Arthritis最新文献_第10页

The effect of hip bracing on gait in patients with medial knee osteoarthritis. 髋部支具对膝关节内侧骨关节炎患者步态的影响。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-07-25 DOI: 10.1155/2012/240376

David Wallace, Christa Barr

{"title":"The effect of hip bracing on gait in patients with medial knee osteoarthritis.","authors":"David Wallace, Christa Barr","doi":"10.1155/2012/240376","DOIUrl":"https://doi.org/10.1155/2012/240376","url":null,"abstract":"Objective. Impaired hip motion has been associated with heightened medial knee joint loading in patients with knee osteoarthritis (OA). A hip external rotation strap designed to pull the femur into external rotation and abduction may serve as one protective mechanism. The primary aim of our study is to determine if the strap decreases medial knee joint loading during level walking in people with knee OA. Design. This study is a single-day repeated measures design. Methods. 15 volunteers with medial knee OA underwent motion analysis data collection during two randomly assigned walking conditions: (1) wearing the strap and (2) control (no strap). Primary outcome measures were peak pelvis, hip and knee joint motions, and torques. These outcomes were averaged across five trials for each condition. Results. Hip abduction (P < 0.01), trunk lean towards the stance limb (P = 0.04) and pelvic tilt (P = 0.02) significantly increased with the strap versus control trials. Knee adduction loading did not significantly change with the strap (P = 0.33). Conclusion. The use of the hip external rotation strap resulted in angular changes at the hip and pelvis which may be beneficial for patients with medial knee osteoarthritis.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"240376"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/240376","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30830065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A review of translational animal models for knee osteoarthritis. 膝关节骨关节炎动物模型的研究进展。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-12-27 DOI: 10.1155/2012/764621

Martin H Gregory, Nicholas Capito, Keiichi Kuroki, Aaron M Stoker, James L Cook, Seth L Sherman

引用次数: 197

Expression of Angiotensin II Receptor-1 in Human Articular Chondrocytes. 血管紧张素受体-1在人关节软骨细胞中的表达。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-12-30 DOI: 10.1155/2012/648537

Yuki Kawakami, Kosuke Matsuo, Minako Murata, Kazuo Yudoh, Hiroshi Nakamura, Hiroyuki Shimizu, Moroe Beppu, Yutaka Inaba, Tomoyuki Saito, Tomohiro Kato, Kayo Masuko

{"title":"Expression of Angiotensin II Receptor-1 in Human Articular Chondrocytes.","authors":"Yuki Kawakami, Kosuke Matsuo, Minako Murata, Kazuo Yudoh, Hiroshi Nakamura, Hiroyuki Shimizu, Moroe Beppu, Yutaka Inaba, Tomoyuki Saito, Tomohiro Kato, Kayo Masuko","doi":"10.1155/2012/648537","DOIUrl":"https://doi.org/10.1155/2012/648537","url":null,"abstract":"Background. Besides its involvement in the cardiovascular system, the renin-angiotensin-aldosterone (RAS) system has also been suggested to play an important role in inflammation. To explore the role of this system in cartilage damage in arthritis, we investigated the expression of angiotensin II receptors in chondrocytes. Methods. Articular cartilage was obtained from patients with osteoarthritis, rheumatoid arthritis, and traumatic fractures who were undergoing arthroplasty. Chondrocytes were isolated and cultured in vitro with or without interleukin (IL-1). The expression of angiotensin II receptor types 1 (AT1R) and 2 (AT2R) mRNA by the chondrocytes was analyzed using reverse transcription-polymerase chain reaction (RT-PCR). AT1R expression in cartilage tissue was analyzed using immunohistochemistry. The effect of IL-1 on AT1R/AT2R expression in the chondrocytes was analyzed by quantitative PCR and flow cytometry. Results. Chondrocytes from all patient types expressed AT1R/AT2R mRNA, though considerable variation was found between samples. Immunohistochemical analysis confirmed AT1R expression at the protein level. Stimulation with IL-1 enhanced the expression of AT1R/AT2R mRNA in OA and RA chondrocytes. Conclusions. Human articular chondrocytes, at least partially, express angiotensin II receptors, and IL-1 stimulation induced AT1R/AT2R mRNA expression significantly.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"648537"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/648537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31180592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Prescribing optimal nutrition and physical activity as "first-line" interventions for best practice management of chronic low-grade inflammation associated with osteoarthritis: evidence synthesis. 处方最佳营养和身体活动作为最佳实践管理慢性低度炎症与骨关节炎相关的“一线”干预措施:证据综合

