Bioengineered最新文献_第7页

Phenolic amides (avenanthramides) in oats - an update review. 燕麦中的酚酰胺（venanthramides）--最新综述。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-01-23 DOI: 10.1080/21655979.2024.2305029

Xi Xie, Miaoyan Lin, Gengsheng Xiao, Huifan Liu, Feng Wang, Dongjie Liu, Lukai Ma, Qin Wang, Zhiyong Li

{"title":"Phenolic amides (avenanthramides) in oats - an update review.","authors":"Xi Xie, Miaoyan Lin, Gengsheng Xiao, Huifan Liu, Feng Wang, Dongjie Liu, Lukai Ma, Qin Wang, Zhiyong Li","doi":"10.1080/21655979.2024.2305029","DOIUrl":"10.1080/21655979.2024.2305029","url":null,"abstract":"Oats (Avena sativa L.) are one of the worldwide cereal crops. Avenanthramides (AVNs), the unique plant alkaloids of secondary metabolites found in oats, are nutritionally important for humans and animals. Numerous bioactivities of AVNs have been investigated and demonstrated in vivo and in vitro. Despite all these, researchers from all over the world are taking efforts to learn more knowledge about AVNs. In this work, we highlighted the recent updated findings that have increased our understanding of AVNs bioactivity, distribution, and especially the AVNs biosynthesis. Since the limits content of AVNs in oats strictly hinders the demand, understanding the mechanisms underlying AVN biosynthesis is important not only for developing a renewable, sustainable, and environmentally friendly source in both plants and microorganisms but also for designing effective strategies for enhancing their production via induction and metabolic engineering. Future directions for improving AVN production in native producers and heterologous systems for food and feed use are also discussed. This summary will provide a broad view of these specific natural products from oats.","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2305029"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10807472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139519920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retracted article: Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease. 被撤回的文章：二硝酸异山梨酯与运动训练康复相结合调动冠心病患者内皮祖细胞的机制。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2021-11-05 DOI: 10.1080/21655979.2021.2000258

Ruozhu Dai, Huilin Zhuo, Yangchun Chen, Kelian Zhang, Yongda Dong, Chengbo Chen, Wei Wang

{"title":"Retracted article: Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease.","authors":"Ruozhu Dai, Huilin Zhuo, Yangchun Chen, Kelian Zhang, Yongda Dong, Chengbo Chen, Wei Wang","doi":"10.1080/21655979.2021.2000258","DOIUrl":"10.1080/21655979.2021.2000258","url":null,"abstract":"Ruozhu Dai, Huilin Zhuo, Yangchun Chen, Kelian Zhang, Yongda Dong, Chengbo Chen and Wei Wang. Mechanism of isosorbide dinitrate combined with exercise training rehabilitation to mobilize endothelial progenitor cells in patients with coronary heart disease. Bioengineered. 2021 Nov. doi: 10.1080/21655979.2021.2000258.Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article.When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record's integrity, we are retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted.'","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":" ","pages":"2000258"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39859334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Exosome-delivered BMP-2 and polyaspartic acid promotes tendon bone healing in rotator cuff tear via Smad/RUNX2 signaling pathway. 撤回声明：外泌体递送的BMP-2和聚天冬氨酸通过Smad/RUNX2信号通路促进肩袖撕裂的肌腱骨愈合。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299604

引用次数: 0

Statement of Retraction: Long non-coding RNA DCST1-AS1/hsa-miR-582-5p/HMGB1 axis regulates colorectal cancer progression. 撤回声明：长非编码 RNA DCST1-AS1/hsa-miR-582-5p/HMGB1 轴调控结直肠癌的进展。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2023.2299524

引用次数: 0

Statement of Retraction: Propofol inhibits oxidative stress injury through the glycogen synthase kinase 3 beta/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway. 撤回声明：丙泊酚通过糖原合成酶激酶 3 beta/核因子红细胞 2 相关因子 2/血红素加氧酶 1 信号通路抑制氧化应激损伤。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299589

引用次数: 0

Genetically engineered IgG1 and nanobody oligomers acquire strong intrinsic CD40 agonism. 基因工程 IgG1 和纳米抗体寡聚体具有很强的 CD40 本征激动作用。

IF 4.9 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-01-12 DOI: 10.1080/21655979.2024.2302246

Nienke Hesen, Mohamed Anany, Andre Freidel, Mediya Baker, Daniela Siegmund, Olena Zaitseva, Harald Wajant, Isabell Lang

