发布求助
文献互助 智能选刊 最新文献

Anti-infective agents in medicinal chemistry最新文献

筛选
英文 中文
Oxazolidinone Antibacterials and Our Experience 恶唑烷酮抗菌剂和我们的经验
Anti-infective agents in medicinal chemistry Pub Date : 2008-09-30 DOI: 10.2174/187152108785908820
Brijesh Kumar Srivastava, R. Soni, Jayendra Z. Patel, Mukul R Jain, P. Patel
{"title":"Oxazolidinone Antibacterials and Our Experience","authors":"Brijesh Kumar Srivastava, R. Soni, Jayendra Z. Patel, Mukul R Jain, P. Patel","doi":"10.2174/187152108785908820","DOIUrl":"https://doi.org/10.2174/187152108785908820","url":null,"abstract":"The Oxazolidinones are a promising novel chemical synthetic class of antibiotics identified in the last two dec- ades and have been subjected to intensive discovery efforts. They possess impressive antibacterial activity against Gram- positive pathogens. Oxazolidinones act through a unique mechanism of inhibitory bacterial protein biosynthesis. Linezolid (Zyvox TM ) has been the only drug of oxazolidinone class to reach the market after USFDA approval. Here we review our efforts directed to the discovery of novel oxazolidinone antibacterials evolved through structure-activity relationship (SAR) and an overview of contemporary on going efforts.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"121 1","pages":"258-280"},"PeriodicalIF":0.0,"publicationDate":"2008-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108785908820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Antibodies as Anti-Infective Agents in Medicinal Chemistry 抗体在药物化学中的抗感染作用
Anti-infective agents in medicinal chemistry Pub Date : 2008-09-30 DOI: 10.2174/187152108785908811
Jarbas R. Oliveira, F. B. Nunes, M. Pires, Denizar Melo, M. Donadio
{"title":"Antibodies as Anti-Infective Agents in Medicinal Chemistry","authors":"Jarbas R. Oliveira, F. B. Nunes, M. Pires, Denizar Melo, M. Donadio","doi":"10.2174/187152108785908811","DOIUrl":"https://doi.org/10.2174/187152108785908811","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"249-257"},"PeriodicalIF":0.0,"publicationDate":"2008-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108785908811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Tenofovir Disoproxil Fumarate in the Clinical Practice: An Overview 富马酸替诺福韦二吡酯的临床应用综述
Anti-infective agents in medicinal chemistry Pub Date : 2008-09-30 DOI: 10.2174/187152108785908839
M. Foggia, S. Nappa, G. Bonadies, M. Cotugno, G. D. Filippo, F. Borrelli, R. Orlando, G. Borgia
{"title":"Tenofovir Disoproxil Fumarate in the Clinical Practice: An Overview","authors":"M. Foggia, S. Nappa, G. Bonadies, M. Cotugno, G. D. Filippo, F. Borrelli, R. Orlando, G. Borgia","doi":"10.2174/187152108785908839","DOIUrl":"https://doi.org/10.2174/187152108785908839","url":null,"abstract":"Tenofovir disoproxil fumarate (tenofovir DF) is the generic name of the chemical compound 9[R(2[[bis]]isopropoxycarbonyl) oxy]methoxy]phosphonyl]methoxy]propyl] adenine fumarate (1:1), the prodrug of tenofovir, the first nucleotide analogue reverse transcriptase inhibitor approved in October 2001 by the Food and Drugs Administration in USA and then, in February 2002, by the European Medicines Evaluation Agency in Europe for the treatment of","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"285-295"},"PeriodicalIF":0.0,"publicationDate":"2008-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108785908839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Antiviral Unsaturated Nucleosides 抗病毒不饱和核苷
Anti-infective agents in medicinal chemistry Pub Date : 2008-09-30 DOI: 10.2174/187152108785908848
D. Komiotis, S. Manta, E. Tsoukala, Niki Tzioumaki
{"title":"Antiviral Unsaturated Nucleosides","authors":"D. Komiotis, S. Manta, E. Tsoukala, Niki Tzioumaki","doi":"10.2174/187152108785908848","DOIUrl":"https://doi.org/10.2174/187152108785908848","url":null,"abstract":"In the search for effective, selective and nontoxic antiviral agents, a variety of nucleoside analogues have been synthesized, with different functionalities in the carbohydrate moiety. Unsaturated nucleoside analogues are recognized as an important class of biologically active compounds and appear to be prominent drugs in the management of several viral infections, including HSV, HIV, HBV, HCV and HCMV infections. Currently, unsaturated nucleoside mimetics, such as stavudine, abacavir and entecavir have been approved for the treatment of viral infections, while elvucitabine and � -L-2� - F-d4C are in clinical trials. The purpose of this review is to give an update of the recent developments on unsaturated nu- cleoside and nucleoside analogues, in both cyclic and acyclic forms, which possess promising therapeutic potential, mainly antiviral. It covers analogues with ring sizes from three to six and provides useful data, in the aim to enhance chemical reactivity or to study the fixation of the sugar conformation.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"219-244"},"PeriodicalIF":0.0,"publicationDate":"2008-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108785908848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Multivalent Presentation Strategies in Novel Inhibitors of Bacterial (Toxin) Adhesion and Synthetic Vaccines 新型细菌(毒素)粘附抑制剂和合成疫苗的多价呈递策略
