Arthritis最新文献_第4页

Early metacarpal bone mineral density loss using digital x-ray radiogrammetry and 3-tesla wrist MRI in established rheumatoid arthritis: a longitudinal one-year observational study. 使用数字x线放射测量和3-特斯拉手腕MRI诊断类风湿关节炎的早期掌骨骨密度损失：一项为期一年的纵向观察研究。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-02-17 DOI: 10.1155/2015/852989

Anshul Rastogi, Jakob Algulin, Pamela Mangat, Adrian K P Lim, Keshthra Satchithananda, Joseph V Hajnal, Peter C Taylor

{"title":"Early metacarpal bone mineral density loss using digital x-ray radiogrammetry and 3-tesla wrist MRI in established rheumatoid arthritis: a longitudinal one-year observational study.","authors":"Anshul Rastogi, Jakob Algulin, Pamela Mangat, Adrian K P Lim, Keshthra Satchithananda, Joseph V Hajnal, Peter C Taylor","doi":"10.1155/2015/852989","DOIUrl":"10.1155/2015/852989","url":null,"abstract":"Objectives. Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg/cm(2)/month) to longitudinal changes in hand and feet radiographic and wrist MRI scores over 1 year. Materials and Methods. 10 RA patients completed the study and had wrist 3T-MRI and hand and feet X-rays at various time points over 1 year. MRI was scored by RAMRIS, X-ray was done by van der Heijde modified Sharp scoring, and RC-BMD was analysed using dxr-online. Results. There was good correlation amongst the two scorers for MRI measures and ICC for erosions: 0.984, BME: 0.943, and synovitis: 0.657. Strong relationships were observed between RC-BMD at 12-week and 1-year change in wrist marrow oedema (BME) (r = 0.78, P = 0.035) but not with erosion, synovitis, or radiographic scores. Conclusion. Early RC-BMD correlates with 1-year wrist BME change, which is a known predictor of future erosion and joint damage. However, in our pilot study, early RC-BMD did not show relationships to MRI erosion or radiographic changes over 1 year. This may reflect a slower kinetic in the appearance of MRI/radiographic erosions, generating the hypothesis that RC-BMD may be a more sensitive and early structural prognostic marker in RA follow-up. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"852989"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33142104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study. 活动期类风湿性关节炎女性的疼痛致敏:一项比较横断面研究。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-07-21 DOI: 10.1155/2015/434109

Nora Vladimirova, Anders Jespersen, Else Marie Bartels, Anton W Christensen, Henning Bliddal, Bente Danneskiold-Samsøe

{"title":"Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study.","authors":"Nora Vladimirova, Anders Jespersen, Else Marie Bartels, Anton W Christensen, Henning Bliddal, Bente Danneskiold-Samsøe","doi":"10.1155/2015/434109","DOIUrl":"https://doi.org/10.1155/2015/434109","url":null,"abstract":"Objectives. In some rheumatoid arthritis (RA) patients, joint pain persists without signs of inflammation. This indicates that central pain sensitisation may play a role in the generation of chronic pain in a subgroup of RA. Our aim was to assess the degree of peripheral and central pain sensitisation in women with active RA compared to healthy controls (HC). Methods. 38 women with active RA (DAS28 > 2.6) and 38 female HC were included in, and completed, the study. Exclusion criteria were polyneuropathy, pregnancy, and no Danish language. Cuff Pressure Algometry measurements were carried out on the dominant lower leg. Pain threshold, pain tolerance, and pain sensitivity during tonic painful stimulation were recorded. Results. Women with active RA had significantly lower pain threshold (p < 0.01) and pain tolerance (p < 0.01) than HC. The mean temporal summation- (TS-) index in RA patients was 0.98 (SEM: 0.09) and 0.71 (SEM: 0.04) in HC (p < 0.01). Conclusion. Patients with active RA showed decreased pressure-pain threshold compared to HC. In addition, temporal summation of pressure-pain was increased, indicating central pain sensitization, at least in some patients. Defining this subgroup of patients may be of importance when considering treatment strategies. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"434109"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/434109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33982585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. 全食物、植物性饮食可以减轻骨关节炎的症状。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-02-28 DOI: 10.1155/2015/708152

