Bioengineered最新文献_第8页

Statement of Retraction: Long non-coding RNA placentaspecific protein 2 regulates micorRNA-19a/tumor necrosis factor α to participate in polycystic ovary syndrome. 撤回声明：长非编码RNA胎盘特异性蛋白2调控micorRNA-19a/肿瘤坏死因子α参与多囊卵巢综合征的研究

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299562

引用次数: 0

Statement of Retraction: microRNA-10a-5p from gastric cancer cell-derived exosomes enhances viability and migration of human umbilical vein endothelial cells by targeting zinc finger MYND-type containing 11. 撤回声明：胃癌细胞衍生外泌体中的microRNA-10a-5p通过靶向含锌手指MYND型11增强人脐静脉内皮细胞的活力和迁移。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299590

引用次数: 0

Statement of Retraction: miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury. 撤稿声明：在 I 型糖尿病肾病小鼠模型中，miR-188-3p 通过引发线粒体损伤取消了胚芽鞘介导的荚膜细胞保护作用。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299558

引用次数: 0

Statement of Retraction: The myocardial infarction-associated transcript 2 inhibits lipid accumulation and promotes cholesterol efflux in oxidized low-density lipoprotein-induced THP-1-derived macrophages via inhibiting mitogen-activated protein kinase signaling and activating the nuclear factor erythroid-related factor 2 signaling pathway. 撤回声明：心肌梗死相关转录本 2 通过抑制丝裂原活化蛋白激酶信号传导和激活核因子红细胞相关因子 2 信号传导途径，抑制氧化低密度脂蛋白诱导的 THP-1 衍生巨噬细胞中的脂质积累并促进胆固醇外流。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299617

引用次数: 0

miR-148-3p inhibits gastric cancer cell malignant phenotypes and chemotherapy resistance by targeting Bcl2. miR-148-3p 通过靶向 Bcl2 抑制胃癌细胞的恶性表型和化疗耐药性。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2021-11-16 DOI: 10.1080/21655979.2021.2005742

Hongyan Zhang, Feng Liang, Fei Wang, Qianru Xu, Yuxuan Qiu, Xin Lu, Lin Jiang, Kaiyu Jian

{"title":"miR-148-3p inhibits gastric cancer cell malignant phenotypes and chemotherapy resistance by targeting Bcl2.","authors":"Hongyan Zhang, Feng Liang, Fei Wang, Qianru Xu, Yuxuan Qiu, Xin Lu, Lin Jiang, Kaiyu Jian","doi":"10.1080/21655979.2021.2005742","DOIUrl":"10.1080/21655979.2021.2005742","url":null,"abstract":"Gastric cancer (GC) is the fourth most common cancer in the world. This work was designed to explore the biological effects of miR-148-3p on GC. Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) was utilized to analyze the mRNA expression of miR-148-3p in GC cell lines. The mimics and inhibitors of miR-148-3p were carefully transfected into GC cells to up-regulate or down-regulate miR-148-3p expression. Observe the effect on miR-148-3p expression change to GC cell proliferation, colony formation, tumorigenesis, chemotherapy sensitivity, transwell migration, and invasion. Use online database tool to predict the miR-148-3p promising targets, and can be verified via RT-qPCR, Western blot, and luciferase report. We found that miR-148-3p expression level in GC cells was markedly down-regulated (P < 0.05), as compared with human normal gastric mucosal cells GES-1. Otherwise, miR-148-3p overexpression could effectively inhibit the cell proliferation, cell cycle progress, colony formation, anti-apoptosis, anti-migration and anti-invasion in gastric cancer cells, whereas miR-148-3p inhibition exhibited the opposite phenomenon (P < 0.05). Further research revealed that Bcl2 set as a direct downstream target of miR-148-3p. Our study firstly confirmed that, miR-148-3p might play a crucial role in tumorigenesis, as well as development of gastric cancer by targeting Bcl2, and could become a promising target for gastric cancer treatment.","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":" ","pages":"2005742"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39895119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Long noncoding RNA UBA6-AS1 inhibits the malignancy of ovarian cancer cells via suppressing the decay of UBA6 mRNA. 撤回声明：长非编码 RNA UBA6-AS1 通过抑制 UBA6 mRNA 的衰变抑制卵巢癌细胞的恶性程度。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/21655979.2024.2299622

引用次数: 0

Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line. 高转移性肝癌细胞系的建立和特征描述。

IF 4.9 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-01-07 DOI: 10.1080/21655979.2023.2296775

Jiacheng Huang, Mengqing Sun, Menglan Wang, Anning Yu, Huilin Zheng, Chiwen Bu, Jie Zhou, Yu Zhang, Yiting Qiao, Zhenhua Hu