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-12-31 DOI: 10.1155/2012/560634

Elizabeth Dean, Rasmus Gormsen Hansen

{"title":"Prescribing optimal nutrition and physical activity as \"first-line\" interventions for best practice management of chronic low-grade inflammation associated with osteoarthritis: evidence synthesis.","authors":"Elizabeth Dean, Rasmus Gormsen Hansen","doi":"10.1155/2012/560634","DOIUrl":"10.1155/2012/560634","url":null,"abstract":"Low-grade inflammation and oxidative stress underlie chronic osteoarthritis. Although best-practice guidelines for osteoarthritis emphasize self-management including weight control and exercise, the role of lifestyle behavior change to address chronic low-grade inflammation has not been a focus of first-line management. This paper synthesizes the literature that supports the idea in which the Western diet and inactivity are proinflammatory, whereas a plant-based diet and activity are anti-inflammatory, and that low-grade inflammation and oxidative stress underlying osteoarthritis often coexist with lifestyle-related risk factors and conditions. We provide evidence-informed recommendations on how lifestyle behavior change can be integrated into \"first-line\" osteoarthritis management through teamwork and targeted evidence-based interventions. Healthy living can be exploited to reduce inflammation, oxidative stress, and related pain and disability and improve patients' overall health. This approach aligns with evidence-based best practice and holds the promise of eliminating or reducing chronic low-grade inflammation, attenuating disease progression, reducing weight, maximizing health by minimizing a patient's risk or manifestations of other lifestyle-related conditions hallmarked by chronic low-grade inflammation, and reducing the need for medications and surgery. This approach provides an informed cost effective basis for prevention, potential reversal, and management of signs and symptoms of chronic osteoarthritis and has implications for research paradigms in osteoarthritis.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"560634"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/560634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31180593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

The Influence of Obesity on Patient Reported Outcomes following Total Knee Replacement. 肥胖对全膝关节置换术后患者报告结果的影响。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-17 DOI: 10.1155/2012/185208

Vandana Ayyar, Richard Burnett, Fiona J Coutts, Marietta L van der Linden, Thomas H Mercer

{"title":"The Influence of Obesity on Patient Reported Outcomes following Total Knee Replacement.","authors":"Vandana Ayyar, Richard Burnett, Fiona J Coutts, Marietta L van der Linden, Thomas H Mercer","doi":"10.1155/2012/185208","DOIUrl":"10.1155/2012/185208","url":null,"abstract":"This study retrospectively analysed the effects of obesity as described by Body Mass Index (BMI) on patient reported outcomes following total knee replacement. Participants (105 females and 66 males) who had undergone surgery under the care of a single surgeon were included in the review and were grouped according to their preoperative BMI into nonobese (BMI < 30 kg/m(2)), (n = 73) obese (BMI ≥ 30 kg/m(2)) (n = 98). Oxford Knee Score (OKS) and Short Form 12 scores (SF12) were taken preoperatively and 6 and 12 months after surgery to analyse differences between groups in the absolute scores as well as changes from before to after surgery. Preoperatively, the obese group had a significantly poorer OKS compared to non obese (44.7 versus 41.2, P = 0.003). There were no statistically significant group effects on follow-up or change scores of the OKS and SF12. Correlations coefficients between BMI and follow-up and change scores were low (r < 0.201). There were no significant differences in the number of complications and revisions (local wound infection, 6.7% non obese, 11% obese, postoperative systemic complication, 8% non obese, 12% obese, revision, 4% nonobese, 3% obese). In conclusion, our findings indicate similar degrees of benefits from the surgery irrespective of patient BMI.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"185208"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31018814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostaglandins and rheumatoid arthritis. 前列腺素和类风湿性关节炎。

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-11-07 DOI: 10.1155/2012/239310

