Arthritis最新文献_第5页

A technique of predicting radiographic joint line and posterior femoral condylar offset of the knee. 一种预测膝关节x线和股骨后髁偏移的技术。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-02-11 DOI: 10.1155/2014/121069

Nicholas D Clement, David F Hamilton, Richard Burnett

{"title":"A technique of predicting radiographic joint line and posterior femoral condylar offset of the knee.","authors":"Nicholas D Clement, David F Hamilton, Richard Burnett","doi":"10.1155/2014/121069","DOIUrl":"https://doi.org/10.1155/2014/121069","url":null,"abstract":"Purpose. To describe a reliable method of predicting native joint line and posterior condylar offset (PCO) using true lateral digital radiographs of the distal femur. Methods. PCO was measured relative to a line drawn parallel to the posterior cortex of the distal femur and the joint line was measured from the posterior condylar flare to the articular surface. A ratio was then calculated for these measurements relative to the width of the femur at the level of the flare. Two independent observers measured PCO and joint line ratio for 105 radiographs of the different knees and one repeated these measurements after one week. Results. There was a significant correlation between the width of the femoral diaphysis at the level of the posterior condylar flare with joint line (P = 0.008) and PCO (P = 0.003). Joint line and PCO could be predicted within 4 mm and 2 mm, respectively, using the identified ratio between the width of the femoral diaphysis at the level of the posterior condylar flare with measured joint line and PCO. The inter- (P < 0.001) and intra- (P < 0.001) observer reliability for these ratios were high. Conclusion. These ratios could be used to predict the native joint line and PCO. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"121069"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/121069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32211230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Treatment of nongout joint deposition diseases: an update. 非关节沉积病的治疗:最新进展。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-05-08 DOI: 10.1155/2014/375202

Tristan Pascart, Pascal Richette, René-Marc Flipo

{"title":"Treatment of nongout joint deposition diseases: an update.","authors":"Tristan Pascart, Pascal Richette, René-Marc Flipo","doi":"10.1155/2014/375202","DOIUrl":"https://doi.org/10.1155/2014/375202","url":null,"abstract":"This update develops the actual therapeutic options in the management of the joint involvement of calcium pyrophosphate deposition disease (CPPD), basic calcium phosphate (BCP) deposition disease, hemochromatosis (HH), ochronosis, oxalosis, and Wilson's disease. Conventional pharmaceutical treatment provides benefits for most diseases. Anti-interleukine-1 (IL-1) treatment could provide similar results in CPPD than in gout flares. There is only limited evidence about the efficacy of preventive long-term colchicine intake, methotrexate, and hydroxychloroquine in chronic CPPD. Needle aspiration and lavage have satisfactory short and midterm results in BCP. Extracorporeal shockwave therapy has also proved its efficacy for high-doses regimes. Phlebotomy does not seem to have shown real efficacy on joint involvement in HH so far. Iron chelators' effects have not been assessed on joint involvement either, while IL-1 blockade may prove useful. NSAIDs have limited efficacy on joint involvement of oxalosis, while colchicine and steroids have not been assessed either. The use of nitisinone for ochronotic arthropathy is still much debated, but it could provide beneficial effects on joint involvement. The effects of copper chelators have not been assessed either in the joint involvement of Wilson's disease. NSAIDs should be avoided because of the liver affection they may worsen. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"375202"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/375202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32394426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Weight status and differences in mobility performance, pain symptoms, and physical activity in older, knee osteoarthritis patients. 老年膝关节骨关节炎患者的体重状况与活动能力、疼痛症状和体力活动的差异

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-05-25 DOI: 10.1155/2014/375909

Matthew J Garver, Brian C Focht, Justin Dials, Mark Rose, Alexander R Lucas, Steven T Devor, Charles F Emery, Kevin V Hackshaw, W Jack Rejeski