{"title":"Genetically engineered IgG1 and nanobody oligomers acquire strong intrinsic CD40 agonism.","authors":"Nienke Hesen, Mohamed Anany, Andre Freidel, Mediya Baker, Daniela Siegmund, Olena Zaitseva, Harald Wajant, Isabell Lang","doi":"10.1080/21655979.2024.2302246","DOIUrl":"10.1080/21655979.2024.2302246","url":null,"abstract":"Most anti-CD40 antibodies show robust agonism only upon binding to FcγR+ cells, such as B cells, macrophages, or DCs, but a few anti-CD40 antibodies display also strong intrinsic agonism dependent on the recognized epitope and/or isotype. It is worth mentioning, however, that also the anti-CD40 antibodies with intrinsic agonism can show a further increase in agonistic activity when bound by FcγR-expressing cells. Thus, conventional antibodies appear not to be sufficient to trigger the maximum possible CD40 activation independent from FcγR-binding. We proved here the hypothesis that oligomeric and oligovalent anti-CD40 antibody variants generated by genetic engineering display high intrinsic, thus FcγR-independent, agonistic activity. We generated tetra-, hexa- and dodecavalent variants of six anti-CD40 antibodies and a CD40-specific nanobody. All these oligovalent variants, even when derived of bivalent antagonistic anti-CD40 antibodies, showed strongly enhanced CD40 agonism compared to their conventional counterparts. In most cases, the CD40 agonism reached the maximum response induced by FcγR-bound anti-CD40 antibodies or membrane CD40L, the natural engager of CD40. In sum, our data show that increasing the valency of anti-CD40 antibody constructs by genetic engineering regularly results in molecules with high intrinsic agonism and level out the specific limitations of the parental antibodies.","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2302246"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139429538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: The mechanism of α2-macroglobulin against oxidative stress and promoting cell proliferation in intervertebral disc degeneration. 撤回声明：α2-巨球蛋白在椎间盘退变中抗氧化应激和促进细胞增殖的机制。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-01 DOI: 10.1080/21655979.2024.2302658

引用次数: 0

Exploring biorefinery alternatives for biowaste valorization: a techno-economic assessment of enzymatic hydrolysis coupled with anaerobic digestion or solid-state fermentation for high-value bioproducts. 探索生物废弃物价值化的生物精炼替代方案：对酶水解与厌氧消化或固态发酵相结合生产高价值生物产品的技术经济评估。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-01-24 DOI: 10.1080/21655979.2024.2307668

Esther Molina-Peñate, Adriana Artola, Antoni Sánchez

{"title":"Exploring biorefinery alternatives for biowaste valorization: a techno-economic assessment of enzymatic hydrolysis coupled with anaerobic digestion or solid-state fermentation for high-value bioproducts.","authors":"Esther Molina-Peñate, Adriana Artola, Antoni Sánchez","doi":"10.1080/21655979.2024.2307668","DOIUrl":"10.1080/21655979.2024.2307668","url":null,"abstract":"Enzymatic hydrolysis of organic waste is gaining relevance as a complementary technology to conventional biological treatments. Moreover, biorefineries are emerging as a sustainable scenario to integrate waste valorization and high-value bioproducts production. However, their application on municipal solid waste is still limited. This study systematically evaluates the techno-economic feasibility of the conversion of the organic fraction of municipal solid waste (OFMSW) into high-value bioproducts through enzymatic hydrolysis. Two key variables are examined: (a) the source of the enzymes: commercial or on-site produced using OFMSW, and (b) the treatment of the solid hydrolyzate fraction: solid-state fermentation (SSF) for the production of biopesticides or anaerobic digestion for the production of energy. As a result, four different biorefinery scenarios are generated and compared in terms of profitability. Results showed that the most profitable scenario was to produce enzymes on-site and valorize the solid fraction via SSF, with an internal rate of return of 13%. This scenario led to higher profit margins (74%) and a reduced payback time (6 years), in contrast with commercial enzymes that led to an unprofitable biorefinery. Also, the simultaneous production of higher-value bioproducts and energy reduced the economic dependence of OFMSW treatment on policy instruments while remaining energetically self-sufficient. The profitability of the biorefinery scenarios evaluated was heavily dependent on the enzyme price and the efficiency of the anaerobic digestion process, highlighting the importance of cost-efficient enzyme production alternatives and high-quality OFMSW. This paper contributes to understanding the potential role of enzymes in future OFMSW biorefineries and offers economical insights on different configurations.","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2307668"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Protective effects of ulinastatin on rats with acute lung injury induced by lipopolysaccharide. 撤回声明：乌利那他汀对脂多糖诱发急性肺损伤大鼠的保护作用

IF 4.9 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-01-25 DOI: 10.1080/21655979.2024.2302647

引用次数: 0

Retracted article: Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p. 被撤回的文章：敲除长非编码RNA AGAP2-AS1通过靶向microRNA-497-5p抑制胶质瘤的增殖和转移

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2021-10-28 DOI: 10.1080/21655979.2021.1995573

Yi Sun, Yulong Shen, Xing Li

引用次数: 0