Mohammad Javad Fattahi, Abbas Mirshafiey

{"title":"Prostaglandins and rheumatoid arthritis.","authors":"Mohammad Javad Fattahi, Abbas Mirshafiey","doi":"10.1155/2012/239310","DOIUrl":"https://doi.org/10.1155/2012/239310","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic, autoimmune, and complex inflammatory disease leading to bone and cartilage destruction, whose cause remains obscure. Accumulation of genetic susceptibility, environmental factors, and dysregulated immune responses are necessary for mounting this self-reacting disease. Inflamed joints are infiltrated by a heterogeneous population of cellular and soluble mediators of the immune system, such as T cells, B cells, macrophages, cytokines, and prostaglandins (PGs). Prostaglandins are lipid inflammatory mediators derived from the arachidonic acid by multienzymatic reactions. They both sustain homeostatic mechanisms and mediate pathogenic processes, including the inflammatory reaction. They play both beneficial and harmful roles during inflammation, according to their site of action and the etiology of the inflammatory response. With respect to the role of PGs in inflammation, they can be effective mediators in the pathophysiology of RA. Thus the use of agonists or antagonists of PG receptors may be considered as a new therapeutic protocol in RA. In this paper, we try to elucidate the role of PGs in the immunopathology of RA.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"239310"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/239310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31082877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86

Usefulness of patients-reported outcomes in rheumatoid arthritis focus group. 类风湿关节炎焦点组患者报告结果的有效性

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-09-28 DOI: 10.1155/2012/935187

Jenny Amaya-Amaya, Diana Botello-Corzo, Omar-Javier Calixto, Rolando Calderón-Rojas, Aura-Maria Domínguez, Paola Cruz-Tapias, Gladis Montoya-Ortiz, Ruben-Dario Mantilla, Juan-Manuel Anaya, Adriana Rojas-Villarraga

{"title":"Usefulness of patients-reported outcomes in rheumatoid arthritis focus group.","authors":"Jenny Amaya-Amaya, Diana Botello-Corzo, Omar-Javier Calixto, Rolando Calderón-Rojas, Aura-Maria Domínguez, Paola Cruz-Tapias, Gladis Montoya-Ortiz, Ruben-Dario Mantilla, Juan-Manuel Anaya, Adriana Rojas-Villarraga","doi":"10.1155/2012/935187","DOIUrl":"10.1155/2012/935187","url":null,"abstract":"Objective. Patient-reported outcomes (PROs) have become an essential part of the assessment of patients with rheumatoid arthritis (RA). We aimed to evaluate the agreement and correlation between PROs and the physician's measurements. Methods. This was a cross-sectional analytical study in which 135 patients with RA were clinically evaluated during two different sessions of focus group interviews. Rheumatologist recorded 28 swollen (SJCs) and tender joint counts (TJCs). The patients filled out the PROs instruments (MDHAQ, RADAI, RAPID3, 4, and 5 and self-report articular index (SAI) diagram for pain and joint swelling). DAS28 was calculated (C-reactive protein). An adjusted multiple lineal regression model was done (DAS28 as dependent variable). Results. Highly significant agreements were found between SJC and TJC registered by the physician and patient. There was moderate correlation between DAS28 with patient SJC (r = 0.52), patient TJC (r = 0.55), RADAI (r = 0.56), RAPID3 (r = 0.52), RAPID4 (r = 0.56), RAPID5 (r = 0.66), and VAS-Global (r = 0.51). Likewise, we found moderate to high correlations between CDAI and SDAI with all variable measurements done by the patients. The resulting predictive equation was DAS28(CRP) = 2.02 + 0.037 × RAPID4 + 0.042× patient SJC. Conclusion. PROs applied in focus groups interview are a useful tool for managing patients with RA regardless of gender, educational level, and duration of disease.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2012 ","pages":"935187"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/935187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31001527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Silicon, a Possible Link between Environmental Exposure and Autoimmune Diseases: The Case of Rheumatoid Arthritis. 硅:环境暴露与自身免疫性疾病之间的可能联系:类风湿关节炎的案例

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-10-18 DOI: 10.1155/2012/604187

Cesar A Speck-Hernandez, Gladis Montoya-Ortiz

引用次数: 27

Inflammation and immune response of intra-articular serotype 2 adeno-associated virus or adenovirus vectors in a large animal model. 大型动物模型中血清2型腺相关病毒或腺病毒载体的关节内炎症和免疫反应

Arthritis Pub Date : 2012-01-01 Epub Date: 2012-01-11 DOI: 10.1155/2012/735472

Akikazu Ishihara, Jeffrey S Bartlett, Alicia L Bertone

引用次数: 19

Developmental mechanisms in articular cartilage degradation in osteoarthritis. 骨关节炎中关节软骨退化的发育机制。

Arthritis Pub Date : 2011-01-01 Epub Date: 2010-12-29 DOI: 10.1155/2011/683970

Elena V Tchetina

引用次数: 94