BioMedical Engineering OnLine最新文献

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Human acellular amniotic membrane/polycaprolactone vascular grafts prepared by electrospinning enable vascular remodeling in vivo. 电纺丝法制备的人细胞羊膜/聚己内酯血管移植物可实现体内血管重塑。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-11-06 DOI: 10.1186/s12938-024-01302-3
Jiayi Wu, Yixin Chen, Xiaoxi Liu, Shun Liu, Long Deng, Kai Tang
{"title":"Human acellular amniotic membrane/polycaprolactone vascular grafts prepared by electrospinning enable vascular remodeling in vivo.","authors":"Jiayi Wu, Yixin Chen, Xiaoxi Liu, Shun Liu, Long Deng, Kai Tang","doi":"10.1186/s12938-024-01302-3","DOIUrl":"10.1186/s12938-024-01302-3","url":null,"abstract":"<p><strong>Background: </strong>Vascular transplantation is an effective treatment for severe vascular lesions. The design of the bioactive and mechanical properties of small-caliber vascular grafts is critical for their application in tissue engineering. In this study, we sought to develope a small-caliber vascular graft by electrospinning a mixture of a human acellular amniotic membrane (HAAM) and polycaprolactone (PCL).</p><p><strong>Results: </strong>Mechanical tests showed that the vascular grafts were strong enough to endure stress from adjacent blood vessels and blood pressure. The biocompatibility of the HAAM/PCL vascular grafts was evaluated based on cell proliferation in vitro. The tubular formation test demonstrated that vascular grafts containing HAAM could improve human umbilical vein endothelial cell function, and in vivo implantation was performed by replacing the rat abdominal aorta. The HAAM/PCL vascular graft was found to promote attachment and endothelial cell retention. The regenerated smooth muscle layer was similar to native arteries' smooth muscle layer and the endothelium coverage was complete.</p><p><strong>Conclusions: </strong>These results suggest that our constructs may be promising vascular graft candidates and can potentially be used to develop vascular grafts that can endothelialize rapidly in vivo.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"112"},"PeriodicalIF":2.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repeatability and agreement of multispectral refraction topography in school children before and after cycloplegia. 环视麻痹前后学龄儿童多光谱屈光地形图的重复性和一致性。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-11-04 DOI: 10.1186/s12938-024-01300-5
Xiaoli Xu, Wansheng Zang, Anken Wang, Chenhao Yang
{"title":"Repeatability and agreement of multispectral refraction topography in school children before and after cycloplegia.","authors":"Xiaoli Xu, Wansheng Zang, Anken Wang, Chenhao Yang","doi":"10.1186/s12938-024-01300-5","DOIUrl":"10.1186/s12938-024-01300-5","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to evaluate the repeatability and agreement of multispectral refraction topography (MRT) in measuring retinal refraction before and after cycloplegia in children. The results of this study will provide valuable insights into the accuracy and reliability of MRT as a tool for assessing retinal refraction in pediatric patients.</p><p><strong>Methods: </strong>Children aged 7 to 18 years old were recruited for this prospective research. The central and peripheral retinal refraction was measured three times using multispectral refraction topography (MRT) before and after cycloplegia. The retinal deviation value (RDV) was used to describe the average peripheral refractive error of the retina. In addition, objective refraction (OR) and subjective refraction (SR) measurements were also performed.</p><p><strong>Results: </strong>A total of 60 children with a mean age of 10.50 ± 1.81 years were enrolled. Before cycloplegia, all the central and peripheral retinal refraction parameters showed good repeatability with the lowest intraclass correlation coefficient (ICC) being 0.78 in the retinal deviation value from 45° eccentricity to 53° of the retina (RDV 45-53). After cycloplegia, the repeatability of MRT was significantly enhanced (lowest ICC = 0.91 in RDV-I). The 95% limits of agreement (LoA) of the central refraction and OR ranged from - 2.1 to 1.8 D before cycloplegia, and from - 1.69 to 0.27 D after cycloplegia. The 95% LoA of the central refraction and SR ranged from - 1.57 to 0.36 D after cycloplegia. All the 95% LoA demonstrated high agreement.</p><p><strong>Conclusions: </strong>The MRT shows high agreement with autorefractometry and experienced optometrist in measuring central refraction. Additionally, the MRT provides good repeatable measurements of retinal peripheral refraction before and after cycloplegia in schoolchildren.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"110"},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic and impedance analysis of rosemary essential oil: implications for dental health. 迷迭香精油的微流体和阻抗分析:对牙齿健康的影响。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-11-04 DOI: 10.1186/s12938-024-01301-4
