Arthritis最新文献_第3页

A Systematic Review Investigating the Presence of Inflammatory Synovitis in Hip and Knee Joint Replacement Surgery 髋关节和膝关节置换术中炎性滑膜炎存在的系统综述

Arthritis Pub Date : 2015-10-18 DOI: 10.1155/2015/729410

Sherif Hosny, F. Strambi, N. Sofat, R. Field

{"title":"A Systematic Review Investigating the Presence of Inflammatory Synovitis in Hip and Knee Joint Replacement Surgery","authors":"Sherif Hosny, F. Strambi, N. Sofat, R. Field","doi":"10.1155/2015/729410","DOIUrl":"https://doi.org/10.1155/2015/729410","url":null,"abstract":"Synovial tissue can display an inflammatory response in the presence of OA. There is increasing interest to better understand the role of inflammation in OA, particularly with regard to those who require joint replacement. A systematic review of inflammatory synovitis in OA of literature databases was undertaken from their inception until October 14, 2014. Independent critical appraisal of each study was undertaken using the CASP appraisal tool. From a total of sixty-six identified citations, twenty-three studies were deemed eligible for review. The studies presented moderate to strong methodological quality. Strong correlation was identified between histological and imaging synovitis severity. Correlation was weaker between clinical symptoms and imaging and/or histological synovitis severity. There was little consensus, with regard to expressed cytokines and chemokines at the different stages of OA disease progression. Few studies investigated the influence of inflammatory synovitis on the outcome of major joint replacement. Research into inflammatory synovitis in OA is an emerging field. Longitudinal studies applying proven imaging modalities, histological analysis, and longer follow-up are required in order to further define our understanding of the role of synovitis in the pathogenesis of OA and its effects on outcomes following major joint replacement.","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/729410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65124742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Screening Optimization of Latent Tuberculosis Infection in Rheumatoid Arthritis Patients. 类风湿关节炎患者潜伏结核感染的筛选优化。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-07-29 DOI: 10.1155/2015/569620

Bella Mehta, Ekaterini Zapantis, Olga Petryna, Petros Efthimiou

{"title":"Screening Optimization of Latent Tuberculosis Infection in Rheumatoid Arthritis Patients.","authors":"Bella Mehta, Ekaterini Zapantis, Olga Petryna, Petros Efthimiou","doi":"10.1155/2015/569620","DOIUrl":"https://doi.org/10.1155/2015/569620","url":null,"abstract":"Objective. Rheumatoid arthritis (RA) patients are at increased risk of latent tuberculosis infection (LTBI) but there are no clear guidelines for LTBI screening with Tuberculin Skin Test (TST) or Quantiferon TB Gold testing (QFT-G). Methods. A retrospective study was conducted in a high risk, largely foreign-born, inner city, RA population. After screening 280 RA patients, 134 patients who had both TST and QFT-G testing performed during their initial evaluation were included. Results. Out of 132 RA patients included in our analysis, 50 (37.8%) patients were diagnosed with LTBI with either positive TST 42 (31.8%) or QFT-G 23 (17.4%). 15 (11.4%) were positive and 82 (62.1%) were negative for both tests. The agreement between TST and QFT-G was 73.5% (Kappa 0.305, CI = 95% 0.147-0.463, p = 0.081). Conclusions. There was low-moderate agreement (κ = 0.305) between TST and QFT-G. In the absence of clearly defined gold standard and limitations associated with both tests, we propose early screening with both tests for patients who need prompt treatment with BRMs. Patients who are not immediate candidates for BRM treatment may be safely and cost effectively screened with a two-step process: initial screening with TST and if negative, IGRA testing. Patients positive for either test should be promptly treated. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"569620"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/569620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34111164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Antibodies to infliximab and adalimumab in patients with rheumatoid arthritis in clinical remission: a cross-sectional study. 英夫利昔单抗和阿达木单抗在临床缓解的类风湿关节炎患者中的抗体:一项横断面研究

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-02-11 DOI: 10.1155/2015/784825

Grith P Eng, Klaus Bendtzen, Henning Bliddal, Michael Stoltenberg, Marcin Szkudlarek, Viktoria Fana, Hanne M Lindegaard, Emina Omerovic, Pil Højgaard, Elmo K Jensen, Pierre N Bouchelouche

