Anti-infective agents in medicinal chemistry最新文献_第10页

Editorial [Chemical Evolution of Natural Product Antibiotics Guest Editor: Mark L. Nelson ] 社论[天然产物抗生素的化学演变客串编辑:Mark L. Nelson]

Anti-infective agents in medicinal chemistry Pub Date : 2006-06-30 DOI: 10.2174/187152106777697862

M. Nelson

引用次数: 0

Suitable Antibacterial Substances for the Treatment of Urinary Tract Infections 治疗尿路感染的合适抗菌物质

Anti-infective agents in medicinal chemistry Pub Date : 2006-06-30 DOI: 10.2174/187152106777697853

Florian M.E Wagenlehner and Kurt G. Naber

引用次数: 1

Mitochondrial, Metabolic and Genotoxic Effects of Antiretroviral Nucleoside Reverse-Transcriptase Inhibitors 抗逆转录病毒核苷类逆转录酶抑制剂的线粒体、代谢和基因毒性作用

Anti-infective agents in medicinal chemistry Pub Date : 2006-06-30 DOI: 10.2174/187152106777697871

Anissa Igoudjil, Karima Begriche, D. Pessayre, B. Fromenty

引用次数: 27

Antiviral Agents in the Prevention and Treatment of Virus-Induced Diabetes 抗病毒药物在预防和治疗病毒性糖尿病中的作用

Anti-infective agents in medicinal chemistry Pub Date : 2006-06-30 DOI: 10.2174/187152106777697826

A. Angelova

引用次数: 5

Structural Motifs of Lipid II-Binding Lantibiotics as a Blueprint for Novel Antibiotics 脂质ii结合抗生素的结构基序作为新型抗生素的蓝图

Anti-infective agents in medicinal chemistry Pub Date : 2006-06-30 DOI: 10.2174/187152106777697880

S. Hsu, E. Breukink, R. Kaptein

引用次数: 7

Free Radical Attack on Cholesterol: Oxysterols as Markers of Oxidative Stress and as Bioactive Molecules 自由基对胆固醇的攻击:氧甾醇作为氧化应激和生物活性分子的标记

Anti-infective agents in medicinal chemistry Pub Date : 2006-05-31 DOI: 10.2174/187152206777435618

F. Iuliano

引用次数: 8

Current Status of Target-Based Antimycobacterial Natural Products 靶向抗细菌天然产物的现状

Anti-infective agents in medicinal chemistry Pub Date : 2006-03-31 DOI: 10.2174/187152106776359011

S. Jain

引用次数: 13

Medicinal Chemistry of Ureido Derivatives as Anti-Infectives 脲醛衍生物抗感染药物化学研究

Anti-infective agents in medicinal chemistry Pub Date : 2006-03-31 DOI: 10.2174/187152106776359048

S. Batra, Z. Tusi, Sudharshan Madapa

{"title":"Medicinal Chemistry of Ureido Derivatives as Anti-Infectives","authors":"S. Batra, Z. Tusi, Sudharshan Madapa","doi":"10.2174/187152106776359048","DOIUrl":"https://doi.org/10.2174/187152106776359048","url":null,"abstract":"Ureides are compounds, which essentially incorporate urea as a substructural component either in open or cyclic form. Ureido derivatives are one of the oldest classes of bioactives, widely used as antiinfective agents. Several of these compounds, including aminoquinuride, aminocarbalide, imidurea, cloflucarban, nitrofurazone, urosulfan, viomycin are used in clinical situations. One of the ureides, the triclocarban is compulsorily used as antibacterial agent in cleansing and disinfecting solutions in hospital, household, cosmetics, toys, textile and plastics. It disables the activity of ENR, an enzyme vital for building the cell wall of the bacteria and fungus. Besides, the ureido-penicillins in clinical use there have been several ureido-lactam derivatives which have been reported to exhibit significant antibacterial activity. A urea containing dipeptide TAN-1057A isolated from Flexibacter spp. has potent bioactivity against MRSA. The metal complexes of sulphonyl ureido derivatives are effective antifungal agents by inhibiting the activity of phosphomannose isomerase, a key enzyme in the biosynthesis of yeast cell walls. There have been number of ureides including the cyclic ureas which are potent HIV protease inhibitors and display significant anti-HIV activity. The urea derivative, merimepodip that has been derived using structure based design, is potent inhibitor of IMPDH and is active against Hepatitis-C infection. This review will primarily focus on the significant work reported for this class of compounds including design, synthesis and biological activity.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"5 1","pages":"135-160"},"PeriodicalIF":0.0,"publicationDate":"2006-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152106776359048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68019782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

The Bananins: New Anticorona-RNA-Viral Agents with Unique Structural Signature 香蕉素:具有独特结构特征的新型抗冠状病毒rna试剂

Anti-infective agents in medicinal chemistry Pub Date : 2006-03-31 DOI: 10.2174/187152106776359039

A. J. Kesel

引用次数: 7

Advances in Chagas Disease Chemotherapy 恰加斯病化疗进展

Anti-infective agents in medicinal chemistry Pub Date : 2006-03-31 DOI: 10.2174/187152106776359020

P. Guedes, J. Fietto, M. Lana, M. T. Bahia

{"title":"Advances in Chagas Disease Chemotherapy","authors":"P. Guedes, J. Fietto, M. Lana, M. T. Bahia","doi":"10.2174/187152106776359020","DOIUrl":"https://doi.org/10.2174/187152106776359020","url":null,"abstract":"Chagas disease is endemic from Mexico to Argentina, where it is estimated that 16 to 18 million people are in- fected with its causative agent, Trypanosoma cruzi, and 100 million remain at risk of infection, emphasizing the necessity to sustain and extend control measures and strategies to combat this disease. Specific chemotherapy with benznidazole or nifurtimox has been recommended for treatment of recent and congenital infection. However, clinical trials with nifurti- mox and benznidazole have shown that these compounds have very low activity in preventing the development of chronic Chagas disease. Moreover, the drugs induce a number of toxic side effects. The discovery of new active, non-toxic com- pounds would probably expand treatment, including those patients in which clinical manifestations are absent or can only be disclosed by more elaborate medical procedures. Recent developments in the study of basic biochemical aspects of T. cruzi have allowed for the identification of new targets for chemotherapy. Like many fungi, T. cruzi has a strict require- ment for specific endogenous sterol synthesis for cell viability and growth and is extremely susceptible to sterol biosyn- thesis inhibitors (SBI). An intensive investigation of the potential trypanocidal effect of specific SBI has been performed, and it was demonstrated that some of these compounds exhibited suppressive and curative activity in murine and dog models of acute and chronic Chagas disease. Other potential targets for anti-T. cruzi chemotherapy that include the anti- proliferative lysophospholipid analogs (evaluated in clinical trials as the first oral treatment for visceral leishmaniasis), cysteine protease inhibitors and compounds that interfere with purine salvage and inositol metabolism are also discussed.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"5 1","pages":"175-186"},"PeriodicalIF":0.0,"publicationDate":"2006-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152106776359020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68020210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27