Anti-infective agents in medicinal chemistry最新文献_第4页

Antifungal and Antiparasitic Activities of Lactoferrin 乳铁蛋白的抗真菌和抗寄生虫活性

Anti-infective agents in medicinal chemistry Pub Date : 2009-03-31 DOI: 10.2174/187152109787846105

Loris Leboffe, F. Giansanti, G. Antonini

引用次数: 22

Molecular Mechanics Force Fields and their Applications in Drug Design 分子力学力场及其在药物设计中的应用

Anti-infective agents in medicinal chemistry Pub Date : 2009-03-31 DOI: 10.2174/187152109787846088

Raghuvir R. S. Pissurlenkar, M. Shaikh, R. Iyer, E. Coutinho

引用次数: 16

Interaction of Melittin with Phospholipid- and Lipopolysaccharide- Containing Model Membranes 蜂毒素与含磷脂和脂多糖模型膜的相互作用

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109787047797

M. Hanulová, J. Andrä, P. Garidel, C. Olak, J. Howe, S. Funari, T. Gutsmann, K. Brandenburg

{"title":"Interaction of Melittin with Phospholipid- and Lipopolysaccharide- Containing Model Membranes","authors":"M. Hanulová, J. Andrä, P. Garidel, C. Olak, J. Howe, S. Funari, T. Gutsmann, K. Brandenburg","doi":"10.2174/187152109787047797","DOIUrl":"https://doi.org/10.2174/187152109787047797","url":null,"abstract":"Up to now the details of the mechanisms of melittin action on biological bilayer model sys- tems in dependence on lipid composition, in particular on the kind of head groups, temperature, and ionic strength are not well understood. In particular, the influence of cholesterol present in most eu- caryotic cells and the influence of glycolipids present in bacterial membranes are far from being clear. Here, data are presented from investigations by small-angle X-ray scattering (SAXS), Fourier- transform infrared spectroscopy (FTIR), circular dichroism (CD) spectroscopy, Forster resonance electron transfer (FRET) spectroscopy, and calorimetric techniques (DSC: differential scanning calorimetry and ITC: isothermal titration calorimetry) on the interaction of melittin with different (glyco)lipids, in order to elucidate 1) the peptide secondary struc- ture during the melittin-lipid interaction, 2) to monitor the intercalation of the peptide into membranes, 3) to characterize the aggregate structure of the lipids, 4) to characterize the influence of lipid:melittin ratio with regard to the acyl chain melting behaviour as well as 5) to determine the peptide-lipid binding stoichiometry. These experiments are correlated with results from biological test systems, in which the inhibition of the lipopolysaccharide-induced cytokine expression in human immune cells by melittin was monitored. Furthermore, the findings are related to data found in literature with various membrane systems and different techniques. In this way, it is now possible to better understand the details of the melittin-membrane interactions, which is important with respect to the understanding of its anti-inflammatory and antimicrobial properties.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"8 1","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152109787047797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68021742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Current Status of Imaging Infections with Radiolabeled Anti-Infective Agents 放射性标记抗感染药物成像感染的现状

