Bioengineered最新文献

{"title":"Statement of Retraction: Yin Yang 1 (YY1)-induced long intergenic non-protein coding RNA 472 (LINC00472) aggravates sepsis-associated cardiac dysfunction via the micro-RNA-335-3p (miR-335-3p)/Monoamine oxidase A (MAOA) cascade.","authors":"","doi":"10.1080/21655979.2024.2299616","DOIUrl":"10.1080/21655979.2024.2299616","url":null,"abstract":"","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"15 1","pages":"2299616"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139904977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial-mesenchymal transition.","authors":"","doi":"10.1080/21655979.2024.2401722","DOIUrl":"https://doi.org/10.1080/21655979.2024.2401722","url":null,"abstract":"","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"4 1","pages":"2401722"},"PeriodicalIF":4.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142203970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: MYCN contributes to the sensitization of acute myelogenous leukemia cells to cisplatin by targeting SRY-box transcription factor 4","authors":"","doi":"10.1080/21655979.2024.2340165","DOIUrl":"https://doi.org/10.1080/21655979.2024.2340165","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"21 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel","authors":"","doi":"10.1080/21655979.2024.2302646","DOIUrl":"https://doi.org/10.1080/21655979.2024.2302646","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"142 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p","authors":"","doi":"10.1080/21655979.2024.2299547","DOIUrl":"https://doi.org/10.1080/21655979.2024.2299547","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"179 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: F-box and WD repeat domain-containing 7 (FBXW7) mediates the hypoxia inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway to affect hypoxic-ischemic brain damage in neonatal rats","authors":"","doi":"10.1080/21655979.2024.2299599","DOIUrl":"https://doi.org/10.1080/21655979.2024.2299599","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"41 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway","authors":"","doi":"10.1080/21655979.2024.2299577","DOIUrl":"https://doi.org/10.1080/21655979.2024.2299577","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"310 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139923559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: miR-134-5p promotes inflammation and apoptosis of trophoblast cells via regulating FOXP2 transcription in gestational diabetes mellitus","authors":"","doi":"10.1080/21655979.2024.2299586","DOIUrl":"https://doi.org/10.1080/21655979.2024.2299586","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"6 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139967745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer","authors":"","doi":"10.1080/21655979.2024.2302649","DOIUrl":"https://doi.org/10.1080/21655979.2024.2302649","url":null,"abstract":"Published in Bioengineered (Vol. 15, No. 1, 2024)","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"29 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139579050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GXMR-CAR containing distinct GXM-specific single-chain variable fragment (scFv) mediated the cell activation against <i>Cryptococcus</i> spp. And had difference in the strength of tonic signaling.","authors":"Michele Procópio Machado, Matheus Henrique Dos Santos, Júlia Garcia Guimarães, Gabriela Yamazaki de Campos, Patrícia Kellen Martins Oliveira Brito, Camilly Melo Garcia Ferreira, Caroline Patini Rezende, Natália Fernandes Frota, Sandro Gomes Soares, Pappanaicken R Kumaresan, Marcos Roberto Lourenzoni, Thiago Aparecido da Silva","doi":"10.1080/21655979.2023.2281059","DOIUrl":"10.1080/21655979.2023.2281059","url":null,"abstract":"<p><p><i>Cryptococcus</i> spp. has a polysaccharide capsule composed of glucuronoxylomannan-GXM, a major virulence factor that can prevent the recognition of fungi by immune cells. Chimeric Antigen Receptor (CAR) redirects T cells to target <i>Cryptococcus</i> spp. as previously demonstrated by a CAR specific to GXM, GXMR-CAR. The current study evaluated the strength of the signal transduction triggered by GXMR-CAR, composed of a distinct antigen-binding domain sourced from a single-chain variable fragment (scFv). GXM-specific scFv derived from mAbs 2H1 and 18B7, 2H1-GXMR-CAR and 18B7-GXMR-CAR, respectively, were designed to express CD8 molecule as hinge/transmembrane, and the costimulatory molecule CD137 (4-1BB) coupled to CD3ζ. The 2H1-GXMR-CAR or 18B7-GXMR-CAR Jurkat cells recognized soluble GXM from C. gattii and C. neoformans, and the levels of IL-2 released by the modified cells did not differ between the GXMR-CAR constructs after exposure to <i>Cryptococcus</i> spp. 18B7-GXMR-CAR triggered tonic signaling was more pronounced in modified Jurkat cells, and a protein kinase inhibitor of the Src family (dasatinib) significantly reduced GXMR-CAR tonic signaling and inhibited cell activation against ligands. 18B7 scFv showed a structural modification of the variable heavy (VH) chain that clarified the difference in the strength of tonic signaling and the level of cell activation between 2H1-GXMR-CAR and 18B7-GXMR-CAR. GXMR-CAR constructs induced T-cell activation against clinical isolates of <i>Cryptococcus</i> spp. and serum from patients with cryptococcosis induced high levels of IL-2, mainly in cells modified with 18B7-GXMR-CAR. Thus, 18B7-GXMR-CAR and 2H1-GXMR-CAR mediated T cell activation against Cryptococcus spp. and 18B7 and 2H1 scFv influenced the strength of tonic signaling.</p>","PeriodicalId":8919,"journal":{"name":"Bioengineered","volume":"14 1","pages":"2281059"},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136396055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}