Karunan Joseph, Bojan Petrović, Syarifah Aisyah Syed Ibrahim, Aung Thiha, Lazar Milić, Mohd Yazed Ahmad, Nebojša Pavlović, Sanja Kojić, Fatimah Ibrahim, Goran M Stojanović
{"title":"Microfluidic and impedance analysis of rosemary essential oil: implications for dental health.","authors":"Karunan Joseph, Bojan Petrović, Syarifah Aisyah Syed Ibrahim, Aung Thiha, Lazar Milić, Mohd Yazed Ahmad, Nebojša Pavlović, Sanja Kojić, Fatimah Ibrahim, Goran M Stojanović","doi":"10.1186/s12938-024-01301-4","DOIUrl":"10.1186/s12938-024-01301-4","url":null,"abstract":"<p><strong>Background: </strong>Oral health is closely linked to systemic conditions, particularly non-communicable diseases (NCDs), which can exacerbate oral issues. Essential oils (EOs) have emerged as potential alternatives for oral health due to their antibacterial, anti-inflammatory, and antioxidant properties. Among these, rosemary essential oil (REO) shows promise due to its various biological activities. This study investigates the potential of REO in dental applications using microfluidic devices and electrochemical impedance spectroscopy (EIS) to analyze the electrical properties of REO in artificial saliva (AS) mixtures.</p><p><strong>Results: </strong>The study demonstrated significant variations in impedance across different REO concentrations and their mixtures with AS. Higher impedance was observed in REO mixtures, particularly at lower frequencies, indicating distinct electrical properties compared to pure AS. The impedance of REO was influenced by its concentration, with a 1% REO solution showing higher impedance than a 4% solution, possibly due to micelle formation and changes in dielectric properties. Additionally, microfluidic devices enabled precise control over fluid interactions and real-time monitoring, offering valuable insights into REO's behavior in a simulated oral environment. The impedance data demonstrated significant differences in REO-AS mixtures, highlighting potential interactions critical for oral care applications.</p><p><strong>Conclusions: </strong>Rosemary essential oil exhibits unique electrical properties, making it a promising candidate for dental applications, particularly in preventing and treating oral diseases. Microfluidic devices enhance the accuracy and reliability of studying REO's interactions with AS, providing a robust platform for future dental research. The findings suggest that REO could be effectively incorporated into oral care products, offering a natural alternative for combating oral pathogens, reducing inflammation, and protecting against oxidative stress. Future research should focus on clinical trials to validate these findings and explore the synergistic effects of REO with other essential oils.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"111"},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A modified deep learning method for Alzheimer's disease detection based on the facial submicroscopic features in mice. 基于小鼠面部亚显微特征的阿尔茨海默病检测改进型深度学习方法。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-31 DOI: 10.1186/s12938-024-01305-0
Guosheng Shen, Fei Ye, Wei Cheng, Qiang Li
{"title":"A modified deep learning method for Alzheimer's disease detection based on the facial submicroscopic features in mice.","authors":"Guosheng Shen, Fei Ye, Wei Cheng, Qiang Li","doi":"10.1186/s12938-024-01305-0","DOIUrl":"10.1186/s12938-024-01305-0","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a chronic disease among people aged 65 and older. As the aging population continues to grow at a rapid pace, AD has emerged as a pressing public health issue globally. Early detection of the disease is important, because increasing evidence has illustrated that early diagnosis holds the key to effective treatment of AD. In this work, we developed and refined a multi-layer cyclic Residual convolutional neural network model, specifically tailored to identify AD-related submicroscopic characteristics in the facial images of mice. Our experiments involved classifying the mice into two distinct groups: a normal control group and an AD group. Compared with the other deep learning models, the proposed model achieved a better detection performance in the dataset of the mouse experiment. The accuracy, sensitivity, specificity and precision for AD identification with our proposed model were as high as 99.78%, 100%, 99.65% and 99.44%, respectively. Moreover, the heat maps of AD correlation in the facial images of the mice were acquired with the class activation mapping algorithm. It was proven that the facial images contained AD-related submicroscopic features. Consequently, through our mouse experiments, we validated the feasibility and accuracy of utilizing a facial image-based deep learning model for AD identification. Therefore, the present study suggests the potential of using facial images for AD detection in humans through deep learning-based methods.