BioMedical Engineering OnLine最新文献

{"title":"Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects.","authors":"Jie Sun, Cao Chen, Bo Zhang, Chen Yao, Yafeng Zhang","doi":"10.1186/s12938-025-01381-w","DOIUrl":"https://doi.org/10.1186/s12938-025-01381-w","url":null,"abstract":"<p><p>The treatment of large bone defects remains a significant clinical challenge due to the limitations of current grafting techniques, including donor site morbidity, restricted availability, and suboptimal integration. Recent advances in 3D bioprinting technology have enabled the fabrication of structurally and functionally optimized scaffolds that closely mimic native bone tissue architecture. This review comprehensively examines the latest developments in 3D-printed scaffolds for bone regeneration, focusing on three critical aspects: (1) material selection and composite design encompassing metallic; (2) structural optimization with hierarchical porosity (macro/micro/nano-scale) and biomechanical properties tailored; (3) biological functionalization through growth factor delivery, cell seeding strategies and surface modifications. We critically analyze scaffold performance metrics from different research applications, while discussing current translational barriers, including vascular network establishment, mechanical stability under load-bearing conditions, and manufacturing scalability. The review concludes with a forward-looking perspective on innovative approaches such as 4D dynamic scaffolds, smart biomaterials with stimuli-responsive properties, and the integration of artificial intelligence for patient-specific design optimization. These technological advancements collectively offer unprecedented opportunities to address unmet clinical needs in complex bone reconstruction.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"51"},"PeriodicalIF":2.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of a convolutional neural network to automate radiologic scoring of computed tomography of paranasal sinuses.","authors":"Daniel J Lee, Mohammad Hamghalam, Lily Wang, Hui-Ming Lin, Errol Colak, Muhammad Mamdani, Amber L Simpson, John M Lee","doi":"10.1186/s12938-025-01376-7","DOIUrl":"https://doi.org/10.1186/s12938-025-01376-7","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is diagnosed with symptoms and objective endoscopy or computed tomography (CT). The Lund-Mackay score (LMS) is often used to determine the radiologic severity of CRS and make clinical decisions. This proof-of-concept study aimed to develop an automated algorithm combining a convolutional neural network (CNN) for sinus segmentation with post-processing to compute LMS directly from CT scans.</p><p><strong>Results: </strong>Radiology Information System was queried for outpatient paranasal sinus CTs at a tertiary institution. We identified 1,399 CT scans which were manually labelled with LMS of individual sinuses. Seventy-seven CT scans with 13,668 coronal images were segmented manually for individual sinuses. Our model for segmentation achieved a mean Dice score of 0.85 for all sinus regions, except for the osteomeatal complex. For individual Dice scores were 0.95, 0.71, 0.78, 0.93, 0.86 for the maxillary, anterior ethmoid, posterior ethmoid, sphenoid, and frontal sinuses, respectively. LMS was computed automatically by applying adaptive image thresholding and pixel counting to the CNN's segmented regions. A convolutional neural network (CNN) model was trained to segment each sinus region. Overall, the LMS model showed a high degree of accuracy with a score of 0.92, 0.99, 0.99, 0.97, 0.99, 0.86 for the maxillary, anterior ethmoid, posterior ethmoid, sphenoid, and frontal sinuses, respectively.</p><p><strong>Conclusions: </strong>Reporting of paranasal sinus CT can be automated and potentially standardized with a CNN model to provide accurate Lund-Mackay score.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"49"},"PeriodicalIF":2.9,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Alzheimer and mild cognitive impairment patients by Poincare and Entropy methods based on electroencephalography signals.","authors":"Umut Aslan, Mehmet Feyzi Akşahin","doi":"10.1186/s12938-025-01369-6","DOIUrl":"https://doi.org/10.1186/s12938-025-01369-6","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is characterized by deficits in cognition, behavior, and intellectual functioning, and Mild Cognitive Impairment (MCI) refers to individuals whose cognitive impairment deviates from what is expected for their age but does not significantly interfere with daily activities. Because there is no treatment for AD, early prediction of AD can be helpful to reducing the progression of this disease. This study examines the Electroencephalography (EEG) signal of 3 distinct groups, including AD, MCI, and healthy individuals. Recognizing the non-stationary nature of EEG signals, two nonlinear approaches, Poincare and Entropy, are employed for meaningful feature extraction. Data should be segmented into epochs to extract features from EEG signals, and feature extraction approaches should be implemented for each one. The obtained features are given to machine learning algorithms to classify the subjects. Extensive experiments were conducted to analyze the features comprehensively. The results demonstrate that our proposed method surpasses previous studies in terms of accuracy, sensitivity, and specificity, indicating its effectiveness in classifying individuals with AD, MCI, and those without cognitive impairment.