Bioarchitecture最新文献_第7页

Gradual recruitment and selective clearing generate germ plasm aggregates in the zebrafish embryo. 在斑马鱼胚胎中，逐渐的招募和选择性的清除产生了种质聚集体。

Bioarchitecture Pub Date : 2013-07-01 DOI: 10.4161/bioa.26538

Celeste Eno, Francisco Pelegri

引用次数: 21

Integration of signaling and cytoskeletal remodeling by Nck in directional cell migration. 定向细胞迁移中Nck信号传导和细胞骨架重塑的整合。

Bioarchitecture Pub Date : 2013-05-01 Epub Date: 2013-07-17 DOI: 10.4161/bioa.25744

Sankar P Chaki, Gonzalo M Rivera

引用次数: 30

The vacuole within: how cellular organization dictates notochord function. 内部液泡:细胞组织如何支配脊索功能。

Bioarchitecture Pub Date : 2013-05-01 Epub Date: 2013-06-26 DOI: 10.4161/bioa.25503

Kathryn Ellis, Brenton D Hoffman, Michel Bagnat

引用次数: 29

Periodicities designed in the tropomyosin sequence and structure define its functions. 原肌球蛋白序列和结构的周期性定义了它的功能。

Bioarchitecture Pub Date : 2013-05-01 Epub Date: 2013-07-08 DOI: 10.4161/bioa.25616

Bipasha Barua

引用次数: 22

Insights from an erroneous kinetochore-microtubule attachment state. 从一个错误的着丝细胞-微管附着状态的见解。

Bioarchitecture Pub Date : 2013-05-01 Epub Date: 2013-07-15 DOI: 10.4161/bioa.25734

Stuart Cane, Philip T McGilvray, Thomas J Maresca

引用次数: 3

Supracellular actomyosin assemblies during development. 发育过程中的细胞上肌动球蛋白聚集。

Bioarchitecture Pub Date : 2013-03-01 DOI: 10.4161/bioa.25339

Katja Röper

引用次数: 55

Dickkopf-3 function in the prostate: implications for epithelial homeostasis and tumor progression. 前列腺Dickkopf-3功能:对上皮稳态和肿瘤进展的影响

Bioarchitecture Pub Date : 2013-03-01 DOI: 10.4161/bioa.25243

Diana Romero, Robert Kypta

引用次数: 12

Aged skeletal muscle retains the ability to fully regenerate functional architecture. 衰老的骨骼肌保留了完全再生功能结构的能力。

Bioarchitecture Pub Date : 2013-03-01 Epub Date: 2013-07-01 DOI: 10.4161/bioa.24966

Antonio S J Lee, Judy E Anderson, Josephine E Joya, Stewart I Head, Nalini Pather, Anthony J Kee, Peter W Gunning, Edna C Hardeman

{"title":"Aged skeletal muscle retains the ability to fully regenerate functional architecture.","authors":"Antonio S J Lee, Judy E Anderson, Josephine E Joya, Stewart I Head, Nalini Pather, Anthony J Kee, Peter W Gunning, Edna C Hardeman","doi":"10.4161/bioa.24966","DOIUrl":"https://doi.org/10.4161/bioa.24966","url":null,"abstract":"While the general understanding of muscle regenerative capacity is that it declines with increasing age due to impairments in the number of muscle progenitor cells and interaction with their niche, studies vary in their model of choice, indices of myogenic repair, muscle of interest and duration of studies. We focused on the net outcome of regeneration, functional architecture, compared across three models of acute muscle injury to test the hypothesis that satellite cells maintain their capacity for effective myogenic regeneration with age. Muscle regeneration in extensor digitorum longus muscle (EDL) of young (3 mo-old), old (22 mo-old) and senescent female mice (28 mo-old) was evaluated for architectural features, fiber number and central nucleation, weight, collagen and fat deposition. The 3 injury paradigms were: a myotoxin (notexin) which leaves the blood vessels and nerves intact, freezing (FI) that damages local muscle, nerve and blood vessels and denervation-devascularization (DD) which dissociates the nerves and blood vessels from the whole muscle. Histological analyses revealed successful architectural regeneration following notexin injury with negligible fibrosis and fully restored function, regardless of age. In comparison, the regenerative response to injuries that damaged the neurovascular supply (FI and DD) was less effective, but similar across the ages. The focus on net regenerative outcome demonstrated that old and senescent muscle has a robust capacity to regenerate functional architecture. ","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"3 2","pages":"25-37"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.24966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31539750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

New insights on vertebrate olivo-cerebellar climbing fibers from computerized morphological reconstructions. 脊椎动物橄榄-小脑攀爬纤维的计算机形态重建新认识。

Bioarchitecture Pub Date : 2013-03-01 DOI: 10.4161/bioa.24062

Izumi Sugihara, Kerry M Brown, Giorgio A Ascoli

{"title":"New insights on vertebrate olivo-cerebellar climbing fibers from computerized morphological reconstructions.","authors":"Izumi Sugihara, Kerry M Brown, Giorgio A Ascoli","doi":"10.4161/bioa.24062","DOIUrl":"https://doi.org/10.4161/bioa.24062","url":null,"abstract":"Characterization of neuronal connectivity is essential to understanding the architecture of the animal nervous system. Specific labeling and imaging techniques can visualize axons and dendrites of single nerve cells. Two-dimensional manual drawing has long been used to describe the morphology of labeled neuronal elements. However, quantitative morphometry, which is essential to understanding functional significance, cannot be readily extracted unless the detailed neuronal geometry is comprehensively reconstructed in three-dimensional space. We have recently applied an accurate and robust digital reconstruction system to cerebellar climbing fibers, which form highly dense and complex terminal arbors as one of the strongest presynaptic endings in the vertebrate nervous system. Resulting statistical analysis has shown how climbing fibers morphology is special in comparison to other axonal terminals. While thick primary branches may convey excitation quickly and faithfully to the far ends, thin tendril branches, which have a larger bouton density, form the majority of presynaptic outputs. This data set, now publicly available from NeuroMorpho.Org for further modeling and analysis, may constitute the first detailed and comprehensive digital reconstruction of the complete axonal terminal field with identified branch types and full accounting of boutons for any neuronal class in the vertebrate brain. ","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"3 2","pages":"38-41"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/bioa.24062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31497804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rotary ATPases: models, machine elements and technical specifications. 旋转式atp酶:型号、机器部件及技术规格。

Bioarchitecture Pub Date : 2013-01-01 DOI: 10.4161/bioa.23301

Alastair G Stewart, Meghna Sobti, Richard P Harvey, Daniela Stock

引用次数: 24