Biomedical Journal最新文献

{"title":"Mitochondrial bioenergetics deficiency in cisd-1 mutants is linked to AMPK-mediated lipid metabolism","authors":"Kuei-Ching Hsiung ,&nbsp;Hsiang-Yu Tang ,&nbsp;Mei-Ling Cheng ,&nbsp;Li-Man Hung ,&nbsp;Bertrand Chin-Ming Tan ,&nbsp;Szecheng J. Lo","doi":"10.1016/j.bj.2024.100806","DOIUrl":"10.1016/j.bj.2024.100806","url":null,"abstract":"<div><h3>Background</h3><div>CISD-1 is a mitochondrial iron-sulfate [2Fe–2S] protein known to be associated with various human diseases, including cancer and diabetes. Previously, we demonstrated that CISD-1 deficiency in worms lowers glucose and ATP levels. In this study, we further explored how worms compensate for lower ATP levels by analyzing changes in cytoplasmic and mitochondrial iron content, AMPK activities, and total lipid profiles.</div></div><div><h3>Materials and methods</h3><div>Expression levels of CISD-1 and CISD-1GFP fusion proteins in wild-type worms (N2), <em>cisd-1</em>-deletion mutants (<em>tm4993</em> and <em>syb923</em>) and GFP insertion transgenic worms (PHX953 and SJL40) were examined by Western blot. Fluorescence microscopy analyzed CISD-1GFP pattern in PHX953 embryos and adults, and lipid droplet sizes in N2, <em>cisd-1</em>, <em>aak-2</em> and <em>aak-2</em>;<em>cisd-1</em> worms. Total and mitochondrial iron content, electron transport complex profiles, and AMPK activity were investigated in <em>tm4993</em> and <em>syb923</em> mutants. mRNA levels of mitochondrial β-oxidation genes, <em>acs-2</em>, <em>cpt-5</em>, and <em>ech-1</em>, were quantified by RT-qPCR in various genetic worm strains. Lipidomic analyses were performed in N2 and <em>cisd-1</em>(<em>tm4993)</em> worms.</div></div><div><h3>Results</h3><div>Defects in <em>cisd-1</em> lead to an imbalance in iron transport and cause proton leak, resulting in lower ATP production by interrupting the mitochondrial electron transport chain. We identified a signaling pathway that links ATP deficiency-induced AMPK (AMP activated protein kinase) activation to the expression of genes that facilitate lipolysis via β-oxidation.</div></div><div><h3>Conclusion</h3><div>Our data provide a functional coordination between CISD-1 and AMPK constitutes a mitochondrial bioenergetics quality control mechanism that provides compensatory energy resources.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100806"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-424/322 attenuates cardiac remodeling by modulating the nuclear factor-activated T-cell 3/furin pathway","authors":"Hsiao-Ya Tsai ,&nbsp;Jen-Chun Wang ,&nbsp;Yu-Juei Hsu ,&nbsp;Chih-Yuan Lin ,&nbsp;Po-Hsun Huang ,&nbsp;Min-Chien Tsai ,&nbsp;Chin-Wang Hsu ,&nbsp;Shang-Feng Yang ,&nbsp;Shih-Hung Tsai","doi":"10.1016/j.bj.2024.100818","DOIUrl":"10.1016/j.bj.2024.100818","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac remodeling is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure, and cardiac arrhythmias. Nuclear factor-activated T-cell cytoplasmic (NFATc) is a crucial transcription factor that regulates cardiac remodeling. MicroRNA (miR)-424/322 has pathophysiological roles in the cardiovascular and respiratory systems by modulating hypoxia and inflammatory pathways. The role of miR-424/322 in regulating cardiac remodeling is under investigation. We identified several cardiac hypertrophy and fibrosis-related molecules as putative targets of miR-424/322. We propose that miR-424/322 could have crucial roles in cardiac remodeling by modulating several key molecules for cardiac fibrosis and hypertrophy.</div></div><div><h3>Methods</h3><div>Human cardiac fibroblasts (HCFs) and a myogenic cell line H9c2 cells were used for <em>in vitro</em> experiments. A murine model of angiotensin II (AngII)-induced cardiac remodeling was used to assess the roles of miR-322 on cardiac hypertrophy and fibrosis <em>in vivo</em>. Immunoblotting, immunofluorescence, real-time polymerase chain reaction and cell proliferation, Sirius Red, and dual-luciferase reporter assays were used to decipher the molecular mechanism.