{"title":"Weight status and differences in mobility performance, pain symptoms, and physical activity in older, knee osteoarthritis patients.","authors":"Matthew J Garver, Brian C Focht, Justin Dials, Mark Rose, Alexander R Lucas, Steven T Devor, Charles F Emery, Kevin V Hackshaw, W Jack Rejeski","doi":"10.1155/2014/375909","DOIUrl":"https://doi.org/10.1155/2014/375909","url":null,"abstract":"Knee osteoarthritis (OA) is a leading cause of functional disability among American adults. Obesity is a strong independent risk factor for OA. While research emphasizes the role of obesity in the OA-physical function relationship, the extent to which weight status impacts salient physical, health, and pain measures in older, knee OA patients is not well delineated. The primary aim of this study was to assess differences in mobility performance (stair climb and 400-meter walk), mobility-related self-efficacy, pain symptoms (WOMAC), and measures of accelerometer-determined physical activity (PA) as a function of weight status. Analysis of covariance was conducted to examine differences on the dependent variables. Obese class III patients were outperformed by their counterparts on nearly every measure of mobility, mobility-related self-efficacy, and the assessment of pain symptoms. These outcomes did not differ among other weight comparisons. Normal weight subjects outperformed classes I, II, and III counterparts on most measures of PA (engagement in moderate or greater PA and total weekly steps). Additionally, overweight participants outperformed obese class II participants and obese class I participants outperformed obese classes II and III participants on total weekly steps. Collectively, these findings underscore the meaningful differences observed in relevant OA outcomes as a function of increasing levels of body weight. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"375909"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/375909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32454569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Quantitative Gait Analysis Detects Significant Differences in Movement between Osteoarthritic and Nonosteoarthritic Guinea Pig Strains before and after Treatment with Flunixin Meglumine. 定量步态分析检测骨关节炎和非骨关节炎豚鼠品系在氟尼辛大明治疗前后的运动显著差异。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-05-19 DOI: 10.1155/2014/503519

K S Santangelo, A C Kaeding, S A Baker, A L Bertone

{"title":"Quantitative Gait Analysis Detects Significant Differences in Movement between Osteoarthritic and Nonosteoarthritic Guinea Pig Strains before and after Treatment with Flunixin Meglumine.","authors":"K S Santangelo, A C Kaeding, S A Baker, A L Bertone","doi":"10.1155/2014/503519","DOIUrl":"https://doi.org/10.1155/2014/503519","url":null,"abstract":"A computer-aided gait analysis system was used to contrast two guinea pig strains with differing propensity for osteoarthritis (OA), with/without administration of a nonsteroidal anti-inflammatory drug. Walking speed and static/dynamic gait parameters were determined at baseline. Flunixin meglumine was given and animals were evaluated 4, 24, and 72 hours after treatment. Body weight was compared using unpaired t-tests. Knee joints were histologically evaluated using species-specific criteria; indices were analyzed using one-way ANOVA, Kruskal-Wallis test, followed by Dunn's multiple comparisons. A generalized linear model followed by Tukey's posttests juxtaposed gait parameters; walking speed was a covariate for other outcome measures. Body weight was not different between strains; OA-prone animals demonstrated more progressive chondropathy. At baseline, OA-prone animals had slower walking speeds, narrower hind limb bases of support, shorter stride lengths, and slower limb swing speeds relative to OA-resistant animals. These differences were not detected 4 or 24 hours after treatment. By 72 hours, OA-prone animals had returned to baseline values. These findings indicate a distinct voluntary gait pattern in a rodent model of bilateral primary OA, modification of which may allow rapid screening of novel therapies. Flunixin meglumine temporarily permitted OA-prone animals to move in a manner that was analogous to OA-resistant animals. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"503519"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/503519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32454570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Epicardial fat thickness as cardiovascular risk factor and therapeutic target in patients with rheumatoid arthritis treated with biological and nonbiological therapies. 生物和非生物治疗类风湿关节炎患者心外膜脂肪厚度作为心血管危险因素和治疗靶点

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-12-10 DOI: 10.1155/2014/782850