Chelsea M Clinton, Shanley O'Brien, Junwen Law, Colleen M Renier, Mary R Wendt

{"title":"Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis.","authors":"Chelsea M Clinton, Shanley O'Brien, Junwen Law, Colleen M Renier, Mary R Wendt","doi":"10.1155/2015/708152","DOIUrl":"https://doi.org/10.1155/2015/708152","url":null,"abstract":"Objective. To evaluate the effectiveness of a whole-foods, plant-based diet (WFPB) to reduce symptoms of osteoarthritis. Methods. Six-week, prospective randomized open-label study of patients aged 19-70 with osteoarthritis. Participants were randomized to a WFPB (intervention) or continuing current diet (control). Outcomes were assessed by mixed models analysis of participant self-assessed weekly SF-36v2 domain t scores, weekly Patient Global Impression of Change (PGIC) scales, and mean weekly Visual Analog Scale (VAS) pain assessment. Mixed models analysis also evaluated pre-post change from baseline level for standard clinical measures: weight, BMI, body temperature, pulse, and blood pressure. Results. Forty participants were randomized. Thirty-seven of them, 18 control and 19 intervention, completed the study. The intervention group reported a significantly greater improvement than the control group in SF-36v2 energy/vitality, physical functioning, role physical, and the physical component summary scale. The differences between the intervention and control PGIC scales were statistically significant over time. Intervention group improvement in VAS weekly mean was also significantly greater than that of the control group from week 2 onward. Conclusion. Study results suggest that a whole-foods, plant-based diet significantly improves self-assessed measures of functional status among osteoarthritis patients. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"708152"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/708152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33046996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Psychometric properties of the 8-item english arthritis self-efficacy scale in a diverse sample. 八项英国关节炎自我效能量表在不同样本中的心理测量特性。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-08-21 DOI: 10.1155/2014/385256

Sara Wilcox, Danielle E Schoffman, Marsha Dowda, Patricia A Sharpe

{"title":"Psychometric properties of the 8-item english arthritis self-efficacy scale in a diverse sample.","authors":"Sara Wilcox, Danielle E Schoffman, Marsha Dowda, Patricia A Sharpe","doi":"10.1155/2014/385256","DOIUrl":"https://doi.org/10.1155/2014/385256","url":null,"abstract":"Arthritis self-efficacy is important for successful disease management. This study examined psychometric properties of the 8-item English version of the Arthritis Self-Efficacy Scale (ASES-8) and differences in ASES-8 scores across sample subgroups. In 401 participants with self-reported doctor-diagnosed arthritis, exploratory factor analysis and tests of internal consistency were conducted. Concurrent validity was examined by associating ASES-8 scores with disease-specific, psychosocial, functional, and behavioral measures expected to be related to arthritis self-efficacy. All analyses were conducted for the full sample and within subgroups (gender, race, age, education, and weight status). Exploratory factor analysis for the entire sample and in all 12 subgroups demonstrated a one factor solution (factor loadings: 0.61 to 0.89). Internal consistency was high for measures of Cronbach's alpha (0.87 to 0.94), omega (0.87 to 0.93), and greatest lower bound (0.90 to 0.95). ASES-8 scores were significantly correlated with all measures assessed (P < 0.05), demonstrating concurrent validity. Those with a high school education or greater had higher ASES-8 scores than those with less than a high school education (P < .001); no other subgroup differences were found. The ASES-8 is a valid and reliable tool to measure arthritis self-efficacy efficiently and thereby reduce participant burden in research studies. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"385256"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/385256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32661942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. 葡萄糖胺治疗骨关节炎:生物效应、临床疗效和葡萄糖代谢的安全性。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-02-11 DOI: 10.1155/2014/432463

Juan Salazar, Luis Bello, Mervin Chávez, Roberto Añez, Joselyn Rojas, Valmore Bermúdez

{"title":"Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism.","authors":"Juan Salazar, Luis Bello, Mervin Chávez, Roberto Añez, Joselyn Rojas, Valmore Bermúdez","doi":"10.1155/2014/432463","DOIUrl":"https://doi.org/10.1155/2014/432463","url":null,"abstract":"Osteoarthritis is a chronic degenerative disorder that currently represents one of the main causes of disability within the elderly population and an important presenting complaint overall. The pathophysiologic basis of osteoarthritis entails a complex group of interactions among biochemical and mechanical factors that have been better characterized in light of a recent spike in research on the subject. This has led to an ongoing search for ideal therapeutic management schemes for these patients, where glucosamine is one of the most frequently used alternatives worldwide due to their chondroprotective properties and their long-term effects. Its use in the treatment of osteoarthritis is well established; yet despite being considered effective by many research groups, controversy surrounds their true effectiveness. This situation stems from several methodological aspects which hinder appropriate data analysis and comparison in this context, particularly regarding objectives and target variables. Similar difficulties surround the assessment of the potential ability of glucosamine formulations to alter glucose metabolism. Nevertheless, evidence supporting diabetogenesis by glucosamine remains scarce in humans, and to date, this association should be considered only a theoretical possibility.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"432463"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/432463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32215132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Productivity improvements in hip and knee surgery. 髋关节和膝关节手术效率的提高。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-02-20 DOI: 10.1155/2014/615784

Frank A Sloan, Linda K George, Linyan Hu

引用次数: 0

Zingiber officinale: A Potential Plant against Rheumatoid Arthritis. 姜科植物：一种治疗类风湿关节炎的潜在植物

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-05-27 DOI: 10.1155/2014/159089

Abdullah Al-Nahain, Rownak Jahan, Mohammed Rahmatullah

引用次数: 0

Evaluation of Antiarthritic Potential of Methanolic Extract of Gentiana kurroo Royle. 龙胆甲醇提取物抗关节炎作用的评价。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-11-06 DOI: 10.1155/2014/810615