</div></div><div><h3>Results</h3><div>We found that miR-322 knockout mice were susceptible to AngII-induced cardiac fibrosis and hypertrophy <em>in vivo</em>. Administration of miR-424/322 inhibitors aggravated AngII-induced overexpression of NFATc3, furin, natriuretic peptides and collagen 1A1 in H9c2 cells and HCFs. miR-424/322 mimics reversed the AngII-induced fibrosis, hypertrophy, and proliferation by targeting NFATc3 and furin <em>in vitro</em>. miR-424/322 could be transactivated by NFATc3. Exogenous miR-322 ameliorated AngII-induced hypertrophy and cardiac fibrosis <em>in vivo</em>.</div></div><div><h3>Conclusions</h3><div>The NFATc3/miR-424/322/furin axis is crucial for developing cardiac remodeling, and exogenous miR-322 mimics could have therapeutic potential in cardiac remodeling.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100818"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox: A narrative review on current knowledge","authors":"Jun-Yuan Zheng ,&nbsp;Shie-shian Huang ,&nbsp;Jung-Jr Ye ,&nbsp;Ching-Tai Huang","doi":"10.1016/j.bj.2024.100823","DOIUrl":"10.1016/j.bj.2024.100823","url":null,"abstract":"","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100823"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive overview of gastric cancer management from a surgical point of view","authors":"Jun-Te Hsu ,&nbsp;Yu-Ning Lin ,&nbsp;Yi-Fu Chen ,&nbsp;Hao-Wei Kou ,&nbsp;Shan-Yu Wang ,&nbsp;Wen-Chi Chou ,&nbsp;Ting-Rong Wu ,&nbsp;Ta-Sen Yeh","doi":"10.1016/j.bj.2024.100817","DOIUrl":"10.1016/j.bj.2024.100817","url":null,"abstract":"<div><div>Despite advancements in medical care, surgical technologies, and the development of novel treatments over the past decade, the prognosis for patients with gastric cancer (GC) has only modestly improved. This is primarily due to the fact that the majority of patients are diagnosed at advanced stages or present with metastatic disease. Radical resection remains the cornerstone of potentially curative treatment, yet the overall 5-year survival rate remains below 35%. The management of GC varies globally, influenced by factors such as geographical disparities, patient comorbidities and performance status, surgical approaches, and available medical resources. Multidisciplinary collaboration and a multimodal treatment approach are essential for optimizing patient outcomes. Surgeons must stay updated on emerging surgical concepts and make informed decisions regarding patient selection, timing of intervention, and the adoption of appropriate surgical techniques to improve both quality of life and prognosis. This review aims to provide a surgical perspective on the management of GC across all stages, highlighting the importance of a comprehensive treatment approach. Endoscopic resection may be a viable option for early GC in patients with minimal risk of lymph node metastasis, particularly in elderly patients with high surgical risk or severe comorbidities. For advanced GC, neoadjuvant therapy followed by surgery could be a promising strategy to improve patient outcomes. Conversion surgery offers a potential survival benefit for patients who respond to treatment with tumor downstaging. The treatment of peritoneal carcinomatosis remains challenging; however, hyperthermic intraperitoneal chemotherapy combined with complete cytoreductive surgery or pressurized intraperitoneal aerosolized chemotherapy may prolong survival or improve quality of life in highly selected patients.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100817"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning significantly boosts CRT response prediction using synthetic longitudinal strain data: Training on synthetic data and testing on real patients","authors":"Ying-Feng Chang ,&nbsp;Kun-Chi Yen ,&nbsp;Chun-Li Wang ,&nbsp;Sin-You Chen ,&nbsp;Jenhui Chen ,&nbsp;Pao-Hsien Chu ,&nbsp;Chao-Sung Lai","doi":"10.1016/j.bj.2024.100803","DOIUrl":"10.1016/j.bj.2024.100803","url":null,"abstract":"<div><h3>Background</h3><div>Recently, as a relatively novel technology, artificial intelligence (especially in the deep learning fields) has received more and more attention from researchers and has successfully been applied to many biomedical domains. Nonetheless, just a few research works use deep learning skills to predict the cardiac resynchronization therapy (CRT)-response of heart failure patients.