{"title":"Antibodies to infliximab and adalimumab in patients with rheumatoid arthritis in clinical remission: a cross-sectional study.","authors":"Grith P Eng, Klaus Bendtzen, Henning Bliddal, Michael Stoltenberg, Marcin Szkudlarek, Viktoria Fana, Hanne M Lindegaard, Emina Omerovic, Pil Højgaard, Elmo K Jensen, Pierre N Bouchelouche","doi":"10.1155/2015/784825","DOIUrl":"https://doi.org/10.1155/2015/784825","url":null,"abstract":"Objective. To investigate if antibodies towards biological TNF-α inhibitors (anti-TNFi Abs) are present in patients with rheumatoid arthritis (RA) in clinical remission and to relate any anti-TNFi Abs to circulating level of TNF-α inhibitor (TNFi). Methods. Patients with RA, treated with infliximab or adalimumab, and in clinical remission (DAS28(CRP) < 2.6) were included from 6 out-patient clinics. In blood samples, presence of anti-TNFi Abs was determined by radioimmunoassay, and concentration of bioactive TNFi was measured by a cell-based reporter gene assay. Results. Anti-TNFi Abs were present in 8/44 patients (18%) treated with infliximab and 1/49 patients (2%) treated with adalimumab (p = 0.012). In the former group, anti-TNFi Abs corresponded with low levels of TNFi (p = 0.048). Anti-TNFi Ab-positive patients had shorter disease duration at initiation of TNFi therapy (p = 0.023) but were similar for the rest of the compared parameters. Conclusions. In RA patients in clinical remission, anti-TNFi Abs occur frequently in patients treated with infliximab, while they occur rarely in patients treated with adalimumab. Presence of anti-infliximab Abs is accompanied by low or undetectable levels of infliximab. These data suggest that continued infliximab treatment may be redundant in a proportion of RA patients treated with infliximab and in clinical remission. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"784825"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/784825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33120869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. 酶联合治疗成人膝关节骨关节炎疼痛的安全性和有效性:一项随机、双盲、安慰剂对照试验。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-01-31 DOI: 10.1155/2015/251521

Wolfgang W Bolten, Michael J Glade, Sonja Raum, Barry W Ritz

{"title":"The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial.","authors":"Wolfgang W Bolten, Michael J Glade, Sonja Raum, Barry W Ritz","doi":"10.1155/2015/251521","DOIUrl":"https://doi.org/10.1155/2015/251521","url":null,"abstract":"This randomized, double-blind, placebo-controlled, and comparator-controlled trial evaluated the safety and efficacy of an enzyme combination, as Wobenzym, in adults with moderate-to-severe osteoarthritis (OA) of the knee. Adults (n = 150) received Wobenzym, diclofenac (a nonsteroidal anti-inflammatory drug, NSAID), or placebo for 12 weeks. Improvement in pain scores (Lequesne Functional Index) did not differ between subjects treated with Wobenzym or diclofenac, and both treatment groups improved compared to placebo (P < 0.05). Reduction in total WOMAC scores (secondary outcome measure) did not differ between Wobenzym and diclofenac, although only diclofenac emerged as different from placebo (P < 0.05). The median number of rescue medication (paracetamol) tablets consumed was less in the Wobenzym group compared to placebo (P < 0.05), while there was no difference between diclofenac and placebo. Adverse events were similar in frequency in Wobenzym and placebo groups (7.2% and 9.1% of subjects, resp.) and higher in diclofenac group (15.6%). Wobenzym is comparable to the NSAID diclofenac in relieving pain and increasing function in adults with moderate-to-severe painful knee OA and reduces reliance on analgesic medication. Wobenzym is associated with fewer adverse events and, therefore, may be appropriate for long-term use. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"251521"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/251521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33156372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Depression and the Overall Burden of Painful Joints: An Examination among Individuals Undergoing Hip and Knee Replacement for Osteoarthritis. 抑郁和关节疼痛的总体负担:在接受髋关节和膝关节置换术治疗骨关节炎的个体中进行的检查。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-03-11 DOI: 10.1155/2015/327161

Rajiv Gandhi, Michael G Zywiel, Nizar N Mahomed, Anthony V Perruccio

{"title":"Depression and the Overall Burden of Painful Joints: An Examination among Individuals Undergoing Hip and Knee Replacement for Osteoarthritis.","authors":"Rajiv Gandhi, Michael G Zywiel, Nizar N Mahomed, Anthony V Perruccio","doi":"10.1155/2015/327161","DOIUrl":"https://doi.org/10.1155/2015/327161","url":null,"abstract":"The majority of patients with hip or knee osteoarthritis (OA) report one or more symptomatic joints apart from the one targeted for surgical care. Therefore, the purpose of the present study was to investigate the association between the burden of multiple symptomatic joints and self-reported depression in patients awaiting joint replacement for OA. Four hundred and seventy-five patients at a single centre were evaluated. Patients self-reported joints that were painful and/or symptomatic most days of the previous month on a homunculus, with nearly one-third of the sample reporting 6 or more painful joints. The prevalence of depression was 12.2% (58/475). When adjusted for age, sex, education level, hip or knee OA, body mass index, chronic condition count, and joint-specific WOMAC scores, each additional symptomatic joint was associated with a 19% increased odds (odds ratio: 1.19 (95% CI: 1.08, 1.31, P < 0.01)) of self-reported depression. Individuals reporting 6 or more painful joints had 2.5-fold or greater odds of depression when compared to those patients whose symptoms were limited to the surgical joint. A focus on the surgical joint alone is likely to miss a potentially important determinant of postsurgical patient-reported outcomes in patients undergoing hip or knee replacement. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"327161"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/327161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33206322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Role of Health Literacy in Self-Reported Musculoskeletal Disorders. 健康素养在自我报告的肌肉骨骼疾病中的作用。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-08-18 DOI: 10.1155/2015/607472