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"47"},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexity of post-concussion syndrome assessment and management: a case for customizing rehabilitation.","authors":"Nicholas Moser, Milos R Popovic, Sukhvinder Kalsi-Ryan","doi":"10.1186/s12938-025-01380-x","DOIUrl":"https://doi.org/10.1186/s12938-025-01380-x","url":null,"abstract":"<p><strong>Background: </strong>Post-concussion syndrome is a challenging condition to manage for even the most experienced chronic pain experts. Patients' presentations are heterogeneous with symptoms spanning physical, cognitive and emotional domains. The symptoms reported are often non-specific, making it difficult for health professionals to prescribe effective rehabilitation. The aim of the present study was to examine the effectiveness of a customized rehabilitation program based on subgroup determination following a standardized clinical exam in adults with post-concussion syndrome.</p><p><strong>Methods: </strong>A total of 16 adults (mean age ± SD, 38.3 ± 12.5 years) with post-concussion syndrome participated in a 6-week rehabilitation program. Participants were recruited from external community concussion clinics around the greater Toronto area, Canada. Participants underwent a comprehensive standardized clinical exam to subgroup the ostensible symptom generators into either autonomic, cervical or vestibulo-ocular. Customized rehabilitation was then prescribed based on their subgroupings. The primary outcome measure was the Rivermead Post-Concussion Questionnaire (RPQ). Secondary outcome measures included the Patient Health Questionnaire-9 (PHQ-9), the Neck Disability Index (NDI), and exercise tolerance as assessed via the Buffalo Concussion Treadmill Test (BCTT).</p><p><strong>Results: </strong>Following 6 weeks of customized rehabilitation, participants on average experienced a significant and clinically meaningful change with respect to the RPQ-3 and RPQ-13 (p < 0.001). We also observed a significant change in all secondary outcome measures including a reduction in PHQ-9 (p < 0.01), NDI (p < 0.001) and exercise tolerance, expressed as heart rate threshold (p < 0.001).</p><p><strong>Conclusion: </strong>The standardized exam was feasible and useful in assisting the clinician in prescribing effective rehabilitation. The 6-week customized rehabilitation program demonstrated significant changes in patient-reported persistent post-concussion symptoms and exercise tolerance. The implementation of a customized program based on a standardized exam performed to subgroup the ostensible symptom generators may be key to successful management in this population.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"48"},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and optimization of bioengineering strategies in facilitating tendon-bone healing.","authors":"Chenhui Yang, Changshun Chen, Rongjin Chen, Fei Yang, Hefang Xiao, Bin Geng, Yayi Xia","doi":"10.1186/s12938-025-01368-7","DOIUrl":"https://doi.org/10.1186/s12938-025-01368-7","url":null,"abstract":"<p><p>Tendon-bone insertion trauma is prevalent in both rotator cuff and anterior cruciate ligament injuries, which are frequently encountered conditions in the field of sports medicine. The main treatment for such injuries is reconstructive surgery. The primary determinant impacting this process is the graft's capacity to integrate with the bone tunnel. In recent years, researchers have attempted to use a variety of methods to facilitate tendon-bone healing after reconstructive surgery. Such as the implantation of biological materials, cytokines and the local application of permanently differentiated cells from various sources. However, there are limitations to the efficacy of one therapy alone in facilitating tendon-bone healing. Therefore, researchers are trying to combine strategies to overcome this conundrum. At present, most studies are based on biomaterial combined with other therapeutic strategies for tissue repair and regeneration. Biomaterials mainly include the application of bioengineering scaffolds, hydrogels and bioabsorbable interference screws. By conducting a thorough review of relevant literature, this study provides a comprehensive overview of the present research progress in enhancing tendon-bone healing using biomaterials. Additionally, it explores the potential benefits of combining biomaterials with other approaches to promote tendon-bone healing. The ultimate goal is to offer insights for future basic research endeavors and establish a solid groundwork for advancing clinical applications in the near future.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"46"},"PeriodicalIF":2.