</div></div><div><h3>Objective</h3><div>We try to use the deep learning-based technique to construct a model which is used to predict the CRT response of patients with high prediction accuracy, precision, and sensitivity.</div></div><div><h3>Methods</h3><div>Using two-dimensional echocardiographic strain traces from 131 patients, we pre-processed the data and synthesized 2000 model inputs through the synthetic minority oversampling technique (SMOTE). These inputs trained and optimized deep neural networks (DNN) and one-dimensional convolution neural networks (1D-CNN). Visualization of prediction results was performed using t-distributed stochastic neighbor embedding (t-SNE), and model performance was evaluated using accuracy, precision, sensitivity, F1 score, and specificity. Variable importance was assessed using Shapley additive explanations (SHAP) analysis.</div></div><div><h3>Results</h3><div>Both the optimal DNN and 1D-CNN models demonstrated exceptional predictive performance, with prediction accuracy, precision, and sensitivity all around 90%. Furthermore, the area under the receiver operating characteristic curve (AUROC) of the optimal 1D-CNN and DNN models achieved 0.8734 and 0.9217, respectively. Crucially, the most significant input variables for both models align well with clinical experience, further corroborating their robustness and applicability in real-world settings.</div></div><div><h3>Conclusions</h3><div>We believe that both the DL models could be an auxiliary to help in treatment response prediction for doctors because of the excellent prediction performance and the convenience of obtaining input data to predict the CRT response of patients clinically.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100803"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial activation, cell-cell interactions, and inflammatory pathways in postoperative atrial fibrillation following cardiac surgery","authors":"Raquel López-Gálvez ,&nbsp;José Miguel Rivera-Caravaca ,&nbsp;Darío Mandaglio-Collados ,&nbsp;Antonio J. Ruiz-Alcaraz ,&nbsp;Álvaro Lahoz-Tornos ,&nbsp;Diana Hernández-Romero ,&nbsp;Esteban Orenes-Piñero ,&nbsp;María Pilar Ramos-Bratos ,&nbsp;Carlos M. Martínez ,&nbsp;Marina Carpes ,&nbsp;José María Arribas-Leal ,&nbsp;Sergio Cánovas ,&nbsp;Gregory Y.H. Lip ,&nbsp;Francisco Marín","doi":"10.1016/j.bj.2024.100821","DOIUrl":"10.1016/j.bj.2024.100821","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative atrial fibrillation (POAF) is common after cardiac surgery and related to endothelial activation and systemic inflammation. Herein, we investigate the pathophysiological mechanisms of AF through endothelial activation and cell-cell interactions related to the development of POAF.</div></div><div><h3>Methods</h3><div>Patients without previous AF undergoing cardiac surgery were studied. Permanent AF patients were included as positive controls. Interleukin (IL)-6, Von Willebrand factor (vWF), N-terminal pro-brain natriuretic peptide (NT-proBNP), and high sensitivity troponin T (hsTnT) were evaluated by electrochemiluminescence. Vascular cell adhesion molecule-1 (VCAM-1) and human Growth Differentiation Factor 15 (GDF-15) were assessed by ELISA. Connexins (Cxs) 40 and 43 were measured by tissue immunolabelling, and apoptosis by TUNEL assay.</div></div><div><h3>Results</h3><div>We included 117 patients (median age 67: 27.8% female): 17 with permanent AF; 27 with POAF, and 73 with non-AF. Patients with permanent AF and POAF had higher levels of NT-proBNP, hs-TnT, apoptotic nuclei, and decreased Cx43 expression, compared to non-AF patients (all p-value &lt;0.05). VCAM-1 and GDF-15 were significantly higher in permanent AF vs. non-AF (p = 0.013 and p = 0.035).</div></div><div><h3>Conclusions</h3><div>Greater endothelial activation and inflammation in AF patients compared to those without AF were found. The proinflammatory state in AF patients, in addition to the lower expression of Cx43, seems to be associated with atrial remodeling processes occurring in AF.