Catherine L Hill, Sarah L Appleton, Julie Black, Elizabeth Hoon, Rima E Rudd, Robert J Adams, Tiffany Gill

{"title":"Role of Health Literacy in Self-Reported Musculoskeletal Disorders.","authors":"Catherine L Hill, Sarah L Appleton, Julie Black, Elizabeth Hoon, Rima E Rudd, Robert J Adams, Tiffany Gill","doi":"10.1155/2015/607472","DOIUrl":"https://doi.org/10.1155/2015/607472","url":null,"abstract":"Self-report of musculoskeletal conditions is often used to estimate population prevalence and to determine disease burden and influence policy. However, self-report of certain musculoskeletal conditions is frequently inaccurate, suggesting inadequate communication to the patient of their diagnosis. The aim of this study is to determine the association between functional health literacy (FHL) and self-reported musculoskeletal conditions in a representative population survey. FHL was measured using Newest Vital Sign in 2824 randomly selected adults. Participants also self-reported medically diagnosed arthritis, gout, and osteoporosis. Multiple logistic regression was adjusted for age and sex. The prevalence of self-reported arthritis, gout, and osteoporosis was 25.2%, 4.9%, and 5.6%, respectively. The prevalence of those at risk for inadequate FHL was 24.0% and high likelihood of inadequate FHL was 21.0%. However, over 50% of respondents with arthritis or gout had at risk/inadequate FHL, increasing to 70% of those self-reporting osteoporosis. After adjustment for age and sex, respondents in the arthritis subgroup of \"don't know\" and self-reported osteoporosis were significantly more likely to have inadequate FHL than the general population. This study indicates a substantial burden of low health literacy amongst people with musculoskeletal disease. This has implications for provider-patient communication, individual healthcare, population estimates of musculoskeletal disease, and impact of public health messages. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"607472"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/607472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34164128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Relationship between Tibial Baseplate Design and Rotational Alignment Landmarks in Primary Total Knee Arthroplasty. 初次全膝关节置换术中胫骨基板设计与旋转对齐标志的关系。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-09-28 DOI: 10.1155/2015/189294

Pier Francesco Indelli, Angelo Graceffa, Andrea Baldini, Brielle Payne, Gennaro Pipino, Massimiliano Marcucci

{"title":"Relationship between Tibial Baseplate Design and Rotational Alignment Landmarks in Primary Total Knee Arthroplasty.","authors":"Pier Francesco Indelli, Angelo Graceffa, Andrea Baldini, Brielle Payne, Gennaro Pipino, Massimiliano Marcucci","doi":"10.1155/2015/189294","DOIUrl":"https://doi.org/10.1155/2015/189294","url":null,"abstract":"This study evaluated the influence of modern tibial baseplate designs when using the anterior tibial cortex as a primary rotational landmark for the tibial baseplate in TKA. Eighty patients undergoing TKA were randomized in two groups. Group 1 included 25 females and 15 males receiving a posterior-stabilized (PS) symmetric tibial baseplate while Group 2 included 24 females and 16 males receiving a PS anatomical tibial component. Identical surgical technique, including the use of the surgical transepicondylar femoral axis (sTEA) and the anterior tibial cortex (\"Curve-on-Curve\") as rotational alignment landmarks, was used. All patients underwent CT evaluation performed with the knee in full extension. Three observers independently measured the rotational alignment of the tibial component in relation to the sTEA. The rotational alignment of the symmetric baseplate showed an average external rotation of 1.3° (minimum 5°, maximum -1°): 91% of the knees showed 0 ± 3° with respect to the surgical sTEA, being internally rotated in 20%. The rotational alignment of the anatomical baseplate showed an average external rotation of 4.1° (minimum 0.4°, maximum 8.9°): only 47.5% of the knees showed 0 ± 3°, being externally rotated in 100%. The difference between the two groups was statistically significant. This study confirms the reliability of the \"Curve-on-Curve\" technique as an adequate rotational alignment anatomical landmark in TKA: the use of an asymmetric tibial baseplate might lead to external rotation of the tibial component when this technique is intraoperatively chosen. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"189294"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/189294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34278121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Adherence to methotrexate in rheumatoid arthritis: a danish nationwide cohort study. 类风湿关节炎患者坚持使用甲氨蝶呤:丹麦全国队列研究。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-02-25 DOI: 10.1155/2015/915142