Khan Mubashir, Bashir A Ganai, Khalid Ghazanfar, Seema Akbar

{"title":"Evaluation of Antiarthritic Potential of Methanolic Extract of Gentiana kurroo Royle.","authors":"Khan Mubashir, Bashir A Ganai, Khalid Ghazanfar, Seema Akbar","doi":"10.1155/2014/810615","DOIUrl":"https://doi.org/10.1155/2014/810615","url":null,"abstract":"Rheumatoid arthritis is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic the development of this disease involves different mechanisms and thus the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure for this disease. In the current study the rat carrageenin paw was used as a model for acute inflammation and mycobacterium induced adjuvant arthritic model was used for exploring the antiarthritic potential of methanolic extract of Gentiana kurroo. In this study the different extracts tested showed less inhibition of acute inflammation than methanolic extract. The methanolic extract was further used in different doses and the anti-inflammatory efficacy was found to be dose dependent. The results obtained were significant with the control and the standard groups. In the arthritic model the methanolic extract showed decrease in the paw volume of arthritic animals and also in the arthritic symptoms. Again the results obtained were found to be significantly dose dependent. From the results obtained it can be concluded that this extract may serve as a source of drug against the rheumatoid arthritis. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"810615"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/810615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32844353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Individual and community socioeconomic status: impact on mental health in individuals with arthritis. 个人和社区社会经济地位:对关节炎患者心理健康的影响

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-08-04 DOI: 10.1155/2014/256498

Chivon A Mingo, Kathryn R Martin, Jack Shreffler, Britta Schoster, Leigh F Callahan

{"title":"Individual and community socioeconomic status: impact on mental health in individuals with arthritis.","authors":"Chivon A Mingo, Kathryn R Martin, Jack Shreffler, Britta Schoster, Leigh F Callahan","doi":"10.1155/2014/256498","DOIUrl":"https://doi.org/10.1155/2014/256498","url":null,"abstract":"To examine the impact of individual and community socioeconomic status (SES) measures on mental health outcomes in individuals with arthritis, participants with self-reported arthritis completed a telephone survey assessing health status, health attitudes and beliefs, and sociodemographic variables. Regression analyses adjusting for race, gender, BMI, comorbidities, and age were performed to determine the impact of individual and community level SES on mental health outcomes (i.e., Medical Outcomes Study SF-12v2 mental health component, the Centers for Disease Control and Prevention Health-Related Quality of Life Healthy Days Measure, Center for Epidemiological Studies Depression [CES-D] scale). When entered singly, lower education and income, nonmanagerial occupation, non-homeownership, and medium and high community poverty were all significantly associated with poorer mental health outcomes. Income, however, was more strongly associated with the outcomes in comparison to the other SES variables. In a model including all SES measures simultaneously, income was significantly associated with each outcome variable. Lower levels of individual and community SES showed most consistent statistical significance in association with CES-D scores. Results suggest that both individual and community level SES are associated with mental health status in people with arthritis. It is imperative to consider how interventions focused on multilevel SES factors may influence existing disparities. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"256498"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/256498","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32609990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Short Term Recovery of Function following Total Knee Arthroplasty: A Randomised Study of the Medial Parapatellar and Midvastus Approaches. 全膝关节置换术后功能的短期恢复:髌旁内侧入路和股中入路的随机研究。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-10-01 DOI: 10.1155/2014/173857

Richard W Nutton, Frazer A Wade, Fiona J Coutts, Marietta L van der Linden

{"title":"Short Term Recovery of Function following Total Knee Arthroplasty: A Randomised Study of the Medial Parapatellar and Midvastus Approaches.","authors":"Richard W Nutton, Frazer A Wade, Fiona J Coutts, Marietta L van der Linden","doi":"10.1155/2014/173857","DOIUrl":"https://doi.org/10.1155/2014/173857","url":null,"abstract":"This pilot double blind randomised controlled study aimed to investigate whether the midvastus (MV) approach without patellar eversion in total knee arthroplasty (TKA) resulted in improved recovery of function compared to the medial parapatellar (MP) approach. Patients were randomly allocated to either the MV approach or the MP approach. Achievements of inpatient mobility milestones were recorded. Knee kinematics, muscle strength, Timed Up and Go, WOMAC, and daily step count were assessed before and up to six months after surgery. Cohen's effect size d was calculated to inform the sample size in future trials. Twenty-eight participants (16 males, 12 females) participated. Patient mobility milestones such as straight leg raise were achieved on average 1.3 days (95% CI -3.4 to 0.7, d = 0.63) earlier in the MV group. Knee extensor strength at 6 weeks after surgery was higher (95% CI -0.38 to 0.61, d = 0.73) in the MV group. No trends for differences between the groups were observed in knee kinematics, TUG, WOMAC, or step count. Our results suggest a short term advantage in the first 6 weeks after surgery of the MV approach over the MP approach, but a larger study is required to confirm these findings. This trial is registered with NCT056445. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"173857"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/173857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20