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100821"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic surveillance of SARS-CoV-2 in Taiwan: A perspective on evolutionary data interpretation and sequencing issues","authors":"Yu-Nong Gong ,&nbsp;Nai-Yu Kuo ,&nbsp;Ting-Syuan Yeh ,&nbsp;Shin-Ru Shih ,&nbsp;Guang-Wu Chen","doi":"10.1016/j.bj.2024.100820","DOIUrl":"10.1016/j.bj.2024.100820","url":null,"abstract":"<div><div>This review presents a comprehensive perspective on the genomic surveillance of SARS-CoV-2 in Taiwan, with a focus on next-generation sequencing and phylogenetic interpretation. This article aimed to explore how Taiwan has utilized genomic sequencing technologies and surveillance to monitor and mitigate the spread of COVID-19. We examined databases and sources of genomic sequences and highlighted the role of data science methodologies in the explanation and analyses of evolutionary data. This review addressed the challenges and limitations inherent in genomic surveillance, such as concerns regarding data quality and the necessity for interdisciplinary expertise for accurate data interpretation. Special attention was given to the unique challenges faced by Taiwan, including its high population density and major transit destination for international travelers. We underscored the far-reaching implications of genomic surveillance data for public health policy, particularly in influencing decisions regarding travel restrictions, vaccine administration, and public health decision-making. Studies were examined to demonstrate the effectiveness of using genomic data to implement public health measures. Future research should prioritize the integration of methodologies and technologies in evolutionary data science, particularly focusing on phylodynamic analytics. This integration is crucial to enhance the precision and applicability of genomic data. Overall, we have provided an overview of the significance of genomic surveillance in tracking SARS-CoV-2 variants globally and the pivotal role of data science methodologies in interpreting these data for effective public health interventions.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100820"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma systemic treatment update: From early to advanced stage","authors":"Wei Teng ,&nbsp;Tai-Chi Wu ,&nbsp;Shi-Ming Lin","doi":"10.1016/j.bj.2024.100815","DOIUrl":"10.1016/j.bj.2024.100815","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) ranks the sixth most common malignancy but the third leading cause of cancer-related mortality in the world. Significant breakthroughs have been made in systemic treatment for HCC over the past two decades, which have improved treatment outcomes. In addition to multiple tyrosine kinase inhibitors (mTKIs), immune checkpoint inhibitors (ICIs) and antiangiogenic drugs are increasingly being applied. The combination of ICI and antiangiogenic or dual ICIs has become the new standard of care due to remarkable response rates. However, currently available systemic regimens are primarily reserved for certain patients in the intermediate and advanced stages who will not benefit from locoregional treatments. Evidence supporting the use of systemic treatment as neoadjuvant or adjuvant therapies in patients with early-stage HCC, especially the high risk of recurrence after curative treatments, remains limited. This review identified recent developments in systemic therapy, including mTKIs and ICIs, considering results on first- and second-line treatment, role of neoadjuvant and adjuvant settings, and combination with loco-regional therapy. Various ongoing clinical trials regarding the role of systemic therapies and potential novel targets in patients with early-, intermediate-, and advanced-stage HCC were also summarized and revealed that systemic therapy is no longer limited to advanced-stage HCC. Moreover, the introduction of T-cell redirecting strategies, including bispecific antibodies and chimeric antigen receptor T cells, has revolutionized the treatment landscape for HCC. Future research should focus on an in-depth exploration of the mechanisms governing the establishment of tumor barriers.