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"109"},"PeriodicalIF":2.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the development and application of non-contact intraoperative image access systems. 非接触式术中图像存取系统的开发和应用进展。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-30 DOI: 10.1186/s12938-024-01304-1
Zhengnan Liu, Chengrun Li, Jixing Lin, Hengliang Xu, Yan Xu, Haoning Nan, Wei Cheng, Jie Li, Bin Wang
{"title":"Advances in the development and application of non-contact intraoperative image access systems.","authors":"Zhengnan Liu, Chengrun Li, Jixing Lin, Hengliang Xu, Yan Xu, Haoning Nan, Wei Cheng, Jie Li, Bin Wang","doi":"10.1186/s12938-024-01304-1","DOIUrl":"10.1186/s12938-024-01304-1","url":null,"abstract":"<p><p>This article provides an overview of recent progress in the achievement of non-contact intraoperative image control through the use of vision and sensor technologies in operating room (OR) environments. A discussion of approaches to improving and optimizing associated technologies is also provided, together with a survey of important challenges and directions for future development aimed at improving the use of non-contact intraoperative image access systems.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"108"},"PeriodicalIF":2.9,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-supervised learning framework application for medical image analysis: a review and summary. 自监督学习框架在医学图像分析中的应用:回顾与总结。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-27 DOI: 10.1186/s12938-024-01299-9
Xiangrui Zeng, Nibras Abdullah, Putra Sumari
{"title":"Self-supervised learning framework application for medical image analysis: a review and summary.","authors":"Xiangrui Zeng, Nibras Abdullah, Putra Sumari","doi":"10.1186/s12938-024-01299-9","DOIUrl":"10.1186/s12938-024-01299-9","url":null,"abstract":"<p><p>Manual annotation of medical image datasets is labor-intensive and prone to biases. Moreover, the rate at which image data accumulates significantly outpaces the speed of manual annotation, posing a challenge to the advancement of machine learning, particularly in the realm of supervised learning. Self-supervised learning is an emerging field that capitalizes on unlabeled data for training, thereby circumventing the need for extensive manual labeling. This learning paradigm generates synthetic pseudo-labels through pretext tasks, compelling the network to acquire image representations in a pseudo-supervised manner and subsequently fine-tuning with a limited set of annotated data to achieve enhanced performance. This review begins with an overview of prevalent types and advancements in self-supervised learning, followed by an exhaustive and systematic examination of methodologies within the medical imaging domain from 2018 to September 2024. The review encompasses a range of medical image modalities, including CT, MRI, X-ray, Histology, and Ultrasound. It addresses specific tasks, such as Classification, Localization, Segmentation, Reduction of False Positives, Improvement of Model Performance, and Enhancement of Image Quality. The analysis reveals a descending order in the volume of related studies, with CT and MRI leading the list, followed by X-ray, Histology, and Ultrasound. Except for CT and MRI, there is a greater prevalence of studies focusing on contrastive learning methods over generative learning approaches. The performance of MRI/Ultrasound classification and all image types segmentation still has room for further exploration. Generally, this review can provide conceptual guidance for medical professionals to combine self-supervised learning with their research.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"107"},"PeriodicalIF":2.9,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The probability density function of the surface electromyogram and its dependence on contraction force in the vastus lateralis. 外侧肌表面肌电图的概率密度函数及其与收缩力的关系。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-26 DOI: 10.1186/s12938-024-01285-1
Javier Rodriguez-Falces, Armando Malanda, Cristina Mariscal, Silvia Recalde, Javier Navallas
