Arthritis最新文献_第9页

Possible influence of resistance to malaria in clinical presentation of rheumatoid arthritis: biological significance of natural selection. 抗疟疾对类风湿关节炎临床表现的可能影响:自然选择的生物学意义。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-11-14 DOI: 10.1155/2012/670579

Fabio Bonilla-Abadía, Gabriel J Tobón, Carlos A Cañas

{"title":"Possible influence of resistance to malaria in clinical presentation of rheumatoid arthritis: biological significance of natural selection.","authors":"Fabio Bonilla-Abadía, Gabriel J Tobón, Carlos A Cañas","doi":"10.1155/2012/670579","DOIUrl":"https://doi.org/10.1155/2012/670579","url":null,"abstract":"Rheumatoid arthritis (RA) is a common autoimmune disease that affects all ethnic groups. Genetic factors, mainly HLA alleles, are highly associated with increased risk to develop RA. However, there are few available data about the role of these genetic polymorphisms in the prevalence or severity of RA in the Afrodescendant population, who have evolutionarily and by natural selection developed mutations that allowed them to acquire resistance to infectious diseases like malaria. Some of the mechanisms, by which this resistance was developed as a product of natural selection, are involved in different forms of immunological response, many of them of a well-known importance in the pathophysiology of RA. This paper focuses on presenting the known mechanisms of resistance to malaria and their possible contribution to the pathophysiology of RA, including \"loss-of-function\" mutations, lack of expression of chemokine receptors, decrease of immune complexes clearance by asplenia, or increase of immune reactivity mediated by B cells, among other mechanisms in this special group of patients.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"670579"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/670579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31098225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Psoriatic arthritis: an update. 银屑病关节炎：最新进展。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-17 DOI: 10.1155/2012/176298

Peter Lloyd, Caitriona Ryan, Alan Menter

引用次数: 0

The Columbus Knee System: 4-Year Results of a New Deep Flexion Design Compared to the NexGen Full Flex Implant. 哥伦布膝关节系统：新型深屈曲设计与 NexGen 全屈曲假体的四年对比结果。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.1155/2012/213817

D Goebel, W Schultz

引用次数: 0

The Global Economic Cost of Osteoarthritis: How the UK Compares. 骨关节炎的全球经济成本：英国的比较。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-02 DOI: 10.1155/2012/698709

A Chen, C Gupte, K Akhtar, P Smith, J Cobb

{"title":"The Global Economic Cost of Osteoarthritis: How the UK Compares.","authors":"A Chen, C Gupte, K Akhtar, P Smith, J Cobb","doi":"10.1155/2012/698709","DOIUrl":"10.1155/2012/698709","url":null,"abstract":"Aims. To examine all relevant literature on the economic costs of osteoarthritis in the UK, and to compare such costs globally. Methods. A search of MEDLINE was performed. The search was expanded beyond peer-reviewed journals into publications by the department of health, national orthopaedic associations, national authorities and registries, and arthritis charities. Results. No UK studies were identified in the literature search. 3 European, 6 North American, and 2 Asian studies were reviewed. Significant variation in direct and indirect costs were seen in these studies. Costs for topical and oral NSAIDs were estimated to be £19.2 million and £25.65 million, respectively. Cost of hip and knee replacements was estimated to exceed £850 million, arthroscopic surgery for osteoarthritis was estimated to be £1.34 million. Indirect costs from OA caused a loss of economic production over £3.2 billion, £43 million was spent on community services and £215 million on social services for osteoarthritis. Conclusions. While estimates of economic costs can be made using information from non-published data, there remains a lack of original research looking at the direct or indirect costs of osteoarthritis in the UK. Differing methodology in calculating costs from overseas studies makes direct comparison with the UK difficult.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"698709"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30987208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheumatoid arthritis and primary biliary cirrhosis: cause, consequence, or coincidence? 类风湿性关节炎和原发性胆汁性肝硬化:原因、后果还是巧合?

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-24 DOI: 10.1155/2012/391567

Daniel S Smyk, Dimitrios P Bogdanos, Maria G Mytilinaiou, Andrew K Burroughs, Eirini I Rigopoulou

