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Anti-infective agents in medicinal chemistry最新文献

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Targeting Bacterial Metalloenzymes: A New Strategy for the Development of Anti-Infective Agents 靶向细菌金属酶:开发抗感染药物的新策略
Anti-infective agents in medicinal chemistry Pub Date : 2008-06-30 DOI: 10.2174/187152108784911232
J. Winum, S. Köhler, A. Scozzafava, J. Montero, C. Supuran
{"title":"Targeting Bacterial Metalloenzymes: A New Strategy for the Development of Anti-Infective Agents","authors":"J. Winum, S. Köhler, A. Scozzafava, J. Montero, C. Supuran","doi":"10.2174/187152108784911232","DOIUrl":"https://doi.org/10.2174/187152108784911232","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"169-179"},"PeriodicalIF":0.0,"publicationDate":"2008-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108784911232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Celastrol and Terpenes as Anti-Infective Agents 雷公藤红素和萜烯作为抗感染剂
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954632
N. A. H. Ho
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引用次数: 4
Potential of Selected Antioxidants for Influenza Chemotherapy 选定抗氧化剂用于流感化疗的潜力
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954605
N. Uchide, H. Toyoda
{"title":"Potential of Selected Antioxidants for Influenza Chemotherapy","authors":"N. Uchide, H. Toyoda","doi":"10.2174/187152108783954605","DOIUrl":"https://doi.org/10.2174/187152108783954605","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2008-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Multi-Functional Anti-HIV Agents Based on Amino Acid Sequences Present in Serpin C-Terminal Peptides 基于蛇形蛋白c端肽氨基酸序列的多功能抗hiv药物
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954614
L. Congote
{"title":"Multi-Functional Anti-HIV Agents Based on Amino Acid Sequences Present in Serpin C-Terminal Peptides","authors":"L. Congote","doi":"10.2174/187152108783954614","DOIUrl":"https://doi.org/10.2174/187152108783954614","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"126-133"},"PeriodicalIF":0.0,"publicationDate":"2008-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108783954614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Non-Nucleoside Reverse Transcriptase Inhibitors for Anti- HIV Therapy 抗HIV治疗用非核苷类逆转录酶抑制剂的研究进展
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954597
C. Sahlberg, Xiao-Xiong Zhou
{"title":"Development of Non-Nucleoside Reverse Transcriptase Inhibitors for Anti- HIV Therapy","authors":"C. Sahlberg, Xiao-Xiong Zhou","doi":"10.2174/187152108783954597","DOIUrl":"https://doi.org/10.2174/187152108783954597","url":null,"abstract":"The NNRTIs play an important role in the present therapy against HIV/AIDS. This review discusses the basic principles in the development of NNRTIs for HIV therapy. It also summarizes the NNRTIs in clinical use and the major series of NNRTIs in development phases. The authors intend to provide an overview of the NNRTI research and to eluci- date some important factors in directing the future in the field such as genetic barrier, QD dosing, safety profile and combination with other anti-HIV agents. Despite the enormous progress that has been achieved in the NNRTI field in the past two decades, the present clinical pipeline appears to be insufficient to tackle the huge medical need. The efforts of finding new NNRTIs are certainly much motivated and can be highly rewarding.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"101-117"},"PeriodicalIF":0.0,"publicationDate":"2008-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108783954597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Fungicidal Activity of Azole Antifungal Agents 唑类抗真菌剂的杀真菌活性
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954623
L. Majoros, G. Kardos
{"title":"Fungicidal Activity of Azole Antifungal Agents","authors":"L. Majoros, G. Kardos","doi":"10.2174/187152108783954623","DOIUrl":"https://doi.org/10.2174/187152108783954623","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2008-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Genetic Determinants of Tetracycline Resistance and their Effect on Tetracycline and Glycylcycline Antibiotics 四环素耐药性的遗传决定因素及其对四环素和甘环素类抗生素的影响
