations among multi-frequency rhythms present in blood pressure (BP) and heart rate (HR).</div></div><div><h3>Subjects</h3><div>and Methods: We performed 7-day/24-h Ambulatory BP Monitoring in 220 (133 women) residents (23–74 years) of a rural Japanese town in Kochi Prefecture under everyday life conditions.</div></div><div><h3>Results</h3><div>A symphony of biological clocks contributes to the preservation of a synchronized circadian system. (1) Citizens with an average 12.02-h period had fewer vascular variability disorders than those with shorter (11.37-h) or longer (12.88-h) periods (<em>p</em> < 0.05), suggesting that the circasemidian rhythm is potentially important for human health. (2) An appropriate BP-HR coupling promoted healthier circadian profiles than a phase-advanced BP: lower 7-day nighttime SBP (106.8 vs. 112.9 mmHg, <em>p</em> = 0.0469), deeper nocturnal SBP dip (20.5% vs. 16.8%, <em>p</em> = 0.0101), and less frequent incidence of masked non-dipping (0.53 vs. 0.86, <em>p</em> = 0.0378), identifying the night as an important time window.</div></div><div><h3>Conclusion</h3><div>Adaptation to irregular schedules in everyday life occurs unconsciously at night, probably initiated from the brain default mode network, in coordination with the biological clock system, including a reinforced about 12-h clock, as “a biological clock-guided core integration system.”</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100753"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes 进食-禁食节律的昼夜节律中断及其对代谢、免疫、癌症和认知过程的影响。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100827

Manuel Tomás Crespo , Laura Lucía Trebucq , Camila Agustina Senna , Guido Hokama , Natalia Paladino , Patricia Verónica Agostino , Juan José Chiesa

{"title":"Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes","authors":"Manuel Tomás Crespo , Laura Lucía Trebucq , Camila Agustina Senna , Guido Hokama , Natalia Paladino , Patricia Verónica Agostino , Juan José Chiesa","doi":"10.1016/j.bj.2025.100827","DOIUrl":"10.1016/j.bj.2025.100827","url":null,"abstract":"<div><div>The circadian system is composed by a central hypothalamic clock at the suprachiasmatic nuclei (SCN) that communicates with peripheral circadian oscillators for daily coordination of behavior and physiology. The SCN entrain to the environmental 24-h light-dark (LD) cycle and drive daily rhythms of internal synchronizers such as core body temperature, hypothalamic-hypophysary hormones, sympathetic/parasympathetic activity, as well as behavioral and feeding-fasting rhythms, which supply signals setting core molecular clocks at central and peripheral tissues. Steady phase relationships between the SCN and peripheral oscillators keep homeostatic processes such as microbiota/microbiome composition/activity, metabolic supply/demand, energy balance, immunoinflammatory process, sleep amount and quality, psychophysiological stress, etc. Indeed, the risk of health alterations increase when these phase relationships are chronically changed prompting circadian disruption (CD), as occurring after sudden LD cycle changes (so-called jet-lag), or due to changes of activity/feeding-rest/fasting rhythm with respect to LD cycles (as humans subjected to nightwork, or restricting food access at rest in mice). Typical pathologies observed in animal models of CD and epidemiological studies include metabolic syndrome, type-2 diabetes, obesity, chronic inflammation, cancer, sleep disruption, decrease in physical and cognitive performance, and mood, among others. The present review discusses different aspects of such physiological dysregulations observed in animal models of CD having altered feeding-fasting rhythms, with potential translation to human health.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100827"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of light, electromagnetic fields and water on biological rhythms 光、电磁场和水对生物节律的影响。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2024.100824

Jan Martel , Nicolas Rouleau , Nirosha J. Murugan , Wei-Chun Chin , David M. Ojcius , John D. Young

{"title":"Effects of light, electromagnetic fields and water on biological rhythms","authors":"Jan Martel , Nicolas Rouleau , Nirosha J. Murugan , Wei-Chun Chin , David M. Ojcius , John D. Young","doi":"10.1016/j.bj.2024.100824","DOIUrl":"10.1016/j.bj.2024.100824","url":null,"abstract":"<div><div>The circadian rhythm controls a wide range of functions in the human body and is required for optimal health. Disruption of the circadian rhythm can produce inflammation and initiate or aggravate chronic diseases. The modern lifestyle involves long indoor hours under artificial lighting conditions as well as eating, working, and sleeping at irregular times, which can disrupt the circadian rhythm and lead to poor health outcomes. Seasonal solar variations, the sunspot cycle and anthropogenic electromagnetic fields can also influence biological rhythms. The possible mechanisms underlying these effects are discussed, which include photoentrainment, resonance, radical-pair formation, ion cyclotron resonance, and interference, ultimately leading to variations in melatonin and cortisol. Intracellular water, which represents a coherent, ordered phase that is sensitive to infrared light and electromagnetic fields, may also respond to solar variations and man-made electromagnetic fields. We describe here various factors and underlying mechanisms that affect the regulation of biological rhythms, with the aim of providing practical measures to improve human health.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 3","pages":"Article 100824"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of SARS-CoV2 S protein on red blood cells parameters. Some comments SARS-CoV2 S蛋白对红细胞参数的影响一些评论。

IF 4.1 3区医学

Biomedical Journal Pub Date : 2025-06-01 DOI: 10.1016/j.bj.2025.100857

Geir Bjørklund , Umberto Tirelli , Salvatore Chirumbolo , Luigi Valdenassi

引用次数: 0