{"title":"Rheumatoid arthritis and primary biliary cirrhosis: cause, consequence, or coincidence?","authors":"Daniel S Smyk, Dimitrios P Bogdanos, Maria G Mytilinaiou, Andrew K Burroughs, Eirini I Rigopoulou","doi":"10.1155/2012/391567","DOIUrl":"https://doi.org/10.1155/2012/391567","url":null,"abstract":"Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterized serologically by cholestasis and the presence of high-titre antimitochondrial antibodies and histologically by chronic nonsuppurative cholangitis and granulomata. PBC patients often have concomitant autoimmune diseases, including arthropathies. This raises the question as to whether there are shared features in the pathogenesis of those diseases with the pathogenesis of PBC. Epidemiological and large case studies have indicated that although the incidence of rheumatoid arthritis (RA) is not significantly raised in PBC patients, there appears to be a higher rate of RA in PBC patients and their relatives. Genetic studies have demonstrated that several genes implicated in PBC have also been implicated in RA. Epigenetic studies provided a wealth of data regarding RA, but the findings on epigenetic changes in PBC are very limited. As well, certain infectious agents identified in the pathogenesis of PBC may also play a role in the pathogenesis of RA. These data suggest that although RA is not significantly present in PBC, some individuals with certain genetic traits and environmental exposures may develop both conditions. This concept may also apply to other concomitant diseases found in PBC patients.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"391567"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/391567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31045565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Relationships between Pain, Function and Radiographic Findings in Osteoarthritis of the Knee: A Cross-Sectional Study. 膝关节骨关节炎的疼痛、功能和影像学表现之间的关系:一项横断面研究。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-11-19 DOI: 10.1155/2012/984060

Duygu Cubukcu, Ayse Sarsan, Hakan Alkan

{"title":"Relationships between Pain, Function and Radiographic Findings in Osteoarthritis of the Knee: A Cross-Sectional Study.","authors":"Duygu Cubukcu, Ayse Sarsan, Hakan Alkan","doi":"10.1155/2012/984060","DOIUrl":"https://doi.org/10.1155/2012/984060","url":null,"abstract":"Objectives. The aim of this study was to investigate the relationships between pain, disability, and radiographic findings in patients with knee osteoarthritis (OA). Patients and Methods. A total of 114 patients with knee OA who attended the physical medicine and rehabilitation outpatient clinic were included in this study. The diagnosis was based on the American College of Rheumatology (ACR) criteria for knee OA. Age, duration of disease, and body mass index (BMI) of the patients were recorded. Radiographic features on the two-sided knee radiography were assessed with the Kellgren-Lawrence scale. The severity of knee pain, stiffness, and disability were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results. The mean age of the patients was 56.98 (±8.28) years and the mean disease duration was 4.14 (±4.15) years. Kellgren-Lawrence grading scale and age or disease duration were positively and significantly associated, whereas none of the WOMAC subscores were found to be related with Kellgren-Lawrence grading scale (P > 0.05). On the other hand, WOMAC disability scores were significantly associated with WOMAC pain and WOMAC stiffness (P < 0.01). Conclusions. Knee pain, stiffness, and duration of disease may affect the level of disability in the patients with knee OA. Therefore treatment of knee OA could be planned according to the clinical features and functional status instead of radiological findings.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"984060"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/984060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31098226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 111

A synoviocyte model for osteoarthritis and rheumatoid arthritis: response to Ibuprofen, betamethasone, and ginger extract-a cross-sectional in vitro study. 骨关节炎和类风湿性关节炎的滑膜细胞模型:对布洛芬、倍他米松和生姜提取物的反应——一项横断面体外研究。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-12-31 DOI: 10.1155/2012/505842

Søren Ribel-Madsen, Else Marie Bartels, Anders Stockmarr, Arne Borgwardt, Claus Cornett, Bente Danneskiold-Samsøe, Henning Bliddal

{"title":"A synoviocyte model for osteoarthritis and rheumatoid arthritis: response to Ibuprofen, betamethasone, and ginger extract-a cross-sectional in vitro study.","authors":"Søren Ribel-Madsen, Else Marie Bartels, Anders Stockmarr, Arne Borgwardt, Claus Cornett, Bente Danneskiold-Samsøe, Henning Bliddal","doi":"10.1155/2012/505842","DOIUrl":"https://doi.org/10.1155/2012/505842","url":null,"abstract":"This study aimed at determining if synovial cell cultures from rheumatoid arthritis (RA), osteoarthritis (OA), and healthy controls (HC) differ and are suitable disease models in pharmacological studies, and tested their response to some anti-inflammatory drugs. Synovial cells were isolated from synovial membrane or joint fluid. Cells were cultivated and exposed to no or TNF-α stimulation without, or in the presence of, betamethasone, ibuprofen, or a standardized ginger extract. Concentrations of a panel of cytokines, growth factors, and chemokines were mapped for each culture and condition. Our cells secreted an increased amount of the cytokines IL-1β, IL-6, and IL-8 in response to TNF-α stimulation in all conditions. OA cells showed a higher IL-6 and IL-8 and a lower IL-1β production, when not stimulated, than RA and HC cells, which were similar. TNF-α stimulation caused similar IL-1β, IL-6, and IL-8 release in all groups. Ibuprofen showed no effect on cytokine production, while ginger extract was similar to betamethasone. Ginger extract was as effective an anti-inflammatory agent as betamethasone in this in vitro model. Cultured fibroblast-like synoviocytes from OA and RA subjects promise to be a useful pharmacological disease model, but further studies, to support results from such a model are needed.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"505842"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/505842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31201691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48