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911269
R. Pieters, R. Liskamp
{"title":"Multivalent Presentation Strategies in Novel Inhibitors of Bacterial (Toxin) Adhesion and Synthetic Vaccines","authors":"R. Pieters, R. Liskamp","doi":"10.2174/187152108784911269","DOIUrl":"https://doi.org/10.2174/187152108784911269","url":null,"abstract":"Multi-arm constructs were synthesized and used in three different contexts, all involving pathogenic bacteria. Glycodendrimers containing either the GM1os ligand or its greatly simplified relative galactose, were found to be very strong cholera toxin inhibitors, especially at higher valencies. Related glycodendrimers containing the galabiose epitope were strong inhibitors of the adhesion of the bacterial pathogen Streptococcus suis. Finally, a synthetic vaccine against Bordetella pertussis was prepared by conjugating three different relevant peptidic epitopes to a single scaffold.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"193-200"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108784911269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
HIV-1 Infection: Recent Developments in Treatment and Current Management Strategies HIV-1感染:治疗和当前管理策略的最新进展
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911296
C. Armbruster
{"title":"HIV-1 Infection: Recent Developments in Treatment and Current Management Strategies","authors":"C. Armbruster","doi":"10.2174/187152108784911296","DOIUrl":"https://doi.org/10.2174/187152108784911296","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"13 1","pages":"201-214"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108784911296","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Antimicrobial Host Defence Peptides of Human Neutrophils – Roles in Innate Immunity 人中性粒细胞抗微生物宿主防御肽-在先天免疫中的作用
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911278
Å. Björstad, K. Brown, H. Forsman, C. Dahlgren, A. Karlsson, J. Bylund
{"title":"Antimicrobial Host Defence Peptides of Human Neutrophils – Roles in Innate Immunity","authors":"Å. Björstad, K. Brown, H. Forsman, C. Dahlgren, A. Karlsson, J. Bylund","doi":"10.2174/187152108784911278","DOIUrl":"https://doi.org/10.2174/187152108784911278","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"155-168"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Anti-inflammatory Properties of Lactic Acid Bacteria: Current Knowledge,Applications and Prospects 乳酸菌的抗炎特性:现状、应用与展望
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911287
J. Leblanc, A. LeBlanc, G. Perdigón, A. Miyoshi, T. Rochat, L. Bermúdez-Humarán, P. Langella, F. Sesma, V. Azevedo
{"title":"Anti-inflammatory Properties of Lactic Acid Bacteria: Current Knowledge,Applications and Prospects","authors":"J. Leblanc, A. LeBlanc, G. Perdigón, A. Miyoshi, T. Rochat, L. Bermúdez-Humarán, P. Langella, F. Sesma, V. Azevedo","doi":"10.2174/187152108784911287","DOIUrl":"https://doi.org/10.2174/187152108784911287","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"148-154"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108784911287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Design and Synthesis of Imidazole and Benzimidazole Derivatives as Antifungal Agents 咪唑和苯并咪唑衍生物抗真菌药物的设计与合成
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911250
S. Khabnadideh, Z. Rezaei, A. Khalafi‐Nezhad, K. Pakshir, A. Roosta, Z. Baratzadeh
{"title":"Design and Synthesis of Imidazole and Benzimidazole Derivatives as Antifungal Agents","authors":"S. Khabnadideh, Z. Rezaei, A. Khalafi‐Nezhad, K. Pakshir, A. Roosta, Z. Baratzadeh","doi":"10.2174/187152108784911250","DOIUrl":"https://doi.org/10.2174/187152108784911250","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"215-218"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108784911250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Peptidoglycan Glycosyltransferase Inhibition: New Perspectives for An Old Target. 肽聚糖糖基转移酶抑制:一个老靶点的新视角。
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911241
M. Terrak
{"title":"Peptidoglycan Glycosyltransferase Inhibition: New Perspectives for An Old Target.","authors":"M. Terrak","doi":"10.2174/187152108784911241","DOIUrl":"https://doi.org/10.2174/187152108784911241","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"180-192"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108784911241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书