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music interventions and obstructive sleep apnea: a brain connectivity analysis.","authors":"J Rajeswari, S Navaneethan, P Siva Satya Sreedhar, M Jagannath","doi":"10.1186/s12938-025-01382-9","DOIUrl":"https://doi.org/10.1186/s12938-025-01382-9","url":null,"abstract":"<p><strong>Background: </strong>The blockage in the upper airway that occurs, while sleeping is represented as obstructive sleep apnea (OSA). This seem to be a major issue which cause breathing difficulties also increases the risk of severe complications, such as heart attacks and strokes. Therefore, in this proposed study the impact of OSA using brain connectivity analysis under various conditions such as Neelambari, Kapi, and no music has been investigated. The electroencephalogram (EEG) recordings of twelve subjects were acquired in two different conditions, such as listening to music 1 and 2 (Neelambari and Kapi) and the absence of music. The raw EEG signals were then pre-processed using both bandpass and notch filters. Meanwhile, the EEG sub-bands were obtained using the wavelet packet decomposition (WPD) method. These sub-bands, including delta, theta, alpha, and beta, were used for brain connectivity analysis. This approach provides the visualization of frequency-specific regional brain connectivity patterns by applying Pearson Correlation to the absolute values of the detail coefficients from WPD using a graph theory metric, node strength.</p><p><strong>Results: </strong>Increased connectivity in the right hemisphere of the brain was observed among the nodes in the frontal and temporal regions (F8, FC6, and T8) when participants listened to Neelambari music (Music 1). In the beta band, the correlation values for Neelambari music ranged from a minimum of 0.943 to a maximum of 0.998. In the delta band, positive correlation values ranged from 0.945 (minimum) to 0.999 (maximum). The alpha and theta bands exhibited moderate correlations, ranging from 0.746 (minimum) to 0.996 (maximum). Compared to Kapi music, Neelambari music showed stronger neural synchronization, evidenced by consistently higher correlation values across all frequency bands. This increased connectivity suggests that Neelambari music may profoundly impact brain dynamics, potentially enhancing cognitive or physiological responses.</p><p><strong>Conclusions: </strong>In conclusion, it has been analyzed that OSA patients have positive brain connectivity while listening to music 1 (Neelambari).</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"45"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video microscopy: an old story with a bright biological future.","authors":"Léa-Isabelle Renaud, Kelliane Béland, Eric Asselin","doi":"10.1186/s12938-025-01375-8","DOIUrl":"https://doi.org/10.1186/s12938-025-01375-8","url":null,"abstract":"<p><p>Single-cell analysis is increasingly popular in the field of biology, enabling more precise analyses of heterogeneous phenomena, particularly in the fields of embryology and the study of different diseases. At the heart of this evolution is video microscopy, an ancient but revolutionary technique. From its first use on embryos, through the study of C. Elegans, with the development of algorithms for its automation, the history of video microscopy has been fascinating. Unfortunately, many unresolved issues remain, such as the sheer volume of data produced and the quality of the images taken. The aim of this review is to explore the past, present and future of this technique, which could become indispensable in recent decades, to understand cell fate and how diseases affect their destiny.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"44"},"PeriodicalIF":2.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic and metabolomic insights into neutrophil activity in COPD complicated by metabolic syndrome.","authors":"Juan Li, Xue Wu, Yufen Fu, Jiliu Liu, Yao Liu, Jiahuan Li, Bomiao Qing, Yi Zhang, Jie Gao, Xiang He, Junyi Wang, Guoping Li","doi":"10.1186/s12938-025-01378-5","DOIUrl":"https://doi.org/10.1186/s12938-025-01378-5","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic obstructive pulmonary disease (COPD) frequently coexists with metabolic syndrome (MS), compounding its impact on patients' health and quality of life. This study aimed to elucidate the immune and metabolic response characteristics in COPD patients with and without MS.</p><p><strong>Methods: </strong>A total of 11,315 COPD patients admitted to the Department of Respiratory and Critical Care Medicine at the Third People's Hospital of Chengdu between January 1, 2013, and May 1, 2023, were selected. Multivariate logistic regression was conducted to identify the risk factors for acute exacerbation of chronic obstructive pulmonary disease. Moreover, from this cohort, 30 patients (18 with COPD and 12 with COPD-MS) were recruited for a further study to investigate the underlying mechanisms of COPD and COPD-MS. Blood samples were collected from these participants to perform transcriptomic and metabolomic analyses, aiming to explore the differences in immune responses and metabolic alterations between the two groups.