{"title":"The probability density function of the surface electromyogram and its dependence on contraction force in the vastus lateralis.","authors":"Javier Rodriguez-Falces, Armando Malanda, Cristina Mariscal, Silvia Recalde, Javier Navallas","doi":"10.1186/s12938-024-01285-1","DOIUrl":"10.1186/s12938-024-01285-1","url":null,"abstract":"<p><strong>Introduction: </strong>The probability density function (PDF) of the surface electromyogram (sEMG) depends on contraction force. This dependence, however, has so far been investigated by having the subject generate force at a few fixed percentages of MVC. Here, we examined how the shape of the sEMG PDF changes with contraction force when this force was gradually increased from zero.</p><p><strong>Methods: </strong>Voluntary surface EMG signals were recorded from the vastus lateralis of healthy subjects as force was increased in a continuous manner vs. in a step-wise fashion. The sEMG filling process was examined by measuring the EMG filling factor, computed from the non-central moments of the rectified sEMG signal.</p><p><strong>Results: </strong>(1) In 84% of the subjects, as contraction force increased from 0 to 10% MVC, the sEMG PDF shape oscillated back and forth between the semi-degenerate and the Gaussian distribution. (2) The PDF-force relation varied greatly among subjects for forces between 0 and ~ 10% MVC, but this variability was largely reduced for forces above 10% MVC. (3) The pooled analysis showed that, as contraction force gradually increased, the sEMG PDF evolved rapidly from the semi-degenerate towards the Laplacian distribution from 0 to 5% MVC, and then more slowly from the Laplacian towards the Gaussian distribution for higher forces.</p><p><strong>Conclusions: </strong>The study demonstrated that the dependence of the sEMG PDF shape on contraction force can only be reliably assessed by gradually increasing force from zero, and not by performing a few constant-force contractions. The study also showed that the PDF-force relation differed greatly among individuals for contraction forces below 10% MVC, but this variability was largely reduced when force increased above 10% MVC.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"106"},"PeriodicalIF":2.9,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of stiffness-matched, 3D-printed, NiTi mandibular graft fixation in an ovine model. 在绵羊模型中评估硬度匹配的 3D 打印镍钛下颌骨移植物固定。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-26 DOI: 10.1186/s12938-024-01289-x
Nada Raafat Khattab, Luis H Olivas-Alanis, Agnieszka Chmielewska-Wysocka, Hany Emam, Ryan Brune, Ahmadreza Jahadakbar, Sahil Khambhampati, Joseph Lozier, Keyvan Safaei, Roman Skoracki, Mohammad Elahinia, David Dean
{"title":"Evaluation of stiffness-matched, 3D-printed, NiTi mandibular graft fixation in an ovine model.","authors":"Nada Raafat Khattab, Luis H Olivas-Alanis, Agnieszka Chmielewska-Wysocka, Hany Emam, Ryan Brune, Ahmadreza Jahadakbar, Sahil Khambhampati, Joseph Lozier, Keyvan Safaei, Roman Skoracki, Mohammad Elahinia, David Dean","doi":"10.1186/s12938-024-01289-x","DOIUrl":"10.1186/s12938-024-01289-x","url":null,"abstract":"<p><strong>Background: </strong>Manually bent, standard-of-care, Ti-6Al-4V, mandibular graft fixation devices are associated with a significant post-operative failure rate. These failures require the patient to endure stressful and expensive re-operation. The approach recommended in this report demonstrates the optimization of graft fixation device mechanical properties via \"stiffness-matching\" by varying the fixation device's location, shape, and material composition through simulation of the device's post-operative performance. This provides information during pre-operative planning that may avoid future device failure. Optimized performance may combine translation of all loading into compression of the bone graft with the adjacent bone segments and elimination or minimization of post-healing interruption of normal stress-strain (loading) trajectories.</p><p><strong>Results: </strong>This study reports a sheep mandibular graft model where four animals received virtually optimized, experimental nickel-titanium (NiTi) fixation plates fabricated using laser beam powder bed fusion (LPBF) additive manufacturing (AM). The last animal, our control, received a standard-of-care, manually bent, Ti-6Al-4V (aka Ti64) fixation plate. A 17.5-mm mandibular graft healed completely in all four animals receiving the experimental device. Experimental NiTi-implanted sheep experienced mandibular bone healing and restoration. The Ti64 plate, in the control animal, fractured and dislocated shortly after being implanted.