Work productivity in rheumatoid arthritis: relationship with clinical and radiological features. 类风湿关节炎的工作效率:与临床和放射学特征的关系。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-12-19 DOI: 10.1155/2012/137635

Rafael Chaparro Del Moral, Oscar Luis Rillo, Luciana Casalla, Carolina Bru Morón, Gustavo Citera, José A Maldonado Cocco, María de Los Ángeles Correa, Emilio Buschiazzo, Natalia Tamborenea, Eduardo Mysler, Guillermo Tate, Andrea Baños, Natalia Herscovich

{"title":"Work productivity in rheumatoid arthritis: relationship with clinical and radiological features.","authors":"Rafael Chaparro Del Moral, Oscar Luis Rillo, Luciana Casalla, Carolina Bru Morón, Gustavo Citera, José A Maldonado Cocco, María de Los Ángeles Correa, Emilio Buschiazzo, Natalia Tamborenea, Eduardo Mysler, Guillermo Tate, Andrea Baños, Natalia Herscovich","doi":"10.1155/2012/137635","DOIUrl":"https://doi.org/10.1155/2012/137635","url":null,"abstract":"Objective. To assess the relationship between work productivity with disease activity, functional capacity, life quality and radiological damage in patients with rheumatoid arthritis (RA). Methods. The study included consecutive employed patients with RA (ACR'87), aged over 18. Demographic, disease-related, and work-related variables were determined. The reduction of work productivity was assessed by WPAI-RA. Results. 90 patients were evaluated, 71% women. Age average is 50 years old, DAS28 4, and RAQoL 12. Median SENS is 18 and HAQ-A 0.87. Mean absenteeism was of 14%, presenting an average of 6.30 work hours wasted weekly. The reduction in performance at work or assistance was of 38.4% and the waste of productivity was of 45%. Assistance correlated with DAS28 (r = 0.446; P < 0.001), HAQ-A (r = 0.545; P < 0.001) and RAQoL (r = 0.475; P < 0.001). Lower total productivity was noticed in higher levels of activity and functional disability. Patients with SENS > 18 showed lower work productivity than those with SENS < 18 (50 versus 34; P = 0.04). In multiple regression analysis, variables associated with reduction of total work productivity were HAQ-A and RAQoL. Conclusion. RA patients with higher disease severity showed higher work productivity compromise.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"137635"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/137635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31158737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

The role of different subsets of regulatory T cells in immunopathogenesis of rheumatoid arthritis. 调节性T细胞不同亚群在类风湿关节炎免疫发病机制中的作用。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-24 DOI: 10.1155/2012/805875

Maryam Gol-Ara, Farhad Jadidi-Niaragh, Reza Sadria, Gholamreza Azizi, Abbas Mirshafiey

引用次数: 78

A hierarchy of patient-reported outcomes for meta-analysis of knee osteoarthritis trials: empirical evidence from a survey of high impact journals. 用于膝关节骨关节炎试验荟萃分析的患者报告结果等级：来自高影响力期刊调查的经验证据。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-06-26 DOI: 10.1155/2012/136245

Carsten Juhl, Hans Lund, Ewa M Roos, Weiya Zhang, Robin Christensen

{"title":"A hierarchy of patient-reported outcomes for meta-analysis of knee osteoarthritis trials: empirical evidence from a survey of high impact journals.","authors":"Carsten Juhl, Hans Lund, Ewa M Roos, Weiya Zhang, Robin Christensen","doi":"10.1155/2012/136245","DOIUrl":"10.1155/2012/136245","url":null,"abstract":"Objectives. To develop a prioritised list based on responsiveness for extracting patient-reported outcomes (PROs) measuring pain and disability for performing meta-analyses in knee osteoarthritis (OA). Methods. A systematic search was conducted in 20 highest impact factor general and rheumatology journals chosen a priori. Eligible studies were randomised controlled trials, using two or more PROs measuring pain and/or disability. Results. A literature search identified 402 publications and 38 trials were included, resulting in 54 randomised comparisons. Thirty-five trials had sufficient data on pain and 15 trials on disability. The WOMAC \"pain\" and \"function\" subscales were the most responsive composite scores. The following list was developed. Pain: (1) WOMAC \"pain\" subscale, (2) pain during activity (VAS), (3) pain during walking (VAS), (4) general knee pain (VAS), (5) pain at rest (VAS), (6) other composite pain scales, and (7) other single item measures. Disability: (1) WOMAC \"function\" subscale, (2) SF-36 \"physical function\" subscale, (3) SF-36 (Physical composite score), and (4) Other composite disability scores. Conclusions. As choosing the PRO most favourable for the intervention from individual trials can lead to biased estimates, using a prioritised list as developed in this study is recommended to reduce risk of biased selection of PROs in meta-analyses.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"136245"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30759748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0