Arthritis最新文献_第8页

The effects of bariatric surgery weight loss on knee pain in patients with osteoarthritis of the knee. 减肥手术减重对膝关节骨关节炎患者膝关节疼痛的影响。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-12-03 DOI: 10.1155/2012/504189

Christopher Edwards, Ann Rogers, Scott Lynch, Tamara Pylawka, Matthew Silvis, Vernon Chinchilli, Timothy Mosher, Kevin Black

{"title":"The effects of bariatric surgery weight loss on knee pain in patients with osteoarthritis of the knee.","authors":"Christopher Edwards, Ann Rogers, Scott Lynch, Tamara Pylawka, Matthew Silvis, Vernon Chinchilli, Timothy Mosher, Kevin Black","doi":"10.1155/2012/504189","DOIUrl":"https://doi.org/10.1155/2012/504189","url":null,"abstract":"Studies have shown that osteoarthritis (OA) is highly associated with obesity, and individuals clinically defined as obese (BMI > 30.0 kg/m(2)) are four times more likely to have knee OA over the general population. The purpose of this research was to examine if isolated weight loss improved knee symptoms in patients with osteoarthritis. Adult patients (n = 24; age 18-70; BMI > 35 kg/m(2)) with clinical and radiographic evidence of knee OA participated in a one-year trial in which WOMAC and KOOS surveys were administered at a presurgery baseline and six and twelve months postsurgery. Statistical analysis was performed using Student's t and Wilcoxon Signed Rank tests. Weight loss six and twelve months following bariatric surgery was statistically significant (P < 0.05) compared to presurgery measurements. All variables from both KOOS and WOMAC assessments were significantly improved (P < 0.05) when compared to baseline. Isolated weight loss occurring via bariatric surgery resulted in statistically significant improvement in patient's knee arthritis symptoms at both six and twelve months. Further research will need to be done to determine if symptom relief continues over time, and if the benefits are also applicable to individuals with symptomatic knee arthritis that are overweight but not obese.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"504189"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/504189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31122603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

The pathogenesis of nontraumatic osteonecrosis. 非外伤性骨坏死的发病机制。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-11-08 DOI: 10.1155/2012/601763

Jesse Seamon, Thomas Keller, Jamal Saleh, Quanjun Cui

引用次数: 148

Cardiovascular disease in rheumatoid arthritis: a systematic literature review in latin america. 类风湿关节炎中的心血管疾病:拉丁美洲的系统文献综述。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-31 DOI: 10.1155/2012/371909

Juan Camilo Sarmiento-Monroy, Jenny Amaya-Amaya, Juan Sebastián Espinosa-Serna, Catalina Herrera-Díaz, Juan-Manuel Anaya, Adriana Rojas-Villarraga

{"title":"Cardiovascular disease in rheumatoid arthritis: a systematic literature review in latin america.","authors":"Juan Camilo Sarmiento-Monroy, Jenny Amaya-Amaya, Juan Sebastián Espinosa-Serna, Catalina Herrera-Díaz, Juan-Manuel Anaya, Adriana Rojas-Villarraga","doi":"10.1155/2012/371909","DOIUrl":"https://doi.org/10.1155/2012/371909","url":null,"abstract":"Background. Cardiovascular disease (CVD) is the major predictor of poor prognosis in rheumatoid arthritis (RA) patients. There is an increasing interest to identify \"nontraditional\" risk factors for this condition. Latin Americans (LA) are considered as a minority subpopulation and ethnically different due to admixture characteristics. To date, there are no systematic reviews of the literature published in LA and the Caribbean about CVD in RA patients. Methods. The systematic literature review was done by two blinded reviewers who independently assessed studies for eligibility. The search was completed through PubMed, LILACS, SciELO, and Virtual Health Library scientific databases. Results. The search retrieved 10,083 potential studies. A total of 16 articles concerning cardiovascular risk factors and measurement of any cardiovascular outcome in LA were included. The prevalence of CVD in LA patients with RA was 35.3%. Non-traditional risk factors associated to CVD in this population were HLA-DRB1 shared epitope alleles, rheumatoid factor, markers of chronic inflammation, long duration of RA, steroids, familial autoimmunity, and thrombogenic factors. Conclusions. There is limited data about CVD and RA in LA. We propose to evaluate cardiovascular risk factors comprehensively in the Latin RA patient and to generate specific public health policies in order to diminish morbi-mortality rates.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"371909"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/371909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31082878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Autoimmune thyroid disease in rheumatoid arthritis: a global perspective. 类风湿性关节炎中的自身免疫性甲状腺疾病:全球视角

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-11-18 DOI: 10.1155/2012/864907

Jorge Cárdenas Roldán, Jenny Amaya-Amaya, Juan Castellanos-de la Hoz, Juliana Giraldo-Villamil, Gladys Montoya-Ortiz, Paola Cruz-Tapias, Adriana Rojas-Villarraga, Rubén D Mantilla, Juan-Manuel Anaya