{"title":"Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line.","authors":"Jiacheng Huang, Mengqing Sun, Menglan Wang, Anning Yu, Huilin Zheng, Chiwen Bu, Jie Zhou, Yu Zhang, Yiting Qiao, Zhenhua Hu","doi":"10.1080/21655979.2023.2296775","DOIUrl":"10.1080/21655979.2023.2296775","url":null,"abstract":"The prevalence of alcohol-related hepatocellular carcinoma (HCC) has been increasing during the last decade. Cancer research requires cell lines suitable for both in vitro and in vivo assays. However, there is a lack of cell lines with a high in vivo metastatic capacity for this HCC subtype. Herein, a new HCC cell line was established, named HCC-ZJ, using cells from a patient diagnosed with alcohol-related HCC. The karyotype of HCC-ZJ was 46, XY, del (p11.2). Whole-exome sequencing identified several genetic variations in HCC-Z that occur frequently in alcohol-associated HCC, such as mutations in TERT, CTNNB1, ARID1A, CDKN2A, SMARCA2, and HGF. Cell counting kit-8 assays, colony formation assays, and Transwell assays were performed to evaluate the proliferation, migration, and sensitivity to sorafenib and lenvatinib of HCC-Z in vitro. HCC-ZJ showed a robust proliferation rate, a weak foci-forming ability, a strong migration capacity, and a moderate invasion tendency in vitro. Finally, the tumorigenicity and metastatic capacity of HCC-Z were evaluated using a subcutaneous xenograft model, an orthotopic xenograft model, and a tail-veil injection model. HCCZJ exhibited strong tumorigenicity in the subcutaneous xenograft and orthotopic tumor models. Moreover, HCC-ZJ spontaneously formed pulmonary metastases in the orthotopic tumor model. In summary, a new HCC cell line derived from a patient with alcohol-related HCC was established, which showed a high metastatic capacity and could be applied for in vitro and in vivo experiments during pre-clinical research.Highlights• An alcohol-related HCC cell line, HCC-ZJ, was established• HCC-ZJ was applicable for in vitro functional experiment and gene editing• HCC-ZJ was applicable for in vivo tumor growth and spontaneous metastasis models.","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2296775"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10773622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large intestinal nutritional and physicochemical parameters from different dog sizes reshape canine microbiota structure and functions in vitro. 不同体型犬的大肠营养和理化参数在体外重塑了犬微生物群的结构和功能。

IF 4.9 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-03-12 DOI: 10.1080/21655979.2024.2325713

Charlotte Deschamps, Delphine Humbert, Sandrine Chalancon, Caroline Achard, Emmanuelle Apper, Sylvain Denis, Stéphanie Blanquet-Diot

{"title":"Large intestinal nutritional and physicochemical parameters from different dog sizes reshape canine microbiota structure and functions in vitro.","authors":"Charlotte Deschamps, Delphine Humbert, Sandrine Chalancon, Caroline Achard, Emmanuelle Apper, Sylvain Denis, Stéphanie Blanquet-Diot","doi":"10.1080/21655979.2024.2325713","DOIUrl":"10.1080/21655979.2024.2325713","url":null,"abstract":"Different dog sizes are associated with variations in large intestinal physiology including gut microbiota, which plays a key role in animal health. This study aims to evaluate, using the CANIM-ARCOL (Canine Mucosal Artificial Colon), the relative importance of gut microbes versus physicochemical and nutritional parameters of the canine colonic environment in shaping microbiota structure and functions. CANIM-ARCOL was set up to reproduce nutrient availability, bile acid profiles, colonic pH, and transit time from small, medium, or large dogs according to in vivo data, while bioreactors were all inoculated with a fecal sample collected from medium size dogs (n = 2). Applying different dog size parameters resulted in a positive association between size and gas or SCFA production, as well as distinct microbiota profiles as revealed by 16S Metabarcoding. Comparisons with in vivo data from canine stools and previous in vitro results obtained when CANIM-ARCOL was inoculated with fecal samples from three dog sizes revealed that environmental colonic parameters were sufficient to drive microbiota functions. However, size-related fecal microbes were necessary to accurately reproduce in vitro the colonic ecosystem of small, medium, and large dogs. For the first time, this study provides mechanistic insights on which parameters from colonic ecosystem mainly drive canine microbiota in relation to dog size. The CANIM-ARCOL can be used as a relevant in vitro platform to unravel interactions between food or pharma compounds and canine colonic microbiota, under different dog size conditions. The potential of the model will be extended soon to diseased situations (e.g. chronic enteropathies or obesity).","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2325713"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensor in smart food traceability system for food safety and security. 用于食品安全和安保的智能食品溯源系统中的生物传感器。

IF 4.9 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-02-01 DOI: 10.1080/21655979.2024.2310908

Catarina Meliana, Jingjing Liu, Pau Loke Show, Sze Shin Low

{"title":"Biosensor in smart food traceability system for food safety and security.","authors":"Catarina Meliana, Jingjing Liu, Pau Loke Show, Sze Shin Low","doi":"10.1080/21655979.2024.2310908","DOIUrl":"10.1080/21655979.2024.2310908","url":null,"abstract":"The burden of food contamination and food wastage has significantly contributed to the increased prevalence of foodborne disease and food insecurity all over the world. Due to this, there is an urgent need to develop a smarter food traceability system. Recent advancements in biosensors that are easy-to-use, rapid yet selective, sensitive, and cost-effective have shown great promise to meet the critical demand for onsite and immediate diagnosis and treatment of food safety and quality control (i.e. point-of-care technology). This review article focuses on the recent development of different biosensors for food safety and quality monitoring. In general, the application of biosensors in agriculture (i.e. pre-harvest stage) for early detection and routine control of plant infections or stress is discussed. Afterward, a more detailed advancement of biosensors in the past five years within the food supply chain (i.e. post-harvest stage) to detect different types of food contaminants and smart food packaging is highlighted. A section that discusses perspectives for the development of biosensors in the future is also mentioned.","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2310908"},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10841032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher's Note. 出版商的注意。

IF 4.2 4区生物学

Bioengineered Pub Date : 2024-12-01 Epub Date: 2024-03-01 DOI: 10.1080/21655979.2024.2326360

引用次数: 0