推进癌症诊断和治疗：整合分子生物标志物和新兴技术。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2025-02-01 DOI:10.1016/j.bj.2025.100831

Yu-Sun Chang , David M. Ojcius

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引用次数: 0

摘要

肿瘤生物标志物可以来源于肿瘤细胞或肿瘤微环境中的邻近细胞。在过去的几十年里，各种分子标记，包括DNA（突变，拷贝数变化），RNA (mRNA, microRNA, circular RNA)，蛋白质和代谢物，已经在快速发展的技术的帮助下被鉴定出来。其中一些标志物已被证明具有潜在的临床用途，而另一些则为解除导致肿瘤发生的正常分子和细胞过程的管制提供了新的见解。《生物医学杂志》这期特刊的出版物介绍了旨在加强癌症诊断、监测癌症和治疗方案的现代方法，最终目标是降低死亡率。这些研究强调了将先进技术与癌症治疗的临床策略相结合的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advancing cancer diagnosis and treatment: Integrating molecular biomarkers and emerging technologies

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Advancing cancer diagnosis and treatment: Integrating molecular biomarkers and emerging technologies

Cancer biomarkers can be derived from tumor cells or neighboring cells within the tumor microenvironment. Over the past few decades, various molecular markers, including DNA (mutations, copy number variations), RNA (mRNA, microRNA, circular RNA), proteins, and metabolites, have been identified with the aid of rapidly evolving technologies. Some of these markers have demonstrated potential clinical utility, while others have provided new insights into the deregulation of normal molecular and cellular processes that lead to tumorigenesis. Publications in this special issue of the Biomedical Journal introduce contemporary approaches aimed at enhancing cancer diagnosis, and monitoring of cancer and treatment options, with the ultimate goal of reducing mortality. These studies highlight the importance of integrating advanced technologies with clinical strategies for treatment of cancer.

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.