{"title":"Autoimmune thyroid disease in rheumatoid arthritis: a global perspective.","authors":"Jorge Cárdenas Roldán, Jenny Amaya-Amaya, Juan Castellanos-de la Hoz, Juliana Giraldo-Villamil, Gladys Montoya-Ortiz, Paola Cruz-Tapias, Adriana Rojas-Villarraga, Rubén D Mantilla, Juan-Manuel Anaya","doi":"10.1155/2012/864907","DOIUrl":"10.1155/2012/864907","url":null,"abstract":"Objective. To determine the prevalence and impact of autoimmune thyroid disease (AITD) in patients with rheumatoid arthritis (RA). Methods. Eight-hundred patients were included. The association between AITD and RA was analyzed was analyzed by bivariate and multivariate analysis. In addition, a literature review was done focusing on geographical variations. Results. In our cohort the prevalence of AITD was 9.8% while the presence of antibodies was 37.8% for antithyroperoxidase enzyme (TPOAb) and 20.8% for antithyroglobulin protein (TgAb). The presence of type 2 diabetes, thrombosis, abnormal body mass index, and a high educational level was positively associated with AITD. The literature review disclosed a geographical variation of AITD in RA ranging from 0.5% to 27%. Autoantibody prevalence ranges from 6% to 31% for TgAb, 5% to 37% for TPOAb, and from 11.4% to 32% for the presence of either of the two. Conclusion. AITD is not uncommon in RA and should be systematically assessed since it is a risk factor for developing diabetes and cardiovascular disease. These results may help to further study the common mechanisms of autoimmune diseases, to improve patients' outcome, and to define public health policies. An international consensus to accurately diagnose AITD is warranted.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"864907"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/864907","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31098227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches. 骨性关节炎的炎症和关节组织相互作用:潜在治疗方法的意义。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-06-18 DOI: 10.1155/2012/741582

Roshni Rainbow, Weiping Ren, Li Zeng

引用次数: 62

Osteoarthritis of the Wrist STT Joint and Radiocarpal Joint. 手腕、STT关节和桡腕关节的骨关节炎。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-08-26 DOI: 10.1155/2012/242159

Ronit Wollstein, Julio Clavijo, Louis A Gilula

{"title":"Osteoarthritis of the Wrist STT Joint and Radiocarpal Joint.","authors":"Ronit Wollstein, Julio Clavijo, Louis A Gilula","doi":"10.1155/2012/242159","DOIUrl":"https://doi.org/10.1155/2012/242159","url":null,"abstract":"Our understanding of wrist osteoarthritis (OA) lags behind that of other joints, possibly due to the complexity of wrist biomechanics and the importance of ligamentous forces in the function of the wrist. Scaphotrapeziotrapezoidal (STT) OA is common, but its role in wrist clinical pathology and biomechanics is unclear. We identified the prevalence of radiographic STT joint OA in our hand clinic population and defined the relationship between STT and radiocarpal OA in wrist radiographs. One hundred consecutive wrist clinical and radiographic exams were retrospectively reviewed. Radiographs were evaluated for the presence and stage of OA. The mean age was 61.3 (±14.5) years. The radiographic occurrence of STT joint OA was 59% and of radiocarpal (RC) OA was 29%. Radiographic STT and RC joint OA were inversely related. Tenderness over the STT joint in physical exam was not associated with OA in the STT or other joints. STT OA in our series was not related to wrist pain. These findings support the discrepancy between radiographic and cadaver findings and clinically significant OA in this joint. The inverse relationship between STT and RC OA, as seen in scapholunate advanced collapse (SLAC) wrist, requires further biomechanical study.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"242159"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/242159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30888605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Proinflammatory soluble interleukin-15 receptor alpha is increased in rheumatoid arthritis. 促炎可溶性白介素-15受体α在类风湿关节炎中升高。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-07-25 DOI: 10.1155/2012/943156

Ana Cecilia Machado Diaz, Araceli Chico Capote, Celia Aurora Arrieta Aguero, Yunier Rodríguez Alvarez, Diana García Del Barco Herrera, Miguel Estévez Del Toro, Gerardo E Guillen Nieto, Alicia Santos Savio