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954650
C. H. Jones, E. Murphy, P. Bradford
{"title":"Genetic Determinants of Tetracycline Resistance and their Effect on Tetracycline and Glycylcycline Antibiotics","authors":"C. H. Jones, E. Murphy, P. Bradford","doi":"10.2174/187152108783954650","DOIUrl":"https://doi.org/10.2174/187152108783954650","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"84-96"},"PeriodicalIF":0.0,"publicationDate":"2008-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108783954650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Anti-Mycobacterial Activity of Quinolones. Triazoloquinolones a New Class of Potent Anti-Mycobacterial Agents 喹诺酮类药物的抗分枝杆菌活性。三唑喹诺酮类药物:一类新的强效抗分枝杆菌药物
Anti-infective agents in medicinal chemistry Pub Date : 2008-03-31 DOI: 10.2174/187152108783954641
A. Carta, S. Piras, M. Palomba, D. Jabes, P. Molicotti, S. Zanetti
{"title":"Anti-Mycobacterial Activity of Quinolones. Triazoloquinolones a New Class of Potent Anti-Mycobacterial Agents","authors":"A. Carta, S. Piras, M. Palomba, D. Jabes, P. Molicotti, S. Zanetti","doi":"10.2174/187152108783954641","DOIUrl":"https://doi.org/10.2174/187152108783954641","url":null,"abstract":"A number of novel quinolone derivatives have been recentlyreported to posses in vitro and in vivo anti mycobacterial and DNA gyrase inhibition activities. It is known that mycobacteria expressing resistance to both isoniazid and rifampin (multi-drug resistant, MDR) is sensible to fluoroquinolones. Ciprofloxacin,oxfloxacin, moxifloxacin and levofloxacin are increasingly used for the treatment of tuberculosis, because they inhibit thetopoisomerases II (DNA gyrases) and IV, essential enzymes to maintain the supercoils in bacterial DNA. It has been demonstrated that complex mutations in DNA gyrase GyrA 2 GyrB 2 associated with quinolone resistance or hypersusceptibility take place in several MDR clinical isolates of M. tuberculosis . In this article we report the anti mycobacterial properties, mode of action and structure activity relationship (SAR) studies of the known quinolone derivatives. Furthermore, we report the synthesis and activity of 3,9 disubstituted-6-oxo-6,9-dihydro- 3H -[1,2,3]triazolo[4,5- h ]quinolone carboxylic acids and their esters as a new class of potent anti mycobacterial agents. The triazoloquinolone derivatives are particularly interesting for their activity against MDR M. tuberculosis .","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"134-147"},"PeriodicalIF":0.0,"publicationDate":"2008-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108783954641","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68022039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Present and Future Treatment of Mycobacteria 分枝杆菌的现在和未来治疗
Anti-infective agents in medicinal chemistry Pub Date : 2008-01-01 DOI: 10.2174/187152108783329816
J. C. Rodríguez, I. Escribano, R. A. Gomez, E. G. Pachón, A. Navarro, G. Royo
{"title":"Present and Future Treatment of Mycobacteria","authors":"J. C. Rodríguez, I. Escribano, R. A. Gomez, E. G. Pachón, A. Navarro, G. Royo","doi":"10.2174/187152108783329816","DOIUrl":"https://doi.org/10.2174/187152108783329816","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108783329816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Mode of Inhibition of Mycobacterium tuberculosis Wild-Type and Isoniazid-Resistant 2-Trans-Enoyl-ACP(CoA) Reductase Enzymes by An Inorganic Complex 一种无机配合物抑制野生型结核分枝杆菌和耐异烟肼的2-反式烯酰acp (CoA)还原酶的模式
Anti-infective agents in medicinal chemistry Pub Date : 2008-01-01 DOI: 10.2174/187152108783329799
D. Santos, I. B. Vasconcelos, E. Meyer, F. Sales, Í. Moreira, L. A. Basso
{"title":"The Mode of Inhibition of Mycobacterium tuberculosis Wild-Type and Isoniazid-Resistant 2-Trans-Enoyl-ACP(CoA) Reductase Enzymes by An Inorganic Complex","authors":"D. Santos, I. B. Vasconcelos, E. Meyer, F. Sales, Í. Moreira, L. A. Basso","doi":"10.2174/187152108783329799","DOIUrl":"https://doi.org/10.2174/187152108783329799","url":null,"abstract":"","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"7 1","pages":"50-62"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152108783329799","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
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