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109788680180

M. Welling, G. Ferro-Flores, I. Pirmettis, C. Brouwer

{"title":"Current Status of Imaging Infections with Radiolabeled Anti-Infective Agents","authors":"M. Welling, G. Ferro-Flores, I. Pirmettis, C. Brouwer","doi":"10.2174/187152109788680180","DOIUrl":"https://doi.org/10.2174/187152109788680180","url":null,"abstract":"Infection specific radiopharmaceuticals can be used for diagnosis, decision-making in therapy and treatment follow-up. Research has been ongoing to develop infection specific markers since clinically used tracers cannot discriminate between infection and inflammation. A specific radiopharmaceutical for infection imaging should satisfy the following criteria: high and specific uptake at the infection site, rapid infection detection and background clearance, minimal accumulation in non-target tissues, low toxicity, zero immune response and especially the ability to differentiate infection from sterile inflammation. Radiolabeled anti-infective agents can fulfill the majority of these requirements. Technetium-99m (99mTc) labeled antibiotics have potential to differentiate sterile inflammation from infection. There are numerous studies reporting the use of radiolabeled antibacterial and antifungal agents for infection detection. Other promising agents are antimicrobial peptides (AMPs) since they preferentially bind to bacteria membranes instead of those of mammalian cells thus distinguishing between infection and sterile inflammation. Synthetic AMPs derived from human natural peptides offers possibility for studying the effects of polymerization and substituting the amino acid sequence to design a specific micro-organism seeking tracer. 99mTc-labeled anti-infectives are ideal as infection-seeking agents because of its direct and fast accumulation. Clinical studies already undertaken and further evaluation with different pathogen types such as viruses, fungi, parasites and intracellular pathogens in humans will improve the potential of these compounds. Radiochemical techniques for labeling anti-infectives have been developed to optimize biodistribution and targeting properties of tracers. An important issue is the technetium-99m specific coordination site in the anti-infective molecule and its chemical and biochemical characterization. © 2009 Bentham Science Publishers Ltd.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"8 1","pages":"272-287"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68023372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Dendritic Compounds as Immune Response Modulators. New Approaches for Vaccine Development 树突状化合物作为免疫反应调节剂。疫苗开发的新途径

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109787047832

J. Rojo

{"title":"Dendritic Compounds as Immune Response Modulators. New Approaches for Vaccine Development","authors":"J. Rojo","doi":"10.2174/187152109787047832","DOIUrl":"https://doi.org/10.2174/187152109787047832","url":null,"abstract":"Despite several infectious diseases which have been eradicated or controlled worldwide nowa- days, there are still some infectious diseases such as AIDS, caused by HIV, which are supposed to be a se- rious social health problem and demand the search for new vaccines. A classical approach for generation of vaccines against infection was initially based on the use of killed or attenuated pathogens. With the in- crease of information about mechanisms governing immune responses after microorganism infection, new approaches have been investigated. The use of dendritic cells (DCs) pulsed with whole pathogen organ- isms has been considered and explored; however, this approach still presents serious concerns about safety issues. This fact has conducted to a \"non-classical\" approach where well defined antigens with complete control of mo- lecular design are used. Two strategies are generally envisaged. One is based on the direct stimulation of T and B-cells us- ing immunogenic peptides for producing antibodies and the other one is based on the use of antigen-pulsed dendritic cells producing both cellular and humoral response. This review will be focused on the state of the art of these new approaches for vaccine development to infectious diseases. Synthetic strategies, technical problems, and applications of multivalent dendritic systems will be described and com- mented. This is a topic of enormous interest which could open interesting alternatives and expectancy in infectious dis- eases for the development of effective therapies.","PeriodicalId":89320,"journal":{"name":"Anti-infective agents in medicinal chemistry","volume":"4 1","pages":"50-72"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187152109787047832","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68023247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Polyfunctional Antibiotics Affecting Bacterial Membrane Dynamics 影响细菌膜动力学的多功能抗生素

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109787047779

M. Nelson, Mark C. Grier, S. Barbaro, Mohamed Y. Ismail

引用次数: 22

The Use of Structure-Guided Design to Discover New Anti-Microbial Agents: Focus on Antibacterial Resistance 利用结构导向设计发现新的抗微生物药物:以抗菌药物耐药性为重点

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109787047805

P. Charifson, T. Grossman, P. Mueller

引用次数: 11

β-Lactams as Neuroprotective Agents β-内酰胺作为神经保护剂

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109787047823

M. Konaklieva, B. Plotkin, Terena Herbert

引用次数: 7

Recent Trends in Plant-Derived Antifungal Agents 植物源性抗真菌药物的最新进展

Anti-infective agents in medicinal chemistry Pub Date : 2009-01-01 DOI: 10.2174/187152109787047788

M. Shahid, A. Shahzad, T. Tripathi, F. Sobia, Aastha Sahai, Anuradha Singh, A. Malik, F. Shujatullah, H. Khan

引用次数: 12

Telbivudine for Chronic Hepatitis B. A Review 替比夫定治疗慢性乙型肝炎

Anti-infective agents in medicinal chemistry Pub Date : 2008-09-30 DOI: 10.2174/187152108785908866

E. Palumbo

引用次数: 1