{"title":"Proinflammatory soluble interleukin-15 receptor alpha is increased in rheumatoid arthritis.","authors":"Ana Cecilia Machado Diaz, Araceli Chico Capote, Celia Aurora Arrieta Aguero, Yunier Rodríguez Alvarez, Diana García Del Barco Herrera, Miguel Estévez Del Toro, Gerardo E Guillen Nieto, Alicia Santos Savio","doi":"10.1155/2012/943156","DOIUrl":"https://doi.org/10.1155/2012/943156","url":null,"abstract":"Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease in which many cytokines have been implicated. In particular, IL-15 is a cytokine involved in the inflammatory processes and bone loss. The aim of this study was to investigate the existence in synovial fluid of soluble IL-15Rα, a private receptor subunit for IL-15 which may act as an enhancer of IL-15-induced proinflammatory cytokines. Soluble IL-15Rα was quantified by a newly developed enzyme-linked immunosorbent assay (ELISA) in samples of synovial fluid from patients with RA and osteoarthritis (OA). The levels of IL-15Rα were significantly increased in RA patients compared to OA patients. Also, we studied the presence of membrane-bound IL-15 in cells from synovial fluids, another element necessary to induce pro-inflammatory cytokines through reverse signaling. Interestingly, we found high levels of IL-6 related to high levels of IL-15Rα in RA but not in OA. Thus, our results evidenced presence of IL-15Rα in synovial fluids and suggested that its pro-inflammatory effect could be related to induction of IL-6.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"943156"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/943156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30830066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Tolerance of an aquatic power training program by older adults with symptomatic knee osteoarthritis. 有症状性膝骨关节炎的老年人水中力量训练计划的耐受性。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-09-13 DOI: 10.1155/2012/895495

Neil A Segal, Robert Wallace

{"title":"Tolerance of an aquatic power training program by older adults with symptomatic knee osteoarthritis.","authors":"Neil A Segal, Robert Wallace","doi":"10.1155/2012/895495","DOIUrl":"https://doi.org/10.1155/2012/895495","url":null,"abstract":"Objective. To determine the tolerance and feasibility of aquatic-based power training for improving lower limb muscle power, impairments, and mobility in adults with symptomatic knee OA. Participants. Twenty-nine adults, age 50 years and over, with symptomatic knee OA (ACR clinical criteria) and mobility limitation (400-meter walk time slower than median for sex and decade) completed 45-minute aquatic power training sessions twice weekly for 6 weeks. Main Outcome Measurements. Prospective outcomes included tolerance of the program, as well as change in stair climb power, 400-meter walk time, overall and knee-specific pain, activities of daily living (ADL), quality of life (QOL), and lower limb function at 6- and 12-week follow-up. Results. The training intensity required modification for 9 of the 29 participants. Lower limb muscle power, ADL, QOL, and overall pain were improved immediately and 6 weeks following completion (all P < 0.05). However, 400-meter walk times, and lower limb function did not differ from baseline. Conclusions. A 6-week aquatic rehabilitation program appears to be well tolerated by adults with symptomatic knee OA with mobility limitations and may result in improved lower limb muscle power, symptoms, ADL, and QOL. However, this intervention may have insufficient specificity or intensity for improving physical function.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"895495"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/895495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30930824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Pathological role of interleukin-6 in psoriatic arthritis. 白细胞介素-6在银屑病关节炎中的病理作用。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-11 DOI: 10.1155/2012/713618

Atsushi Ogata, Atsushi Kumanogoh, Toshio Tanaka

引用次数: 33

The Association between Databases for Indexing Studies Intended for an Exercise Meta-Analysis of Arthritis Randomized Controlled Trials. 用于关节炎随机对照试验的运动meta分析的索引研究数据库之间的关联。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-08-09 DOI: 10.1155/2012/624830

George A Kelley, Kristi S Kelley

{"title":"The Association between Databases for Indexing Studies Intended for an Exercise Meta-Analysis of Arthritis Randomized Controlled Trials.","authors":"George A Kelley, Kristi S Kelley","doi":"10.1155/2012/624830","DOIUrl":"https://doi.org/10.1155/2012/624830","url":null,"abstract":"Objective. The purpose of this study was to determine the database indexing of randomized controlled trials (RCTs) for a meta-analysis addressing the effects of exercise on pain and physical function in adults with arthritis and other rheumatic diseases (AORD). Methods. The number, percentage, and 95% confidence intervals (CIs) for included articles at initial and follow-up periods were calculated from PubMed, EMBASE, CENTRAL, CINAHL, SPORTDiscus, and DAO databases. The number needed to review (NNR) was also calculated along with the number of articles retrieved by expert review. Cross-referencing from reviews and included articles also occurred. Results. Thirty-four of 36 articles (94.4%, 95% CI, 81.3-99.3) were located by database searching. PubMed and CENTRAL yielded 32 of 36 articles (88.9%, 73.9-96.9). Two articles not identified in any of the other databases were found in either CINAHL or SPORTDicsus. Two other articles were located by scanning the reference lists of review articles. The NNR ranged from 2 (CINAHL) to 118 (SPORTDiscus). More articles were identified in EMBASE at follow-up (36%, 12.1-42.2 versus 86.1%, 70.5-95.3). Conclusions. Searching multiple databases and cross-referencing from reviews was important for identifying RCTs addressing the effects of exercise on pain and physical function in adults with AORD.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"624830"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/624830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30861294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2