Marcos M Lima-Martínez, Ediris Campo, Johanmary Salazar, Mariela Paoli, Irama Maldonado, Carlota Acosta, Marianela Rodney, Miguel Contreras, Julio O Cabrera-Rego, Gianluca Iacobellis

{"title":"Epicardial fat thickness as cardiovascular risk factor and therapeutic target in patients with rheumatoid arthritis treated with biological and nonbiological therapies.","authors":"Marcos M Lima-Martínez, Ediris Campo, Johanmary Salazar, Mariela Paoli, Irama Maldonado, Carlota Acosta, Marianela Rodney, Miguel Contreras, Julio O Cabrera-Rego, Gianluca Iacobellis","doi":"10.1155/2014/782850","DOIUrl":"https://doi.org/10.1155/2014/782850","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with high cardiovascular morbidity and mortality. Epicardial adipose tissue (EAT) thickness may act as a therapeutic target during treatments with drugs modulating the adipose tissue. We evaluate EAT thickness in RA patients treated with biological and nonbiological disease-modifying antirheumatic drugs (DMARDs). A cross-sectional study was conducted with a cohort of 34 female RA patients and 16 controls matched for age and body mass index (BMI). Plasma glucose, basal insulin, plasma lipids, and high-sensitivity C-reactive protein (hs-CRP) were assessed. EAT thickness and left ventricular mass (LVM) were measured by echocardiography. No significant differences in waist circumference (WC), blood pressure, fasting blood glucose, basal insulin, and lipid parameters were found between the groups. The control group showed lower concentrations (P = 0.033) of hs-CRP and LVM (P = 0.0001) than those of the two RA groups. Patients treated with TNF-α inhibitors showed significantly lower EAT thickness than those treated with nonbiological DMARDs (8.56 ± 1.90 mm versus 9.71 ± 1.45 mm; P = 0.04). Women with no RA revealed reduced EAT thickness (5.39 ± 1.52 mm) as compared to all RA patients (P = 0.001). Results suggest that RA patients have greater EAT thickness than controls regardless of BMI and WC. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"782850"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/782850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32963683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Fibroblast-like synoviocytes induce calcium mineral formation and deposition. 成纤维细胞样滑膜细胞诱导钙矿物的形成和沉积。

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-05-20 DOI: 10.1155/2014/812678

Yubo Sun, David R Mauerhan, Atiya M Franklin, Natalia Zinchenko, Harry James Norton, Edward N Hanley, Helen E Gruber

{"title":"Fibroblast-like synoviocytes induce calcium mineral formation and deposition.","authors":"Yubo Sun, David R Mauerhan, Atiya M Franklin, Natalia Zinchenko, Harry James Norton, Edward N Hanley, Helen E Gruber","doi":"10.1155/2014/812678","DOIUrl":"https://doi.org/10.1155/2014/812678","url":null,"abstract":"Calcium crystals are present in the synovial fluid of 65%-100% patients with osteoarthritis (OA) and 20%-39% patients with rheumatoid arthritis (RA). This study sought to investigate the role of fibroblast-like synoviocytes (FLSs) in calcium mineral formation. We found that numerous genes classified in the biomineral formation process, including bone gamma-carboxyglutamate (gla) protein/osteocalcin, runt-related transcription factor 2, ankylosis progressive homolog, and parathyroid hormone-like hormone, were differentially expressed in the OA and RA FLSs. Calcium deposits were detected in FLSs cultured in regular medium in the presence of ATP and FLSs cultured in chondrogenesis medium in the absence of ATP. More calcium minerals were deposited in the cultures of OA FLSs than in the cultures of RA FLSs. Examination of the micromass stained with nonaqueous alcoholic eosin indicated the presence of birefringent crystals. Phosphocitrate inhibited the OA FLSs-mediated calcium mineral deposition. These findings together suggest that OA FLSs are not passive bystanders but are active players in the pathological calcification process occurring in OA and that potential calcification stimuli for OA FLSs-mediated calcium deposition include ATP and certain unidentified differentiation-inducing factor(s). The OA FLSs-mediated pathological calcification process is a valid target for the development of disease-modifying drug for OA therapy. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"812678"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/812678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32454571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Progression of Gene Expression Changes following a Mechanical Injury to Articular Cartilage as a Model of Early Stage Osteoarthritis. 作为早期骨关节炎模型的关节软骨机械损伤后基因表达变化的进展