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100815"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytidine deaminase enhances liver cancer invasion by modulating epithelial-mesenchymal transition via NFκB signaling","authors":"Chia-Jung Liao ,&nbsp;Yang-Hsiang Lin ,&nbsp;Huei-Tzu Chien ,&nbsp;Yi-Wen Wang ,&nbsp;Tzu-Kang Lin ,&nbsp;Chau-Ting Yeh ,&nbsp;Kwang-Huei Lin","doi":"10.1016/j.bj.2024.100789","DOIUrl":"10.1016/j.bj.2024.100789","url":null,"abstract":"<div><h3>Background</h3><div>Cancer metastasis is the leading cause of cancer-related deaths, underscoring the importance of understanding its underlying mechanisms. Hepatocellular carcinoma (HCC), a highly malignant type of cancer, was selected as our research model.</div></div><div><h3>Material and methods</h3><div>We aimed to develop high-metastatic cell lines using <em>in vitro</em> and <em>in vivo</em> selection strategies and identify critical metastasis-related genes through microarray analyses by comparing them with parental cells.</div></div><div><h3>Results</h3><div>Our results showed that the high-metastatic cell lines exhibited significantly stronger invasion abilities than parental cells. Microarray analyses identified cytidine deaminase (CDA), a gene associated with systemic chemotherapy resistance, as one of the overexpressed genes in the high-metastatic cells. Data analysis from The Cancer Genome Atlas Program revealed that while CDA is downregulated in HCC, patients with high CDA expression tend to have poorer prognoses. Cell models confirmed that CDA overexpression enhances cell migration and invasion, whereas CDA knockdown inhibits these abilities. Investigating the key molecules involved in the epithelial-mesenchymal transition (EMT), we found that CDA overexpression increases the expression of fascin, N-cadherin, β-catenin, and snail while decreasing E-cadherin expression. Conversely, CDA knockdown produced opposite results. Additionally, we discovered that CDA regulates NF-κB signaling, which controls the expression of N-cadherin, thereby promoting the invasion capability of HCC cells.</div></div><div><h3>Conclusions</h3><div>We isolated highly metastatic cells and identified potential HCC metastasis-related genes. CDA promotes cell invasion by regulating EMT through the NF-κB pathway. Future studies are warranted to explore the potential of CDA as a biomarker for prognosis and therapeutic decision-making.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100789"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geography, genes, and germs: An evolutionary entanglement","authors":"Aila Akosua Kattner","doi":"10.1016/j.bj.2025.100888","DOIUrl":"10.1016/j.bj.2025.100888","url":null,"abstract":"<div><div>This journal issue presents an article on genomic surveillance and phylogenetic analysis for monitoring SARS-CoV-2, alongside reviews of recent advances in the treatment of hepatocellular carcinoma and gastric cancer, and current insights into mpox. It includes a perspective on the role of extended reality techniques in pediatric neurosurgery, as well as updates on cleft care and the relationship between mitochondrial bioenergetics and iron. Further contributions explore the link between metastatic potential and cytidine deaminase, miRNA targets involved in hypertrophy and fibrosis during cardiac remodeling, and new deep-learning models for predicting response to cardiac resynchronization therapy. The expression of connexin gap junction proteins in atrial fibrillation is examined in detail, along with a retrospective study on enteral autonomy in pediatric short bowel syndrome. The issue concludes with novel insights into the rare genetic disorder Bietti crystalline dystrophy.</div></div>","PeriodicalId":8934,"journal":{"name":"Biomedical Journal","volume":"48 4","pages":"Article 100888"},"PeriodicalIF":4.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}