Henning Bliddal, Stine A Eriksen, Robin Christensen, Tove Lorenzen, Michael S Hansen, Mikkel Østergaard, Lene Dreyer, George Luta, Peter Vestergaard

{"title":"Adherence to methotrexate in rheumatoid arthritis: a danish nationwide cohort study.","authors":"Henning Bliddal, Stine A Eriksen, Robin Christensen, Tove Lorenzen, Michael S Hansen, Mikkel Østergaard, Lene Dreyer, George Luta, Peter Vestergaard","doi":"10.1155/2015/915142","DOIUrl":"https://doi.org/10.1155/2015/915142","url":null,"abstract":"Objectives. To study adherence to methotrexate (MTX) and factors of importance thereof in patients with rheumatoid arthritis (RA). Methods. Patients with a hospital diagnosis of RA (ICD10 codes M05.X or M06.X) after January 1, 1997, and aged ≥18 years at the date of first diagnosis/contact, with at least one prescription of MTX (L04AX03), were included. Results. A total of 18,703 (47.6%) patients had ever used MTX among 39,286 with a diagnosis of RA; among the MTX users, 16,503 (88.2%) had filed more than one MTX prescription. The median time from diagnosis to first MTX prescription was 0.66 (IQR 0.26-1.80) years. In those who filed more than one MTX prescription, the mean adherence time for ≥7.5 mg MTX per week was 1,925 (IQR 467-3,056) days for patients treated in private practice versus 1,892 (IQR 452-3,316) days for patients treated in hospital. The main determinants of nonadherence were female gender, younger age, and time from diagnosis to initiation of MTX. Conclusions. Treatment at hospital or in private practice did not influence the adherence to MTX. Nonmodifiable factors of importance were gender and age, while adherence to MTX therapy decreased with time lapse between diagnosis and prescription. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"915142"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/915142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33038013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The Interchangeability of Plasma and Whole Blood Metal Ion Measurement in the Monitoring of Metal on Metal Hips. 血浆和全血金属离子测量在监测金属对金属髋关节中的互换性。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-12-20 DOI: 10.1155/2015/216785

Ibrahim A Malek, Joanne Rogers, Amanda Christina King, Juliet Clutton, Daniel Winson, Alun John

引用次数: 0

Validity and Agreement between the 28-Joint Disease Activity Score Based on C-Reactive Protein and Erythrocyte Sedimentation Rate in Patients with Rheumatoid Arthritis. 基于C反应蛋白的28种关节疾病活动评分与类风湿性关节炎患者红细胞沉降率之间的有效性和一致性。

Arthritis Pub Date : 2015-01-01 Epub Date: 2015-01-14 DOI: 10.1155/2015/401690

Louise Nielung, Robin Christensen, Bente Danneskiold-Samsøe, Henning Bliddal, Christian Cato Holm, Karen Ellegaard, Hanne Slott Jensen, Else Marie Bartels

{"title":"Validity and Agreement between the 28-Joint Disease Activity Score Based on C-Reactive Protein and Erythrocyte Sedimentation Rate in Patients with Rheumatoid Arthritis.","authors":"Louise Nielung, Robin Christensen, Bente Danneskiold-Samsøe, Henning Bliddal, Christian Cato Holm, Karen Ellegaard, Hanne Slott Jensen, Else Marie Bartels","doi":"10.1155/2015/401690","DOIUrl":"10.1155/2015/401690","url":null,"abstract":"Objective. To validate the agreement between the 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) and the 28-joint disease activity score based on C-reactive protein (DAS28-CRP) in a group of Danish patients with rheumatoid arthritis (RA). Methods. Data from 109 Danish RA patients initiating biologic treatment were analysed at baseline and following one year of treatment. Participants were retrospectively enrolled from a previous cohort study and were considered eligible for this project if CRP and ESR were measured at baseline and at the follow-up visit. To assess the extent of agreement between the two DAS28 definitions, the \"European League Against Rheumatism\" (EULAR) response criteria based on each definition were calculated with cross-classification. Weighted Kappa (κ) coefficients were calculated, and Bland-Altman plots were used to illustrate degree of agreement between DAS28 definitions. Results. The 75 eligible patients were classified as EULAR good, moderate, and nonresponders with good agreement (61/75; 81%) between DAS28-CRP and DAS28-ESR (κ = 0.75 (95% CI: 0.63 to 0.88)). Conclusions. According to our findings, DAS28-CRP and DAS28-ESR are interchangeable when assessing RA patients and the two versions of DAS28 are comparable between studies. ","PeriodicalId":89323,"journal":{"name":"Arthritis","volume":"2015 ","pages":"401690"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/401690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33012488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28