</p><p><strong>Conclusion: </strong>The use of stiffness-matched implants, by means of plate material (NiTi) and geometry (porosity) enhanced bone healing and promoted better load transfer to the healed bone when compared to the bulk Ti64 found in the fixation plate that the Control animal received. The design technique and screw orientation and depth planning improved throughout the study leading to more rapid healing. The large animal model reported here provides data useful for a follow-on clinical trial.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"105"},"PeriodicalIF":2.9,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the estimation of PaCO2 from etCO2 during ventilation through non-invasive parameters in the ovine model. 在绵羊模型中,通过非侵入性参数加强通气过程中根据 etCO2 估算 PaCO2。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-24 DOI: 10.1186/s12938-024-01292-2
Mike Grüne, Lena Olivier, Valerie Pfannschmidt, Matthias Hütten, Thorsten Orlikowsky, Andre Stollenwerk, Mark Schoberer
{"title":"Enhancing the estimation of PaCO<sub>2</sub> from etCO<sub>2</sub> during ventilation through non-invasive parameters in the ovine model.","authors":"Mike Grüne, Lena Olivier, Valerie Pfannschmidt, Matthias Hütten, Thorsten Orlikowsky, Andre Stollenwerk, Mark Schoberer","doi":"10.1186/s12938-024-01292-2","DOIUrl":"10.1186/s12938-024-01292-2","url":null,"abstract":"<p><strong>Background: </strong>In mechanically ventilated neonates, the arterial partial pressure of <math><msub><mtext>CO</mtext> <mn>2</mn></msub> </math> ( <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> ) is an important indicator for the adequacy of ventilation settings. Determining the <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> is commonly done using invasive blood gas analyses, which constitute risks for neonates and are typically only available infrequently. An accurate, reliable, and continuous estimation of <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> is of high interest for medical staff, giving the possibility of a closer monitoring and faster reactions to changes. We aim to present a non-invasive estimation method for <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> in neonates on the basis of end-tidal <math><msub><mtext>CO</mtext> <mn>2</mn></msub> </math> ( <math><msub><mtext>etCO</mtext> <mn>2</mn></msub> </math> ) with inclusion of different physiological and ventilation parameters. The estimation method should be more accurate than an estimation by unaltered <math><msub><mtext>etCO</mtext> <mn>2</mn></msub> </math> measurements with regard to the mean absolute error and the standard deviation.</p><p><strong>Methods: </strong>Secondary data from 51 preterm lambs are used, due to its high comparability to preterm human data. We utilize robust linear regression on 863 <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> measurements below or equal to 75 mmHg from the first day of life. <math><msub><mtext>etCO</mtext> <mn>2</mn></msub> </math> along with a set of ventilation settings and measurements as well as vital parameters are included in the regression. Included independent variables are chosen iteratively by highest Pearson correlation to the remaining estimation deviation.</p><p><strong>Results: </strong>The evaluation is carried out on 12 additional neonatal lambs with 246 <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> measurements below or equal to 75 mmHg from the first two days of life. The estimation method shows a mean absolute error of 3.80 mmHg with a 4.92 mmHg standard deviation of differences and a standard error of 0.31 mmHg in comparison to measured <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> by blood gas analysis.</p><p><strong>Conclusions: </strong>The estimation of <math><msub><mtext>PaCO</mtext> <mn>2</mn></msub> </math> by the proposed equation is less biased than unaltered <math><msub><mtext>etCO</mtext> <mn>2</mn></msub> </math> . The usage of this method in clinical practice or in applications like the automation of ventilation needs further investigation.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"23 1","pages":"104"},"PeriodicalIF":2.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four-phase CT lesion recognition based on multi-phase information fusion framework and spatiotemporal prediction module. 基于多相信息融合框架和时空预测模块的四相 CT 病灶识别。
IF 2.9 4区 医学
BioMedical Engineering OnLine Pub Date : 2024-10-21 DOI: 10.1186/s12938-024-01297-x
Shaohua Qiao, Mengfan Xue, Yan Zuo, Jiannan Zheng, Haodong Jiang, Xiangai Zeng, Dongliang Peng
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