Arthritis Pub Date : 2014-01-01 Epub Date: 2014-11-16 DOI: 10.1155/2014/371426

R S McCulloch, M S Ashwell, C Maltecca, A T O'Nan, P L Mente

{"title":"Progression of Gene Expression Changes following a Mechanical Injury to Articular Cartilage as a Model of Early Stage Osteoarthritis.","authors":"R S McCulloch, M S Ashwell, C Maltecca, A T O'Nan, P L Mente","doi":"10.1155/2014/371426","DOIUrl":"https://doi.org/10.1155/2014/371426","url":null,"abstract":"An impact injury model of early stage osteoarthritis (OA) progression was developed using a mechanical insult to an articular cartilage surface to evaluate differential gene expression changes over time and treatment. Porcine patellae with intact cartilage surfaces were randomized to one of three treatments: nonimpacted control, axial impaction (2000 N), or a shear impaction (500 N axial, with tangential displacement to induce shear forces). After impact, the patellae were returned to culture for 0, 3, 7, or 14 days. At the appropriate time point, RNA was extracted from full-thickness cartilage slices at the impact site. Quantitative real-time PCR was used to evaluate differential gene expression for 18 OA related genes from four categories: cartilage matrix, degradative enzymes and inhibitors, inflammatory response and signaling, and cell apoptosis. The shear impacted specimens were compared to the axial impacted specimens and showed that shear specimens more highly expressed type I collagen (Col1a1) at the early time points. In addition, there was generally elevated expression of degradative enzymes, inflammatory response genes, and apoptosis markers at the early time points. These changes suggest that the more physiologically relevant shear loading may initially be more damaging to the cartilage and induces more repair efforts after loading. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2014 ","pages":"371426"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/371426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32882127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Determination of the diagnostic values of asymmetric dimethylarginine as an indicator for evaluation of the endothelial dysfunction in patients with rheumatoid arthritis. 不对称二甲基精氨酸作为评估类风湿关节炎患者内皮功能障碍指标的诊断价值

Arthritis Pub Date : 2013-01-01 Epub Date: 2013-05-15 DOI: 10.1155/2013/818037

Dejan Spasovski, Arif Latifi, Bashkim Osmani, Svetlana Krstevska-Balkanov, Irena Kafedizska, Maja Slaninka-Micevska, Beti Dejanova, Sonja Alabakovska, Trajan Balkanov

{"title":"Determination of the diagnostic values of asymmetric dimethylarginine as an indicator for evaluation of the endothelial dysfunction in patients with rheumatoid arthritis.","authors":"Dejan Spasovski, Arif Latifi, Bashkim Osmani, Svetlana Krstevska-Balkanov, Irena Kafedizska, Maja Slaninka-Micevska, Beti Dejanova, Sonja Alabakovska, Trajan Balkanov","doi":"10.1155/2013/818037","DOIUrl":"https://doi.org/10.1155/2013/818037","url":null,"abstract":"Introduction. To compare the diagnostic values of laboratory variables, to present evaluations of the diagnostic test for asymmetric dimethyl arginine (ADMA), rheumatoid factor (RF), C-reactive protein (CRP), and DAS28 index, and to define the effect of untreated rheumatoid arthritis on endothelial function. In order to determine whether ADMA changes depending on the disease evolution, ADMA was used as an indicator for endothelial dysfunction. Methods. Using an ELISA technology of DLD-Diagnostika-GMBH for the detection of ADMA, the samples of serum and urine have been examined in 70 participants (35 RA who were not treated, 35 healthy controls). RF was defined with the test for agglutination (Latex RF test) in the same participants. Results. Out of 35 examined patients with RA, RF appeared in 17 patients (sensitivity of the test, 51.42%). In 20 of the 35 examined patients with RA, we found the presence of ADMA (sensitivity of the test, 57.14%). Anti-CCP antibody was present in 24 examined patients with RA (sensitivity of the test, 68.57%). Conclusion. ADMA has equal or very similar sensitivity and specificity to RF in untreated RA (sensitivity of 57.14% versus 48.57%, specificity of 88.57% versus 91.42%) in the detection of asymptomatic endothelial dysfunction in untreated RA.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2013 ","pages":"818037"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/818037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31503546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review. 关键蛋白聚糖和糖蛋白基因改变对肌腱、韧带和椎体缺陷的影响:综述。