</p><p><strong>Results: </strong>Our findings indicate a significant enhancement of neutrophil-mediated immune responses in COPD-MS patients. Transcriptomic analysis revealed 327 differentially expressed genes (DEGs) significantly involved in neutrophil-mediated immunity. Key metabolic pathways were disrupted, with 39 differential metabolites identified. Notably, metabolites, such as L-homoarginine and diethanolamine, which were elevated in COPD-MS patients, showed strong correlations with DEGs involved in neutrophil pathways and immune checkpoint regulation. The study also found decreased levels of IL4 and IL5RA in COPD-MS patients, suggesting a shift from Th2 to Th1 inflammatory responses, potentially contributing to glucocorticoid resistance.</p><p><strong>Conclusions: </strong>COPD patients with metabolic syndrome exhibit a heightened neutrophil-mediated inflammatory response and significant metabolic disturbances, which underscores the need for precise therapeutic strategies targeting both metabolic and inflammatory pathways to improve patient outcomes and manage COPD-MS complexities effectively.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"43"},"PeriodicalIF":2.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the effect of morphology and location on hemodynamics of small aneurysms: a variable-controlled study based on two cases with tandem aneurysms.","authors":"Jun Wan, Yeqing Jiang, Ligang Xu, Qimin Zhang, Guanghu Xu, Long Yu, Xinzhuo Li, Xiaolong Zhang, Shengzhang Wang","doi":"10.1186/s12938-025-01379-4","DOIUrl":"https://doi.org/10.1186/s12938-025-01379-4","url":null,"abstract":"<p><strong>Introduction: </strong>Small aneurysms are usually treated with a flow diverter alone, without coils. However, some continue to exhibit incomplete occlusion after treatment, even after an extended period. This study aimed to investigate the effects of aneurysm morphology and location on the hemodynamic parameters related to poor outcomes.</p><p><strong>Methods: </strong>Two patients with tandem aneurysms were enrolled. Flow diverter deployment was simulated, and preoperative and postoperative hemodynamics were analyzed using computational fluid dynamics. The preoperative and postoperative hemodynamics of the actual surgical plan were simulated using finite element analysis and computational fluid dynamics. The correlation between morphology, hemodynamics, and incomplete occlusion was evaluated by calculating the hemodynamics of aneurysm models with different heights and neck widths, adjusted according to the original geometry.</p><p><strong>Results: </strong>Simulation of the actual surgical plan showed that the incompletely occluded aneurysm had a larger postoperative velocity at the sac and neck region (v_a and v_neck) and residual flow volume than the occluded aneurysm in both cases. The inflow rate (Q_inflow), inflow concentration index (ICI), v_a, and residual flow volume increased when the aneurysm neck width was expanded; with the increase in height, Q_inflow and ICI increased up to a certain point, while v_a and residual flow volume showed a decreasing trend. Aneurysms located on the superior wall of the internal carotid artery ophthalmic segment had a larger v_neck than those on the inferior wall.</p><p><strong>Conclusion: </strong>Aneurysms located on the superior wall of the internal carotid artery ophthalmic segment or with a larger neck or height present a more severe hemodynamic environment, requiring careful consideration when planning surgery. This study provides hemodynamic evidence demonstrating how morphology affects aneurysm progression.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"42"},"PeriodicalIF":2.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges.","authors":"Hui Li, Zhenhe Zhang, Jing Liu, Huiwen Wang","doi":"10.1186/s12938-025-01370-z","DOIUrl":"10.1186/s12938-025-01370-z","url":null,"abstract":"<p><p>Bone regeneration is integral to maintaining bone function and integrity in the body, as well as treating bone diseases, such as osteoporosis and defects. However, oxidative stress often poses a significant obstacle during bone regeneration, leading to cell damage, inflammatory responses, and subsequent impediment of normal bone tissue formation. Therefore, to maintain bone regeneration, antioxidant therapy is essential. Bone scaffolds, serving as a temporary support for bone tissue, can provide an ideal microenvironment for cell proliferation and differentiation, effectively promoting bone tissue formation. In recent years, with in-depth research on antioxidants and their mechanisms of action, the development and application of antioxidant bone scaffolds have shown tremendous potential. These antioxidant bone scaffolds not only promote osteogenic differentiation and angiogenesis, but also effectively inhibit the inflammatory response and osteoclast formation, significantly improving the efficiency of bone regeneration. Notably, with the rapid development of nanotechnology, nanozymes with multi-enzyme-like activities have been successfully constructed and encapsulated within bone scaffolds, leading to the proposal of multifunctional antioxidant strategies. Therefore, this review summarizes recent research progress, categorically introducing types of bone scaffolds and antioxidants, elucidating therapeutic strategies of antioxidant bone scaffolds, and identifying current challenges, aiming to provide valuable guidance for subsequent research.</p>","PeriodicalId":8927,"journal":{"name":"BioMedical Engineering OnLine","volume":"24 1","pages":"41"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}