Arthritis Pub Date : 2013-01-01 Epub Date: 2013-11-10 DOI: 10.1155/2013/154812

Subhash C Juneja, Christian Veillette

{"title":"Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.","authors":"Subhash C Juneja, Christian Veillette","doi":"10.1155/2013/154812","DOIUrl":"https://doi.org/10.1155/2013/154812","url":null,"abstract":"This review summarizes the genetic alterations and knockdown approaches published in the literature to assess the role of key proteoglycans and glycoproteins in the structural development, function, and repair of tendon, ligament, and enthesis. The information was collected from (i) genetically altered mice, (ii) in vitro knockdown studies, (iii) genetic variants predisposition to injury, and (iv) human genetic diseases. The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small leucine-rich proteoglycans by converting glucuronic to iduronic acid; matricellular proteins (thrombospondin 2, secreted phosphoprotein 1 (Spp1), secreted protein acidic and rich in cysteine (Sparc), periostin, and tenascin X) including human tenascin C variants; and others, such as tenomodulin, leukocyte cell derived chemotaxin 1 (chondromodulin-I, ChM-I), CD44 antigen (Cd44), lubricin (Prg4), and aggrecan degrading gene, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (Adamts5). Understanding these genes represents drug targets for disrupting pathological mechanisms that lead to tendinopathy, ligamentopathy, enthesopathy, enthesitis and tendon/ligament injury, that is, osteoarthritis and ankylosing spondylitis. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2013 ","pages":"154812"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/154812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis. 银屑病和类风湿关节炎的毛细管镜检查:鉴别诊断的有用工具。

Arthritis Pub Date : 2013-01-01 Epub Date: 2013-12-12 DOI: 10.1155/2013/957480

Dario Graceffa, Beatrice Amorosi, Elisa Maiani, Claudio Bonifati, Maria Sole Chimenti, Roberto Perricone, Aldo Di Carlo

{"title":"Capillaroscopy in psoriatic and rheumatoid arthritis: a useful tool for differential diagnosis.","authors":"Dario Graceffa, Beatrice Amorosi, Elisa Maiani, Claudio Bonifati, Maria Sole Chimenti, Roberto Perricone, Aldo Di Carlo","doi":"10.1155/2013/957480","DOIUrl":"https://doi.org/10.1155/2013/957480","url":null,"abstract":"Impairment of capillaries permeability and changes of microcirculation are associated with inflammatory arthritis. In order to demonstrate microvascular differences between psoriatic arthritis (PsA) and rheumatoid arthritis (RA) we analyzed capillaroscopic abnormalities such as megacapillaries, haemorrhages, ramifications, and avascular areas in patients affected by these two rheumatic disorders. Moreover to identify specific capillaroscopy patterns we analyzed the following parameters: venous limb diameter, arterial limb diameter, capillary loop diameter, amplitude of the capillary loop, linear density of capillaries (on 2 mm), and number of twisted capillaries (on 4 mm). Through a comparative morphometric analysis of capillaroscopy, our study demonstrated the presence of specific microvascular differences between PsA and RA providing an additional diagnostic tool for the differential diagnosis. We also suggest that capillaries structural abnormalities might reflect endothelial injury due to systemic inflammation during chronic arthritis. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2013 ","pages":"957480"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/957480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32005491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35